Search

BACKGROUND: Valacyclovir is the only treatment demonstrated to be effective for the prevention of vertical transmission of cytomegalovirus within a clinical randomized, placebo-controlled trial and has been reimbursed by the Italian National Health System since December 2020. OBJECTIVE: This study reported the results of a real-life Italian multicenter observational study on cytomegalovirus infection in pregnancy evaluating the effect of the introduction of valacyclovir in the clinical practice for the prevention of vertical transmission of cytomegalovirus. STUDY DESIGN: The outcomes of women who received valacyclovir treatment and their fetuses or newborns were compared with those of a retrospective cohort observed between 2010 and 2020 who did not receive the antiviral treatment. The inclusion criterion was the diagnosis of cytomegalovirus primary infection occurring in the periconceptional period or up to 24 weeks of gestation. The primary outcome was the transmission by the time of amniocentesis. The secondary outcomes were termination of pregnancy, transmission at birth, symptomatic infection at birth, and a composite outcome (termination of pregnancy or transmission at birth). RESULTS: A total of 447 pregnant women from 10 centers were enrolled, 205 women treated with valacyclovir (called the valacyclovir group, including 1 twin pregnancy) and 242 women not treated with valacyclovir (called the no-valacyclovir group, including 2 twin pregnancies). Valacyclovir treatment was significantly associated with a reduction of the diagnosis of congenital cytomegalovirus infection by the time of amniocentesis (weighted odds ratio, 0.39; 90% confidence interval, 0.22–0.68; P=.005; relative reduction of 61%), termination of pregnancy (weighted odds ratio, 0.36; 90% confidence interval, 0.17–0.75; P=.0021; relative reduction of 64%), symptomatic congenital cytomegalovirus infection at birth (weighted odds ratio, 0.17; 90% confidence interval, 0.06–0.49; P=.006; relative re

Jupiter's moon Europa has a subsurface ocean beneath an icy crust. Conditions within the ocean are unknown, and it is unclear whether it is connected to the surface. We observed Europa with the James Webb Space Telescope (JWST) to search for active release of material by probing its surface and atmosphere. A search for plumes yielded no detection of water, carbon monoxide, methanol, ethane, or methane fluorescence emissions. Four spectral features of carbon dioxide (CO2) ice were detected; their spectral shapes and distribution across Europa's surface indicate that the CO2 is mixed with other compounds and concentrated in Tara Regio. The 13CO2 absorption is consistent with an isotopic ratio of 12C/13C = 83 ± 19. We interpret these observations as indicating that carbon is sourced from within Europa., QC 20231003

The Solar Occultation (SO) channel of the Nadir and Occultation for Mars Discovery (NOMAD) instrument has been scanning the Martian atmosphere for almost 2 Martian years. In this work, we present a subset of the NOMAD SO data measured at the mesosphere at the terminator. From the data set, we investigated 968 vertical profiles of carbon dioxide density and temperature covering the Martian Year (MY) 35 as well as MY 36 up to a solar longitude (Ls) of 135° and altitudes around 60–100 km. While carbon dioxide density profiles are directly retrieved from the spectral signature in the spectra, temperature profiles are more challenging to retrieve as unlike density profiles, temperature profiles can present some spurious features if the regularization is not correctly managed. Comparing seven regularization methods, we found that the expected error estimation method provides the best regularization parameters. The vertical resolution of the profiles is on average 1.6 km. Numerous warm layers and cold pockets appear in this data set. The warm layers are found in the Northern hemisphere at dawn and dusk as well as in the Southern hemisphere at dawn. Strong warm layers are present in more than 13.5% of the profiles. The Southern hemisphere at dusk does not present any warm layer between Ls 50° and 150°. The height and latitudinal distribution of those warm layers were similar in MY 35 and MY 36 during the first half of the year (Ls = 0°–135°). © 2023. The Authors.

The Solar Occultation (SO) channel of the Nadir and Occultation for Mars Discovery (NOMAD) instrument scans the Martian atmosphere since 21 April 2018. In this work, we present a subset of the NOMAD SO data measured at the mesosphere. We focused on a spectral range that started to be recorded in Martian year (MY) 35. A total of 968 vertical profiles of carbon dioxide density and temperature covering MY 35 and the beginning of MY 36 were investigated until 135° of solar longitude. We compared 47 profiles with co-located profiles of the Mars Climate Sounder onboard the Mars Reconnaissance Orbiter. Most profiles show a good agreement as SO temperatures are only 1.8 K higher, but some biases lead to an average absolute difference of 7.4°K. The SO data set is also compared with simulations from the Global Environmental Multiscale-Mars general circulation model. Both data sets are in good agreement except for the presence of a cold layer in the winter hemisphere and a warm layer at dawn in the Northern hemisphere for solar longitudes between 240° and 360°. Five profiles contain temperatures lower than the limit for CO2 condensation. Strong warm layers were found in 13.5% of the profiles. They are present mainly at dawn and in the winter hemisphere, while the Northern dusks appear featureless. The data set mainly covers high latitudes around 60° and we derived some non-migrating tides. In the Southern winter hemisphere, we derived apparent zonal wavenumber-1 (WN-1) and WN-3 tidal components with a maximum amplitude of 10% and 5% at 63 km, respectively. © 2023. The Authors.

We present water vapor vertical distributions on Mars retrieved from 3.5 years of solar occultation measurements by Nadir and Occultation for Mars Discovery onboard the ExoMars Trace Gas Orbiter, which reveal a strong contrast between aphelion and perihelion water climates. In equinox periods, most of water vapor is confined into the low-middle latitudes. In aphelion periods, water vapor sublimated from the northern polar cap is confined into very low altitudes—water vapor mixing ratios observed at the 0–5 km lower boundary of measurement decrease by an order of magnitude at the approximate altitudes of 15 and 30 km for the latitudes higher than 50°N and 30–50°N, respectively. The vertical confinement of water vapor at northern middle latitudes around aphelion is more pronounced in the morning terminators than evening, perhaps controlled by the diurnal cycle of cloud formation. Water vapor is also observed over the low latitude regions in the aphelion southern hemisphere (0–30°S) mostly below 10–20 km, which suggests north-south transport of water still occurs. In perihelion periods, water vapor sublimated from the southern polar cap directly reaches high altitudes (>80 km) over high southern latitudes, suggesting more effective transport by the meridional circulation without condensation. We show that heating during perihelion, sporadic global dust storms, and regional dust storms occurring annually around 330° of solar longitude (LS) are the main events to supply water vapor to the upper atmosphere above 70 km. © 2022. The Authors.