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Your search keyword '"Liu, I-Chen"' showing total 16 results
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16 results on '"Liu, I-Chen"'

5. The Design, Structure–Activity, and Kinetic Studies of 3-Benzyl-5-oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl Sulfamates as Steroid Sulfatase Inhibitors

Author

Chang, Chiao-Nien, primary, Lin, I-Chun, additional, Lin, Tzung-Sheng, additional, Chiu, Pei-Fang, additional, Lu, Yeh-Lin, additional, Narwane, Manmath, additional, Liu, I-Chen, additional, Hng, Yue, additional, Tsai, Keng-Chang, additional, Lin, Mei-Hsiang, additional, Hsieh, Yves S. Y., additional, Chen, Mei-Jou, additional, and Liang, Pi-Hui, additional

Published
2022
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9. Improved Deep Learning in Citrus Canker Recognition System Based on FPGA

Author

Liu-I Chen and Chang-Ming Wu

Subjects
Identification (information), Speedup, business.industry, Computer science, Deep learning, Citrus canker, Recognition system, Memory bandwidth, Artificial intelligence, Field-programmable gate array, business, Object detection, Computer hardware
Abstract

This paper constructs a recognition system for citrus canker disease. Through the development of deep learning technology, the training module of citrus canker disease has plasticity and accuracy. This technology can easily add new diseases and insect pests to identify. In addition, in combination with hardware accelerators. In order to reduce storage capacity and memory bandwidth, a deep separable convolution operation is implemented on FPGA to speed up the identification speed, and the image obtained by the web camera is used to identify citrus that has suffered from canker disease.

Published
2021

16. A gastro-resistant peptide from Momordica charantia improves diabetic nephropathy in db / db mice via its novel reno-protective and anti-inflammatory activities.

Author

Liao PY, Lo HY, Liu IC, Lo LC, Hsiang CY, and Ho TY

Subjects
Animals, Diabetes Mellitus, Experimental complications, Disease Models, Animal, Kidney drug effects, Mice, Mice, Inbred Strains, Signal Transduction drug effects, Anti-Inflammatory Agents pharmacology, Diabetic Nephropathies drug therapy, Momordica charantia, Peptides pharmacology
Abstract

Diabetic nephropathy (DN), a principal diabetic microvascular complication, is a chronic inflammatory immune disorder. A gastro-resistant peptide mcIRBP-9 from Momordica charantia has shown modulation of blood glucose homeostasis in diabetic mice. Here we conducted a long-term experiment to evaluate the therapeutic effects and mechanisms of mcIRBP-9 on DN. Type 2 diabetic mice ( db / db mice) were orally given mcIRBP-9 once daily for 12 consecutive weeks. The amelioration of DN was evaluated by renal function indexes, vascular leakage, and pathological lesions. Possible effective mechanisms of mcIRBP-9 on DN were analyzed by gene expression profiles. A pharmacokinetic study in rats was carried out to evaluate the oral bioavailability of mcIRBP-9. Our data showed that mcIRBP-9 was able to enter systemic circulation in rats after oral administration. In comparison with mock, long-term administration of mcIRBP-9 significantly decreased blood glucose (572.25 ± 1.55 mg dL -1 vs. 213.50 ± 163.39 mg dL -1 ) and HbA1c levels (13.58 ± 0.30% vs. 8.23 ± 2.98%) and improved the survival rate (85.7% vs. 100%) in diabetic mice. mcIRBP-9 ameliorated DN by reducing renal vascular leakage and histopathological changes. mcIRBP-9 altered the pathways involved in inflammatory and immune responses, and the nuclear factor-κB played a central role in the regulation of mcIRBP-9-affected pathways. Moreover, mcIRBP-9 improved the inflammatory characteristic of DN in diabetic and non-diabetic mice. In conclusion, mcIRBP-9 displayed a novel anti-inflammatory activity and exhibited a reno-protective ability in addition to controlling the blood glucose and HbA1c levels. These findings suggested the role of mcIRBP-9 from M. charantia as a nutraceutical agent for diabetes and subsequent DN.

Published
2022
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