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10. Development of a Biodegradable PLGA Carrier to Provide Wnt Agonists and Antibiotics to Meet the Requirements for Patients with Bone Infections.

Author

Lin, Song-Shu, Liu, Shih-Jung, Chan, Err-Cheng, Chong, Kowit-Yu, Chan, Yi-Sheng, Tsai, Tsung-Ting, Niu, Chi-Chien, Yuan, Li-Jen, Yang, Chuen-Yung, Hsiao, Hui-Yi, Hsueh, Yi-Jen, Chen, Chung-An, and Ueng, Steve W. N.

Subjects
*MESENCHYMAL stem cells, *DRUG delivery systems, *BONE morphogenetic proteins, *LITHIUM chloride, *PROTEIN expression
Abstract

Antibiotic beads can be used to treat surgical infections. In this study, polylactide–polyglycolide (PLGA) was mixed with vancomycin, the osteogenic enhancer lithium chloride (LiCl), and hot compression to form PLGA-vancomycin-LiCl delivery beads to treat bone infection. An elution method was used to characterize in vitro release characteristics of vancomycin and Li over a 42-day period. The release profiles lasted for more than 42 days for vancomycin and 28 days for Li. The concentration of vancomycin in each sample was well above the breakpoint sensitivity. Lithium cotreatment enhanced the bactericidal effect of vancomycin. Released Li and vancomycin increased the mRNA or protein expressions of osteogenic markers of mesenchymal stem cells (MSCs). In vivo, the PLGA delivery systems were implanted into the distal femoral cavities of rabbits, and the cavity fluid content was aspirated and analyzed at each time point. The released Li and vancomycin lasted more than 6 weeks, and the vancomycin concentrations were much greater than the breakpoint sensitivity. Four rabbits in each group were sacrificed at 8 weeks for histological observation. More mature bone tissue was observed in the Li treatment group. This study provides a PLGA drug delivery system to meet the requirements of patients with bone infections. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Effects of Hyperbaric Oxygen Intervention on the Degenerated Intervertebral Disc: From Molecular Mechanisms to Animal Models

Author

Lin, Song-Shu, primary, Ueng, Steve W. N., additional, Chong, Kowit-Yu, additional, Chan, Yi-Sheng, additional, Tsai, Tsung-Ting, additional, Yuan, Li-Jen, additional, Liu, Shih-Jung, additional, Yang, Chuen-Yung, additional, Hsiao, Hui-Yi, additional, Hsueh, Yi-Jen, additional, Chen, Chung-An, additional, and Niu, Chi-Chien, additional

Published
2023
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44. Simvastatin-Loaded Nanofibrous Membrane Efficiency on the Repair of Achilles Tendons

Author

Weng,Chun-Jui, Liao,Chieh-Tun, Hsu,Ming-Yi, Chang,Fu-Pang, Liu,Shih-Jung, Weng,Chun-Jui, Liao,Chieh-Tun, Hsu,Ming-Yi, Chang,Fu-Pang, and Liu,Shih-Jung

Abstract

Chun-Jui Weng,1– 3 Chieh-Tun Liao,2 Ming-Yi Hsu,2,4 Fu-Pang Chang,5 Shih-Jung Liu1,2 1Department of Orthopedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; 2Department of Mechanical Engineering, Chang Gung University, Taoyuan, Taiwan; 3Department of Orthopaedics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; 4Department of Radiology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; 5Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, TaiwanCorrespondence: Shih-Jung Liu, Department of Orthopedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital at Linkou and Department of Mechanical Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Taoyuan, 33302, Taiwan, Tel +886-3-2118166, Fax +886-3-2118558, Email shihjung@mail.cgu.edu.twIntroduction: In this study, simvastatin-incorporated poly(D,L-lactide-co-glycolide) (PLGA) nanofibrous mats were fabricated via electrospinning, and their efficacy in the repair of the Achilles tendon was evaluated.Methods: The morphology of spun nanofibers and the in vitro drug release kinetics were assessed, while the in vivo efficacy in tendon repair was tested using a rat model.Results: Images obtained by scanning electron microscopy revealed that spun nanofibers exhibit a porous structure with a fiber diameter of approximately 350 nm. Fourier-transform infrared spectrometry and differential scanning calorimetry demonstrated successful incorporation of pharmaceutical agents into the PLGA nanofibers. The drug-loaded nanofibrous membranes sustainably discharged high concentrations of simvastatin for > 28 days at the target site, and drug concentrations in blood were low. Tendons repaired using simvastatin-eluting nanofibers exhibited superior mechanical strength and animal activities to those repaired without nanofibers or with pure PLGA nanofibers.Discussion: Simvastatin-loaded nanofibers d

Published
2022

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