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The influence of foundation pit excavation on deformation and stability of the supporting structure of underlying adjacent existing tunnel is a comprehensive geotechnical engineering problem, including unloading effect of foundation pit excavation and the coupling effect of deformation of the tunnel surrounding rock and supporting structure. Using numerical calculation methods, this paper changes the different excavation depths and widths of foundation pit and discusses the evolution law about force and deformation of tunnel supporting structure, and the changing relationship of the axial force of tunnel anchor with the distance between foundation pit and tunnel is obtained and compares the influence of different excavation way of foundation pit on the axial force of anchor rod near the existing tunnel. It is found that with the increase of distance between foundation pit and tunnel, the axial force of anchor rod at the top of tunnel under the foundation pit entirely symbolizes a trend of increases first and then decreases, the axial force of the leftmost anchor rod changes from pressure to tension, then decreases gradually. When the foundation pit depth increases, the axial force of the anchor rod at the top of the tunnel increases, the axial force of the leftmost anchor rod decreases, and the width of foundation pit absolutely has little effect on the axial force of the leftmost and the top tunnel. [ABSTRACT FROM AUTHOR]

Background: The brain is one of the most vulnerable metastasis sites in lung cancer; approximately 40-50% of lung cancer patients develop brain metastasis during the disease course, contributing to the poor prognosis and high mortality of lung cancer patients. Therefore, it is important to clarify the molecular mechanism underlying brain metastasis of lung cancer for improving the overall survival of lung cancer patients. The present study aimed to investigate the potential role of blood-brain barrier (BBB) permeability in the development of brain metastasis of lung cancer and explore the effect of aspirin in an in-vitro BBB model., Methods: An in-vitro BBB model was established. The expression of heat shock protein 70 (HSP 70), zonula occludens-1 (ZO-1), and occludin in rat brain microvascular endothelial cells was detected using Western blot at different time points following the administration of aspirin., Results: HSP70, ZO-1, and occludin expressions did not show significant changes before aspirin administration, but increased noticeably after aspirin administration. Tumor necrosis factor-α (TNF-α) could significantly attenuate the increased expression of these proteins induced by aspirin. Additionally, TNF-α also significantly reversed the aspirin-induced decrease of BBB permeability., Conclusions: Aspirin may inhibit brain metastasis of lung cancer in a time-dependent manner via upregulating tight junction proteins to reduce BBB permeability, and this effect can be reversed by TNF-α., Competing Interests: The authors declare no conflict of interest., (© 2023 The Author(s). Published by IMR Press.)