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682 results on '"Liu, Jiankun"'

24. Synergistic antitumor effects of circularly permuted TRAIL with doxorubicin in triple-negative breast cancer

Author

Liu Jia, Zhu Tienian, Liu Jiankun, Cui Yujie, Yang Shifang, and Zhao Ruijing

Subjects
apoptosis, TRAIL, doxorubicin, death receptor, triple-negative breast cancer, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

Circularly permuted TRAIL (CPT), a novel recombinant TRAIL mutant, is a potent antitumor agent. However, its efficacy in triple-negative breast cancer (TNBC) remains unclear. Treatment with CPT alone and in combination with doxorubicin (Dox) is explored for its effects on the proliferation and apoptosis of MDA-MB-231 (MB231) and MDA-MB-436 (MB436) breast cancer cells in vitro and in vivo. Here, we show that CPT combined with Dox exhibits time- and dose-dependent synergy to inhibit cell viability and enhance apoptosis of MB231 and MB436 cells. Combined treatment substantially increases caspase-8, caspase-3, and PARP cleavage in both cell lines and significantly suppresses tumor growth in nude mice bearing MB231 xenografts. Collectively, our findings demonstrate that treatment with CPT in combination with Dox exerts synergistic antitumor effects through activation of the caspase cascade pathway, a mechanism that is partly dependent on the Dox-induced upregulation of death receptor 4 and death receptor 5. Therefore, CPT combined with Dox may be a feasible therapeutic strategy for the management of TNBC.

Published
2023
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28. Neural Architecture Optimization with Graph VAE

Author

Li, Jian, Liu, Yong, Liu, Jiankun, and Wang, Weiping

Subjects
Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

Due to their high computational efficiency on a continuous space, gradient optimization methods have shown great potential in the neural architecture search (NAS) domain. The mapping of network representation from the discrete space to a latent space is the key to discovering novel architectures, however, existing gradient-based methods fail to fully characterize the networks. In this paper, we propose an efficient NAS approach to optimize network architectures in a continuous space, where the latent space is built upon variational autoencoder (VAE) and graph neural networks (GNN). The framework jointly learns four components: the encoder, the performance predictor, the complexity predictor and the decoder in an end-to-end manner. The encoder and the decoder belong to a graph VAE, mapping architectures between continuous representations and network architectures. The predictors are two regression models, fitting the performance and computational complexity, respectively. Those predictors ensure the discovered architectures characterize both excellent performance and high computational efficiency. Extensive experiments demonstrate our framework not only generates appropriate continuous representations but also discovers powerful neural architectures.

Published
2020

41. Template Mask Based Image Fusion Built-in Algorithm for Wide Field Fundus Cameras

Author

Wu, Jun, He, Mingxin, Liu, Yang, Zhang, Hanwen, Zhao, Jianchun, Shen, Xiaohou, Liu, Jiankun, Yang, Gang, Li, Xirong, Ding, Dayong, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Antony, Bhavna, editor, Fu, Huazhu, editor, Lee, Cecilia S., editor, MacGillivray, Tom, editor, Xu, Yanwu, editor, and Zheng, Yalin, editor

Published
2022
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42. Fundus Photograph Defect Repair Algorithm Based on Portable Camera Empty Shot

Author

Wu, Jun, Zhang, Hanwen, He, Mingxin, Zhao, Jianchun, Shen, Xiaohou, Liu, Jiankun, Yang, Gang, Li, Xirong, Ding, Dayong, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Antony, Bhavna, editor, Fu, Huazhu, editor, Lee, Cecilia S., editor, MacGillivray, Tom, editor, Xu, Yanwu, editor, and Zheng, Yalin, editor

Published
2022
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44. Behavior of Compacted Collapsible Soil After Adding Calcium Chloride

Author

Geng, Weijuan, Zhou, Weiyang, Liu, Jiankun, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Tutumluer, Erol, editor, Nazarian, Soheil, editor, Al-Qadi, Imad, editor, and Qamhia, Issam I.A., editor

Published
2022
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