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Your search keyword '"Liu, Xiao'an"' showing total 14 results
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14 results on '"Liu, Xiao'an"'

3. Promotion effect of FOXCUT as a microRNA sponge for miR-24-3p on progression in triple-negative breast cancer through the p38 MAPK signaling pathway

Author

Yu, Xiafei, primary, Qian, Fangze, additional, Zhang, Xiaoqiang, additional, Zhu, Yanhui, additional, He, Gao, additional, Yang, Junzhe, additional, Wu, Xian, additional, Zhou, Yi, additional, Shen, Li, additional, Shi, Xiaoyue, additional, Zhang, Hongfei, additional, and Liu, Xiao'an, additional

Published
2023
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9. Role ofATG10 expression quantitative trait loci in non-small cell lung cancer survival

Author

Xie, Kaipeng, primary, Liang, Cheng, additional, Li, Qin, additional, Yan, Caiwang, additional, Wang, Cheng, additional, Gu, Yayun, additional, Zhu, Meng, additional, Du, Fangzhi, additional, Wang, Hui, additional, Dai, Juncheng, additional, Liu, Xiao'an, additional, Jin, Guangfu, additional, Shen, Hongbing, additional, Ma, Hongxia, additional, and Hu, Zhibin, additional

Published
2016
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10. Role of ATG10 expression quantitative trait loci in non-small cell lung cancer survival.

Author

Xie, Kaipeng, Liang, Cheng, Li, Qin, Yan, Caiwang, Wang, Cheng, Gu, Yayun, Zhu, Meng, Du, Fangzhi, Wang, Hui, Dai, Juncheng, Liu, Xiao'an, Jin, Guangfu, Shen, Hongbing, Ma, Hongxia, and Hu, Zhibin

Abstract

The aim of this article was to evaluate whether genetic variants in autophagy-related genes affect the overall survival (OS) of non-small cell lung cancer (NSCLC) patients. We analyzed 14 single nucleotide polymorphisms (SNPs) in core autophagy-related genes for OS in 1,001 NSCLC patients. Three promising SNPs in ATG10 were subsequently annotated by the expression quantitative trait loci (eQTL) and methylation quantitative trait loci (meQTL) analyses based on Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. We observed that the variants of rs10514231, rs1864182 and rs1864183 were associated with poor lung cancer survival (HR = 1.33, 95% CI = 1.07-1.65; HR = 1.43, 95% CI = 1.13-1.81; HR = 1.38, 95% CI = 1.14-1.68, respectively) and positively correlated with ATG10 expression (all p < 0.05) from GTEx and TCGA datasets. The elevated expression of ATG10 may predict shorter survival time in lung cancer patients in TCGA dataset (HR = 2.10, 95% CI = 1.33-3.29). Moreover, the variants of rs10514231 and rs1864182 were associated with the increased methylation levels of cg17942617 (meQTL), which in turn contributed to the elevated ATG10 expression and decreased survival time. Further functional assays revealed that ATG10 facilitated lung cancer cell proliferation and migration. Our findings suggest that eQTL/meQTL variations of ATG10 could influence lung cancer survival through regulating ATG10 expression. [ABSTRACT FROM AUTHOR]

Published
2016
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12. Evaluation of genetic variants in microRNA biosynthesis genes and risk of breast cancer in Chinese women

Author

Jiang, Yue, primary, Chen, Jiaping, additional, Wu, Jiangping, additional, Hu, Zhibin, additional, Qin, Zhenzhen, additional, Liu, Xiao'an, additional, Guan, Xiaoxiang, additional, Wang, Yanru, additional, Han, Jing, additional, Jiang, Tao, additional, Jin, Guangfu, additional, Zhang, Mingfeng, additional, Ma, Hongxia, additional, Wang, Shui, additional, and Shen, Hongbing, additional

Published
2013
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