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10. A Case Study of Gastric Adenocarcinoma and Squamous Cell Carcinoma of the Cervix

Author

Liu,Suqing, Li,Fengling, Cao,Qinghua, Li,Ning, Gao,Qian, Liu,Suqing, Li,Fengling, Cao,Qinghua, Li,Ning, and Gao,Qian

Abstract

Suqing Liu,1 Fengling Li,1 Qinghua Cao,2 Ning Li,1 Qian Gao1 1Department of Gynaecology and Obstetrics, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, People’s Republic of China; 2Department of Pathology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, People’s Republic of ChinaCorrespondence: Fengling Li, Department of Gynecology and Obstetrics, Yantai Affiliated Hospital of Binzhou Medical University, Muping District, Yantai, Shandong, People’s Republic of China, Email sdbzlsq1989@163.comAbstract: Gastric adenocarcinoma (GAS) is a rare subtype of mucinous adenocarcinoma characterized by gastric differentiation and is unrelated to human papillomavirus (HPV) infection. This report discusses a 40-year-old female who presented with abdominal distension accompanied by increased abdominal circumference. CT of the abdomen and pelvis showed a large 21.0*12.7*26.0 cm mass later diagnosed as GAS combined with squamous cell carcinoma on surgical pathology. Immunohistological staining of GAS was positive for CK7, MUC6, PAX-8 CEA, and P53 (wild type) and negative for CDX2, CK20, ER, PR, P16, and WT1. The proliferative index (Ki-67) was 20%. Immunohistochemical staining of squamous cell carcinoma was positive for P16 and P53 (wild type), and the proliferative index (Ki-67) was 90%. However, the pathogenesis and molecular mechanisms of GAS have not been fully elucidated. As more cases are identified and reported, additional targeted therapies can be developed and tested in these patients.Keywords: cervical cancer, gastric type, adenocarcinoma

Published
2024

12. 书目记录的功能需求 : 最终报告

Author

Wang, Shaoping, Wang, Jing, Lin, Ming, Liu, Suqing, Ji, Lu'en, Gu, Ben, Wang, Shaoping, Wang, Jing, Lin, Ming, Liu, Suqing, Ji, Lu'en, and Gu, Ben

Subjects
LQ. Library automation systems., LR. OPAC systems., IA. Cataloging, bibliographic control.
Abstract

This is a Chinese translation of FRBR (Functional Requirements for Bibliographic Records)

Published
2008

17. Studies on Interpretive Structural Model for Forest Ecosystem Management Decision-Making

Author

Liu, Suqing, Gao, Xiumei, Zen, Qunying, Zhou, Yuanman, Huang, Yuequn, Han, Weidong, Li, Linfeng, Li, Jiping, Pu, Yingshan, Akan, Ozgur, Series editor, Bellavista, Paolo, Series editor, Cao, Jiannong, Series editor, Dressler, Falko, Series editor, Ferrari, Domenico, Series editor, Gerla, Mario, Series editor, Kobayashi, Hisashi, Series editor, Palazzo, Sergio, Series editor, Sahni, Sartaj, Series editor, Shen, Xuemin (Sherman), Series editor, Stan, Mircea, Series editor, Xiaohua, Jia, Series editor, Zomaya, Albert, Series editor, Coulson, Geoffrey, Series editor, and Zhou, Jie, editor

Published
2009
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27. A patch-based method for mechanism analysis on spatial dynamics of mangrove distribution

Author

李春干 Li Chungan, 刘素青 Liu Suqing, 代华兵 Dai Huabing, and 范航清 Fan Hangqing

Subjects
Geographic information system, Ecology, business.industry, Data interpretation, Mechanism analysis, Distribution (economics), Spatial distribution, Boundary (real estate), Patch dynamics, Environmental science, Physical geography, Mangrove, business, Ecology, Evolution, Behavior and Systematics
Abstract

The traditional analysis methods of mangrove spatial dynamic are generally top-down approaches that only summarize the overall dynamic trends and their underlining mechanism.Those methods can help reveal how much area of mangrove has been lost or gained and what possible drivers are but don′t deal with the change procedures and the patch number dynamic.The fact is that a contiguous region of mangrove can be composed with hundreds or thousands of interconnected patches and its overall dynamics is a summation of changes in those individual patches.Therefore,it is important to study patch dynamics,including changes in patch boundary and area,in order to accurately understand and assess mangrove′s overall dynamic processes and mechanisms at a landscape scale.In this paper we introduce a patch-based method for analyzing and monitoring temporal changes in spatial distribution of mangrove.We used two-time,high-resolution remote sensing imagery to quantify spatial distributions of mangrove and their changes over time.We used geographic information systems(GIS) to obtain patch-level spatial properties,including spatial position,shape,and area,at each time when the remote sensing data were acquired.We then compare patch-level mangrove between the two times to group mangrove patches into six categories: stable,expanded,shrank,fragmented,disappeared,and new patches.These six categories reflect the dynamic procedures for mangrove.Following similar remote sensing data interpretation,we identified five causes or drivers of mangrove dynamics,include nature process,inning,marineculture and saltern,construction,and plantation.We assigned each mangrove patch into one of the six dynamic procedures and one of the five drivers.By summing up mangrove patches of the same categories,we built a driver-procedure matrix for patch-numbrer and area,respectively.Thus we were able to calculate a series of indices,including the gross driving amount,gross driving rate,net driving amount,net driving rate,predicted driving rate,gross flowing amount,gross flowing rate,net flowing amount,net flowing rate,predicted flowing rate,and acting force,to assess mangrove patch dynamics in patch number and area.This analysis method is helpful to explicitly reveal changes in mangrove patches,in patch number or area,and what drivers trigger the changes and how the changes take place.The information obtained through such analysis provides important clues about the mechanisms involved in the changes in the mangrove landscape.This method means a site-specific,quantified,and precise analysis on mangrove′s spatial distributions and has scientific values for the protection and restoration of mangrove.

Published
2012

33. GOLPH3 induces epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in epithelial ovarian cancer.

Author

Sun, Jing, Yang, Xiaoming, Zhang, Ru, Liu, Suqing, Gan, Xupei, Xi, Xiaowei, Zhang, Zhenbo, Feng, Youji, and Sun, Yunyan

Subjects
OVARIAN cancer treatment, GOLGI apparatus, WNT signal transduction, OVARIAN cancer, PHOSPHOINOSITIDES, GENETIC overexpression, EPITHELIAL cells, MESENCHYMAL stem cells, PROGNOSIS, CELL physiology
Abstract

Golgi phosphoprotein 3 (GOLPH3), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer. However, its biological role and underlying mechanism in epithelial ovarian cancer (EOC) remain poorly understood. Here, we found that GOLPH3 was overexpressed in EOC tissues and cell lines. This overexpression promoted the migration and invasion of EOC cells. Moreover, GOLPH3 upregulated the expression of epithelial-mesenchymal transition (EMT) markers, such as N-cadherin and Snail, and the Wnt/β-catenin-related genes cyclin-D1 and c-Myc, which were restored via silencing of GOLPH3 expression. Furthermore, the inhibitor and activator of the Wnt/β-catenin pathway, XAV939 and LiCl, enhanced or decreased, respectively, the effect of GOLPH3 on EMT, which further confirmed that GOLPH3 promoted EMT progression via activation of Wnt/β-catenin signaling. In addition, we found that EDD, the human hyperplastic discs gene, was consistent with GOLPH3 expression and also promoted the EMT process and activated Wnt/β-catenin signaling. These findings demonstrate that EDD might be a downstream factor of GOLPH3. Taken together, our findings demonstrate the existence of a GOLPH-Wnt/β-catenin-EMT axis in EOC and provide a new therapeutic target to treat EOC. [ABSTRACT FROM AUTHOR]

Published
2017
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39. Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function

Author

Gao, Jie, primary, Graves, Stephanie, additional, Koch, Ute, additional, Liu, Suqing, additional, Jankovic, Vladimir, additional, Buonamici, Silvia, additional, El Andaloussi, Abdeljabar, additional, Nimer, Stephen D., additional, Kee, Barbara L., additional, Taichman, Russell, additional, Radtke, Freddy, additional, and Aifantis, Iannis, additional

Published
2009
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