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170 results on '"Liu, Chunye"'

24. The Roles of Riblet and Superhydrophobic Surfaces in Energy Saving Using a Spatial Correlation Analysis

Author

Liu, Chunye, Wang, Wene, Hu, Xiaotao, Fang, Juan, Liu, Fulai, Liu, Chunye, Wang, Wene, Hu, Xiaotao, Fang, Juan, and Liu, Fulai

Abstract

Riblet and superhydrophobic surfaces are two typical passive control technologies used to save energy. In this study, three microstructured samples—a micro-riblet surface (RS), a superhydrophobic surface (SHS), and a novel composite surface of micro-riblets with superhydrophobicity (RSHS)—were designed to improve the drag reduction rate of water flows. Aspects of the flow fields of microstructured samples, including the average velocity, turbulence intensity, and coherent structures of water flows, were investigated via particle image velocimetry (PIV) technology. A two-point spatial correlation analysis was used to explore the influence of the microstructured surfaces on coherent structures of water flows. Our results showed that the velocity on microstructured surface samples was higher than that on the smooth surface (SS) samples, and the turbulence intensity of water on the microstructured surface samples decreased compared with that on the SS samples. The coherent structures of the water flow on microstructured samples were restricted by length and structural angles. The drag reduction rates of the SHS, RS, and RSHS samples were −8.37 %, −9.67 %, and −17.39 %, respectively. The novel established RSHS demonstrated a superior drag reduction effect and could improve the drag reduction rate of water flows.

Published
2023

25. Screening of Acetylcholinesterase Inhibitors by Capillary Electrophoresis with Oriented-Immobilized Enzyme Microreactors Based on Gold Nanoparticles.

Author

Zhang, Jian, Li, Yuanyuan, Chen, Lin, Zheng, Zhihong, and Liu, Chunye

Subjects
ENZYME inhibitors, GOLD nanoparticles, ACETYLCHOLINESTERASE inhibitors, MICROREACTORS, CAPILLARY electrophoresis, ENZYMES, ACETYLCHOLINESTERASE
Abstract

A facial and efficient method for the screening of acetylcholinesterase (AChE) inhibitors by capillary electrophoresis was developed. Based on the specific affinity of concanavalin A (Con A) for binding to the glycosyl group of AChE, enzyme molecules were oriented-immobilized on the surface of gold nanoparticles (AuNPs@Con A@AChE). Then, these modified nanoparticles were bounded to the capillary inlet (about 1.0 cm) by electrostatic self-assembly to obtain the oriented-immobilized enzyme microreactor (OIMER). Compared to an IMER with a free enzyme, the peak area of the product obtained by the OIMER increased by 52.6%. The Michaelis–Menten constant (Km) was as low as (0.061 ± 0.003) mmol/L. The method exhibits good repeatability with a relative standard deviation (RSD) of 1.3% for 100 consecutive runs. The system was successfully applied to detect the IC50 values of donepezil and four components from Chinese medicinal plants. This work demonstrates the potential of this method as a low cost, simple, and accurate screening method for other enzyme inhibitors. [ABSTRACT FROM AUTHOR]

Published
2024
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32. A Bioinspired Soft Swallowing Robot Based on Compliant Guiding Structure

Author

Zhou Pan, Li Haili, Yundou Xu, Liu Chunye, Jiantao Yao, and Yongsheng Zhao

Subjects
Mammals, 0209 industrial biotechnology, Computer science, digestive, oral, and skin physiology, Biophysics, Soft robotics, food and beverages, Robotics, 02 engineering and technology, 021001 nanoscience & nanotechnology, Deglutition, 020901 industrial engineering & automation, stomatognathic system, Swallowing, Artificial Intelligence, Control and Systems Engineering, External injury, otorhinolaryngologic diseases, Animals, Robot, %22">Fish , 0210 nano-technology, Simulation
Abstract

From small unicellular organisms to large mammals, swallowing is an important way for them to interact with their external environment. The majority of these animals swallow their targets for the purpose of hunting, and some fish and amphibians protect their cubs from external injury by swallowing them. Thus, swallowing can produce an efficient capture, keep the integrity of targets, and provide effective protection for swallowed objects. Inspired by this, we propose a novel soft swallowing robot (SSR) capable of swallowing various objects that have different shapes and stiffnesses, protecting objects from squeeze and collision, and withstanding high temperature, which are enabled by a compliant guiding structure consisting of a double thin-walled capsule filled with fluid and a linearly movable traction body. In this article, we study the SSR supported by air and water, respectively; furthermore, we experimentally conclude that the working medium has a great influence on the inherent characteristics of the SSR. Our study helps lay the foundation for the research of soft robotic systems with swallowing characteristics, and the SSR is expected to enter the practical application field from the laboratory.

Published
2020
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50. Isolation of mouse pancreatic islet Procr+progenitors and long-term expansion of islet organoids in vitro

Author

Wang, Jingqiang, Wang, Daisong, Chen, Xinyi, Yuan, Shubo, Bai, Lanyue, Liu, Chunye, and Zeng, Yi Arial

Abstract

Insulin production is required for glucose homeostasis. Pancreatic islet β cells are the only cells that produce insulin in humans; however, generation of functional β cells in vitro from embryonic or adult tissues has been challenging. Here, we describe isolation of pancreatic islet progenitors from adult mice, which enables the efficient generation and long-term expansion of functional islet organoids in vitro. This protocol starts with purification of protein C receptor (Procr)-expressing islet progenitors. Coculture with endothelial cells generates islet organoids in vitro that can be expanded by passage. Functional maturation is achieved as a consequence of a prolonged culture period and cyclic glucose stimulation. Primary islet organoids form in 7–10 days. Subsequently, each passage takes 1 week, with the final maturation step requiring 3 weeks of additional culture. The resulting organoids are predominantly composed of β cells but also contain small proportions of α, δ and pancreatic polypeptide cells. The organoids sense glucose and secrete insulin. This approach thus provides a strategy for β cell generation in vitro and an organoid system to study islet regeneration and diseases.

Published
2022
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