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24 results on '"Liu, Ju-Yun"'

16. PPP2R2B CAG repeat length in the Han Chinese in Taiwan: Association analyses in neurological and psychiatric disorders and potential functional implications

Author

Chen, Chiung‐Mei, primary, Hou, Yi‐Ting, additional, Liu, Ju‐Yun, additional, Wu, Yih‐Ru, additional, Lin, Chih‐Hsin, additional, Fung, Hon‐Chung, additional, Hsu, Wen‐Chuin, additional, Hsu, Yuying, additional, Lee, Shen‐Hung, additional, Hsieh‐Li, Hsiu‐Mei, additional, Su, Ming‐Tsan, additional, Chen, Shui‐Tein, additional, Lane, Hsien‐Yuan, additional, and Lee‐Chen, Guey‐Jen, additional

Published
2008
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20. Terminating red imported fire ants using Cinnamomum osmophloeum leaf essential oil

Author

Cheng, Sen-Sung, Liu, Ju-Yun, Lin, Chun-Ya, Hsui, Yen-Ray, Lu, Mei-Chun, Wu, Wen-Jer, and Chang, Shang-Tzen

Subjects
*SOLENOPSIS invicta, *HYMENOPTERA, *INSECT societies, *TOXICITY testing
Abstract

Abstract: Eleven compounds from indigenous cinnamon (Cinnamomum osmophloeum) leaf essential oil were identified by GC–MS and the dominant constituent was trans-cinnamaldehyde (79.85%). The toxicity of leaf essential oil and trans-cinnamaldehyde were then determined to study their effectiveness in controlling the red imported fire ant, Solenopsis invicta Buren. The results of the toxicity tests indicated that both the indigenous cinnamon leaf essential oil and trans-cinnamaldehyde had an excellent inhibitory effect in controlling the red imported fire ant. The LT50 values for both 2% leaf essential oil and 2% trans-cinnamaldehyde after open exposure were 105.0min and 32.2min; after close exposure were 18.5min and 21.2min, respectively. [Copyright &y& Elsevier]

Published
2008
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21. Klebsiella pneumoniaeTranslocates across the Intestinal Epithelium via Rho GTPase- and Phosphatidylinositol 3-Kinase/Akt-Dependent Cell Invasion

Author

Hsu, Chun-Ru, Pan, Yi-Jiun, Liu, Ju-Yun, Chen, Chun-Tang, Lin, Tzu-Lung, and Wang, Jin-Town

Abstract

ABSTRACTKlebsiella pneumoniaeis an important pathogen that causes hospital-acquired septicemia and is associated with the recent emergence of community-acquired pyogenic liver abscess (PLA). Clinical typing suggests that K. pneumoniaeinfections originate from the gastrointestinal reservoir. However, the underlying mechanism remains unknown. Here, we have sought to determine how K. pneumoniaepenetrates the intestinal barrier. We identified that bacteremia and PLA clinical isolates adhered to and invaded intestinal epithelial cells. Internalization of K. pneumoniaein three different human colonic cell lines was visualized by confocal microscopy and three-dimensional (3D) imaging. Using a Transwell system, we demonstrated that these K. pneumoniaeisolates translocated across a polarized Caco-2 monolayer. No disruptions of transepithelial electrical resistance and altered distribution of tight junction protein ZO-1 or occludin were observed. Therefore, K. pneumoniaeappeared to penetrate the intestinal epithelium via a transcellular pathway. Using specific inhibitors, we characterized the host signaling pathways involved. Inhibition by cytochalasin D and nocodazole suggested that actin and microtubule cytoskeleton were both important for K. pneumoniaeinvasion. A Rho inhibitor, ML141, LY294002, and an Akt1/2 inhibitor diminished K. pneumoniaeinvasion in a dose-dependent manner, indicating that Rho family GTPases and phosphatidylinositol 3-kinase (PI3K)/Akt signaling were required. By a mouse model of gastrointestinal colonization, in vivoinvasion of K. pneumoniaeinto colonic epithelial cells was demonstrated. Our results present evidence to describe a possible mechanism of gastrointestinal translocation for K. pneumoniae. Cell invasion by manipulating host machinery provides a pathway for gut-colonized K. pneumoniaecells to penetrate the intestinal barrier and access extraintestinal locations to cause disease.

Published
2014
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23. PPP2R2B CAG repeat length in the Han Chinese in Taiwan: Association analyses in neurological and psychiatric disorders and potential functional implications.

Author

Chen CM, Hou YT, Liu JY, Wu YR, Lin CH, Fung HC, Hsu WC, Hsu Y, Lee SH, Hsieh-Li HM, Su MT, Chen ST, Lane HY, and Lee-Chen GJ

Subjects
Aged, Cloning, Molecular, Female, Humans, Male, Middle Aged, Promoter Regions, Genetic, Taiwan, Alzheimer Disease genetics, Essential Tremor genetics, Ethnicity, Nerve Tissue Proteins genetics, Protein Phosphatase 2 genetics, Trinucleotide Repeats
Abstract

PPP2R2B, a protein widely expressed in neurons throughout the brain, regulates the protein phosphatase 2A (PP2A) activity for the microtubule-associated protein tau and other substrates. Altered PP2A activity has been implicated in spinocerebellar ataxia 12, Alzheimer's disease (AD), and other tauopathies. Through a case-control study and a reporter assay, we investigated the association of PPP2R2B CAG repeat polymorphism with Taiwanese AD, essential tremor (ET), Parkinson's disease (PD), and schizophrenia and clarified the functional implication of this polymorphism. The distribution of the alleles was not significantly different between patients and controls, with 68.6-76.1% alleles at lengths of 10, 13, and 16 triplets. No expanded alleles were detected in either group. However, the frequency of the individuals carrying the short 5-, 6-, and 7-triplet alleles was notably higher in patients with AD (5/180 [2.8%], Fisher's exact test, P = 0.003; including 2 homozygotes) and ET (4/132 [3.0%], Fisher's exact test, P < 0.001) than in the controls (1/625 [0.2%]). The PPP2R2B transcriptional activity was significantly lower in the luciferase reporter constructs containing the (CAG)(5-7) allele than in those containing the common 10-, 13-, and 16-triplet alleles in both neuroblastoma and embryonic kidney cells. Therefore, our preliminary results suggest that the PPP2R2B gene CAG repeat polymorphism may be functional and may, in part, play a role in conferring susceptibility to AD and ET in Taiwan., (2008 Wiley-Liss, Inc.)

Published
2009
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24. Polysaccharides from Dioscorea batatas induce tumor necrosis factor-alpha secretion via Toll-like receptor 4-mediated protein kinase signaling pathways.

Author

Liu JY, Yang FL, Lu CP, Yang YL, Wen CL, Hua KF, and Wu SH

Subjects
Animals, Cell Line, Dioscorea immunology, Macrophages drug effects, Macrophages immunology, Mice, Plant Extracts chemistry, Plant Extracts pharmacology, Polysaccharides chemistry, Dioscorea chemistry, Polysaccharides pharmacology, Protein Kinases immunology, Signal Transduction drug effects, Toll-Like Receptor 4 immunology, Tumor Necrosis Factor-alpha immunology
Abstract

The bioactive polysaccharides (named ZPF1) from yam ( Dioscorea batatas) were chemically determined, suggesting repeating beta-1,4-mannan as mainly having a feature of acetylation on C2-OH and C3-OH, around 28%. The ZPF1 participated in the stimulation of murine wild-type macrophages predominantly in tumor necrosis factor-alpha (TNFalpha). Toll-like receptor 4 is proved to be one of the cellular receptors in ZPF1-mediated TNFalpha secretion. Reactive oxygen species transmission and PI3-kinase are found necessary for regulating TNFalpha secretion by ZPF1 stimulation. Moreover, we found that extracellular signal-regulated kinase 1/2, Jun N-terminal kinase 1/2, and p38 mitogen-activated protein kinase play important roles in the regulation of TNFalpha secretion in ZPF1-stimulated macrophages.

Published
2008
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