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Dr. Pyrsopoulos has assembled the top authors in the field to provide current reviews on acute liver failure, to be the first time this topic is addressed in one volume. Topics are devoted to Classification and Epidemiologic Aspects of Acute Liver Failure; Acute Liver Failure: Mechanisms of disease and multi-systemic involvement; The Pathology of Acute Liver Failure; Liver Regeneration in the Acute Liver Failure Patient; Viral Hepatitis and Acute Liver Failure: Still a Problem; Drug- induced Liver Injury and Acute Liver Failure; Acetaminophen and Acute Liver Failure; Non-Viral Or Drug-Induced Etiologies of Acute Liver Failure; The Clinical Spectrum and Manifestations of Acute Liver Failure; Non ICU Management of Acute Liver Failure; Management of Acute Liver Failure in the ICU Setting; Prognostic Models of Acute Liver Failure; The Role of Liver Transplantation in Acute Liver Failure; and Future Approaches and Therapeutic Modalities for Acute Liver Failure. Readers will come away with a current point of view about how to approach and manage the patient with acute liver failure.

The recently published article “The Burden of Liver Disease in Europe: A Review of Available Epidemiological Data” provides a few figures on the enormous problem that liver disease poses for Europeans. Liver disease is estimated to cause 170,000 deaths annually in Europe, 47,000 of which are attributed to liver cancer; 0.5%-0.7% of the European population is affected by chronic hepatitis B; and prevalence rates of hepatitis C virus (HCV) infection in the last decade in the European population ranged from 0.13 to 3.26%. These HCV-infected populations will develop complications in the years to come. It is of great concern that about 90% of people in Europe infected by viral hepatitis are unaware of their status. Alcoholic and non-alcoholic fatty liver disease (NAFLD) must also be added to the picture. NAFLD is becoming a major concern with the increasing incidence of obesity and type 2 diabetes in Europe. The burden of liver disease is not less pessimistic in North America, Asia and the rest of the world. The neurological complications associated with liver failure are an unsolved problem in clinical practice. Little is known about the mechanisms that underlay their development. This book assembles an internationally recognized array of contributors that address the most important issues associated with this pathology. The book comprises fourteen chapters divided into two sections. The first section is devoted to the complications of liver failure and orthotopic liver transplantation. The second section focuses on the most recent and emerging therapies for liver disease and its complications: the new pharmacological arsenal for hepatitis B and C, cell-free and bioartificial liver support systems, hepatocyte and stem cell therapy, and novel approaches to prevent parenteral nutrition-associated liver failure in children among them.

Dans l'histoire de la réanimation, la réanimation hépatosplanchnique est un domaine de développement récent. Les concepts physiopathologiques et les thérapeutiques sont en effet en pleine mutation. Divisé en trois parties, l'ouvrage présente tout d'abord les différentes formes de l'insuffisance hépatocellulaire et les principes de leur prise en charge. Il fait ensuite le point sur les cirrhoses du foie, avant d'approfondir la réanimation du territoire hépatosplanchnique. Les questions cliniques quotidiennes sont bien entendu abordées, sans que soient négligés les concepts théoriques, allant de la prévention des hémorragies digestives en réanimation ou de la prise en charge des complications digestives en oncohématologie jusqu'aux concepts les plus récents sur la translocation bactérienne ou les concepts d'hémodynamique splanchnique. Cet ouvrage, signé par des experts français et internationaux, s'attache à démontrer l'importance des avancées obtenues ces vingt dernières années dans la prise en charge des maladies graves du foie et de la circulation splanchnique. Il est aussi l'illustration de leurs limites et des progrès restant à faire pour obtenir de réelles avancées thérapeutiques. À l'interface de plusieurs disciplines, Réanimation hépatosplanchnique intéressera donc non seulement les réanimateurs dans leur ensemble – médicaux, chirurgicaux ou spécialisés en chirurgie cardiothoracique –, mais aussi les hépato-gastroentérologues, les oncologues et infectiologues.Toute l'importance des avancées obtenues ces vingt dernières années dans la prise en charge des maladies graves du foie et de la circulation splanchnique. - Les différentes formes de l'insuffisance hépatocellulaire et les principes de leur prise en charge - Le point sur les cirrhoses du foie - La réanimation du territoire hépatosplanchnique

Chronic liver failure is a frequent condition in clinical practice that encompasses all manifestations of patients with end-stage liver diseases. Chronic liver failure is a multiorgan syndrome that affects the liver, kidneys, brain, heart, lungs, adrenal glands, and vascular, coagulation, and immune systems. Chronic Liver Failure: Mechanisms and Management covers for the first time all aspects of chronic liver failure in a single book, from pathogenesis to current management. Each chapter is written by a worldwide known expert in their area and all provide the latest state-of-the-art knowledge. This volume is specifically designed to provide answers to clinical questions to all doctors dealing with patients with liver diseases, not only clinical gastroenterologists and hepatologists, but also to internists, nephrologists, intensive care physicians, and transplant surgeons.