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171 results on '"Liu, Qiuling"'

8. A N‐Cadherin Nano‐Antagonist Hydrogel Enhances Recovery From Spinal Cord Injury by Impeding Glial Scarring.

Author

Liu, Qiuling, Peng, Sufen, Tang, Qiao, Li, Can, Chen, Jiayi, Pang, Peng, Liu, Wen, Zhou, Xiaoyan, Cai, Xianlong, Lin, Hongsheng, Xue, Wei, Ji, Xin, and Ji, Zhisheng

Subjects
*NERVOUS system regeneration, *PHENOTYPIC plasticity, *SPINAL cord injuries, *HYDROGELS, *INFLAMMATION
Abstract

The role of glial scars in the pathophysiology of spinal cord injury (SCI) is widely recognized, as they pose physical barriers against axonal regeneration and persistent chronic inflammation by releasing cytotoxic agents, thereby impeding nerve repair. Consequently, preventing glial scarring has emerged as an important therapeutic objective in SCI management. Following SCI, astrocytes undergo a phenotypic transition into scar‐forming astrocytes, which critically depends on the activation of inflammatory responses and the integrin‐N‐cadherin pathway. To explore improved SCI treatment, a nano‐antagonist hydrogel (Nano‐ant Gel), comprising N‐cadherin nano‐antagonists and a polyphenol hydrogel designed to inhibit glial scarring by mitigating inflammatory response and modulating astrocyte behavior, thereby facilitating spinal cord‐injury repair, is developed and characterized. The hydrogel exhibits notable anti‐inflammatory properties, specific calcium ion‐adsorption capabilities, and antagonistic effects against N‐cadherin, effectively impeding the formation and aggregation of scar‐forming astrocytes. Its efficacy is comprehensively assessed using a model of contusive SCI, with which it effectively inhibits glial scar formation and promotes axonal regeneration. Notably, the Nano‐ant Gel significantly improves the locomotor functions of mice with SCI, suggesting that it represents a promising approach for treating the condition. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Single Image Rain Removal Based on Multi-Scale and Channel Attention Mechanism

Author

Liu, Qiuling, Zhou, Gang, and Jia, Zhenhong

Subjects
other
Abstract

Deep convolutional neural network (CNN) has shown their great advantages in the single image deraining task. However, most existing CNN-based single image deraining methods still suffer from residual rain streaks and details lost. In this paper, we propose a deep neural network including the Multi-scale feature extraction module and the channel attention module, which are embed in the feature extraction sub-network and the rain removal sub-network respectively. In the feature extraction sub-network, the Multi-scale feature extraction module is constructed by a Multi-layer Laplacian pyramid, and is then integrated multi-scale feature maps by a feature fusion module. In the rain removal sub-network, the channel attention module, which assigns different weights to the different channels, is introduced for preserving image details. Experimental results on visually and quantitatively comparison demonstrate that the proposed method performs favorably against other state-of-the-art approaches

Published
2021

48. Fluorescent Multiplex Amplification of Three X-STR Loci

Author

Fang Qun, LU Hui-Ling, Liu Qiuling, LU De-jian, Luo Yan-min, and Zhu Jia-Zhen

Subjects
Male, Genetics, Chromosomes, Human, X, Polymorphism, Genetic, Haplotype, Locus (genetics), Biology, Polymerase Chain Reaction, Molecular biology, Fluorescence, Forensic identification, Gene Frequency, Haplotypes, Multiplex polymerase chain reaction, Humans, Analysis software, Female, Multiplex, Allele, Molecular Biology, Microsatellite Repeats
Abstract

This study was carried out to evaluate the value of three X-STR loci (DXS6803, DXS981and DXS6809) in forensic application and thereby investigate their polymorphism. The primer for each locus was labeled with fluorochrome 6-FAM. A fluorescent multiplex PCR for simultaneously amplifying three X-STR loci was set up. The PCR products that were obtained were analyzed using capillary electrophoresis and ABI PRISM 3100 Genetic Analyzer, with GENESCAN Analysis Software. When 340 male and 195 female individuals of Han population in China were tested, 13, 12, and 11 alleles were observed for DXS6803, DXS981 and DXS6809, respectively. One hundred and eighty three haplotypes were detected in the male individuals. The haplotype diversity reached 0.9926. The results show that the three loci of the multiplex system provide significant information on polymorphism for forensic identification and paternity testing, particularly for complicated paternity deficient cases.

Published
2006
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49. 9-(2-Chloro-phen-yl)-4a-hy-droxy-3,4,4a,5,6,7,9,9a-octa-hydro-2H-xanthene-1,8-dione

Author

Liu Qiuling, Fang-Ming Wang, Gao Feng, Wu Xinyan, and Bao Dan

Subjects
Xanthene, Hydrogen bond, Chemistry, Cyclohexane conformation, General Chemistry, Condensed Matter Physics, Bioinformatics, Ring (chemistry), Medicinal chemistry, Organic Papers, Crystal, lcsh:Chemistry, chemistry.chemical_compound, lcsh:QD1-999, Atom, General Materials Science
Abstract

In the title compound, C19H19ClO4, the dihydropyran ring and the cyclohexane ring adopt a half-chair conformation and a chair conformation, respectively. The cyclohexene ring has an envelope conformation with the central CH2C atom as the flap. This atom is disordered over two positions [site-occupancy ratio = 0.744 (12):0.256 (12)] above and below the mean plane formed by the other five atoms. In the crystal, O—H...O hydrogen bonds between hydroxy and carbonyl groups link molecules into chains propagating along [001].

Published
2014

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