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Objective The formation of monsoon climates is attributed to the seasonal reversal of wind direction and precipitation caused by the difference in thermal capacity between land and ocean. Asia is recognized as the most prominent region globally, with monsoon climates, that affect the largest population. The heavy rainfall accompanying monsoons can result in various secondary disasters, substatially jeopardizing human safety and productivity in the region. Consequently, comprehending the formation process of the Asian monsoon holds paramount importance. Methods This study aim to employ geological concepts to establish a connection between the past and present, providing an overview of the components of Asian monsoons, identifying the primary factors influencing their formation and evolution, and summarizing research progress on the South Asian and East Asian monsoons based on sediment records from key Asian locations. Results The findings indicate that during the Cenozoic, the collision between the Indian Plate and the southern margin of the Asian continent altered the distribution of land and sea in Asia. Consequently, the Tibetan Plateau experienced initial uplift, contributing to the emergence of monsoon climates in South Asia and East Asia. However, at this stage, the East Asian region was still primarily influenced by the planetary wind system, and the East Asian monsoon was in its early stages, predominantly restricted to the southern margin of the South China Plate in a localized manner. In contrast, the South Asian Monsoon covered a relatively extensive area. This discrepancy may be attributed to the delayed opening of marginal seas in the East Asian region compared to the relatively earlier occurrence of land and sea distribution in South Asia. However, as the Tibetan Plateau continued to uplift and approach its current altitude during the middle to late Cenozoic, the Asian monsoon entered a strengthening phase, notably impacting regional geological evolution processes. Since the middle to late Cenozoic, the development of the North and South Polar ice caps and the upliftment of the Tibetan Plateau have controlled the Asian monsoon, leading it to undergo multiple stable periods of development. Conclusion The development and evolution of the East Asian and South Asian monsoons are mainly driven by the distribution of sea and land in the Asia, the upliftment of the Tibetan Plateau and the global climate change during the Cenozoic. Significance These findings provide valuable insights into the scientific and rational utilization of the Asian monsoon for conducting systematic Earth science research in Asia.

Organophosphate pesticides (OPs) are often used as insecticides and acaricides in agriculture, thus improving yields. OP residues may pose a serious threat, duetoinhibitionof the enzymeacetylcholinesterase(AChE). Therefore, a competitive bio-barcode immunoassay was designed for simultaneous quantification of organophosphate pesticide residues using AuNP signal amplification technology and Au@Pt catalysis. The AuNP probes were labelled with antibodies and corresponding bio-barcodes (ssDNAs), MNP probes coated with ovalbumin pesticide haptens and Au@Pt probes functionalized with the complementary ssDNAs were then prepared. Subsequently, pesticides competed with MNP probes to bind the AuNP probes. The recoveries of the developed assay were ranged from 71.26 to 117.47% with RSDs from 2.52 to 14.52%. The LODs were 9.88, 3.91, and 1.47 ng·kg-1, for parathion, triazophos, and chlorpyrifos, respectively. The assay was closely correlated with the data obtained from LC-MS/MS. Therefore, the developed method has the potential to be used as an alternative approach for detection of multiple pesticides.

Objective: To compare and analyze the efficacy and safety of different methods for injecting polidocanol in the treatment of venous malformations. Methods: The medical records of patients with venous malformations in our hospital from April 2021 to April 2023 were analyzed retrospectively, and they were divided into control group (n = 38) and observation group (n = 20) according to different treatment methods. Control group was injected with polidocanol under ultrasound guidance, while observation group was injected with polidocanol under digital subtraction angiography (DSA) monitoring. Therapeutic effects of observation group and control group after 3-6 months of treatment were compared and analyzed, and complications that can be used to reflect the safety of treatment in two groups were collected and recorded. Results: After treatment, the total effective rates of observation group and control group were 97.37% (37/38) and 75.00% (15/20) respectively, with significant differences (both p <.05). After 3-6 months of treatment, 13 complications occurred in observation group, while 16 occurred in control group. The number of complications in observation group was 6, with an incidence rate of 15.78%; while that in control group was 9, with an incidence rate of 45.00%, with a significant difference (p <.05). There were no significant differences among other baseline data, age and complications between two groups (all p >.05). Conclusion: Injection of polidocanol in patients with venous malformations under DSA monitoring was more effective and safer. [ABSTRACT FROM AUTHOR]

In patients with relapsed or refractory neuroblastoma (NB), the limited efficacy of conventional chemotherapies necessitates the exploration of new treatment options. Previous studies have highlighted the anti-tumor properties of arsenic trioxide (ATO) in high-risk NB (HR-NB). This study aims to assess the effectiveness and safety of ATO combined with salvage chemotherapy regimens, featuring cyclophosphamide and topotecan, as a foundational treatment for children with relapsed or refractory NB. Eleven patients (four relapsed, seven refractory NB) were retrospectively analyzed for efficacy and treatment relevance. Salvage treatments, incorporating ATO (0.18 mg/kg daily for 8 h intravenously on days 1 to 10), were administered upon disease progression or relapse, with assessments conducted every two cycles. Treatments had 63.6% efficacy, with six cases of partial response, one case of stable disease, and four cases of disease progression. The overall response rate was 54.5%, and the disease control rate was 63.6%. Importantly, the systemic toxicity experienced by patients following salvage chemotherapy with ATO was mild. Salvage chemotherapy regimens featuring ATO demonstrated potential for prolonging disease stabilization for relapsed or refractory HR-NB patients, exhibiting both favorable efficacy and safety profiles. This suggests further clinical exploration and promotion of this therapeutic approach in the treatment of NB. Clinical perspectives summary: Point 1. The inadequate effectiveness of traditional chemotherapy in individuals with recurrent or resistant neuroblastoma (NB) necessitates the investigation of novel therapeutic approaches. Point 2. Arsenic trioxide (ATO)-based salvage treatments are both effective and less toxic in relapsed or refractory NB. Point 3. Salvage chemotherapy regimens incorporating ATO have shown promise in extending disease stabilization in relapsed or refractory high-risk NB patients, with favorable efficacy and safety profiles, which suggests further clinical exploration and promotion of this therapeutic approach in the treatment of NB. [ABSTRACT FROM AUTHOR]