Search

This report discusses the design and demonstration of β -(Al0.17Ga0.83)2O3/Ga2O3 modulation doped heterostructures to achieve high sheet charge density. The use of a thin spacer layer between the Si delta-doping and the heterojunction interface was investigated in a β -(AlGa)2O3/Ga2O3 modulation doped structure. It is shown that this strategy enables a higher two-dimensional electron gas (2DEG) sheet charge density up to 4.7 × 1012 cm−2 with an effective mobility of 150 cm2/V s. The presence of a degenerate 2DEG channel was confirmed by the measurement of a low temperature effective mobility of 375 cm2/V s and the lack of carrier freeze out from low temperature capacitance voltage measurements. The electron density of 4.7 × 1012 cm−2 is the highest reported 2DEG density obtained without parallel conducting channels in a β -(AlxGa(1−x))2O3/Ga2O3 heterostructure system. [ABSTRACT FROM AUTHOR]

Objective To investigate the fatty acid metabolism profile characteristics of patients with type 2 diabetes mellitus (T2DM) and metabolic associated fatty liver disease (MAFLD). Methods This was a retrospective study. All patients who visited the Department of Endocrinology of the Second Affiliated Hospital of Dalian Medical University from October 2018 to December 2019 were enrolled. Height and weight of the subjects were measured and body mass index (BMI) were calculated, fasting plasma glucose (FPG), fasting insulin (FINS) were measured, and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated and their insulin-like growth factor 1 (IGF-1), triglyceride (TG), palmitoleic acid, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, linoleic acid, total omega-3, total omega-6 were measured. According to the results of liver ultrasound and transient elastography technology, the participants were divided into group A (T2DM alone), group B (T2DM combined with fatty liver group) and group C (T2DM combined with liver fibrosis group). One-way analysis of variance (ANOVA), Kruskal-Wallis H test and χ² test were used to compare between groups, Spearman correlation analysis was used to analyze the correlation between fatty acids and various indices, and binary logistic regression was used to analyze the factors influencing T2DM combined with MAFLD. Results A total of 426 patients with T2DM were enrolled. There were 165 cases in group A, 170 in group B, and 91 in group C. Compared with group A, BMI, HOMA-IR, TG, FINS and palmitoleic acid were all increased, and IGF-1, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, linoleic acid, total omega-3 and total omega-6 were decreased in groups B and C (P<0.05). Compared with group B, BMI and HOMA-IR were increased in group C, and IGF-1, linoleic acid and total omega-6 were decreased (P<0.05). The results of Spearman correlation analysis showed that palmitoleic acid (r=0.174, P<0.001) was positively correlated with BMI, linoleic acid (r=-0.121, P=0.012), total omega-6 (r=-0.108, P=0.026) and BMI were negatively correlated. Eicosapentaenoic acid (r=-0.109, P=0.025) was negatively correlated with HOMA-IR. The results of binary logistic regression analysis showed that BMI, TG, FINS, HOMA-IR, and IGF-1 were the influencing factors of T2DM combined with MAFLD. Conclusions Patients with T2DM and MAFLD had lower levels of omega-3 and omega-6 fatty acids, with eicosapentaenoic acid and docosahexaenoic acid representing the omega-3 series and linoleic acid and arachidonic acid representing the omega-6 series. [ABSTRACT FROM AUTHOR]