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Your search keyword '"Liu, Xue-Chun"' showing total 186 results
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186 results on '"Liu, Xue-Chun"'

29. Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD.

Author

Wu, Zhao-Min, Wang, Peng, Liu, Xue-Chun, Zhou, Qing-Chao, Cao, Xiao-Lan, Sun, Li, Liu, Lu, Cao, Qing-Jiu, Yang, Li, Wang, Yu-Feng, Qian, Ying, and Yang, Bin-Rang

Abstract

Objectives: The current study aimed to investigate the structural and functional connectivity of the subregions of the amygdala in children with Attention Deficit/Hyperactivity Disorder (ADHD) only or comorbid with Oppositional Defiant Disorder (ODD). Methods: A total of 354 children with ADHD-only, 161 children with ADHD and ODD (ADHD + ODD), and 100 healthy controls were enrolled. The Child Behavior Checklist (CBCL) and the Behavior Rating Inventory of Executive Function (BRIEF) were filled out by caregivers. Analysis of covariance (ANCOVA) was performed to test group-wise differences in these behavioral measures. A subsample comprising 209 participants underwent a resting-state functional MRI scan and a diffusion-weighted imaging (DWI) scan. Functional connectivity and structural connectivity were calculated using bilateral subregions of the Amygdala as seeds. Between-group voxel-wise comparisons were conducted. Results: The ADHD + ODD group had more anxious/depressed moods, more delinquent and aggressive behaviors, more emotional control problems, and more inhibition deficits than the ADHD-only group (all PBonferroni−corrected < 0.05). Compared with the control and ADHD + ODD groups, the ADHD-only group displayed increased FC strength between the amygdala subregions and the left caudate, left putamen, and frontal cortex. Regarding structural connectivity (SC), the ADHD-only group demonstrated higher streamline density in the left internal capsule, corpus callosum, and the right superior corona radiata. The altered SC was associated with emotional problems in children with ADHD, while the altered FC was associated with other ADHD-related clinical features. Conclusions: Altered structural and functional connectivity of the subregions of the amygdala in children with ADHD compared with their healthy counterparts were respectively associated with ADHD-related behavioral and emotional problems. Clinical trial number: : not applicable. [ABSTRACT FROM AUTHOR]

Published
2025
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30. Alterations of amino acids in older adults with Alzheimer's Disease and Vascular Dementia.

Author

Ma, Xin, Wang, Xin-Meng, Tang, Guo-Zhang, Wang, Yi, Liu, Xue‑Chun, Wang, Shuai-Deng, Peng, Peng, Qi, Xiu-Hong, Qin, Xin-Ya, Wang, Yue‑Ju, Wang, Chen-Wei, and Zhou, Jiang-Ning

Subjects
ALZHEIMER'S disease, VASCULAR dementia, AMINO acids, MEDICAL sciences, OLDER people
Abstract

Metabolomics provide a promising tool for understanding dementia pathogenesis and identifying novel biomarkers. This study aimed to identify amino acid biomarkers for Alzheimer's Disease (AD) and Vascular Dementia (VD). By amino acid metabolomics, the concentrations of amino acids were determined in the serum of AD and VD patients as well as age-matched healthy controls. Several differences in the concentration of amino acids were observed in AD patients compared to both healthy controls and VD patients. However, no significant distinction was found between healthy controls and VD patients. Considering comorbidities, cystine levels were higher in AD than in VD among non-diabetic patients, but not in those with diabetes. Notably, creatine, spermidine, cystine, and tyrosine demonstrated favorable results in decision curve analyses and good discriminative performances, suggesting their potential for clinical application. These fundings give novel perspectives of serum amino acids for predicting metabolic pathways in AD and VD pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2025
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