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Coronary artery disease (CAD) is defined as one of the most common cardiovascular diseases (CVDs). Periodontitis is one of the risk factors for CAD. PubMed, Embase and Cochrane Library databases were carefully and thoroughly retrieved until October 2021. On the basis of the inclusion and exclusion criteria, eligible articles were selected strictly to identify randomized controlled trials (RCTs). Using Cochran's Q statistic, Review Manager 5.4 and Stata 16, data were extracted, and a comprehensive analysis was carried out. Six RCTs of 619 patients were included in this study, including 360 in the intervention group (IG) and 259 in the control group (CG). Meta-analysis showed significant difference for C-reactive protein (CRP) (1.20mg/L, 95% CI: 1.13 to 1.27, p < 0.00001) after non-surgical periodontal therapy (NSPT), but showed no significant difference for interleukin-6 (IL-6) (1.19mg/L, 95% CI: -1.03 to 3.40, p=0.29), flow-mediated dilation (FMD) (-1.64%, 95% CI: -4.95 to 1.67, p=0.33), triacylglycerol (TG) (-0.02mg/dL, 95% CI: -0.31 to 0.27, p=0.90), total cholesterol (TC) (0.04mg/dL, 95% CI: -0.25 to 0.33, p=0.90), low-density lipoprotein cholesterol (LDL-C) (0.00mg/dL, 95% CI: -0.29 to 0.29, p=0.99) and high-density lipoprotein cholesterol (HDL-C) (0.11mg/dL, 95% CI: -0.18 to 0.40, p=0.46). The impact of NSPT on the reduction of CRP in patients of CAD with periodontitis is significant. NSPT can be considered as an important preventive strategy for major cardiovascular events in CAD.

Purpose. Using network pharmacology and in vivo experiments, we investigated the antidrug-induced liver injury components and functional processes of Sedum sarmentosum Bunge (SSBE). Methods. The effective components, primary active ingredients, and possible target in the therapy of DILI were predicted using network pharmacology and bioinformatics. APAP was inducing the DILI model. In vivo testing of the pharmacodynamic foundation of SSBE in the treatment of DILI was performed. Results. The TCMSP database evaluated five main active components and 299 related targets. In addition, 707 differential genes for DILI were obtained from the DisGeNET database, DigSee database, and OMIM database. 61 related targets were mapped to predict the targets of SSBE acting on DILI. The protein-protein interaction (PPI) core network contained 59 proteins, including IL-β, MARK14, SSP1, and MMP9. These genes are closely related to the Nrf2/ARE signaling pathway, and they may play a key role in the hepatoprotective effect of SSBE. Verification experiment results showed that, in the DILI mouse model, SSBE promoted inflammation diminution and regulation of Nrf2-ARE cascade. SSBE protected normal hepatocyte growth and inhibited apoptosis of normal liver cells induced by APAP. SSBE inhibited the expression of Nrf2 and ARE proteins in the liver tissue of the DILI mouse model in vivo. Conclusion. By modulating the Nrf2 signaling pathway, the active components in SSBE may protect against drug-induced liver damage.

Based on the summary of elements and evaluation of the core competences of vocational college students,the elements are defined from the sight of the connotation of management and indicators system are subdivided around the resource optimization and configuration management activities on the target for self-career. Combined with Delphi method, basic capability, adaptation ability and development ability are determined to be the fist-level indicators of the core competences of vocational students; learning ability, communication skills, information capabilities, relationship ability, collaboration, business ability, emotional ability, planning ability, innovation ability are the second-level indicators and 36 third-level indicators are selected. Recommendations are proposed such as setting goal-oriented, competency-based "theory and practice integration" curriculum, carrying out second classes through multi-carriers and multi-dimensional special psychological training activities.

As China's ever-increasing e-commerce transactions, the integrity of e-commerce transactions has become an increasingly prominent problem. Integrity in China has become the main bottleneck in the healthy development of e-commerce. As we all know, E-commerce is a commercial activity. It can not do without the support of reputation. Under complete information static game, there are some methods for people to establish credit system for the e-commerce transactions. At first, People should strengthen the publicity for innovative content and create a social credit environment. Then, people can also establish a complete legal system and increase efforts to crack down fraudulent operators. At the same time, people can set up the credit evaluation system and the regulatory bodies with strengthening the credit control measures.

With the rapid development of e-commerce, the protection of copyright will face enormous challenges. Network has many characteristic such as the borderless nature, complexity of information sources and so on. Therefore, the traditional jurisdiction standards based on the dependant’s domicile and the infringement place will not apply for the new situation. Before the jurisdiction principle of copyright infringement based on e-commerce comes into reality, this paper put forward some principles to follow. These principles include the principle of jurisdiction with agreement, the principle of the plaintiff’s domicile, the principle of inconvenient court and the principle of the infringement place.

This paper firstly analyzes government and enterprises behavior in the reverse logistics activities by means of constructing game model. Then it puts forward strategies from the aspects of government and enterprises.