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155 results on '"Liu, Chien-Cheng"'

9. Predictive Efficacy of the Perfusion Index for Hypotension following Spinal Anesthesia in Parturient Undergoing Elective Cesarean Section: A Systematic Review and Meta-Analysis

Author

Hung, Kuo-Chuan, primary, Liu, Chien-Cheng, additional, Huang, Yen-Ta, additional, Wu, Jheng-Yan, additional, Chen, Jen-Yin, additional, Ko, Ching-Chung, additional, Lin, Chien-Ming, additional, Hsing, Chung-Hsi, additional, Yew, Ming, additional, and Chen, I-Wen, additional

Published
2023
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12. Assessing the Efficacy of Inferior Vena Cava Collapsibility Index for Predicting Hypotension after Central Neuraxial Block: A Systematic Review and Meta-Analysis.

Author

Chang, Ying-Jen, Liu, Chien-Cheng, Huang, Yen-Ta, Wu, Jheng-Yan, Hung, Kuo-Chuan, Liu, Ping-Hsin, Lin, Chien-Hung, Lin, Yao-Tsung, Chen, I-Wen, and Lan, Kuo-Mao

Subjects
*VENA cava inferior, *HYPOTENSION, *CESAREAN section
Abstract

The use of ultrasonography to predict spinal-induced hypotension (SIH) has gained significant attention. This diagnostic meta-analysis aimed to investigate the reliability of the inferior vena cava collapsibility index (IVCCI) in predicting SIH in patients undergoing various surgeries. Databases, including Embase, Cochrane Library, Medline, and Google Scholar, were screened until 28 July 2023, yielding 12 studies with 1076 patients (age range: 25.6–79 years) undergoing cesarean section (CS) (n = 4) or non-CS surgeries (n = 8). Patients with SIH had a significantly higher IVCCI than those without SIH (mean difference: 11.12%, 95% confidence interval (CI): 7.83–14.41). The pooled incidence rate of SIH was 40.5%. IVCCI demonstrated satisfactory overall diagnostic reliability (sensitivity, 77%; specificity, 82%). The pooled area under the curve (AUC) was 0.85, indicating its high capability to differentiate patients at risk of PSH. The Fagan nomogram plot demonstrated a positive likelihood ratio (PLR) of 4 and a negative likelihood ratio (NLR) of 0.28. The results underscore the robustness and discriminative ability of IVCCI as a predictive tool for SIH. Nevertheless, future investigations should focus on assessing its applicability to high-risk patients and exploring the potential enhancement in patient safety through its incorporation into clinical practice. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Dynamics and reversibility of oxygen doping and de-doping for conjugated polymer.

Author

Liao, Hua-Hsien, Yang, Chia-Ming, Liu, Chien-Cheng, Horng, Sheng-Fu, Meng, Hsin-Fei, and Shy, Jow-Tsong

Subjects
CHEMICAL reactions, FIELD-effect transistors, SEPARATION (Technology), SURFACE chemistry, ANALYTICAL chemistry
Abstract

We perform comprehensive long-time monitoring of the p-doping and de-doping of poly(3-hexyl thiophene) under changing external conditions of oxygen, light, and temperature. They are shown to be controlled by the complex adsorption and desorption process with time scales ranging from seconds to weeks. The oxygen doping at atmospheric pressure takes several hours in the dark. The doping is dramatically accelerated to be within seconds with light of wavelength of 500–700 nm. Even at low oxygen pressure of 10-4 torr doping occurs within minutes with light. The de-doping by oxygen desorption takes as long as weeks at room temperature and vacuum of 10-4 torr, but when the temperature is raised to near the polymer glass temperature of 370 K, the de-doping is accelerated to minutes as the enhanced chain motion releases the trapped oxygen. Even though visible and near infrared light causes very efficient doping within seconds or minutes depending on vacuum level, such light-induced doping is not a chemical reaction and is fully reversible by thermal annealing at the end without sacrificing the mobility. For the polymer field-effect transistors, only the carrier density is changed while the mobility remains roughly a constant for all the conditions. [ABSTRACT FROM AUTHOR]

Published
2008
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38. Lentiviral vector-encoded micro RNA-based sh RNA-mediated gene knockdown of N-methyl-D-aspartate receptors in skin reduces pain.

Author

Liu, Chien‐Cheng, Cheng, Jiin‐Tsuey, Hung, Kuo‐Chuan, Chia, Yuan‐Yi, and Tan, Ping‐Heng

Subjects
*RNA polymerases, *BRAIN diseases, *GENE knockout, *GENETIC engineering, *LABORATORY organisms
Abstract

Background and Purpose RNA polymerase II promoters that drive the expression of rationally designed primary micro RNA-based sh RNA, for example, sh RNAmir, can produce more potent gene knockdown than RNA polymerase III promoters. Antagonists of peripheral N methyl-D-aspartate ( NMDA) receptors that do not interfere with central glutamate processing would prevent the development of adverse central nervous system effects. Thus, in this study, we examined the effects of gene silencing and antinociception on formalin- and Complete Freund's adjuvant ( CFA)-induced pain in rats by subcutaneously injecting a lentiviral vector encoding a sh RNAmir that targets the NR1 subunit of the NMDA receptor. Methods Rats received intradermal injections of different doses of NR1 sh RNAmir at different time points before injection of formalin. Pain behavior was assessed by monitoring the paw flinch response, paw withdrawal threshold, and thermal withdrawal latency. We then analyzed NR1 messenger RNA and protein expression in skin and the L5 dorsal root ganglion ( DRG). Results We found that intradermal injection of 1, 5, and 10 μg of sh RNAmir significantly inhibited flinch responses ( p < .05). Administration of 5 μg of sh RNAmir resulted in the attenuation of CFA-induced mechanical allodynia, but did not affect the time spent on the rotarod. Real-time polymerase chain reaction and western blotting revealed that NR1 mRNA and protein levels were significantly lower in all NR1 sh RNAmir1 groups than in controls ( p < .05). There was a significant reduction in the percentage of NR1- and pERK-positive neurons in the DRG ipsilateral to sh RNAmir treated paws ( p < .05). The effect of antinociception and inhibition of NR1 expression by NR1 sh RNAmir was evident on day 3 and persisted for 7 days after injection of 5 μg of vector. Conclusion Peripheral administration of the vector-encoded NR1 sh RNAmir is a promising therapy for persistent inflammatory pain. [ABSTRACT FROM AUTHOR]

Published
2017
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