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Microstructural characterization of spontaneous combustion coal gangue (SCCG), the hydration products and mechanism of spontaneous combustion coal gangue concrete (SCCGC) were discerned through microscopic analysis. The bond performance was assessed employing a central pull-out test on samples variably substituted with SCCG (0%, 25%, 50%, 75%, and 100%) and augmented with basalt fiber (BF) (0%, 0.1%, 0.15%, and 0.2%). The failure mode and bonding mechanism were also revealed by this test. The bond-slip curves were fitted by various bond-slip constitutive models and a suitable model was found for each section. As indicated by the results, SCCGC possessed a lower carbon content and higher Al and Si element contents. These elements would undergo secondary hydration reactions with CH, which could enhance the strength of the ITZ and the compactness of the bond interface between BFRP bars and concrete. The failure modes were splitting and pull-out. An inverse correlation was observed between bond strength and the increment in SCCG aggregate substitution, ranging from a decline of 2.6% to 23.1%. As the BF content increased, the bond strength and peak slip increased by 3.9% ∼ 19.7% and 4.0% ∼ 14.6%, respectively. Furthermore, the reinforcing effect of BF on bond strength increased from 3.9% ∼ 10.3% to 8.8% ∼ 19.7% as the SCCG replacement rate increased, which was noticeable. The Malvar model and the Continuous Curve model were the best fitting models for the ascending and descending sections of bond-slip curves, respectively, while the residual stage was well fitted by the Hao Qingduo model. [ABSTRACT FROM AUTHOR]

Background: As an indicator of tumor invasiveness, microvascular invasion (MVI) is a crucial risk factor for postoperative relapse, metastasis, and unfavorable prognosis in hepatocellular carcinoma (HCC). Nevertheless, the genetic mechanisms underlying MVI, particularly for Chinese patients, remain mostly uncharted. Methods: We applied deep targeted sequencing on 66 Chinese HCC samples. Focusing on the telomerase reverse transcriptase (TERT) promoter (TERTp) and TP53 co‐mutation (TERTp+/TP53+) group, gene set enrichment analysis (GSEA) was used to explore the potential molecular mechanisms of the TERTp+/TP53+ group on tumor progression and metastasis. Additionally, we evaluated the tumor immune microenvironment of the TERTp+/TP53+ group in HCC using multiplex immunofluorescence (mIF) staining. Results: Among the 66 HCC samples, the mutated genes that mostly appeared were TERT, TP53, and CTNNB1. Of note, we found 10 cases with TERTp+/TP53+, of which nine were MVI‐positive and one was MVI‐negative, and there was a co‐occurrence of TERTp and TP53 (p < 0.05). Survival analysis demonstrated that patients with the TERTp+/TP53+ group had lower the disease‐free survival (DFS) (p = 0.028). GSEA results indicated that telomere organization, telomere maintenance, DNA replication, positive regulation of cell cycle, and negative regulation of immune response were significantly enriched in the TERTp+/TP53+ group (all adjusted p‐values (p.adj) < 0.05). mIF revealed that the TERTp+/TP53+ group decreased CD8+ T cells infiltration (p = 0.25) and enhanced PDL1 expression (p = 0.55). Conclusions: TERTp+/TP53+ was significantly enriched in MVI‐positive patients, leading to poor prognosis for HCC patients by promoting proliferation of HCC cell and inhibiting infiltration of immune cell surrounding HCC. TERTp+/TP53+ can be utilized as a potential indicator for predicting MVI‐positive patients and poor prognosis, laying a preliminary foundation for further exploration of co‐mutation in HCC with MVI and clinical treatment. [ABSTRACT FROM AUTHOR]

An efficient method for the construction of 2‐methyl‐1‐sulfonylindoles and 2,3‐dimethyl‐1‐sulfonylindoles using solid calcium carbide as an alkyne source and o‐sulfonamidobenzaldehyde hydrazones or o‐sulfonamidoacetophenone hydrazones as starting materials is described. This protocol has the salient feature of the use of an inexpensive, abundant and easy‐to‐handle solid alkyne source, effectively avoiding the use of flammable and explosive gaseous acetylene as an original alkyne source. Noble‐metal‐free conditions, wide substrate scope, high yield, and simple workup procedures are advantages of this method. The transformation can also be carried out on a gram scale. [ABSTRACT FROM AUTHOR]

In order to improve the drying process of oat noodles, the effects of temperature, relative humidity and addition amount of oat on its quality were studied. Wheat flour and oat powder were used as raw materials to prepare oat noodles with different content of oat (0, 10%, 20%, 30%), which were dried at different temperatures (40, 50, 60 $) and relative humidity (55%, 65%, 75%). The color, bending resistance, cooking quality, texture quality, acidity, fatty acid value, !-glucan content, microstructure, and sensory quality were measured, and analyzed the effects of different temperature, relative humidity and different amount of oat on the quality of oat noodle. The results showed that the dried noodles had lower b* value, longer breaking distance, lower acidity, and fatty acid content when dried at 40 $ (P<0.05). When the relative humidity was 75%, the b* value, bending strength, breaking distance, acidity and fatty acid content of the noodles were higher "P <0.05). When the addition amount of oat flour was 30%, the L* value was lower, the a* value was higher, the bending strength breaking distance was smaller, and the acidity, fatty acid and /3-glucan contents were higher "P < 0.05). The temperature of 45 and relative humidity of 75% were reasonable drying process of oat noodles. Drying at low temperature and high humidity (40 !/75%) can improve the color, cooking, and texture quality of oat noodles, the microstructure is compact and the sensory score is good. It can be used for drying oat noodles. [ABSTRACT FROM AUTHOR]

The pull-out test was performed in this study to investigate the bond performance between basalt fiber reinforced polymer (BFRP) bars and recycled concrete. Three factors were considered: aggregate size (5–10 mm, 11–15 mm, and 16–20 mm), bond anchorage length of bars (3D, 5D, and 7D), and the recycled aggregate replacement rate (0%, 30%, 60%, and 100%). The bond–slip mechanism, failure mode, bond stress distribution, and bond–slip curves were all analysed. Based on the results, it was found that situations with a high recycled aggregate replacement rate, large aggregate particle sizes, or long bond lengths have an increased likelihood of experiencing splitting failure. As the aggregate size increases, the bond strength between the BFRP bars and the concrete would also increase, in ordinary concrete, a 22.54% increase was observed, whereas in recycled concrete, the maximum increase reached 48.20%. The effect would be more pronounced on recycled concrete compared to ordinary concrete, and it would also be more significant in specimens with BFRP bars compared to steel bars. Additionally, the optimal bond anchorage length was determined to be 5D. The bond strength exhibited a trend of decrease followed by an increase as the recycled aggregate replacement rate increased. The maximum reduction of 59.7% in bond strength was observed when the replacement rate of recycled aggregate reached 60%. Moreover, when the replacement rate of recycled aggregate increased to 100%, there was a decrease of 19.05% in bond strength compared to the specimen without recycled aggregates. Based on the experimental test data and existing models, an improved two-stage bond–slip constitutive model was proposed. [ABSTRACT FROM AUTHOR]

A multivariate linear regression model between the coupling factor and the quality index of oat noodles in the drying system was established, and the drying coupling factor predicted the quality index of oat noodles. Taking the quality index of oat noodles as the dependent variables, and the coupling factors (temperature, air absolute water potential, air absolute water potential and accumulated temperature) as the independent variables, through multiple linear regression, the prediction model of each quality index of oat noodles was established, evaluated and verified. The results showed that the established quality index regression models of optimal cooking time, cooking loss, cooking water absorption, ductility, hardness, chewability, adhesion, flexural strength, breaking distance, acidity and fatty acid value, were significant (P <0.01), and the model's coefficients R2 for quality index prediction were 0.8075, 0.9981, 0.8485, 0.8354, 0.8118, 0.8194, 0.8030, 0.8416, 0.8838, 0.8100 and 0.8888, respectively. The drying coupling factor can be used to predict the quality index of oat noodles, and the study provided a theoretical basis for the quality control of oat noodles in the drying process. [ABSTRACT FROM AUTHOR]

For efficient combustion of aquatic biomass, the effects of heating rate on the combustion and dynamic characteristics of two typical aquatic species (water hyacinth, Pistia stratiotes), and the effects of temperature and additives on ash K and Cl concentrations are studied. The two types of pellets have ignition temperatures of 252.7 and 250.3 °C, respectively. At a heating rate of 10 °C min−1, where combustion is most stable, the comprehensive combustion efficiencies reach their maximum at 4.7 × 10−6 and 2.2 × 10−6 mg2min−1°C−2, respectively. The K and Cl concentrations in the ash decrease steadily with increasing temperature, falling to 10.3% and 0.41% for water hyacinth and 11.1% and 1.85% for P. stratiotes, respectively. X‐ray diffraction (XRD)shows that abundant Ca minerals form in the ash after the addition of CaO, which inhibit KCl formation, and K and Al silicates form in the ash after the addition of kaoline, which reserve K in the ash. These findings provide a starting point for the development of efficient aquatic biomass combustion. [ABSTRACT FROM AUTHOR]