Search

Objective·To explore the relationship of screen time and dietary behaviors with depressive symptoms in junior high school students in 5 provinces in China.Methods·A total of 1 067 junior high school students were selected from Zhejiang and Guangdong in the eastern region, Jiangxi in the central region, Sichuan and Guizhou in the western region of China by using stratified random cluster sampling method for a questionnaire survey, which included general demographic characteristics, health behaviors, diatery behaviors, and depressive symptoms. Univariate analysis was used to analyze the report rates of depressive symptoms, daily screen time and dietary behaviors of the students with variant demographic characteristics, and Logistic regression analysis was used to analyze the relationship of daily screen time and dietary behaviors with depressive symptoms and the interaction effects as well.Results·The report rate of depressive symptoms was 12.9% in the junior high school students in 5 provinces. The students who were in the western region, were not only children, had a weekly allowance of over 100 yuan, had smoked or consumed alcohol, had daily screen time≥2 h, or had unhealthy dietary behaviors, had higher reporting rates of depressive symptoms (P

Immunogenic cell death (ICD), a unique form of cancer cell death, has therapeutic potential in anti-tumour immunotherapy. The aim of this study is to explore the predictive potential of ICD in the prognosis and immunotherapy outcomes of glioblastoma multiforme (GBM). RNA sequencing data and clinical information were downloaded from three databases. Unsupervised consistency clustering analysis was used to identify ICD-related clusters and gene clusters. Additionally, the ICD scores were determined using principal component analysis and the Boruta algorithm via dimensionality reduction techniques. Subsequently, three ICD-related clusters and three gene clusters with different prognoses were identified, with differences in specific tumour immune infiltration-related lymphocytes in these clusters. Moreover, the ICD score was well differentiated among patients with GBM, and the ICD score was considered an independent prognostic factor for patients with GBM. Furthermore, two datasets were used for the external validation of ICD scores as predictors of prognosis and immunotherapy outcomes. The validation analysis suggested that patients with high ICD scores had a worse prognosis. Additionally, a higher proportion of patients with high ICD scores were non-responsive to immunotherapy. Thus, the ICD score has the potential as a biomarker to predict the prognosis and immunotherapy outcomes of patients with GBM.

Understanding long‐term hydroclimate change and its evolution mechanism is beneficial to hydrological assessments and future planning in the Weihe River Basin, a region affected by the East Asian monsoon, as well as addressing increasing concerns about water resources due to social and economic development. The average June–July streamflow reconstruction was performed for the period from 1592 to 1988 for the Weihe River, based on the common growth responses relating tree‐ring width, minimum density and hydrological variables, as inferred from the first principal component series of tree‐ring width and density. The statistical results of calibration and verification confirmed that our model was credible and could explain 47.2% of the variance in the calibration period from 1937 to 1970. According to the criteria of one standard deviation less or greater than the mean value, 59 extremely low flow years and 62 high flow years were identified, accounting for 14.86% and 15.62%, respectively, of the past 397‐year hydrological reconstruction. Severe dryness and wetness periods were in good agreement with other hydrological records in the basin, suggesting the coherence of hydroclimate changes at the basin scale, including extreme drought events from the 1920s to 1930s. The reconstructed streamflow had significant interannual and interdecadal periodic signals associated with spatial correlations with sea surface temperatures in the Pacific, Indian and Atlantic Oceans, indicating the relationships between hydrological variations in the Weihe River and the natural forcing related to the El Niño‐Southern Oscillation, Pacific Decadal Oscillation, Indian Ocean Dipole pattern, North Atlantic Oscillation and Atlantic Multidecadal Oscillation (AMO). Our results provide new evidence for the potential of hydrological research using multiple tree‐ring indicators, such as tree‐ring width and minimum density, in the semiarid and semihumid areas of central China. [ABSTRACT FROM AUTHOR]

In this study, the possibility of using the rail vibration frequency to assess the longitudinal temperature force on the rail of ballasted track was investigated experimentally. An empirical formula was subsequently derived to link the frequency index to multiple factors, including the longitudinal temperature force, under-rail stiffness, and fastener spacing. Further tests were conducted to analyse the applicability and accuracy of the frequency index in continuous longitudinal force measurements under different line conditions (i.e. in the non-expansion zone and expansion zone). A technique for using the frequency index to assess the longitudinal temperature force was finally developed. The main results are as follows. (1) The first-order pinned–pinned modal frequency and peak frequency of the mid-span response are very close, and they both change linearly with the longitudinal temperature force on the rail. The rate of change in the vertical direction is larger than that in the horizontal direction. (2) Even if influenced by multiple factors, the peak frequency of the rail mid-span response is suitable for continuous longitudinal temperature force assessment under appropriate measures, and longitudinal temperature force detection could be realized with proper preparation. (3) Using the mid-span response frequency to detect the temperature force of rail located in the expansion zone causes deviation of the results, and under-rail materials whose stiffnesses are insensitive to temperature help reduce this deviation. [ABSTRACT FROM AUTHOR]