Search

Your search keyword '"Liu, Xiangdong"' showing total 3,782 results
Start Over Author "Liu, Xiangdong"
3,782 results on '"Liu, Xiangdong"'

25. A regulatory variant at 19p13.3 is associated with primary biliary cholangitis risk and ARID3A expression

Author

Li, You, Li, Zhiqiang, Chen, Ruiling, Lian, Min, Wang, Hanxiao, Wei, Yiran, You, Zhengrui, Zhang, Jun, Li, Bo, Li, Yikang, Huang, Bingyuan, Chen, Yong, Liu, Qiaoyan, Lyu, Zhuwan, Liang, Xueying, Miao, Qi, Xiao, Xiao, Wang, Qixia, Fang, Jingyuan, Shi, YongYong, Liu, Xiangdong, Seldin, Michael F, Gershwin, M Eric, Tang, Ruqi, and Ma, Xiong

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Human Genome, Autoimmune Disease, Rare Diseases, Prevention, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, Humans, Genetic Predisposition to Disease, Genome-Wide Association Study, Liver Cirrhosis, Biliary, Genotype, Transcription Factors, DNA-Binding Proteins
Abstract

Genome-wide association studies have identified 19p13.3 locus associated with primary biliary cholangitis (PBC). Here we aim to identify causative variant(s) and initiate efforts to define the mechanism by which the 19p13.3 locus variant(s) contributes to the pathogenesis of PBC. A genome-wide meta-analysis of 1931 PBC subjects and 7852 controls in two Han Chinese cohorts confirms the strong association between 19p13.3 locus and PBC. By integrating functional annotations, luciferase reporter assay and allele-specific chromatin immunoprecipitation, we prioritize rs2238574, an AT-Rich Interaction Domain 3A (ARID3A) intronic variant, as a potential causal variant at 19p13.3 locus. The risk allele of rs2238574 shows higher binding affinity of transcription factors, leading to an increased enhancer activity in myeloid cells. Genome-editing demonstrates the regulatory effect of rs2238574 on ARID3A expression through allele-specific enhancer activity. Furthermore, knock-down of ARID3A inhibits myeloid differentiation and activation pathway, and overexpression of the gene has the opposite effect. Finally, we find ARID3A expression and rs2238574 genotypes linked to disease severity in PBC. Our work provides several lines of evidence that a non-coding variant regulates ARID3A expression, presenting a mechanistic basis for association of 19p13.3 locus with the susceptibility to PBC.

Published
2023

41. Non-sensitive axis feedback control of test mass in full-maglev vertical superconducting gravity instruments

Author

Chen, Daiyong, Liu, Xikai, Wang, Lulu, Chen, Liang, and Liu, Xiangdong

Subjects
Physics - Instrumentation and Detectors, Physics - Applied Physics
Abstract

Non-sensitive axis feedback control is crucial for cross-coupling noise suppression in the application of full-maglev vertical superconducting gravity instruments. This paper introduces the non-sensitive axis feedback control of the test mass in a home-made full-maglev vertical superconducting accelerometer. In the feedback system, special superconducting circuits are designed to decouple and detect the multi-degrees-of-freedom motions of the test mass. Then the decoupled motion signals are dealt with by the PID controller and fed back to the side-wall coils to control the test mass. In our test, the test mass is controlled successfully and the displacement is reduced by about one order of magnitude in the laboratory. Accordingly, the noise level of the vertical superconducting accelerometer in the sensitive axis is also reduced., Comment: 11 pages, 10 figures

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results