1. Discordant pathologic diagnoses of myelodysplastic neoplasms and their implications for registries and therapies.
- Author
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Gore, Steven, Kroft, Steven, Harrington, Alexandra, Saber, Wael, Starczynowski, Daniel, Rollison, Dana, Zhang, Ling, Moscinski, Lynn, Wilson, Steffanie, Thompson, Jason, Borchert, Christine, Sherman, Seth, Hebert, Donnie, Walker, Mary, Padron, Eric, DeZern, Amy, Sekeres, Mikkael, Gorak, Edward, Otterstatter, Michael, Al Baghdadi, Tareq, Gillis, Nancy, Foran, James, Liu, Jane, and Bejar, Rafael
- Subjects
Humans ,Prospective Studies ,Myelodysplastic Syndromes ,Myeloproliferative Disorders ,Leukemia ,Myeloid ,Acute ,Registries - Abstract
Myelodysplastic neoplasms (MDS) are a collection of hematopoietic disorders with widely variable prognoses and treatment options. Accurate pathologic diagnoses present challenges because of interobserver variability in interpreting morphology and quantifying dysplasia. We compared local clinical site diagnoses with central, adjudicated review from 918 participants enrolled in the ongoing National Heart, Lung, and Blood Institute National MDS Natural History Study, a prospective observational cohort study of participants with suspected MDS or MDS/myeloproliferative neoplasms (MPNs). Locally, 264 (29%) were diagnosed as having MDS, 15 (2%) MDS/MPN overlap, 62 (7%) idiopathic cytopenia of undetermined significance (ICUS), 0 (0%) acute myeloid leukemia (AML) with
- Published
- 2023