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The present work synthesizes the studies in flipped language education based on Social Sciences Citation Index publications up to the year 2018. A sum of 33 studies were finalized as the targeted studies and our research questions were formulated regarding (1) the overall trend and features of the existing studies, (2) their research foci, (3) the role of technology, and (4) the integration of FL/L2 learning and teaching theories, models or strategies into flipped classroom. Some research gaps were identified, including a bias toward outcome-oriented quantitative studies over process-oriented qualitative studies. Additionally, an overwhelming majority of the studies were conducted from the learners' perspectives, while few studies took the teachers' perspectives. More importantly, to guide the course design and implementation, the present review proposed a comprehensive 'interaction model' integrating four key elements into flipped FL/L2 education. The model featured two types of interaction, namely 'interaction with content' and 'interaction via content', highlighting the uniqueness of flipped FL/L2 education. The study incorporated learner preparedness in the interaction model, entailing a practical interface for the principle of 'design for failure', that is, predicting and preparing contingencies for the times when in-class interactions do not go as planned for technical or other reasons.

Background: Despite the oral cavity being readily accessible, oral cancer (OC) remains a significant burden. The objective of this study is to develop a DNA ploidy‐based cytology test for early detection of high‐risk oral lesions. Methods: This retrospective study was conducted using 569 oral brushing samples collected from 95 normal and 474 clinically abnormal mucosa with biopsy diagnosis of reactive, low‐grade or high‐grade precancer or cancers. Brushing cells were processed to characterize DNA ploidy. A two‐step DNA ploidy‐based algorithm, the DNA ploidy oral cytology (DOC) test, was developed using a training set, and verified in test and validation sets to differentiate high‐grade lesions (HGLs) from normal. The prognostic value of the test was evaluated by an independent outcome cohort, including progressed and non‐progressing normal, reactive and low‐grade lesions. Classification performance was assessed by accuracy, sensitivity, and specificity, while the prognostic value was evaluated by using the Cox proportional hazards analysis on 3‐year progression‐free survival (PFS). Results: The developed DOC test exhibited high accuracy for detecting HGLs in the test and validation sets, with a sensitivity of 0.97 and 0.96, respectively. Its application to the Outcome cohort demonstrated significant prognostic value for 3‐year PFS (log rank, p < 0.001). Multivariate analysis showed that high‐grade pathology was the only variable explaining positive DOC test, not age, smoking, or lesional site. Conclusion: Clinical implementation of the DOC test could provide an effective screening method for detecting HGLs for biopsy and lesions at risk of progression. [ABSTRACT FROM AUTHOR]

To investigate continental dynamics underneath the south‐central Tibetan plateau, which composes the Himalayan, Lhasa, and Qiangtang blocks, we have conducted comprehensive examinations of seismic azimuthal anisotropy in the crust using receiver functions (RFs) and crustal and mantle anisotropy using teleseismic shear wave splitting (SWS) analysis. In the Qiangtang block, the observed predominantly E‐W fast orientations from RF and SWS analyses with similar magnitude are interpreted as resulting from eastward crustal flow with minor contributions from the mantle. In the Lhasa block, the crustal anisotropy is approximately N‐S oriented, which is parallel to the strike of rift basins and southward crustal flow. Anisotropy revealed by SWS demonstrates a rotation from E‐W in the north to NE‐SW in the south, which can be interpreted as reflecting mantle flow field induced by the northward movement of the subducting Indian plate. The addition of PKS and SKKS measurements and extension of epicentral distance range to 171.8° for SWS analysis revealed dominantly strong E‐W oriented anisotropy in most parts of the Himalayan block, where most previous studies reported pervasively null measurements. The absence of azimuthal anisotropy is observed in two regions in the Himalayan block which is attributable to mantle upwelling through a previously identified slab window. A two‐layered anisotropy structure with different fast orientations for the upper and lower layers can be constrained in the southern Qiangtang and the vicinity of the Main Boundary Thrust. Plain Language Summary: In our study exploring the underground dynamics beneath the south‐central Tibetan plateau, an area encompassing the Himalayan, Lhasa, and Qiangtang blocks, we utilized advanced seismic techniques to uncover the structure and dynamics of the earth's crust and mantle. In the Qiangtang region, our findings suggest an eastward crustal movement with minimal mantle influence. In the Lhasa block, the observed crustal anisotropy aligns with rift basins with a reduced magnitude, indicating a smaller‐scale southward flow. In the same area, we also observed a transition in mantle flow patterns from east‐west in the north to northeast‐southwest in the south, attributed to the northward movement of the Indian plate. Contrary to previous studies that mostly found no anisotropy in the Himalayan block, our research detected strong anisotropy with east‐west orientations. In two areas of the Himalayan block, the absence of anisotropy likely results from molten rock rising through a gap in the Indian plate. Moreover, we discovered a two‐layered structure of rock alignment near the Main Boundary Thrust and the Qiangtang block. Key Points: Significant anisotropy is revealed in the Himalayan block, where previous studies suggest pervasively null measurementsThe crust significantly impacts observed anisotropy in teleseismic shear wave splitting, potentially leading to double‐layered anisotropyAsthenospheric upwelling through a slab window beneath the Himalayan block accounts for the pervasive null measurements [ABSTRACT FROM AUTHOR]

Simple Summary: Oral cancers are associated with high mortality in advanced stages. Early diagnosis is associated with better patient outcomes, but this is challenging to achieve as benign lesions look similar to lesions of concern, and multiple biopsies may be required to ensure the most pathologic tissue is sampled. This work leverages a previously developed endoscopic imaging system and deep learning segmentation tool to provide measurements of subsurface changes in the first few millimeters of oral tissue. We present seven quantitative features that allow for rapid examination of tissue, which we propose may be useful for biopsy site or treatment margin selection. Optical coherence tomography is a noninvasive imaging technique that provides three-dimensional visualization of subsurface tissue structures. OCT has been proposed and explored in the literature as a tool to assess oral cancer status, select biopsy sites, or identify surgical margins. Our endoscopic OCT device can generate widefield (centimeters long) imaging of lesions at any location in the oral cavity—but it is challenging for raters to quantitatively assess and score large volumes of data. Leveraging a previously developed epithelial segmentation network, this work develops quantifiable biomarkers that provide direct measurements of tissue properties in three dimensions. We hypothesize that features related to morphology, tissue attenuation, and contrast between tissue layers will be able to provide a quantitative assessment of disease status (dysplasia through carcinoma). This work retrospectively assesses seven biomarkers on a lesion-contralateral matched OCT dataset of the lateral and ventral tongue (40 patients, 70 sites). Epithelial depth and loss of epithelial–stromal boundary visualization provide the strongest discrimination between disease states. The stroma optical attenuation coefficient provides a distinction between benign lesions from dysplasia and carcinoma. The stratification biomarkers visualize subsurface changes, which provides potential for future utility in biopsy site selection or treatment margin delineation. [ABSTRACT FROM AUTHOR]

The Banda arc‐continent collision zone signifies one of the most seismically active and tectonically intricate zones. The high convergence rate across the region, coupled with the exceptionally arcuate arc and subducted slab, makes it an ideal locale for investigating interactions between plate (slab) kinematics and plastic flow in the asthenosphere, which can be diagnosed by seismic anisotropy from shear wave splitting analyses. In total, 206 pairs of splitting measurements using teleseismic SKS, SKKS, and PKS, along with 43 pairs using local S phases, are obtained by utilizing broadband seismic data from five permanent seismic stations. To reduce the ambiguity in determining the origin of anisotropy leading to the teleseismic splittings, which lack vertical resolution, crustal anisotropy is constrained according to the sinusoidal moveout of converted S phases at the Moho using receiver functions. A layered anisotropic structure based on joint analyses of the anisotropy measurements characterizing different depth layers suggests the presence of trench‐parallel flow both in the mantle wedge and the sub‐slab region. The northeastward motion of the slab, entrained by the fast‐moving Australian Plate, deflects asthenospheric materials. The modulation results in trench‐parallel plastic mantle flows and leads to the steepening of the southern portion of the asymmetric spoon‐shaped Banda slab. In the shallower part of the sub‐slab region, the northeastward Australian Plate motion produces simple shear in the transitional layer between the rigid lithosphere and the viscous asthenosphere. The shear deformation induces seismic anisotropy with resulting fast orientations in accordance with the plate motion direction. Plain Language Summary: The Banda region represents a nascent arc‐continent collision with the Australian continental lithosphere. The volcanic arc and non‐volcanic arc‐islands display a unique horseshoe shape. The subducted slab is anomalously bent 180°, leading to a spoon‐shaped morphology with a steeper southern portion. The role of the kinematics of the Australian Plate and this bent slab in shaping the asthenosphere is not clear. This study uses seismic anisotropy measured using data recorded over 14 years by five broadband seismic stations on the non‐volcanic arc‐islands to explore this intriguing problem. Results suggest that the northeastward movement of the Australian Plate makes asthenospheric materials flow along the depth contour of the slab, steepening the Banda slab's southern part. In the sub‐slab region, the upper portion follows the movement direction of the Australian Plate, while the deeper part is influenced more by slab deflection, directing asthenospheric flow. Key Points: Mantle flow field associated with the spoon‐shaped Banda slab is investigated using seismic azimuthal anisotropy measurementsObservations can be explained by trench‐parallel flow both in the mantle wedge and the sub‐slab regionNortheastward movement of the slab relative to the asthenosphere induces the two flow systems and leads to steepening of the southern slab [ABSTRACT FROM AUTHOR]