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The remaining life prediction problem of gear is studied and a new set of gear life prediction program is put forward based on double exponential smoothing（ DES） and improved incremental support vector machine for regression（ SVR）. The new program utilizes principal component analysis（ PCA） to filtrate fusion index set,and then using DES to process fusion index set as the input of improved incremental SVR. Meanwhile,the improved incremental SVR prediction model is constructed based on incremental Latin hyper- cube sampling（ LHD） and Direct search algorithm. Compared with the standard SVR prediction model based on original characteristic values,the interference of signal randomness and mutation of the new model sre overcome,furthermore,the latest evolution trend information of the gear status is obtained,the optimization effect and prediction performance is obviously improved. The validation analysis of the new model is carried out by using the full life- cycle test data,the results show that the improved incremental SVR prediction model obtained a more reliable,more stable predictions,it has certain practical value in engineering.

To evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated urinary tract infection (UTI) or complicated UTI. In this randomized, active-controlled clinical trial, the patients with acute uncomplicated UTI were randomized to receive sitafloxacin 100-mg once-daily (qd) or levofloxacin 500-mg qd orally for 3–5 days. The patients with complicated UTI were randomized to receive sitafloxacin 100-mg twice daily or levofloxacin 500-mg qd orally for 10–14 days. The primary endpoint was the clinical efficacy at test-of-cure (TOC) visit. At TOC visit, the clinical cure rate was 89.2% (58/65) in sitafloxacin group and 97.1% (68/70) in levofloxacin group for the patients with acute uncomplicated UTI corresponding to the bacterial eradication rate of 97.1% (34/35) and 97.6% (41/42) (all p >.05), respectively. For the patients with complicated UTI, the clinical cure rate was 81.8% (27/33) in sitafloxacin group and 76.9% (20/26) in levofloxacin group corresponding to the bacterial eradication rate of 93.3% (14/15) and 63.6% (7/11) (all p >.05), respectively. Sitafloxacin and levofloxacin showed similar incidence of drug-related adverse events. Oral sitafloxacin is as effective and safe as levofloxacin in treating acute uncomplicated and complicated UTI. Oral sitafloxacin showed similar clinical cure rate and bacterial eradication rate as levofloxacin for treatment of complicated and uncomplicated urinary tract infections (UTIs) in a randomized, active-controlled, multicentre clinical trial. Oral sitafloxacin is safe and well-tolerated in treating acute uncomplicated and complicated UTIs in Chinese adults. Sitafloxacin is a promising alternative treatment option for UTIs in adults. [ABSTRACT FROM AUTHOR]

Base promoted [4+3] annulation of trifluoromethylpyrazole(TFPZ) derived α,β‐unsaturated ketones with crotonate‐derived sulfur ylides provided a diverse set of CF3‐containing oxepino[2,3‐c]pyrazole motif in good to excellent yields through a simple, mild and fast manner. Significantly, one‐pot strategy could be successfully applied to this transformation from available materials. Also, the utility of our versatile protocol was further demonstrated by gram‐scale reaction and useful derivation. [ABSTRACT FROM AUTHOR]

Certain miRNAs, called oncomiRs, play a causal role in the onset and maintenance of cancer when overexpressed, thus, representing a potential new class of targets for therapeutic intervention. RNA-cleaving DNAzymes, mainly aimed at mRNA, have shown potential as therapeutic agents for various diseases. However, it's rarely reported that a DNAzyme was used for intracellular miRNA cleavage to suppress cell growth. Herein, we have developed a MnO2 nanosheet-mediated photo-controlled DNAzyme (NPD) for intracellular miRNA cleavage to suppress cell growth. MnO2 nanosheets adsorb photocaged DNAzymes, protect them from enzymatic digestion, and efficiently deliver them into cells. In the presence of intracellular glutathione (GSH), MnO2 nanosheets are reduced to Mn2+ ions, which serve as cofactors of the 8–17 DNAzyme for miRNA cleavage. Once the DNAzyme is activated by light, it can cyclically cleave endogenous miR-21 inside cells, which would suppress cancer cell migration and invasion, and finally induce cancer cell apoptosis. [ABSTRACT FROM AUTHOR]