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This paper proposes a novel Non-linear Camera Assisted-Received Signal Strength (nCA-RSS) algorithm. The basic idea of nCA-RSS is to simultaneously utilize camera and Photo-Diode (PD) to capture visual information and signal strength information to achieve both high coverage and accurate positioning. First, based on single-view geometry theorem, nCA-RSS algorithm estimates incidence angle of visible light based on visual information. Then, based on the estimated incidence angle, nCA-RSS algorithm utilizes signal strength to determine the location of the receiver. Due to the use of visual information, nCA-RSS no longer has orientation limitations. Based on Levenberg-Marquardt, nCA-RSS can use three Light Emitting Diode (LED) to achieve precise 3-Dimensional (3D) positioning. Therefore, compared with perspective n point algorithm, nCA-RSS can achieve high coverage. Simulation results show that nCA-RSS can achieve 80th percentile accuracies of less than 2.5 cm for positioning regardless of the orientation of the receiver.

Modified suction caisson is a new type of suction foundation for offshore wind power engineering. Model tests were carried out to investigate the variation of cumulative rotation angle and its influencing factors of the regular suction caisson (RSC) and modified suction caisson (MSC) under horizontal cyclic loading. The cyclic loading mode includes one-way cyclic loading and variable-amplitude cyclic loading. The experimental results showed that the cumulative rotation angle of the RSC and MSC under horizontal cyclic loading mainly occurs within the first 200 loading cycles. The cumulative rotation angle was found to increase with the increase of cyclic loading amplitude and the number of loading cycles. However, the increasing rate of cumulative rotation angle decreases with the increase of loading cycle number. The relationship between the cumulative rotation angle and the number of loading cycles can be well fitted by a power function. By using Leblanc method and Miner’s rule, the cumulative rotation angle of the suction caisson foundation under long-term variable-amplitude cyclic loading was transformed into that under constant amplitude cyclic loading and then can be estimated. It was found that when the loading amplitude increases step by step, the predicted cumulative rotation angle of the RSC and MSC obtained by using the Leblanc method and Miner’s law is slightly higher than the measured model test results, indicating that the sequence and amplitude of cyclic loading have a certain influence on the cumulative rotation angle of the suction caisson foundation. In addition, the influence of cyclic loading on the ultimate bearing capacity of suction caisson foundation was studied and it was found that the ultimate bearing capacities of the RSC and MSC after cyclic loading are higher than those before cyclic loading. The research results can provide a basis for the design of the suction caisson foundation of offshore wind power.

The chemical structure of vitamin B 12. [Display omitted] Vitamin B 12 (VB 12) is a vital micronutrient to maintain the normal state of the hematopoietic system. It must be obtained from the diet since the human body cannot synthesize it. Moreover, the absorption of VB 12 needs to be mediated by intrinsic factor on the gastrointestinal (GI) track. The abnormalities in the stomach or lack of such intrinsic factors may result in poor oral absorption of VB 12. However, the very advanced formulation strategies were generally very costly and still in the development stage. Thus, the objectives of the present study were to increase the VB 12 intestinal absorption by conventional excipients of Gelucire 44/14 (G44/14) or Labrasol, which could be potentially formulated as a cost effect balanced product. The in vitro Caco-2 cell model was applied for the absorption study. A novel VB 12 solid dispersion was subsequently prepared and further characterized by Differential scanning calorimetry, Fourier transform infrared spectroscopy, and Scanning electron microscopy, respectively. The membrane permeability of the VB 12 solid dispersion was finally evaluated using ex vivo rat everted gut sac method. The results suggested that G44/14 could significantly enhance the intestinal absorption of VB 12 via P-glycoprotein inhibition in vitro (P < 0.01). The membrane permeability of VB 12 could be significantly (P < 0.01) improved by G44/14-VB 12 solid dispersion at a proportion of carrier: drug ratio of 20:1.The liquidfied solid dispersion was finally directly filled in the hard gelatin capsules. In conclusion, the cheap and simplified process of VB 12 complex prepared by G44/14 could potentially increase VB 12 intestinal absorption, which may be liable to commercial manufacturing. [ABSTRACT FROM AUTHOR]