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A series of novel perfluoropropan-2-yl-based quinoline derivatives was designed and synthesized utilizing tebufloquin as the lead compound. The structures of all the newly synthesized compounds were confirmed by spectroscopic data 1HNMR, MS and elemental analysis. The results of bioassay indicated that these compounds exhibited potent fungicidal activities against Erysiphe graminis. Especially, compound 8c displayed excellent activity with EC50 value at 1.48 mg / L, which was better than that of the commercialized fungicide --- tebufloquin. The structure-activity relationship for these new compounds was also discussed.

A series of novel imidazo[4,5-b]pyridine derivatives were synthesized and their structures were characterized by NMR spectroscopy, mass spectrometry and elemental analysis. The results of bioassays showed that some compounds exhibit good fungicidal activity against Puccinia polysora In particular, compound 7b showed an EC50 value of 4.00 mg/L, which was comparable with that of tebuconazole. Besides, preliminary structure-activity relationship was discussed.

Alzheimer's disease (AD) is a fatal neurodegenerative disorder that is difficult to identify early in clinical practice. To overcome the existing limitations, we designed a label-free and highly accurate serum analysis platform for identifying AD in rats. Specifically, the closely ordered Nano Stellar Array (NASA) substrate was prepared to measure the serum of Aβ1–40-induced AD rats. Next, a recognition model was constructed using the principal component analysis (PCA)–linear discriminant analysis (LDA) algorithm. The prepared NASA substrate exhibited uniformity, high stability, reproducibility, high sensitivity, and cleanliness, enabling the acquisition of high-quality surface-enhanced Raman spectroscopy (SERS) spectra. The PCA-LDA model demonstrated good performance in differentiating the SERS spectra of serum from AD rats, with an accuracy of 95.8%, a sensitivity of 100%, a specificity of 92%, and an area under curve (AUC) of 0.97. This study not only provides a practical platform for label-free serum analysis to identify AD but also presents an approach for serum profiling at the spectral level. [ABSTRACT FROM AUTHOR]

In an effort to discover a new insecticide, we designed and synthesized a series of novel meta‐diamide compounds containing 1,2,4‐triazole with cyproflanilide as a lead compound. All the compounds were characterized by 1H NMR, 13C NMR, and HR‐MS. Both Plutella xylostella and Mythimna separata were tested for their insecticidal activity at 200 mg/L (P. xylostella: 0%–100%; M. separata: 0%–100%), 20 mg/L (P. xylostella: 0%–97%; M. separata: 0%–100%), and 2 mg/L (P. xylostella: 0%–97%; M. separata: 0%–100%), while Aphis craccivora was tested for its insecticidal activity at 400 mg/L (A. craccivora: 0%–36%). Further studies are needed to investigate the insecticidal activity of A. craccivora. Preliminary bioactivity results showed that most of the compounds had good insecticidal activity at 200 mg/L against P. xylostella and M. separata. Especially, the compound 7p, N‐(cyclopropylmethyl)‐N‐(5‐((2,6‐dibromo‐4‐(perfluoropropan‐2‐yl)phenyl) carbamoyl)‐2‐(1H‐1,2,4‐triazol‐1‐yl)phenyl)‐6‐(trifluoromethyl)nicotinamide (7p), showed good insecticidal activity at even lower doses of 2 mg/L (P. xylostella: 97%; M. separata: 100%), which was equivalent to that of the lead compound cyproflanilide (P. xylostella: 100%; M. separata: 100%), as well as significantly better than the two known compounds Ia (P. xylostella: 97%; M. separata: 0%) and Ib (P. xylostella: 60%; M. separata: 0%). Preliminary structure–activity relationship was also discussed based on insecticidal tests. The results indicate that meta‐diamide compounds containing 1,2,4‐triazole can be developed as novel insecticides. [ABSTRACT FROM AUTHOR]

As an introduction to a selection of current research on the theme of interpreting and technology this article offers an overview of the technologization of interpreting in the course of the past century, with particular emphasis on developments during recent decades. The application of various types of technology in different professional domains and settings is discussed with reference to the main functions of technology: enabling service delivery, assisting the process and replacing human agency. A brief review of some (proto)typical applications of technology in different settings and modalities of interaction then serves as a backdrop to a summary discussion of the technology-related literature to date and an introduction to the current research presented in Interpreting 26:2 (2024). [ABSTRACT FROM AUTHOR]

Oxidative stress is considered as a major factor causing retinal pigment epithelium (RPE) dysfunction and finally leading to retinal diseases such as age-related macular degeneration (AMD). Developing hydrogels for RPE cell delivery, especially those with antioxidant feature, is emerging as a promising approach for AMD treatment. Herein, a readily prepared antioxidant alginate-based hydrogel was developed to serve as a cytoprotective agent for RPE cells against oxidative damage. Alg-BOB was synthesized via conjugation of benzoxaborole (BOB) to the polysaccharide backbone. Hydrogels were formed through self-crosslinking of Alg-BOB based on benzoxaborole-diol complexation. The resulting hydrogel showed porous micro-structure, pH dependent mechanical strength and excellent self-healing, remolding, and injectable properties. Moreover, the hydrogel exhibited excellent cytocompatibility and could efficiently scavenge reactive oxygen species (ROS) to achieve an enhanced viability of ARPE-19 cells under oxidative condition. Altogether, our study reveals that the antioxidant Alg-BOB hydrogel represents an eligible candidate for RPE delivery and AMD treatment. [ABSTRACT FROM AUTHOR]

This article reports part of the first phase of the AIIC Lifespan Study, for which ten conference interpreters over 70 years old were interviewed to learn how interpreters' professional language experiences interact with their cognitive functions and, specifically, if they demonstrate different patterns of cognitive decline regarding language use. The interview transcripts were coded to identify examples that matched the items in the research-informed interview guide or any emerging patterns that informed the theme of cognitive changes. The interview-ees experienced some aging-induced cognitive challenges, such as comprehension difficulties in less than optimal environments, concentration and memory issues, and slowness in lexical retrieval. Some of these challenges had an impact on some interview-ees' decision to quit interpreting. [ABSTRACT FROM AUTHOR]

Reading is a critical process for conscious learning and enhancing knowledge; however, little is known about reading in interpreters' professional lives. We used an online survey to collect information about the reading habits of signed language interpreters (n = 1,382) and spoken language interpreters (n = 601) to examine overall patterns, as well as variations, between the groups. The interpreters responded to questions regarding (a) engagement with reading types, (b) hours spent reading, (c) motivations for reading, (d) factors that reduce engagement in reading, (e) reading in which interpreters should engage, (f) relevance of reading to professional practice, and (g) priority of research topics for reading. Similarities were found between the groups, with divergence in three areas – reading preparation materials, reading research studies, and the types of research studies the participants wish to read. The results provide insights into professional interpreters' engagement with reading and its application to their professional practice. [ABSTRACT FROM AUTHOR]

This article reports part of the first phase of the AIIC Lifespan Study, for which ten conference interpreters over 70 years old were interviewed to learn how interpreters' professional language experiences interact with their cognitive functions and, specifically, if they demonstrate different patterns of cognitive decline regarding language use. The interview transcripts were coded to identify examples that matched the items in the research-informed interview guide or any emerging patterns that informed the theme of cognitive changes. The interview-ees experienced some aging-induced cognitive challenges, such as comprehension difficulties in less than optimal environments, concentration and memory issues, and slowness in lexical retrieval. Some of these challenges had an impact on some interview-ees' decision to quit interpreting. [ABSTRACT FROM AUTHOR]