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This paper deals with the conflict between the input-output response and the disturbance-output response, which cannot be completely eliminated by traditional and advanced control strategies without using the accurate process model. The inherently close association of these two responses and the unavailability of the accurate process model pose a great challenge to field test engineers of a coal-fired power plant, that is, the design requirements of reference tracking and disturbance rejection are compromised. In this paper, a novel two-degree-of-freedom controller-feedforward compensated (FC) desired dynamic equational (DDE) proportional-integral-derivative (PID) (FC-DDE PID)-is proposed as a viable alternative. In addition to achieving independent reference tracking performance and disturbance rejection performance, its simple structure and tuning procedure are specifically appealing to practitioners. Simulations, experiments, and field tests demonstrate the advantages of the proposed controller in both reference tracking and disturbance rejection, thus making FC-DDE PID a convenient and effective controller for the control of the coal-fired power plants, readily implementable on the distributed control system (DCS).

The 2022 Fudan university doctorate academic public health forum hosted by the graduate school of Fudan university， the graduate work department of the party committee of Fudan university， and the school of public health of Fudan university was successfully held on December 10， 2022 in the school of public health of Fudan university. In the early stage， a total of 53 manuscripts from nationwide universities and research institutes were received， and 10 were selected as excellent papers to participate in the forum report. More than 100 teachers and students attended the forum. Focusing on the theme of " Adhering to the original ambition of scientific research to serve the country and practicing the mission of public health youth"， the major contents of the forums included excellent paper reports in the morning and round-table discussion in the afternoon. Experts and students conducted discussions and communications on prevention， control and management of public health emergencies. It is of great benefit for students to uphold the original intention，practice the mission and further improve public health research.

Solid pseudopapillary neoplasms （SPN） of the pancreas are a type of mostly single and rare low-grade malignant tumors, which are mainly treated by surgery. In this article, the diagnosis and treatment of one case of SPN who was treated using hand-assisted laparoscopy were reported. The 29-year-old woman patient was admitted to the hospital due to retrosternal pain accompanied by suppressed discomfort for more than 3 months. Enhanced abdominal CT revealed cystic space-occupying lesions between the spleen and pancreas （approximately 5.4 cm×3.7 cm）. Hand-assisted laparoscopic caudal pancreatic resection combined with splenectomy was performed. The diagnosis of SPN was confirmed by postoperative pathology. The patient had anal exhaust and feeding fluid at 3 days after surgery,and she was discharged at 1 week after surgery. No tumor recurrence was observed during 8 months of follow-up. This case provides clinical reference for the treatment of SPN in China.

Conventional androgen deprivation therapy (ADT) targets the androgen receptor (AR) inhibiting prostate cancer (PCa) progression; however, it can eventually lead to recurrence as castration‐resistant PCa (CRPC), which has high mortality rates and lacks effective treatment modalities. The study confirms the presence of high glutathione peroxidase 4 (GPX4) expression, a key regulator of ferroptosis (i.e., iron‐dependent program cell death) in CRPC cells. Therefore, inducing ferroptosis in CRPC cells might be an effective therapeutic modality for CRPC. However, nonspecific uptake of ferroptosis inducers can result in undesirable cytotoxicity in major organs. Thus, to precisely induce ferroptosis in CRPC cells, a genetic engineering strategy is proposed to embed a prostate‐specific membrane antigen (PSMA)‐targeting antibody fragment (gy1) in the macrophage membrane, which is then coated onto mesoporous polydopamine (MPDA) nanoparticles to produce a biomimetic nanoplatform. The results indicate that the membrane‐coated nanoparticles (MNPs) exhibit high specificity and affinity toward CRPC cells. On further encapsulation with the ferroptosis inducers RSL3 and iron ions, MPDA/Fe/RSL3@M‐gy1 demonstrates superior synergistic effects in highly targeted ferroptosis therapy eliciting significant therapeutic efficacy against CRPC tumor growth and bone metastasis without increased cytotoxicity. In conclusion, a new therapeutic strategy is reported for the PSMA‐specific, CRPC‐targeting platform for ferroptosis induction with increased efficacy and safety. [ABSTRACT FROM AUTHOR]

Policymakers demonstrate a keen interest in understanding risky driving behaviors to formulate effective countermeasures aimed at reducing accidents and economic losses. With the increasing deployment of millimeter-wave (MMW) radars on roadways, there exists a viable opportunity to gather extensive vehicle information at big data levels from individual drivers traversing through the radar detection range. This study endeavors to analyze traffic flow characteristics and identify risky driving behaviors using the noisy raw vehicle position and speed profiles obtained from MMW radars installed on a highway in China. A series of data cleaning procedures are meticulously implemented to address several typical trajectory errors stemming from MMW radars. Subsequently, after data cleaning, the study identifies risky driving behaviors through established methods found in the literature and evaluates the prevalence of these behaviors across different times of day and days of the week. This research mitigates the gap between raw vehicle trajectories from MMW radar and popular existing risk analysis methods. In addition, this research analyzes the temporal pattern of different risks and pinpoints their inherent connections. The outcomes of this research endeavor hold the potential to furnish practical insights for the formulation of targeted safety enhancement policies by governmental bodies or relevant agencies. [ABSTRACT FROM AUTHOR]