Search

Your search keyword '"Liu, Shuli"' showing total 1,143 results
Start Over Author "Liu, Shuli"
1,143 results on '"Liu, Shuli"'

3. A compendium of genetic regulatory effects across pig tissues.

Author

Teng, Jinyan, Gao, Yahui, Yin, Hongwei, Bai, Zhonghao, Liu, Shuli, Zeng, Haonan, Bai, Lijing, Cai, Zexi, Zhao, Bingru, Li, Xiujin, Xu, Zhiting, Lin, Qing, Pan, Zhangyuan, Yang, Wenjing, Yu, Xiaoshan, Guan, Dailu, Hou, Yali, Keel, Brittney, Rohrer, Gary, Lindholm-Perry, Amanda, Oliver, William, Ballester, Maria, Crespo-Piazuelo, Daniel, Quintanilla, Raquel, Canela-Xandri, Oriol, Rawlik, Konrad, Xia, Charley, Yao, Yuelin, Zhao, Qianyi, Yao, Wenye, Yang, Liu, Li, Houcheng, Zhang, Huicong, Liao, Wang, Chen, Tianshuo, Karlskov-Mortensen, Peter, Fredholm, Merete, Amills, Marcel, Clop, Alex, Giuffra, Elisabetta, Wu, Jun, Cai, Xiaodian, Diao, Shuqi, Pan, Xiangchun, Wei, Chen, Li, Jinghui, Cheng, Hao, Wang, Sheng, Su, Guosheng, Sahana, Goutam, Lund, Mogens, Dekkers, Jack, Kramer, Luke, Tuggle, Christopher, Corbett, Ryan, Groenen, Martien, Madsen, Ole, Gòdia, Marta, Rocha, Dominique, Charles, Mathieu, Li, Cong-Jun, Pausch, Hubert, Hu, Xiaoxiang, Frantz, Laurent, Luo, Yonglun, Lin, Lin, Zhou, Zhongyin, Zhang, Zhe, Chen, Zitao, Cui, Leilei, Xiang, Ruidong, Shen, Xia, Li, Pinghua, Huang, Ruihua, Tang, Guoqing, Li, Mingzhou, Zhao, Yunxiang, Yi, Guoqiang, Tang, Zhonglin, Jiang, Jicai, Zhao, Fuping, Yuan, Xiaolong, Liu, Xiaohong, Chen, Yaosheng, Xu, Xuewen, Zhao, Shuhong, Zhao, Pengju, Haley, Chris, Zhou, Huaijun, Wang, Qishan, Pan, Yuchun, Ding, Xiangdong, Ma, Li, Li, Jiaqi, Navarro, Pau, Zhang, Qin, Li, Bingjie, Tenesa, Albert, Li, Kui, and Liu, George

Subjects
Swine, Animals, Humans, Gene Expression Regulation, Genotype, Phenotype, Sequence Analysis, RNA, Gene Expression Profiling
Abstract

The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in animal breeding and human biomedicine. Here we show results from the pilot phase of PigGTEx by processing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples passing quality control from pigs. We build a pig genotype imputation panel and associate millions of genetic variants with five types of transcriptomic phenotypes in 34 tissues. We evaluate tissue specificity of regulatory effects and elucidate molecular mechanisms of their action using multi-omics data. Leveraging this resource, we decipher regulatory mechanisms underlying 207 pig complex phenotypes and demonstrate the similarity of pigs to humans in gene expression and the genetic regulation behind complex phenotypes, supporting the importance of pigs as a human biomedical model.

Published
2024

36. Comparative transcriptome in large-scale human and cattle populations

Author

Yao, Yuelin, Liu, Shuli, Xia, Charley, Gao, Yahui, Pan, Zhangyuan, Canela-Xandri, Oriol, Khamseh, Ava, Rawlik, Konrad, Wang, Sheng, Li, Bingjie, Zhang, Yi, Pairo-Castineira, Erola, D’Mellow, Kenton, Li, Xiujin, Yan, Ze, Li, Cong-jun, Yu, Ying, Zhang, Shengli, Ma, Li, Cole, John B, Ross, Pablo J, Zhou, Huaijun, Haley, Chris, Liu, George E, Fang, Lingzhao, and Tenesa, Albert

Subjects
Biological Sciences, Genetics, Human Genome, Biotechnology, Generic health relevance, Animals, Cattle, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Phenotype, Quantitative Trait Loci, Transcriptome, Comparative transcriptome, Gene co-expression, Heritability enrichment, Inter-individual variability, RNA-seq, Environmental Sciences, Information and Computing Sciences, Bioinformatics
Abstract

BackgroundCross-species comparison of transcriptomes is important for elucidating evolutionary molecular mechanisms underpinning phenotypic variation between and within species, yet to date it has been essentially limited to model organisms with relatively small sample sizes.ResultsHere, we systematically analyze and compare 10,830 and 4866 publicly available RNA-seq samples in humans and cattle, respectively, representing 20 common tissues. Focusing on 17,315 orthologous genes, we demonstrate that mean/median gene expression, inter-individual variation of expression, expression quantitative trait loci, and gene co-expression networks are generally conserved between humans and cattle. By examining large-scale genome-wide association studies for 46 human traits (average n = 327,973) and 45 cattle traits (average n = 24,635), we reveal that the heritability of complex traits in both species is significantly more enriched in transcriptionally conserved than diverged genes across tissues.ConclusionsIn summary, our study provides a comprehensive comparison of transcriptomes between humans and cattle, which might help decipher the genetic and evolutionary basis of complex traits in both species.

Published
2022

43. Correlation analysis of lift fan lip feature geometry and aerodynamic performance

Author

WANG Siwei, WANG Yangang, LIU Hanru, CHEN Yanjun, and LIU Shuli

Subjects
涵道唇口, 升力风扇, 曲线斜率, 流场结构, Motor vehicles. Aeronautics. Astronautics, TL1-4050
Abstract

In hover, the lip of a lift fan plays a crucial role, contributing to nearly half of the lift for the VTOL aircraft power plant. Thus, investigating the geometric parameters that influence lip performance is of significant importance. In this study, four types of lift fan lips were designed, tailored to meet specific application requirements. Numerical analysis, validated through experimental data, was employed to examine the flow field and the geometric factors that lead to variations in lip performance. Based on the findings, the relationship between lip geometric parameters and aerodynamic performance was thoroughly investigated and confirmed. The results demonstrate that, at a rotational speed of 10 000 r/min, the non-dimensional lift and non-dimensional mass flow of the lemniscate lip exhibit improvements of 33% and 9.5%, respectively, compared to lips designed based on NACA65. Among the various lip configurations, it is found that the performance parameters of the lip are optimal when the slope of the inner surface equaled twice the slope of the lemniscate. On the other hand, when the slope deviated from this optimal value, whether greater or lesser, a reduction in lip performance was observed. Specifically, at a rotational speed of 10 000 r/min, the lip designed based on a lemniscate slope could increase the total lift of the lift fan by 5.6% when compared to the lemniscate lip.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results