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Training AI foundation models has emerged as a promising large-scale learning approach for addressing real-world healthcare challenges, including digital pathology. While many of these models have been developed for tasks like disease diagnosis and tissue quantification using extensive and diverse training datasets, their readiness for deployment on some arguably simplest tasks, such as nuclei segmentation within a single organ (e.g., the kidney), remains uncertain. This paper seeks to answer this key question, "How good are we?", by thoroughly evaluating the performance of recent cell foundation models on a curated multi-center, multi-disease, and multi-species external testing dataset. Additionally, we tackle a more challenging question, "How can we improve?", by developing and assessing human-in-the-loop data enrichment strategies aimed at enhancing model performance while minimizing the reliance on pixel-level human annotation. To address the first question, we curated a multicenter, multidisease, and multispecies dataset consisting of 2,542 kidney whole slide images (WSIs). Three state-of-the-art (SOTA) cell foundation models-Cellpose, StarDist, and CellViT-were selected for evaluation. To tackle the second question, we explored data enrichment algorithms by distilling predictions from the different foundation models with a human-in-the-loop framework, aiming to further enhance foundation model performance with minimal human efforts. Our experimental results showed that all three foundation models improved over their baselines with model fine-tuning with enriched data. Interestingly, the baseline model with the highest F1 score does not yield the best segmentation outcomes after fine-tuning. This study establishes a benchmark for the development and deployment of cell vision foundation models tailored for real-world data applications.

Unlearning in Large Language Models (LLMs) is essential for ensuring ethical and responsible AI use, especially in addressing privacy leak, bias, safety, and evolving regulations. Existing approaches to LLM unlearning often rely on retain data or a reference LLM, yet they struggle to adequately balance unlearning performance with overall model utility. This challenge arises because leveraging explicit retain data or implicit knowledge of retain data from a reference LLM to fine-tune the model tends to blur the boundaries between the forgotten and retain data, as different queries often elicit similar responses. In this work, we propose eliminating the need to retain data or the reference LLM for response calibration in LLM unlearning. Recognizing that directly applying gradient ascent on the forget data often leads to optimization instability and poor performance, our method guides the LLM on what not to respond to, and importantly, how to respond, based on the forget data. Hence, we introduce Forget data only Loss AjustmenT (FLAT), a "flat" loss adjustment approach which addresses these issues by maximizing f-divergence between the available template answer and the forget answer only w.r.t. the forget data. The variational form of the defined f-divergence theoretically provides a way of loss adjustment by assigning different importance weights for the learning w.r.t. template responses and the forgetting of responses subject to unlearning. Empirical results demonstrate that our approach not only achieves superior unlearning performance compared to existing methods but also minimizes the impact on the model's retained capabilities, ensuring high utility across diverse tasks, including copyrighted content unlearning on Harry Potter dataset and MUSE Benchmark, and entity unlearning on the TOFU dataset., Comment: Paper under review

Graphene-based 2D heterostructures exhibit excellent mechanical and electrical properties, which are expected to exhibit better performances than graphene for nanoelectromechanical pressure sensors. Here, we built the pressure sensor models based on suspended heterostructures of graphene/h-BN, graphene/MoS2, and graphene/MoSe2 by using COMSOL Multiphysics finite element software. We found that suspended circular 2D membranes show the best sensitivity to pressures compared to rectangular and square ones. We simulated the deflections, strains, resonant frequencies, and Young's moduli of suspended graphene-based heterostructures under the conditions of different applied pressures and geometrical sizes, built-in tensions, and the number of atomic layers of 2D membranes. The Young's moduli of 2D heterostructures of graphene, graphene/h-BN, graphene/MoS2, and graphene/MoSe2 were estimated to be 1.001TPa, 921.08 GPa, 551.11 GPa, and 475.68 GPa, respectively. We also discuss the effect of highly asymmetric cavities on device performance. These results would contribute to the understanding of the mechanical properties of graphene-based heterostructures and would be helpful for the design and manufacture of high-performance NEMS pressure sensors.

In recent years, pressure sensors have been widely used as crucial technology components in industrial, healthcare, consumer electronics, and automotive safety applications. With the development of intelligent technologies, there is a growing demand for pressure sensors with higher sensitivity, smaller size, and wider detection range. Graphene and its derivatives, as novel emerging materials in recent years, have received widespread attention from researchers due to their unique mechanical and electrical properties, and are considered as promising sensing materials for the high-performance pressure sensors. In general, graphene-based pressure sensors can be classified into flexible pressure sensors and gas pressure sensors. In this paper, we firstly introduce the basic properties of graphene and its derivatives and then review the research progress of both graphene-based flexible pressure sensors and graphene-based gas pressure sensors respectively, focusing on different sensing mechanisms. Finally, the application prospects of graphene-based pressure sensors as well as future challenges are discussed.

The advent of the 5G era means that the concepts of robot, VR/AR, UAV, smart home, smart healthcare based on IoT (Internet of Things) have gradually entered human life. Since then, intelligent life has become the dominant direction of social development. Humidity sensors, as humidity detection tools, not only convey the comfort of human living environment, but also display great significance in the fields of meteorology, medicine, agriculture and industry. Graphene-based materials exhibit tremendous potential in humidity sensing owing to their ultra-high specific surface area and excellent electron mobility under room temperature for application in humidity sensing. This review begins with the introduction of examples of various synthesis strategies of graphene, followed by the device structure and working mechanism of graphene-based humidity sensor. In addition, several different structural design methods of graphene are summarized, demonstrating the structural design of graphene can not only optimize the performance of graphene, but also bring significant advantages in humidity sensing. Finally, key challenges hindering the further development and practical application of high-performance graphene-based humidity sensors are discussed, followed by presenting the future perspectives.

Large language models are susceptible to jailbreak attacks, which can result in the generation of harmful content. While prior defenses mitigate these risks by perturbing or inspecting inputs, they ignore competing objectives, the underlying cause of alignment failures. In this paper, we propose Alignment-Enhanced Decoding (AED), a novel defense that employs adaptive decoding to address the root causes of jailbreak issues. We first define the Competitive Index to quantify alignment failures and utilize feedback from self-evaluation to compute post-alignment logits. Then, AED adaptively combines AED and post-alignment logits with the original logits to obtain harmless and helpful distributions. Consequently, our method enhances safety alignment while maintaining helpfulness. We conduct experiments across five models and four common jailbreaks, with the results validating the effectiveness of our approach. Code is available at https://github.com/GIGABaozi/AED.git., Comment: 15 pages, 5 figures

Cell nuclei instance segmentation is a crucial task in digital kidney pathology. Traditional automatic segmentation methods often lack generalizability when applied to unseen datasets. Recently, the success of foundation models (FMs) has provided a more generalizable solution, potentially enabling the segmentation of any cell type. In this study, we perform a large-scale evaluation of three widely used state-of-the-art (SOTA) cell nuclei foundation models (Cellpose, StarDist, and CellViT). Specifically, we created a highly diverse evaluation dataset consisting of 2,542 kidney whole slide images (WSIs) collected from both human and rodent sources, encompassing various tissue types, sizes, and staining methods. To our knowledge, this is the largest-scale evaluation of its kind to date. Our quantitative analysis of the prediction distribution reveals a persistent performance gap in kidney pathology. Among the evaluated models, CellViT demonstrated superior performance in segmenting nuclei in kidney pathology. However, none of the foundation models are perfect; a performance gap remains in general nuclei segmentation for kidney pathology.

Moving from animal models to human applications in preclinical research encompasses a broad spectrum of disciplines in medical science. A fundamental element in the development of new drugs, treatments, diagnostic methods, and in deepening our understanding of disease processes is the accurate measurement of kidney tissues. Past studies have demonstrated the viability of translating glomeruli segmentation techniques from mouse models to human applications. Yet, these investigations tend to neglect the complexities involved in segmenting pathological glomeruli affected by different lesions. Such lesions present a wider range of morphological variations compared to healthy glomerular tissue, which are arguably more valuable than normal glomeruli in clinical practice. Furthermore, data on lesions from animal models can be more readily scaled up from disease models and whole kidney biopsies. This brings up a question: ``\textit{Can a pathological segmentation model trained on mouse models be effectively applied to human patients?}" To answer this question, we introduced GLAM, a deep learning study for fine-grained segmentation of human kidney lesions using a mouse model, addressing mouse-to-human transfer learning, by evaluating different learning strategies for segmenting human pathological lesions using zero-shot transfer learning and hybrid learning by leveraging mouse samples. From the results, the hybrid learning model achieved superior performance.

Data sharing in the medical image analysis field has potential yet remains underappreciated. The aim is often to share datasets efficiently with other sites to train models effectively. One possible solution is to avoid transferring the entire dataset while still achieving similar model performance. Recent progress in data distillation within computer science offers promising prospects for sharing medical data efficiently without significantly compromising model effectiveness. However, it remains uncertain whether these methods would be applicable to medical imaging, since medical and natural images are distinct fields. Moreover, it is intriguing to consider what level of performance could be achieved with these methods. To answer these questions, we conduct investigations on a variety of leading data distillation methods, in different contexts of medical imaging. We evaluate the feasibility of these methods with extensive experiments in two aspects: 1) Assess the impact of data distillation across multiple datasets characterized by minor or great variations. 2) Explore the indicator to predict the distillation performance. Our extensive experiments across multiple medical datasets reveal that data distillation can significantly reduce dataset size while maintaining comparable model performance to that achieved with the full dataset, suggesting that a small, representative sample of images can serve as a reliable indicator of distillation success. This study demonstrates that data distillation is a viable method for efficient and secure medical data sharing, with the potential to facilitate enhanced collaborative research and clinical applications.

The Vision Foundation Model has recently gained attention in medical image analysis. Its zero-shot learning capabilities accelerate AI deployment and enhance the generalizability of clinical applications. However, segmenting pathological images presents a special focus on the flexibility of segmentation targets. For instance, a single click on a Whole Slide Image (WSI) could signify a cell, a functional unit, or layers, adding layers of complexity to the segmentation tasks. Current models primarily predict potential outcomes but lack the flexibility needed for physician input. In this paper, we explore the potential of enhancing segmentation model flexibility by introducing various task prompts through a Large Language Model (LLM) alongside traditional task tokens. Our contribution is in four-fold: (1) we construct a computational-efficient pipeline that uses finetuned language prompts to guide flexible multi-class segmentation; (2) We compare segmentation performance with fixed prompts against free-text; (3) We design a multi-task kidney pathology segmentation dataset and the corresponding various free-text prompts; and (4) We evaluate our approach on the kidney pathology dataset, assessing its capacity to new cases during inference.

In digital pathology, the traditional method for deep learning-based image segmentation typically involves a two-stage process: initially segmenting high-resolution whole slide images (WSI) into smaller patches (e.g., 256x256, 512x512, 1024x1024) and subsequently reconstructing them to their original scale. This method often struggles to capture the complex details and vast scope of WSIs. In this paper, we propose the holistic histopathology (HoloHisto) segmentation method to achieve end-to-end segmentation on gigapixel WSIs, whose maximum resolution is above 80,000$\times$70,000 pixels. HoloHisto fundamentally shifts the paradigm of WSI segmentation to an end-to-end learning fashion with 1) a large (4K) resolution base patch for elevated visual information inclusion and efficient processing, and 2) a novel sequential tokenization mechanism to properly model the contextual relationships and efficiently model the rich information from the 4K input. To our best knowledge, HoloHisto presents the first holistic approach for gigapixel resolution WSI segmentation, supporting direct I/O of complete WSI and their corresponding gigapixel masks. Under the HoloHisto platform, we unveil a random 4K sampler that transcends ultra-high resolution, delivering 31 and 10 times more pixels than standard 2D and 3D patches, respectively, for advancing computational capabilities. To facilitate efficient 4K resolution dense prediction, we leverage sequential tokenization, utilizing a pre-trained image tokenizer to group image features into a discrete token grid. To assess the performance, our team curated a new kidney pathology image segmentation (KPIs) dataset with WSI-level glomeruli segmentation from whole mouse kidneys. From the results, HoloHisto-4K delivers remarkable performance gains over previous state-of-the-art models.

Panoramic image segmentation in computational pathology presents a remarkable challenge due to the morphologically complex and variably scaled anatomy. For instance, the intricate organization in kidney pathology spans multiple layers, from regions like the cortex and medulla to functional units such as glomeruli, tubules, and vessels, down to various cell types. In this paper, we propose a novel Hierarchical Adaptive Taxonomy Segmentation (HATs) method, which is designed to thoroughly segment panoramic views of kidney structures by leveraging detailed anatomical insights. Our approach entails (1) the innovative HATs technique which translates spatial relationships among 15 distinct object classes into a versatile "plug-and-play" loss function that spans across regions, functional units, and cells, (2) the incorporation of anatomical hierarchies and scale considerations into a unified simple matrix representation for all panoramic entities, (3) the adoption of the latest AI foundation model (EfficientSAM) as a feature extraction tool to boost the model's adaptability, yet eliminating the need for manual prompt generation in conventional segment anything model (SAM). Experimental findings demonstrate that the HATs method offers an efficient and effective strategy for integrating clinical insights and imaging precedents into a unified segmentation model across more than 15 categories. The official implementation is publicly available at https://github.com/hrlblab/HATs., Comment: arXiv admin note: text overlap with arXiv:2402.19286

Recently, the use of circle representation has emerged as a method to improve the identification of spherical objects (such as glomeruli, cells, and nuclei) in medical imaging studies. In traditional bounding box-based object detection, combining results from multiple models improves accuracy, especially when real-time processing isn't crucial. Unfortunately, this widely adopted strategy is not readily available for combining circle representations. In this paper, we propose Weighted Circle Fusion (WCF), a simple approach for merging predictions from various circle detection models. Our method leverages confidence scores associated with each proposed bounding circle to generate averaged circles. Our method undergoes thorough evaluation on a proprietary dataset for glomerular detection in object detection within whole slide imaging (WSI). The findings reveal a performance gain of 5 %, respectively, compared to existing ensemble methods. Furthermore, the Weighted Circle Fusion technique not only improves the precision of object detection in medical images but also notably decreases false detections, presenting a promising direction for future research and application in pathological image analysis.

In rotating black hole background surrounded by dark matter, we investigated the super-radiant phenomenon of massive scalar field and its associated instability.Using the method of asymptotic matching, we computed the amplification factor of scalar wave scattering to assess the strength of super-radiance. We discussed the influence of dark matter density on amplification factor in this black hole background. Our result indicates that the presence of dark matter has suppressive influence on black hole super-radiance. We also computed the net extracted energy to further support this result. Finally, we analyzed the super-radiant instability caused by massive scalar field using the black hole bomb mechanism and found that the presence of dark matter has no influence on the super-radiant instability condition., Comment: v1:14 pages, 5 figures,1 table. v2:16 pages, 4 figures, 1 tale, figures updated, discussions expanded, reference added, version to appear in Physics of the Dark Universe

Multi-modal learning adeptly integrates visual and textual data, but its application to histopathology image and text analysis remains challenging, particularly with large, high-resolution images like gigapixel Whole Slide Images (WSIs). Current methods typically rely on manual region labeling or multi-stage learning to assemble local representations (e.g., patch-level) into global features (e.g., slide-level). However, there is no effective way to integrate multi-scale image representations with text data in a seamless end-to-end process. In this study, we introduce Multi-Level Text-Guided Representation End-to-End Learning (mTREE). This novel text-guided approach effectively captures multi-scale WSI representations by utilizing information from accompanying textual pathology information. mTREE innovatively combines - the localization of key areas (global-to-local) and the development of a WSI-level image-text representation (local-to-global) - into a unified, end-to-end learning framework. In this model, textual information serves a dual purpose: firstly, functioning as an attention map to accurately identify key areas, and secondly, acting as a conduit for integrating textual features into the comprehensive representation of the image. Our study demonstrates the effectiveness of mTREE through quantitative analyses in two image-related tasks: classification and survival prediction, showcasing its remarkable superiority over baselines.

Deep neural networks (DNNs) have heavily relied on traditional computational units like CPUs and GPUs. However, this conventional approach brings significant computational burdens, latency issues, and high power consumption, limiting their effectiveness. This has sparked the need for lightweight networks like ExtremeC3Net. On the other hand, there have been notable advancements in optical computational units, particularly with metamaterials, offering the exciting prospect of energy-efficient neural networks operating at the speed of light. Yet, the digital design of metamaterial neural networks (MNNs) faces challenges such as precision, noise, and bandwidth, limiting their application to intuitive tasks and low-resolution images. In this paper, we propose a large kernel lightweight segmentation model, ExtremeMETA. Based on the ExtremeC3Net, the ExtremeMETA maximizes the ability of the first convolution layer by exploring a larger convolution kernel and multiple processing paths. With the proposed large kernel convolution model, we extend the optic neural network application boundary to the segmentation task. To further lighten the computation burden of the digital processing part, a set of model compression methods is applied to improve model efficiency in the inference stage. The experimental results on three publicly available datasets demonstrate that the optimized efficient design improved segmentation performance from 92.45 to 95.97 on mIoU while reducing computational FLOPs from 461.07 MMacs to 166.03 MMacs. The proposed the large kernel lightweight model ExtremeMETA showcases the hybrid design's ability on complex tasks.

Registration of point clouds collected from a pair of distant vehicles provides a comprehensive and accurate 3D view of the driving scenario, which is vital for driving safety related applications, yet existing literature suffers from the expensive pose label acquisition and the deficiency to generalize to new data distributions. In this paper, we propose EYOC, an unsupervised distant point cloud registration method that adapts to new point cloud distributions on the fly, requiring no global pose labels. The core idea of EYOC is to train a feature extractor in a progressive fashion, where in each round, the feature extractor, trained with near point cloud pairs, can label slightly farther point cloud pairs, enabling self-supervision on such far point cloud pairs. This process continues until the derived extractor can be used to register distant point clouds. Particularly, to enable high-fidelity correspondence label generation, we devise an effective spatial filtering scheme to select the most representative correspondences to register a point cloud pair, and then utilize the aligned point clouds to discover more correct correspondences. Experiments show that EYOC can achieve comparable performance with state-of-the-art supervised methods at a lower training cost. Moreover, it outwits supervised methods regarding generalization performance on new data distributions., Comment: In Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2024

Understanding the anatomy of renal pathology is crucial for advancing disease diagnostics, treatment evaluation, and clinical research. The complex kidney system comprises various components across multiple levels, including regions (cortex, medulla), functional units (glomeruli, tubules), and cells (podocytes, mesangial cells in glomerulus). Prior studies have predominantly overlooked the intricate spatial interrelations among objects from clinical knowledge. In this research, we introduce a novel universal proposition learning approach, called panoramic renal pathology segmentation (PrPSeg), designed to segment comprehensively panoramic structures within kidney by integrating extensive knowledge of kidney anatomy. In this paper, we propose (1) the design of a comprehensive universal proposition matrix for renal pathology, facilitating the incorporation of classification and spatial relationships into the segmentation process; (2) a token-based dynamic head single network architecture, with the improvement of the partial label image segmentation and capability for future data enlargement; and (3) an anatomy loss function, quantifying the inter-object relationships across the kidney., Comment: IEEE / CVF Computer Vision and Pattern Recognition Conference 2024

Large Language Models (LLMs) have been demonstrated to generate illegal or unethical responses, particularly when subjected to "jailbreak." Research on jailbreak has highlighted the safety issues of LLMs. However, prior studies have predominantly focused on single-turn dialogue, ignoring the potential complexities and risks presented by multi-turn dialogue, a crucial mode through which humans derive information from LLMs. In this paper, we argue that humans could exploit multi-turn dialogue to induce LLMs into generating harmful information. LLMs may not intend to reject cautionary or borderline unsafe queries, even if each turn is closely served for one malicious purpose in a multi-turn dialogue. Therefore, by decomposing an unsafe query into several sub-queries for multi-turn dialogue, we induced LLMs to answer harmful sub-questions incrementally, culminating in an overall harmful response. Our experiments, conducted across a wide range of LLMs, indicate current inadequacies in the safety mechanisms of LLMs in multi-turn dialogue. Our findings expose vulnerabilities of LLMs in complex scenarios involving multi-turn dialogue, presenting new challenges for the safety of LLMs., Comment: working in progress 23pages, 18 figures

We make use of an entropic property to establish a convergence theorem (Main Theorem), which reveals that the conditional entropy measures the asymptotic Gaussianity. As an application, we establish the {\it entropic conditional central limit theorem} (CCLT), which is stronger than the classical CCLT. As another application, we show that continuous input under iterated Hadamard transform, almost every distribution of the output conditional on the values of the previous signals will tend to Gaussian, and the conditional distribution is in fact insensitive to the condition. The results enable us to make a theoretic study concerning Hadamard compression, which provides a solid theoretical analysis supporting the simulation results in previous literature. We show also that the conditional Fisher information can be used to measure the asymptotic Gaussianity., Comment: 40 pages

In this paper, we consider the symmetric KL-divergence between the sum of independent variables and a Gaussian distribution, and obtain a convergence rates of order $O\left( \frac{\ln n}{\sqrt{n}}\right)$. The proof is based on Stein's method. The convergence rate of order $O\left( \frac{1}{\sqrt{n}}\right)$ and $O\left( \frac{1}{n}\right) $ are also obtained under higher moment condition., Comment: 33 pages

In Gale Crater near Mars' equator, dunes and ripples of sand stand out from the general orderless, rocky terrain. In addition, images from Curiosity, the Mars Science Laboratory rover, reveal more subtle orderly forms: widespread, meter-scale domains of evenly spaced, pebble-size rocks (termed clasts) on wind-blown sand in scattered locations. Here, we examine quantitatively several clast domains on both Mars and Earth, and compare their geometry with that of random points. The clast distributions are more orderly than expected by chance; they differ significantlty from those associated with uniform (Poisson) random processes. Moreover, they are hyperuniform, a self-organized state recently recognized in diverse active materials and biological systems but that appears novel for planetary surfaces. These patches are often surrounded by recent wind-borne ripples, suggesting an interplay between sand transport, ripple activity and clasts. Using numerical simulations, we show that clast displacements induced by gravity, combined with the evolution of the sand surface caused by aeolian sand transport and ripple migration, can produce realistic hyperuniform and random clast distributions, as well as distinct clast alignements. Our findings highlight the existence of easily overlooked disordered hyperuniform states on ground surfaces, suggesting novel self-organized states beyond distinct geometric patterns., Comment: 23 pages, 5 figures; updated Fig. 3 and 5

In harsh environments, organisms may self-organize into spatially patterned systems in various ways. So far, studies of ecosystem spatial self-organization have primarily focused on apparent orders reflected by regular patterns. However, self-organized ecosystems may also have cryptic orders that can be unveiled only through certain quantitative analyses. Here we show that disordered hyperuniformity as a striking class of hidden orders can exist in spatially self-organized vegetation landscapes. By analyzing the high-resolution remotely sensed images across the American drylands, we demonstrate that it is not uncommon to find disordered hyperuniform vegetation states characterized by suppressed density fluctuations at long range. Such long-range hyperuniformity has been documented in a wide range of microscopic systems. Our finding contributes to expanding this domain to accommodate natural landscape ecological systems. We use theoretical modeling to propose that disordered hyperuniform vegetation patterning can arise from three generalized mechanisms prevalent in dryland ecosystems, including (1) critical absorbing states driven by an ecological legacy effect, (2) scale-dependent feedbacks driven by plant-plant facilitation and competition, and (3) density-dependent aggregation driven by plant-sediment feedbacks. Our modeling results also show that disordered hyperuniform patterns can help ecosystems cope with arid conditions with enhanced functioning of soil moisture acquisition. However, this advantage may come at the cost of slower recovery of ecosystem structure upon perturbations. Our work highlights that disordered hyperuniformity as a distinguishable but underexplored ecosystem self-organization state merits systematic studies to better understand its underlying mechanisms, functioning, and resilience., Comment: 34 pages, 6 figures; Supplementary Materials, 19 pages, 10 figures, 2 tables

Recent studies have demonstrated that large language models (LLMs) store massive factual knowledge within their parameters. But existing LLMs are prone to hallucinate unintended text due to false or outdated knowledge. Since retraining LLMs is resource intensive, there has been a growing interest in the concept of model editing. Despite the emergence of benchmarks and approaches, these unidirectional editing and evaluation have failed to explore the reversal curse. Intuitively, if "The capital of France is" is edited to be a counterfact "London" within a model, then it should be able to naturally reason and recall the reverse fact, i.e., "London is the capital of" followed by "France" instead of "England". In this paper, we study bidirectional language model editing, aiming to provide rigorous model editing evaluation to assess if edited LLMs can recall the editing knowledge bidirectionally. A new evaluation metric of reversibility is introduced, and a benchmark dubbed as Bidirectional Assessment for Knowledge Editing (BAKE) is constructed to evaluate the reversibility of edited models in recalling knowledge in the reverse direction of editing. We surprisingly observe that while current editing methods and LLMs can effectively recall editing facts in the direction of editing, they suffer serious deficiencies when evaluated in the reverse direction. To mitigate the reversal curse, a method named Bidirectionally Inversible Relationship moDeling (BIRD) is proposed. A set of editing objectives that incorporate bidirectional relationships between subject and object into the updated model weights are designed. Experiments show that BIRD improves the performance of four representative LLMs of different sizes via question answering and judgement.

The application of 3D ViTs to medical image segmentation has seen remarkable strides, somewhat overshadowing the budding advancements in Convolutional Neural Network (CNN)-based models. Large kernel depthwise convolution has emerged as a promising technique, showcasing capabilities akin to hierarchical transformers and facilitating an expansive effective receptive field (ERF) vital for dense predictions. Despite this, existing core operators, ranging from global-local attention to large kernel convolution, exhibit inherent trade-offs and limitations (e.g., global-local range trade-off, aggregating attentional features). We hypothesize that deformable convolution can be an exploratory alternative to combine all advantages from the previous operators, providing long-range dependency, adaptive spatial aggregation and computational efficiency as a foundation backbone. In this work, we introduce 3D DeformUX-Net, a pioneering volumetric CNN model that adeptly navigates the shortcomings traditionally associated with ViTs and large kernel convolution. Specifically, we revisit volumetric deformable convolution in depth-wise setting to adapt long-range dependency with computational efficiency. Inspired by the concepts of structural re-parameterization for convolution kernel weights, we further generate the deformable tri-planar offsets by adapting a parallel branch (starting from $1\times1\times1$ convolution), providing adaptive spatial aggregation across all channels. Our empirical evaluations reveal that the 3D DeformUX-Net consistently outperforms existing state-of-the-art ViTs and large kernel convolution models across four challenging public datasets, spanning various scales from organs (KiTS: 0.680 to 0.720, MSD Pancreas: 0.676 to 0.717, AMOS: 0.871 to 0.902) to vessels (e.g., MSD hepatic vessels: 0.635 to 0.671) in mean Dice., Comment: 14 pages, the source code with our pre-trained model is available at this https://github.com/MASILab/deform-uxnet

The segmentation of kidney layer structures, including cortex, outer stripe, inner stripe, and inner medulla within human kidney whole slide images (WSI) plays an essential role in automated image analysis in renal pathology. However, the current manual segmentation process proves labor-intensive and infeasible for handling the extensive digital pathology images encountered at a large scale. In response, the realm of digital renal pathology has seen the emergence of deep learning-based methodologies. However, very few, if any, deep learning based approaches have been applied to kidney layer structure segmentation. Addressing this gap, this paper assesses the feasibility of performing deep learning based approaches on kidney layer structure segmetnation. This study employs the representative convolutional neural network (CNN) and Transformer segmentation approaches, including Swin-Unet, Medical-Transformer, TransUNet, U-Net, PSPNet, and DeepLabv3+. We quantitatively evaluated six prevalent deep learning models on renal cortex layer segmentation using mice kidney WSIs. The empirical results stemming from our approach exhibit compelling advancements, as evidenced by a decent Mean Intersection over Union (mIoU) index. The results demonstrate that Transformer models generally outperform CNN-based models. By enabling a quantitative evaluation of renal cortical structures, deep learning approaches are promising to empower these medical professionals to make more informed kidney layer segmentation.

Podocytes, specialized epithelial cells that envelop the glomerular capillaries, play a pivotal role in maintaining renal health. The current description and quantification of features on pathology slides are limited, prompting the need for innovative solutions to comprehensively assess diverse phenotypic attributes within Whole Slide Images (WSIs). In particular, understanding the morphological characteristics of podocytes, terminally differentiated glomerular epithelial cells, is crucial for studying glomerular injury. This paper introduces the Spatial Pathomics Toolkit (SPT) and applies it to podocyte pathomics. The SPT consists of three main components: (1) instance object segmentation, enabling precise identification of podocyte nuclei; (2) pathomics feature generation, extracting a comprehensive array of quantitative features from the identified nuclei; and (3) robust statistical analyses, facilitating a comprehensive exploration of spatial relationships between morphological and spatial transcriptomics features.The SPT successfully extracted and analyzed morphological and textural features from podocyte nuclei, revealing a multitude of podocyte morphomic features through statistical analysis. Additionally, we demonstrated the SPT's ability to unravel spatial information inherent to podocyte distribution, shedding light on spatial patterns associated with glomerular injury. By disseminating the SPT, our goal is to provide the research community with a powerful and user-friendly resource that advances cellular spatial pathomics in renal pathology. The implementation and its complete source code of the toolkit are made openly accessible at https://github.com/hrlblab/spatial_pathomics.

Superconductivity is a macroscopic quantum phenomenon and it is commonly believed that the in-plane superconducting transition temperature (Tc) should be isotropic for superconductors with crystal structures of stacking layers (quasi two-dimensional). Here, we report the observation of piezostrain-induced in-plane anisotropy of Tc in FeSe0.5Te0.5 (FST) thin films grown on ferroelectrics. The as-prepared FST shows tetragonal phase with equal in-plane lattice parameters and absence of in-plane anisotropy of Tc. Upon applying electric fields, piezostrain induces difference of the in-plane lattice parameters (a-b) and in-plane anisotropy of Tc. The in-plane anisotropy of Tc correlates with a-b and becomes more remarkable for larger values of a-b. Some possible extrinsic effects were ruled out by experiments and analysis. It is suggested that electronic nematicity with one direction induced by piezostrain and inhomogeneous superconductivity in FST are involved in this unusual phenomenon. This work reveals the exotic behavior of FST and will stimulate exploration of similar behavior in other unconventional superconductors., Comment: 22 pages, 4 figures

We consider the problem of sequential recommendation, where the current recommendation is made based on past interactions. This recommendation task requires efficient processing of the sequential data and aims to provide recommendations that maximize the long-term reward. To this end, we train a farsighted recommender by using an offline RL algorithm with the policy network in our model architecture that has been initialized from a pre-trained transformer model. The pre-trained model leverages the superb ability of the transformer to process sequential information. Compared to prior works that rely on online interaction via simulation, we focus on implementing a fully offline RL framework that is able to converge in a fast and stable way. Through extensive experiments on public datasets, we show that our method is robust across various recommendation regimes, including e-commerce and movie suggestions. Compared to state-of-the-art supervised learning algorithms, our algorithm yields recommendations of higher quality, demonstrating the clear advantage of combining RL and transformers.

Deep neural networks (DNNs) utilized recently are physically deployed with computational units (e.g., CPUs and GPUs). Such a design might lead to a heavy computational burden, significant latency, and intensive power consumption, which are critical limitations in applications such as the Internet of Things (IoT), edge computing, and the usage of drones. Recent advances in optical computational units (e.g., metamaterial) have shed light on energy-free and light-speed neural networks. However, the digital design of the metamaterial neural network (MNN) is fundamentally limited by its physical limitations, such as precision, noise, and bandwidth during fabrication. Moreover, the unique advantages of MNN's (e.g., light-speed computation) are not fully explored via standard 3x3 convolution kernels. In this paper, we propose a novel large kernel metamaterial neural network (LMNN) that maximizes the digital capacity of the state-of-the-art (SOTA) MNN with model re-parametrization and network compression, while also considering the optical limitation explicitly. The new digital learning scheme can maximize the learning capacity of MNN while modeling the physical restrictions of meta-optic. With the proposed LMNN, the computation cost of the convolutional front-end can be offloaded into fabricated optical hardware. The experimental results on two publicly available datasets demonstrate that the optimized hybrid design improved classification accuracy while reducing computational latency. The development of the proposed LMNN is a promising step towards the ultimate goal of energy-free and light-speed AI.

Registration of distant outdoor LiDAR point clouds is crucial to extending the 3D vision of collaborative autonomous vehicles, and yet is challenging due to small overlapping area and a huge disparity between observed point densities. In this paper, we propose Group-wise Contrastive Learning (GCL) scheme to extract density-invariant geometric features to register distant outdoor LiDAR point clouds. We mark through theoretical analysis and experiments that, contrastive positives should be independent and identically distributed (i.i.d.), in order to train densityinvariant feature extractors. We propose upon the conclusion a simple yet effective training scheme to force the feature of multiple point clouds in the same spatial location (referred to as positive groups) to be similar, which naturally avoids the sampling bias introduced by a pair of point clouds to conform with the i.i.d. principle. The resulting fully-convolutional feature extractor is more powerful and density-invariant than state-of-the-art methods, improving the registration recall of distant scenarios on KITTI and nuScenes benchmarks by 40.9% and 26.9%, respectively. Code is available at https://github.com/liuQuan98/GCL., Comment: In Proceedings of the IEEE/CVF International Conference on Computer Vision (ICCV), 2023

The Segment Anything Model (SAM) is a recently proposed prompt-based segmentation model in a generic zero-shot segmentation approach. With the zero-shot segmentation capacity, SAM achieved impressive flexibility and precision on various segmentation tasks. However, the current pipeline requires manual prompts during the inference stage, which is still resource intensive for biomedical image segmentation. In this paper, instead of using prompts during the inference stage, we introduce a pipeline that utilizes the SAM, called all-in-SAM, through the entire AI development workflow (from annotation generation to model finetuning) without requiring manual prompts during the inference stage. Specifically, SAM is first employed to generate pixel-level annotations from weak prompts (e.g., points, bounding box). Then, the pixel-level annotations are used to finetune the SAM segmentation model rather than training from scratch. Our experimental results reveal two key findings: 1) the proposed pipeline surpasses the state-of-the-art (SOTA) methods in a nuclei segmentation task on the public Monuseg dataset, and 2) the utilization of weak and few annotations for SAM finetuning achieves competitive performance compared to using strong pixel-wise annotated data.