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The Primary Care Informatics Working Group (PCIWG) of the American Medical Informatics Association (AMIA) has identified the absence of a national strategy for primary care informatics. Under PCIWG leadership, major national and international societies have come together to create the National Alliance for Primary Care Informatics (NAPCI), to promote a connection between the informatics community and the organisations that support primary care. The PCIWG clinical practice subcommittee has recognised the necessity of a global needs assessment, and proposed work in point-of-care technology, clinical vocabularies, and ambulatory electronic medical record development. Educational needs include a consensus statement on informatics competencies, recommendations for curriculum and teaching methods, and methodologies to evaluate their effectiveness. The research subcommittee seeks to define a primary care informatics research agenda, and to support and disseminate informatics research throughout the primary care community. The AMIA board of directors has enthusiastically endorsed the conceptual basis for this White Paper. [ABSTRACT FROM AUTHOR]

Anemia is a prevalent condition with a variety of underlying causes. Once the etiology has been established, many forms of anemia can be easily managed by the family physician. Iron deficiency, the most common form of anemia, may be treated orally or, rarely, parenterally. Vitamin B12 deficiency has traditionally been treated with intramuscular injections, although oral and intranasal preparations are also available. The treatment of folate deficiency is straightforward, relying on oral supplements. Folic acid supplementation is also recommended for women of child-bearing age to reduce their risk of neural tube defects. Current research focuses on folate's role in reducing the risk of premature cardiovascular disease. [ABSTRACT FROM AUTHOR]

To navigate changes within a highly dynamic and complex environment, it is crucial to compare current visual representations of a scene to previously formed representations stored in memory. This process of mental comparison requires integrating information from multiple sources to inform decisions about changes within the environment. In the present article, we combine a novel systems factorial technology change detection task (Blunden et al., 2022) with a set size manipulation. Participants were required to detect 0, 1, or 2 changes of low and high detectability between a memory and probe array of 1-4 spatially separated luminance discs. Analyses using systems factorial technology indicated that the processing architecture was consistent across set sizes but that capacity was always limited and decreased as the number of distractors increased. We developed a novel model of change detection based on the statistical principles of basic sampling theory (Palmer, 1990; Sewell et al., 2014). The sample size model, instantiated parametrically, predicts the architecture and capacity results a priori and quantitatively accounted for several key results observed in the data: (a) increasing set size acted to decrease sensitivity ( d ') in proportion to the square root of the number of items in the display; (b) the effect of redundancy benefited performance by a factor of the square root of the number of changes; and (c) the effect of change detectability was separable and independent of the sample size costs and redundancy benefits. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Graphical perception is an important part of the scientific endeavour, and the interpretation of graphical information is increasingly important among educated consumers of popular media, who are often presented with graphs of data in support of different policy positions. However, graphs are multidimensional and data in graphs are comprised not only of overall global trends but also local perturbations. We presented a novel function estimation task in which scatterplots of noisy data that varied in the number of data points, the scale of the data, and the true generating function were shown to observers. 170 psychology undergraduates with mixed experience of mathematical functions were asked to draw the function that they believe generated the data. Our results indicated not only a general influence of various aspects of the presented graph (e.g., increasing the number of data points results in smoother generated functions) but also clear individual differences, with some observers tending to generate functions that track the local changes in the data and others following global trends in the data., (© 2024. The Author(s).)

The ability of humans to identify and reproduce short time intervals (in the region of a second) may be affected by many factors ranging from the gender and personality of the individual observer, through the attentional state, to the precise spatiotemporal structure of the stimulus. The relative roles of these very different factors are a challenge to describe and define; several methodological approaches have been used to achieve this to varying degrees of success. Here we describe and model the results of a paradigm affording not only a first-order measurement of the perceived duration of an interval but also a second-order metacognitive judgement of perceived time. This approach, we argue, expands the form of the data generally collected in duration-judgements and allows more detailed comparison of psychophysical behavior to the underlying theory. We also describe a hierarchical Bayesian measurement model that performs a quantitative analysis of the trial-by-trial data calculating the variability of the temporal estimates and the metacognitive judgments allowing direct comparison between an actual and an ideal observer. We fit the model to data collected for judgements of 750 ms (bisecting 1500 ms) and 1500 ms (bisecting 3000 ms) intervals across three stimulus modalities (visual, audio, and audiovisual). This enhanced form of data on a given interval judgement and the ability to track its progression on a trial-by-trial basis offers a way of looking at the different roles that subject-based, task-based and stimulus-based factors have on the perception of time.

Many cultures share common constellations and common narratives about the stars in the night sky. Previous research has shown that this overlap in asterisms, minimal star groupings inside constellations, is clearly present across 27 distinct culture groups and can be explained in part by properties of individual stars (brightness) and properties of pairs of stars (proximity) (Kemp, Hamacher, Little, & Cropper, 2022). The same work, however, found no evidence that properties of triples (angle) and quadruples (good continuation) predicted constellation formation. We developed a behavioral experiment to explore how individuals form constellations under conditions that reduce cultural learning. We found that participants independently selected and connected similar stars, and that their responses were predicted by two properties of triples (angle and even spacing) in addition to the properties of brightness and proximity supported by previous work. Our findings lend further evidence to the theory that commonality of constellations across cultures is not a result of shared human history but rather stems from shared human nature., (© 2024 The Authors. Topics in Cognitive Science published by Wiley Periodicals LLC on behalf of Cognitive Science Society.)

Background: In the United States, more than 30,000 cases of mpox (formerly known as monkeypox) had occurred as of March 1, 2023, in an outbreak disproportionately affecting transgender persons and gay, bisexual, and other men who have sex with men. In 2019, the JYNNEOS vaccine was approved for subcutaneous administration (0.5 ml per dose) to prevent mpox infection. On August 9, 2022, an emergency use authorization was issued for intradermal administration (0.1 ml per dose); however, real-world effectiveness data are limited for either route., Methods: We conducted a case-control study based on data from Cosmos, a nationwide Epic electronic health record (EHR) database, to assess the effectiveness of JYNNEOS vaccination in preventing medically attended mpox disease among adults. Case patients had an mpox diagnosis code or positive orthopoxvirus or mpox virus laboratory result, and control patients had an incident diagnosis of human immunodeficiency virus (HIV) infection or a new or refill order for preexposure prophylaxis against HIV infection between August 15, 2022, and November 19, 2022. Odds ratios and 95% confidence intervals were estimated from conditional logistic-regression models, adjusted for confounders; vaccine effectiveness was calculated as (1 - odds ratio for vaccination in case patients vs. controls) × 100., Results: Among 2193 case patients and 8319 control patients, 25 case patients and 335 control patients received two doses (full vaccination), among whom the estimated adjusted vaccine effectiveness was 66.0% (95% confidence interval [CI], 47.4 to 78.1), and 146 case patients and 1000 control patients received one dose (partial vaccination), among whom the estimated adjusted vaccine effectiveness was 35.8% (95% CI, 22.1 to 47.1)., Conclusions: In this study using nationwide EHR data, patients with mpox were less likely to have received one or two doses of JYNNEOS vaccine than control patients. The findings suggest that JYNNEOS vaccine was effective in preventing mpox disease, and a two-dose series appeared to provide better protection. (Funded by the Centers for Disease Control and Prevention and Epic Research.)., (Copyright © 2023 Massachusetts Medical Society.)

The 'nervous nineties' is a well-known cricket colloquialism that implies that batting within reach of 100 runs is mentally demanding. Despite common acceptance of this phenomenon, no study has used a historical test cricket dataset to examine how batting behaviour and performance changes on approach to a century. Accordingly, we explored opensource ball-by-ball data from 712 test cricket matches played between 2004 and 2022 to model the regression discontinuity of batting performance metrics either side of 100 runs. Models were fit using multi-level regression, adjusted for the clustering of balls within players (and where possible, the clustering of matches and innings within players). The analysis revealed that runs per ball and the probability of scoring a boundary increased as batters approached 100 runs. This was followed by a decline of -0.18 runs per ball (95% CI -0.22 to -0.14) and a three-percentage point decline (95% CI 2.2 to 3.8) in the probability of a boundary once a batter reached 100. The modelling revealed no evidence of a change in the probability of a dismissal before and after 100. Our results suggest many batters cope effectively with the psychological demands of playing through the nineties, including by batting aggressively and/or opportunistically to swiftly reach the milestone., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Roberts et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

In the study of perceptual categorization, a key distinction is made between separable and integral dimensions. Separable dimensions are easy to attend in isolation, while integral dimensions are not. Little et al. (2016) showed that when trial-by-trial responses are analyzed, a consistent pattern of sequential effects was found in a modified Garner paradigm using integral-dimension stimuli. The present experiments investigated whether these pronounced sequential effects are also found with separable-dimension stimuli. Four experiments using two different types of separable dimensions were conducted. The results indicated that similar patterns of sequential effects were present for separable-dimension stimuli, but, unlike for integral dimensions, the effect of a change in the irrelevant dimension in the filtering task was not found. Further, for separable dimensions, the overall pattern of sequential effects did not vary between the Garner tasks (i.e., control, correlated, and filtering). To explain these results, we fit a sequence-sensitive exemplar model and compared the fits of this model to a novel sequence-sensitive feature model, in which only the relevant feature influences the categorization decision. We found that the full exemplar model provided a more compelling account of both our separable dimension data and the integral dimension data of Little et al. (2016). These findings provide a more complete understanding of perceptual categorization and add to the growing body of literature on the prevalence and critical implications of strong sequential effects in cognitive tasks. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Episodic memory theories have postulated that in recognition, a probe is accepted or rejected on the basis of its global similarity to studied items. Mewhort and Johns (2000) directly tested global similarity predictions by manipulating the feature compositions of probes-novelty rejection was facilitated when probes contained novel features even when other features strongly matched, an advantage dubbed the extralist feature effect, which greatly challenged global matching models. In this work, we conducted similar experiments using continuously valued separable- and integral-dimension stimuli. Analogs of extralist lures were constructed where one stimulus dimension contained a value that was more novel than the other dimensions, whereas overall similarity was equated to another class of lures. Facilitated novelty rejection for lures with extralist features was only found for separable-dimension stimuli. While integral-dimension stimuli were well described by a global matching model, the model failed to account for extralist feature effects with separable-dimension stimuli. We applied global matching models-including variants of the exemplar-based linear ballistic accumulator-that employed different means of novelty rejection afforded by separable-dimension stimuli, including decisions based on the global similarity of the individual dimensions and selective attention being directed toward novel probe values (a diagnostic attention model). While these variants produced the extralist feature effect, only the diagnostic attention model succeeded in providing a sufficient account of all of the data. The model was also able to account for extralist feature effects in an experiment with discrete features similar to those from Mewhort and Johns (2000). (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Accumulated studies have suggested that bone morphogenetic proteins (BMPs) are critical for skin development. However, it remains elusive how BMP signaling via ALK2 (aka ACVR1), one of the important BMP type I receptors, regulates keratinocyte differentiation. To address this question, we utilized a genetic system that enhances BMP signaling via ALK2 in an epidermis-specific manner in mice (hereafter ca-Alk2:K14-Cre). Ca-Alk2:K14-Cre mice displayed a sticky and hairless skin phenotype with a thinner epidermis incapable of differentiating. Although cellular proliferation and survival were comparable between wild-type and ca-Alk2:K14-Cre mice, skin differentiation was severely hampered in ca-Alk2:K14-Cre mice. To uncover the mechanism of altered keratinocyte differentiation, we performed a transcriptome analysis. As a result, we found that the expression levels of cell cycle inhibitor p21 were increased in ca-Alk2:K14-Cre mice. Our findings suggest that aberrant BMP signaling via ALK2 positively regulates p21 expression that attenuates keratinocyte differentiation, and further highlights the critical role of BMP signaling in skin development., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Background: In response to the COVID-19 pandemic, countries are introducing digital passports that allow citizens to return to normal activities if they were previously infected with (immunity passport) or vaccinated against (vaccination passport) SARS-CoV-2. To be effective, policy decision-makers must know whether these passports will be widely accepted by the public and under what conditions. This study focuses attention on immunity passports, as these may prove useful in countries both with and without an existing COVID-19 vaccination program; however, our general findings also extend to vaccination passports., Objective: We aimed to assess attitudes toward the introduction of immunity passports in six countries, and determine what social, personal, and contextual factors predicted their support., Methods: We collected 13,678 participants through online representative sampling across six countries-Australia, Japan, Taiwan, Germany, Spain, and the United Kingdom-during April to May of the 2020 COVID-19 pandemic, and assessed attitudes and support for the introduction of immunity passports., Results: Immunity passport support was moderate to low, being the highest in Germany (775/1507 participants, 51.43%) and the United Kingdom (759/1484, 51.15%); followed by Taiwan (2841/5989, 47.44%), Australia (963/2086, 46.16%), and Spain (693/1491, 46.48%); and was the lowest in Japan (241/1081, 22.94%). Bayesian generalized linear mixed effects modeling was used to assess predictive factors for immunity passport support across countries. International results showed neoliberal worldviews (odds ratio [OR] 1.17, 95% CI 1.13-1.22), personal concern (OR 1.07, 95% CI 1.00-1.16), perceived virus severity (OR 1.07, 95% CI 1.01-1.14), the fairness of immunity passports (OR 2.51, 95% CI 2.36-2.66), liking immunity passports (OR 2.77, 95% CI 2.61-2.94), and a willingness to become infected to gain an immunity passport (OR 1.6, 95% CI 1.51-1.68) were all predictive factors of immunity passport support. By contrast, gender (woman; OR 0.9, 95% CI 0.82-0.98), immunity passport concern (OR 0.61, 95% CI 0.57-0.65), and risk of harm to society (OR 0.71, 95% CI 0.67-0.76) predicted a decrease in support for immunity passports. Minor differences in predictive factors were found between countries and results were modeled separately to provide national accounts of these data., Conclusions: Our research suggests that support for immunity passports is predicted by the personal benefits and societal risks they confer. These findings generalized across six countries and may also prove informative for the introduction of vaccination passports, helping policymakers to introduce effective COVID-19 passport policies in these six countries and around the world., (©Paul M Garrett, Joshua P White, Simon Dennis, Stephan Lewandowsky, Cheng-Ta Yang, Yasmina Okan, Andrew Perfors, Daniel R Little, Anastasia Kozyreva, Philipp Lorenz-Spreen, Takashi Kusumi, Yoshihisa Kashima. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 15.07.2022.)

Systems factorial technology (SFT) is a theoretically derived methodology that allows for strong inferences to be made about underlying processing architectures (e.g., whether processing occurs in a pooled, coactive fashion or in serial or in parallel). Measures of mental architecture using SFT have been restricted to the use of error-free response times (RTs). In this article, through formal proofs and demonstrations, we extended the measure of architecture, the survivor interaction contrast (SIC), to RTs conditioned on whether they are correct or incorrect. We show that so long as an ordering relation (between stimulus conditions of different difficulty) is preserved, we learn that the canonical SIC predictions result when exhaustive processing is necessary and sufficient for a response. We further prove that this ordering relation holds for the popular Wiener diffusion model for both correct and error RTs but fails under some classes of a Poisson counter model, which affords a strong potential experimental test of the latter class versus the others. Our exploration also serves to point to the importance of detailed studies of how errors are made in perceptual and cognitive tasks. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Cultures around the world organize stars into constellations, or asterisms, and these groupings are often considered to be arbitrary and culture specific. Yet there are striking similarities in asterisms across cultures, and groupings such as Orion, the Big Dipper, the Pleiades, and the Southern Cross are widely recognized across many different cultures. Psychologists have informally suggested that these shared patterns are explained by Gestalt laws of grouping, but there have been no systematic attempts to catalog asterisms that recur across cultures or to explain the perceptual basis of these groupings. Here, we compiled data from 27 cultures around the world and found that a simple computational model of perceptual grouping accounts for many of the recurring cross-cultural asterisms. Our results suggest that basic perceptual principles account for more of the structure of asterisms across cultures than previously acknowledged and highlight ways in which specific cultures depart from this shared baseline.

Vitis has two subgenera: Euvitis, which includes commercially important Vitis vinifera and interspecific hybrid cultivars, and Muscadinia. Of note, the market for Muscadinia grapes remains small, and only Muscadinia rotundifolia is cultivated as a commercial crop. To establish a basis for the study of Muscadinia species, we generated chromosome-level whole-genome sequences of Muscadinia rotundifolia cv. Noble. A total of 393.8 Mb of sequences were assembled from 20 haploid chromosomes, and 26 394 coding genes were identified from the sequences. Comparative analysis with the genome sequence of V. vinifera revealed a smaller size of the M. rotundifolia genome but highly conserved gene synteny. A genome-wide association study of 12 Muscadinia berry-related traits was performed among 356 individuals from breeding populations of M. rotundifolia. For the transferability of markers between Euvitis and Muscadinia, we used 2000 core genome rhAmpSeq markers developed to allow marker transferability across Euvitis species. A total of 1599 (80%) rhAmpSeq markers returned data in Muscadinia. From the GWAS analyses, we identified a total of 52 quantitative trait nucleotides (QTNs) associated with the 12 berry-related traits. The transferable markers enabled the direct comparison of the QTNs with previously reported results. The whole-genome sequences along with the GWAS results provide a new basis for the extensive study of Muscadinia species., (© The Author(s) 2022. Published by Oxford University Press on behalf of Nanjing Agricultural University.)

We propose a novel modeling framework for characterizing the time course of change detection based on information held in visual short-term memory (VSTM). Specifically, we seek to answer whether change detection is better captured by a first-order integration model, in which information is pooled from each location, or a second-order integration model, in which each location is processed independently. We diagnose whether change detection across locations proceeds in serial or parallel and how processing is affected by the stopping rule (i.e., detecting any change vs. detecting all changes; Experiment 1) and how the efficiency of detection is affected by the number of changes in the display (Experiment 2). We find that although capacity is generally limited in both tasks, the architecture varies from parallel self-terminating in the OR task to serial self-terminating in the AND task. Our novel framework allows model comparisons across a large set of models ruling out several competing explanations of change detection. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

The present study used Systems Factorial Technology (Townsend & Nozawa, 1995) to investigate how people combine dual cues in semantic memory search. Our aims were (a) to understand how cues interact during the process of semantic search in convergent thinking and (b) to determine how workload capacity (i.e. cue-processing efficiency) is related to search performance. In two experiments, participants completed a typical convergent thinking test and a word production task. The results revealed that: (a) collective evidence supports similar patterns in cue-combination strategy despite individual differences in workload capacity, and (b) there exists a negative correlation between workload capacity and performance on convergent thinking test. A potential explanation is that, for the creative individual, loading many candidate answers leads to consumption of substantial processing resources that obtains as low workload capacity but also allows creative individuals to switch more easily from one candidate to another so that there is a higher probability of successfully producing an answer within a limited time. Our results further imply that workload capacity is a significant factor for the semantic search process in convergent thinking and provides new insight on the model of semantic search and creativity. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Little is known of the geospatial architecture of individual cell populations in lung adenocarcinoma (LUAD) evolution. Here, we perform single-cell RNA sequencing of 186,916 cells from five early-stage LUADs and 14 multiregion normal lung tissues of defined spatial proximities from the tumors. We show that cellular lineages, states, and transcriptomic features geospatially evolve across normal regions to LUADs. LUADs also exhibit pronounced intratumor cell heterogeneity within single sites and transcriptional lineage-plasticity programs. T regulatory cell phenotypes are increased in normal tissues with proximity to LUAD, in contrast to diminished signatures and fractions of cytotoxic CD8 + T cells, antigen-presenting macrophages, and inflammatory dendritic cells. We further find that the LUAD ligand-receptor interactome harbors increased expression of epithelial CD24 , which mediates protumor phenotypes. These data provide a spatial atlas of LUAD evolution, and a resource for identification of targets for its treatment. SIGNIFICANCE: The geospatial ecosystem of the peripheral lung and early-stage LUAD is not known. Our multiregion single-cell sequencing analyses unravel cell populations, states, and phenotypes in the spatial and ecologic evolution of LUAD from the lung that comprise high-potential targets for early interception. This article is highlighted in the In This Issue feature, p. 2355 ., (©2021 American Association for Cancer Research.)

Faces are considered a special class of holistically-processed object. The composite face task is a widely-used tool to infer holistic processing. In this task, recognition of 1 half of a composite face is shown to be hampered by interference from the other half of the face. Although this effect has been documented numerous times, when used in different paradigms, composite faces do not always exhibit effects consistent with holistic processing. The present study explored the cause of these discrepant findings by combining a composite face task with a signal-to-respond paradigm. The amount of time to make a face recognition decision was manipulated by introducing a response signal, and the resulting changes in accuracy were mapped over the time course of processing, which was then used to fit a speed-accuracy trade-off model. We found that holistic processing emerges late in the time course after approximately 400 ms processing time for easy-to-discriminate faces and after approximately 1000 ms for difficult-to-discriminate faces. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Differential transcription of identical DNA sequences leads to distinct tissue lineages and then multiple cell types within a lineage, an epigenetic process central to progenitor and stem cell biology. The associated genome-wide changes, especially in native tissues, remain insufficiently understood, and are hereby addressed in the mouse lung, where the same lineage transcription factor NKX2-1 promotes the diametrically opposed alveolar type 1 (AT1) and AT2 cell fates. Here, we report that the cell-type-specific function of NKX2-1 is attributed to its differential chromatin binding that is acquired or retained during development in coordination with partner transcriptional factors. Loss of YAP/TAZ redirects NKX2-1 from its AT1-specific to AT2-specific binding sites, leading to transcriptionally exaggerated AT2 cells when deleted in progenitors or AT1-to-AT2 conversion when deleted after fate commitment. Nkx2-1 mutant AT1 and AT2 cells gain distinct chromatin accessible sites, including those specific to the opposite fate while adopting a gastrointestinal fate, suggesting an epigenetic plasticity unexpected from transcriptional changes. Our genomic analysis of single or purified cells, coupled with precision genetics, provides an epigenetic basis for alveolar cell fate and potential, and introduces an experimental benchmark for deciphering the in vivo function of lineage transcription factors.

The nature of the COVID-19 pandemic may require governments to use privacy-encroaching technologies to help contain its spread. One technology involves co-location tracking through mobile Wi-Fi, GPS, and Bluetooth to permit health agencies to monitor people's contact with each other, thereby triggering targeted social-distancing when a person turns out to be infected. The effectiveness of tracking relies on the willingness of the population to support such privacy encroaching measures. We report the results of two large surveys in the United Kingdom, conducted during the peak of the pandemic, that probe people's attitudes towards various tracking technologies. The results show that by and large there is widespread acceptance for co-location tracking. Acceptance increases when the measures are explicitly time-limited and come with opt-out clauses or other assurances of privacy. Another possible future technology to control the pandemic involves "immunity passports", which could be issued to people who carry antibodies for the COVID-19 virus, potentially implying that they are immune and therefore unable to spread the virus to other people. Immunity passports have been considered as a potential future step to manage the pandemic. We probe people's attitudes towards immunity passports and find considerable support overall, although around 20% of the public strongly oppose passports., Competing Interests: The authors have declared that no competing interests exist.