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Weibo Ma,1,* Yuewen Liu,1,* Ning Wu,1 Hui Zhang,1 Peipei Han,1 Feng Wang,1 Jingru Wang,1 Fandi Xie,2 Shumeng Niu,2 Hao Hu,2 Chenyu Zhang,1 Nuo Chen,1 Yichen Zhang,1 Qi Guo,1 Ying Yu1 1Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, People’s Republic of China; 2Department of Clinical Laboratory Center, Shanghai Jiangwan Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qi GuoDepartment of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences, No. 279 Zhouzhu Road, Pudong New Area, Shanghai, 201318, People’s Republic of ChinaTel +86-21-8333-6977Fax +86-21-8333-6977Email guoqijp@gmail.comYing Yu Email yuying@sumhs.edu.cnObjective: We examined the association between obesity and physical performance under different metabolic status.Methods: The sample included 1395 Chinese community-dwelling participants (mean age, 71.88 ± 5.87 years; 40.9% men). Being metabolically healthy was defined as having the presence of < 3 of 5 components of metabolic syndrome (MetS); obesity was defined as having a BMI > 28 kg/m2. Participants were divided into four groups based on BMI (non-obese/obese) and metabolic health (healthy/unhealthy). Physical performance was measured by grip strength, 4-m walking speed, and the timed up and go test (TUGT).Results: After multiple adjustments, compared with metabolically healthy non-obese group, the metabolically unhealthy obese group showed lower relative grip strength, lower 4-m walking speed, and higher TUGT (P all < 0.05), and only relative grip strength of the metabolically healthy obese group was significantly lower than that of metabolically healthy non-obese (P < 0.01). Relative grip strength was negatively associated with impaired fasting glucose (β = − 0.071), elevated triglycerides (β = − 0.062), abdom

Yuewen Liu,1,* Weibo Ma,2,* Ming Li,3 Peipei Han,1 Ming Cai,1 Feng Wang,2 Jingru Wang,2 Xiaoyu Chen,1 Jianrong Shi,4 Xiaoyan Zhang,4 Yiyi Zheng,1 Mengqiu Chen,1 Qi Guo,1 Ying Yu1 1Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, People’s Republic of China; 2Department of Nursing and Health Management, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 3Office of the President, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, People’s Republic of China; 4Department of Team, Buzhen Community Health Service Center, Chongming District, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qi Guo; Ying Yu Email guoqijp@gmail.com; yuying@sumhs.edu.cnObjective: This study aimed to examine the relationship between physical performance and mild cognitive impairment (MCI) in Chinese older adults.Methods: The sample comprised 956 relatively healthy and aged ≥ 65 years old Chinese community-dwelling participants (mean age, 72.56 ± 5.43 years; 56.8% female), which did not include those with dementia, severe cognitive impairment, mental illness etc. The Mini-Mental State Examination (MMSE) and the Instrumental Activities of Daily Living (IADL) scale were used for the initial classification of patients with MCI. Physical performance was measured via hand grip, Timed Up and Go Test (TUGT), and 4-m walking speed.Results: The physical performance (grip strength, TUGT, and 4-m walking speed) correlated with MCI. The grip strength [odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.93– 0.99] and 4-m walking speed (OR = 0.25, 95% CI = 0.10– 0.64) correlated negatively with MCI, while TUGT (OR = 1.08, 95% CI = 1.03– 1.13) and MCI correlated positively.Conclusion: The physical performance (grip strength, TUGT, and 4-m wa