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12. The prognostic impact of tumor length on pathological stage IA-IC esophageal adenocarcinoma.

Author

Yan, Sen, Liu, Xianben, Xing, Wenqun, Jiang, Duo, Feng, Shao-Kang, Chang, Andrew C, and Sun, Hai-Bo

Subjects
*TUMOR classification, *PROPENSITY score matching, *ADENOCARCINOMA, *PROGNOSIS, *REGRESSION analysis, *ISCHEMIC colitis
Abstract

This study was completed to evaluate the relationship between tumor length and the prognosis of patients with pathological stage IA-IC esophageal adenocarcinoma (EAC). Patients were identified from the Surveillance, Epidemiology, and End Results Program database (United States, 2006–2015). X-tile software and ROC analysis were mainly used to explore the best threshold of tumor length for dividing patients into different groups, and then propensity score matching (PSM) was used to balance other variables between groups. The primary outcome assessed was overall survival (OS). A total of 762 patients were identified, and 500 patients were left after PSM. Twenty millimeters were used as the threshold of tumor length. Patients with longer tumor lengths showed worse OS (median: 93 vs. 128 months; P  = 0.006). Multivariable Cox regression analysis showed that longer tumor length was an independent risk factor (hazard ratio 1.512, 95% confidence interval, 1.158–1.974, P  = 0.002). Tumor length has an impact on patients with pathological stage IA-IC EAC who undergo surgery alone. The prognostic value of the pathological stage group may be improved after combining it with tumor length and age. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Perioperative Toripalimab Plus Neoadjuvant Chemotherapy Improves Outcomes in Resectable Esophageal Cancer: An Interim Analysis of a Phase III Randomized Clinical Trial (HCHTOG1909)

Author

Zheng, Yan, primary, Liang, Guanghui, additional, Yuan, Dongfeng, additional, Liu, Xianben, additional, Ba, Yufeng, additional, Qi, Zimin, additional, Shen, Sining, additional, Li, Zhenxuan, additional, Sun, Haibo, additional, Liu, Baoxing, additional, Gao, Quanli, additional, Li, Peng, additional, Wang, Zongfei, additional, Liu, Shilei, additional, Zhu, Jianping, additional, Ma, Haibo, additional, Liu, Zhenzhen, additional, Zhao, Fei, additional, Zhang, Jun, additional, Zhang, He, additional, Wu, Daoyuan, additional, Qu, Jinrong, additional, Ma, Jie, additional, Zhang, Peng, additional, Ma, Wenjie, additional, Yan, Ming, additional, Yu, Yongkui, additional, Li, Qing, additional, Zhang, Jiangong, additional, and Xing, Wenqun, additional

Published
2023
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22. The Sequence of Chemotherapy and Toripalimab Might Influence the Efficacy of Neoadjuvant Chemoimmunotherapy in Locally Advanced Esophageal Squamous Cell Cancer—A Phase II Study

Author

Xing, Wenqun, primary, Zhao, Lingdi, additional, Zheng, Yan, additional, Liu, Baoxing, additional, Liu, Xianben, additional, Li, Tiepeng, additional, Zhang, Yong, additional, Ma, Baozhen, additional, Yang, Yonghao, additional, Shang, Yiman, additional, Fu, Xiaomin, additional, Liang, Guanghui, additional, Yuan, Dongfeng, additional, Qu, Jinrong, additional, Chai, Xiaofei, additional, Zhang, He, additional, Wang, Zibing, additional, Lin, Hongwei, additional, Liu, Liang, additional, Ren, Xiubao, additional, Zhang, Jiangong, additional, and Gao, Quanli, additional

Published
2021
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24. Toripalimab Used on the Same Day or Third Day With Chemotherapy for Neoadjuvant Chemoimmunotherapy in Locally Advanced Esophageal Squamous Cell Cancer—A Phase II Study

Author

Xing, Wenqun, primary, Zhao, Lingdi, additional, Zheng, Yan, additional, Liu, Baoxing, additional, Liu, Xianben, additional, Li, Tiepeng, additional, Zhang, Yong, additional, Ma, Baozhen, additional, Yang, Yonghao, additional, Shang, Yiman, additional, Fu, Xiaomin, additional, Liang, Guanghui, additional, Yuan, Dongfeng, additional, Qu, Jinrong, additional, Chai, Xiaofei, additional, Zhang, He, additional, Wang, Zibing, additional, Lin, Hongwei, additional, Liu, Liang, additional, Ren, Xiubao, additional, Zhang, Jiangong, additional, and Gao, Quanli, additional

Published
2021
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32. Effectiveness of the Tailored, Early Comprehensive Rehabilitation Program (t-ECRP) Based on ERAS in Improving the Physical Function Recovery for Patients Following Minimally Invasive Esophagectomy: A Prospective Randomized Controlled Trial

Author

Yang, Funa, primary, Li, Lijuan, additional, Mi, Yanzhi, additional, Zou, Limin, additional, Chu, Xiaofei, additional, Sun, Aiying, additional, Sun, Haibo, additional, Liu, Xianben, additional, and Xu, Xiaoxia, additional

Published
2021
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36. negative association between skeletal muscle and fat mass wasting caused by oesophagectomy in patients with oesophageal squamous cell carcinoma.

Author

Wang, Peiyu, Liu, Qi, Chen, Xiankai, Liu, Xianben, and Li, Yin

Subjects
MUSCLE mass, ADIPOSE tissues, SKELETAL muscle, SQUAMOUS cell carcinoma, ESOPHAGECTOMY
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES This prospective observational study aimed to investigate postoperative skeletal muscle and fat mass wasting and their clinical significance in oesophageal cancer patients undergoing minimally invasive McKeown oesophagectomy. METHODS Bioelectrical impedance analyses of body compositions were conducted before surgery and 1, 4 and 12 weeks after surgery. Curve-fitting analysis was used to describe the relationship between changes in the skeletal muscle mass index (ΔSMI) and fat mass index (ΔFMI). A logistic regression-based nomogram was established using the R tool. RESULTS Among the 78 patients, 74.4% were male, and the mean age was 64.8 [standard deviation (SD): 6.6] years. Decreased SMIs and FMIs were concentrated in the first 4 weeks after surgery, with proportions of −3.42% (SD: 4.58) and −17.7% (SD: 11.9), respectively. A negative relationship between ΔFMI and ΔSMI was detected by linear regression (coefficient −0.341, P  <   0.001). Based on the median ΔSMI to ΔFMI ratio (35.5%), 2 postoperative weight loss types were defined: SMI-dominated (SMDT) and FMI-dominated (FMDT) types. SMDT patients reported increased feeding-related problems, poorer functional status and more unhealthy symptoms than FMDT patients within 12 weeks after surgery. SMDT patients also showed poorer 2-year overall survival (71.1% vs 87.3%, P  =   0.021) and disease-free survival (60.5% vs 84.9%, P  =   0.032) than FMDT patients. A nomogram based on baseline and perioperative parameters was established to quantify postoperative SMDT and FMDT tendencies with good accuracy (C-index: 0.897). CONCLUSIONS The negative relationship between ΔFMI and ΔSMI indicated differentiated metabolism post-oesophagectomy. SMDT was associated with adverse therapeutic outcomes and warranted aggressive interventions. Clinical registration number The study protocol was registered at the Chinese Clinical Trial Registry with the registration number ChiCTR1800018511. [ABSTRACT FROM AUTHOR]

Published
2022
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40. The mutation profiles of cell-free DNA in patients with oesophageal squamous cell carcinoma who were responsive and non-responsive to neoadjuvant chemotherapy

Author

Zhang, Ruixiang, primary, Hu, Ying, additional, Zhou, Tao, additional, Han, Wenbo, additional, Liu, Yang, additional, Qian, Juanjuan, additional, Chen, Yanhui, additional, Liu, Xianben, additional, Liu, Shilei, additional, Yu, Yongkui, additional, Zeng, Hui, additional, Zhang, Henghui, additional, and Li, Yin, additional

Published
2020
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43. Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study

Author

Zheng,Yan, Li,Yin, Xing,Wenqun, Qin,Jianjun, Liu,Xianben, Zhang,Ruixiang, Sun,Haibo, and Chen,Xiankai

Subjects
Cancer Management and Research
Abstract

Yan Zheng,1,* Yin Li,1,2,* Wenqun Xing,1,* Jianjun Qin,1,2 Xianben Liu,1 Ruixiang Zhang,1 Haibo Sun,1 Xiankai Chen1,2 1Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, People’s Republic of China; 2Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yin LiThe Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, 127# Dongming Road, Zhengzhou 450000, People’s Republic of ChinaTel +86 371 65587226Email liyin0825@hotmail.comPurpose: To fully elucidate the relationship of serum fibrinogen and the prognosis of esophageal squamous cell carcinoma.Methods: The concentrations of serum fibrinogen were measured by the Clauss method in a total of 1331 operable esophageal squamous cell carcinoma (ESCC) patients from the past 3 years. The correlation of serum fibrinogen concentration and patient outcome and clinical pathological factors was tested.Results: Hyperfibrinogenemia was significantly correlated with advanced pathological T stage and TNM stage. Serum fibrinogen was determined as a worse independent survival predictor in ESCC by survival analysis. The hazard ratio was 1.672 (95% confidence interval [CI] 1.043–2.681). A subgroup analysis further elucidated a significant correlation between hyperfibrinogenemia and younger age (P=0.011), being female (P=0.002), not having a history of smoking (p

Published
2019

48. FA01.03: USE OF ‘NON-TUBE NO FASTING’ ERAS PROTOCOL IN PATIENTS AFTER MIE WITH LI’S ANASTOMOSIS: OUTCOMES IN THE FIRST 113 PATIENTS PERFORMED BY A SURGEON AFTER TRAINING COURSE

Author

Zhang, Ruixiang, primary, Li, Yin, additional, Liu, Shilei, additional, Liu, Xianben, additional, Sun, Haibo, additional, Wang, Zongfei, additional, Zheng, Yan, additional, Chen, Xiankai, additional, Liu, Qi, additional, Zhu, Zhengshuai, additional, and Xu, Lei, additional

Published
2018
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