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2. UBR5 Acts as an Antiviral Host Factor against MERS-CoV via Promoting Ubiquitination and Degradation of ORF4b

Author

Zhou, Yuzheng, primary, Zheng, Rong, additional, Liu, Donglan, additional, Liu, Sixu, additional, Disoma, Cyrollah, additional, Li, Shiqin, additional, Liao, Yujie, additional, Chen, Zongpeng, additional, Du, Ashuai, additional, Dong, Zijun, additional, Zhang, Yongxing, additional, Liu, Pinjia, additional, Razzaq, Aroona, additional, Chen, Dingbin, additional, Chen, Xuan, additional, Zhong, Xiankezi, additional, Liu, Sijie, additional, Tao, Siyi, additional, Liu, Yuxin, additional, Xu, Lunan, additional, Deng, Xu, additional, Li, Jiada, additional, Jiang, Taijiao, additional, Zhao, Jincun, additional, Li, Shanni, additional, and Xia, Zanxian, additional

Published
2022
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3. Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation

Author

Zhou, Yuzheng, primary, Zheng, Rong, additional, Liu, Sixu, additional, Disoma, Cyrollah, additional, Du, Ashuai, additional, Li, Shiqin, additional, Chen, Zongpeng, additional, Dong, Zijun, additional, Zhang, Yongxing, additional, Li, Sijia, additional, Liu, Pinjia, additional, Razzaq, Aroona, additional, Chen, Xuan, additional, Liao, Yujie, additional, Tao, Siyi, additional, Liu, Yuxin, additional, Xu, Lunan, additional, Zhang, Qianjun, additional, Peng, Jian, additional, Deng, Xu, additional, Li, Shanni, additional, Jiang, Taijiao, additional, and Xia, Zanxian, additional

Published
2022
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4. Additional file 1 of M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

Author

Du, Ashuai, Li, Shiqin, Zhou, Yuzheng, Disoma, Cyrollah, Liao, Yujie, Zhang, Yongxing, Chen, Zongpeng, Yang, Qinglong, Liu, Pinjia, Liu, Sixu, Dong, Zijun, Razzaq, Aroona, Tao, Siyi, Chen, Xuan, Liu, Yuxin, Xu, Lunan, Zhang, Qianjun, Li, Shanni, Peng, Jian, and Xia, Zanxian

Abstract

Additional file 1: Supplementary materials and methods. References. Supplementary Table 1. Clinical information of 10 HCC patient samples used for RNA-sequencing. Supplementary Table 2. Clinical information of 35 HCC patients’ samples for validation of circMDK expression. Supplementary Table 3. Associations between the expression levels of circMDK and the clinicopathological characteristics of 35 HCC patients. Supplementary Table 4. Primers, siRNA, shRNA sequences and antibodies. Supplementary Table 5. Blood biochemistry of tumor-bearing mice treatedwith saline, PAE-nsRNA and PAE-siRNA. Abbreviations. Supplementary Figure 1. The correlation characterization of circMDK, MDK expression, and prognosis in HCC, (A, B, C, D, E, F, G). Supplementary Figure 2. The binding site of miR-346 and miR-874-3p with circMDK, (A, B, C, D). Supplementary Figure 3. MiR-346 and miR-874-3p are responsible for circMDK-mediated proliferation, migration, invasion and apoptosis, (A, B, C, D, E). Supplementary Figure 4. Characterization and effects of knockdown of circMDK with PAE-siRNA complex in vitro, (A, B, C, D, E, F, G, H). Supplementary Figure 5. The antitumor effects of PAE-siRNA complex in subcutaneous hepatic tumors, (A, B, C, D, E, F, G, H). Supplementary Figure 6. Biodistribution of PAE-siRNA complex in subcutaneous tumor model, (A, B, C, D, E, F, G, H). Supplementary Figure 7. Antitumor effects of PAE-siRNA complex in metastatic tumor model, (A, B, C, D, E). Supplementary Figure 8. Validation diagrams for PDX model construction and Histological observation of tissue sections, (A, B, C, D).

Published
2022
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5. M6A-Mediated Upregulation of CircMDK Promotes Tumorigenesis and Acts as a Nanotherapeutic Target in Hepatocellular Carcinoma

Author

Du, Ashuai, primary, Li, Shiqin, additional, Zhou, Yuzheng, additional, Disoma, Cyrollah, additional, Liao, Yujie, additional, Zhang, Yongxing, additional, Chen, Zongpeng, additional, Yang, Qinglong, additional, Liu, Pinjia, additional, Liu, Sixu, additional, Dong, Zijun, additional, Razzaq, Aroona, additional, Tao, Siyi, additional, Chen, Xuan, additional, Liu, Yuxin, additional, Xu, Lunan, additional, Zhang, Qianjun, additional, Li, Shanni, additional, Peng, Jian, additional, and Xia, Zanxian, additional

Published
2022
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6. Zika Virus and Its Association with Neurological Disorders

Author

Marcellin, Dama Faniriantsoa Henrio, primary, Guo, Limin, additional, Yu, Haiyang, additional, Wang, Shuchao, additional, Pielnaa, Paul, additional, Saro, Adonira, additional, Masokano, Ismail Bilal, additional, Adil, Malik Muhammad, additional, Yuan, Ling, additional, Huang, Yanxia, additional, Cai, Deyang, additional, Zheng, Ruping, additional, Huang, Zhongjun, additional, Luo, Aixiang, additional, Disoma, Cyrollah, additional, Liu, Pinjia, additional, Xia, Zanxian, additional, and Huang, Jufang, additional

Published
2022
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7. Microbiome Profiling Using Shotgun Metagenomic Sequencing Identified Unique Microorganisms in COVID-19 Patients With Altered Gut Microbiota

Author

Li, Sijia, primary, Yang, Siyuan, additional, Zhou, Yuzheng, additional, Disoma, Cyrollah, additional, Dong, Zijun, additional, Du, Ashuai, additional, Zhang, Yongxing, additional, Chen, Yong, additional, Huang, Weiliang, additional, Chen, Junru, additional, Song, Deqiang, additional, Chen, Zongpeng, additional, Liu, Pinjia, additional, Li, Shiqin, additional, Zheng, Rong, additional, Liu, Sixu, additional, Razzaq, Aroona, additional, Chen, Xuan, additional, Tao, Siyi, additional, Yu, Chengping, additional, Feng, Tianxu, additional, Liao, Wenyan, additional, Peng, Yousong, additional, Jiang, Taijiao, additional, Huang, Jufang, additional, Wu, Wei, additional, Hu, Liqiang, additional, Wang, Linghang, additional, Li, Shanni, additional, and Xia, Zanxian, additional

Published
2021
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8. Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2

Author

Du, Ashuai, primary, Zheng, Rong, additional, Disoma, Cyrollah, additional, Li, Shiqin, additional, Chen, Zongpeng, additional, Li, Sijia, additional, Liu, Pinjia, additional, Zhou, Yuzheng, additional, Shen, Yilun, additional, Liu, Sixu, additional, Zhang, Yongxing, additional, Dong, Zijun, additional, Yang, Qinglong, additional, Alsaadawe, Moyed, additional, Razzaq, Aroona, additional, Peng, Yuyang, additional, Chen, Xuan, additional, Hu, Liqiang, additional, Peng, Jian, additional, Zhang, Qianjun, additional, Jiang, Taijiao, additional, Mo, Long, additional, Li, Shanni, additional, and Xia, Zanxian, additional

Published
2021
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9. SARS‐CoV‐2: Mechanism of infection and emerging technologies for future prospects

Author

Li, Shiqin, primary, Li, Sijia, additional, Disoma, Cyrollah, additional, Zheng, Rong, additional, Zhou, Mei, additional, Razzaq, Aroona, additional, Liu, Pinjia, additional, Zhou, Yuzheng, additional, Dong, Zijun, additional, Du, Ashuai, additional, Peng, Jian, additional, Hu, Liqiang, additional, Huang, Jufang, additional, Feng, Pinghui, additional, Jiang, Taijiao, additional, and Xia, Zanxian, additional

Published
2020
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10. SARS‐CoV‐2: Mechanism of infection and emerging technologies for future prospects.

Author

Li, Shiqin, Li, Sijia, Disoma, Cyrollah, Zheng, Rong, Zhou, Mei, Razzaq, Aroona, Liu, Pinjia, Zhou, Yuzheng, Dong, Zijun, Du, Ashuai, Peng, Jian, Hu, Liqiang, Huang, Jufang, Feng, Pinghui, Jiang, Taijiao, and Xia, Zanxian

Abstract

The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has spread globally to over 200 countries with more than 23 million confirmed cases and at least 800,000 fatalities as of 23 August 2020. Declared a pandemic on March 11 by World Health Organization, the disease caused by SARS‐CoV‐2 infection, called coronavirus disease 2019 (COVID‐19), has become a global public health crisis that challenged all national healthcare systems. This review summarized the current knowledge about virologic and pathogenic characteristics of SARS‐CoV‐2 with emphasis on potential immunomodulatory mechanism and drug development. With multiple emerging technologies and cross‐disciplinary approaches proving to be crucial in our global response against COVID‐19, the application of PROteolysis TArgeting Chimeras strategy, CRISPR‐Cas9 gene editing technology, and Single‐Nucleotide‐Specific Programmable Riboregulators technology in developing antiviral drugs and detecting infectious diseases are proposed here. We also discussed the available but still limited epidemiology of COVID‐19 as well as the ongoing efforts on vaccine development. In brief, we conducted an in‐depth analysis of the pathogenesis of SARS‐CoV‐2 and reviewed the therapeutic options for COVID‐19. We also proposed key research directions in the future that may help uncover more underlying molecular mechanisms governing the pathology of COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2021
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