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5. Складнощі нейропсихологічної діагностики синдрому неглекту в рамках менеджменту пацієнтів з ішемічним інсультом

Author

Vostrotin, Oleksandr, Litovchenko, Tetyana, and Voitiuk, Anna

Subjects
unilateral neglect, hemineglect, neuroaesthetics, stroke, review, одностороннiй неглект, гемінеглект, нейроестетика, інсульт, огляд
Abstract

The article considers the topical problem of neurology, neurobiology and cognitive psychology — the question of pathogenetic mechanisms of origin and development of unilateral neglect after a cerebral infarction. The paper analyzes the scientific literature on the neuropsychological signs of hemineglect syndrome, its causes, features, manifestations and methods of rehabilitation. The role of the laws of neuroaesthetics in the perception and reproduction of environmental information in the brain is shown. New data on the peculiarities of the influence of the laws of neuroaesthetics on the process of the unilateral neglect formation are presented. It is emphasized that the principles of neuroaesthetics in oxidative stress after vascular catastrophe of the brain create conditions for the development of the pathological circle, the manifestation of which is lack of attention and loss of ability to respond to stimuli in one half of the field of view. It is determined that the exact neuroanatomy of unilateral neglect is complex and remains the subject of future researches for further cognitive rehabilitation of patients after cerebral infarction., У статті розглядається актуальна проблема неврології, нейробіології і когнітивної психології — питання патогенетичних механізмів виникнення та розвитку одностороннього неглекту після інфаркту мозку. Проаналізовано наукову літературу щодо нейропсихологічних ознак синдрому гемінеглекту, його причин, особливостей, проявів і методів реабілітації. Показано роль законів нейроестетики у сприйнятті і відтворенні інформації про довкілля в мозку. Наведені нові дані про особливості впливу законів нейроестетики на процес формування одностороннього неглекту. Підкреслюється, що принципи нейроестетики при окиснювальному стресі після судинної катастрофи мозку створюють умови для розвитку патологічного кола, проявом якого є відсутність уваги та втрата здатності реагувати на подразники в одній половині поля зору. Визначено, що точна нейроанатомія одностороннього неглекту є складною і залишається предметом майбутніх досліджень для подальшої когнітивної реабілітації пацієнтів після інфаркту мозку.

Published
2021

10. Long-term efficacy and safety of eslicarbazepine acetate monotherapy for adults with newly diagnosed focal epilepsy: An open-label extension study

Author

Trinka, Eugen, Rocamora, Rodrigo, Chaves, João, Moreira, Joana, Ikedo, Fábio, Soares‐da‐Silva, Patrício, Estol, Conrado, Newton, Mark, Carne, Ross, Kowacs, Pedro, Petrova, Dorina, Syankov, Dimitar, Maslarov, Dimitar, Stanev, Slavi, Lasso, Jorge, Bašić, Silvio, Bar, Michal, Vyskočilová, Dana, Pazdera, Ladislav, Haldre, Sulev, Kaarina Kälviäinen, Reetta, Peltola, Jukka, Georges Maillard, Louis, Deckert‐Schmitz, Maria, Springub, Joachim, Barcs, Gábor, Ménes, Andrea, Tóth, Marianna, Giallonardo, Anna Teresa, Paganini, Marco, Asmane, Santa, Logina, Lnara, Meilute Lescinskiene, Loreta, Cruz, Ana, Umeres, Hugo, Czapiński, Piotr, Trzebińska‐Frydrychowska, Ewa, Sales, Francisco, Falup‐Pecurariu, Cristian Gavril, Silviu Manescu, Emilian, Roceanu, Adina‐Maria, Odinak, Miroslav, Tretyakova, Evgeniya, Volkova, Larisa, Lebedeva, Anna, Lipatova, Liudmila, Bogdanov, Enver, Vladimirovna Polezhaeva, Tatiana, Gebauer‐Bukurov, Ksenija, Jovanovic‐Mihajlovic, Natalija, Milovanovic, Maja, Spasic, Mirjana, Lipovský, L'Ubomír, Perichtová, Magdaléna, Chamilová, Jana, Balaguer, Ernest, Ugarte, Antonio, Dubenko, Andriy, Kharchuk, Sergii, Moroz, Svitlana, Shkrobot, Svitlana, Mar'yenko, Lidiya, Litovchenko, Tetyana, and Cock, Hannah

Subjects
Male, 0301 basic medicine, Time Factors, focal seizures, Epilepsy, 0302 clinical medicine, Responder rate, Dibenzazepines, Medicine, antiseizure medication, Aged, 80 and over, Incidence (epidemiology), responder rate, Middle Aged, Treatment Outcome, Carbamazepine, Neurology, Tolerability, Retention, carbamazepine, Full‐length Original Research, retention, seizure freedom rate, Anticonvulsants, Female, Seizure freedom rate, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Newly diagnosed, Focal seizures, Young Adult, 03 medical and health sciences, Double-Blind Method, Internal medicine, Humans, Adverse effect, Aged, Antiseizure medication, business.industry, medicine.disease, Discontinuation, 030104 developmental biology, Eslicarbazepine acetate, Epilepsies, Partial, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Objective: To assess the efficacy, safety, and tolerability of eslicarbazepine acetate (ESL) monotherapy during long-term treatment. Methods: An open-label extension (OLE) study was conducted in adults completing a phase 3, randomized, double-blind, noninferiority trial, during which they had received monotherapy with either once-daily ESL or twice-daily controlled-release carbamazepine (CBZ-CR) for newly diagnosed focal epilepsy. In the OLE study, all patients received ESL (800-1600 mg/d) for 2 years. Primary efficacy outcome was retention time (from baseline of the OLE study). Secondary efficacy assessments included seizure freedom rate (no seizures during the OLE study) and responder rate (≥50% seizure frequency reduction from baseline of double-blind trial). Safety assessments included evaluation of treatment-emergent adverse events (TEAEs). Results: Of 206 randomized patients, 96 who received ESL in the double-blind trial (ESL/ESL) and 88 who received CBZ-CR in the double-blind trial (CBZ-CR/ESL) were treated with ESL monotherapy (89.3% overall). Treatment retention time was similar between groups, with low probability of ESL withdrawal overall (80% in both groups throughout the study. Incidence of serious TEAEs was similar between groups (7.3% vs 5.7%; 0% vs 1.1% possibly related), as were the incidences of TEAEs considered at least possibly related to treatment (17.7% vs 18.2%) and TEAEs leading to discontinuation (3.1% vs 4.5%). The types of TEAEs were generally consistent with the known safety profile of ESL. Significance: ESL monotherapy was efficacious and generally well tolerated over the long term, including in patients who transitioned from CBZ-CR monotherapy. No new safety concerns emerged. info:eu-repo/semantics/publishedVersion

Published
2020

15. USE OF THE NON-MEDICATION ON THE TREATMENT OF NEUROPATHIC POST-TRAUMATIC PAIN IN THE LIMBS

Author

Litovchenko, Tetyana

Abstract

Background and Aims: The effect of the combination of the physiotherapy (low-frequent variable magnetic field, electrical stimulation) and of the acupuncture on the patients having neuropathic post-traumatic pain in the limbs was investigated. Method: 96 patients aged from 25 to 65 (39 females and 57 males) having neuropathic post-traumatic pain in the limbs for 5 u2013 24 days after injury were observed. All patients were examined for MRI, ultrasound, electroneuromyography, examination by a traumatologist and neurosurgeon. The pain was examined and measured according to the visual analogue scale (5 u2013 8 points). The patients were divided into two groups. The first group (68 patients) received in addition acupuncture (individual points) and physiotherapeutic complex with low-frequent variable magnetic field and electrical stimulation treatment on the projection of pain. Every procedure exposure was 12 u2013 15 min. The complete course was 10 u2013 12 procedures. The second group (control, 28 patients), received only the basic medication (non-steroid anti-inflammations and anticonvulsants). Results: The pain intensity of the patients in the first group was reduced after 10 u2013 12 days of treatment (65.3% patients) compared to the control group, where pain reduction after 20 u2013 22 days of treatment (31.6% patients); p

Published
2017

17. Randomized phase III study 306

Author

Krauss, G.L., primary, Serratosa, J.M., additional, Villanueva, V., additional, Endziniene, M., additional, Hong, Z., additional, French, J., additional, Yang, H., additional, Squillacote, D., additional, Edwards, H.B., additional, Zhu, J., additional, Laurenza, A., additional, Berkovic, Samuel, additional, D'Souza, Wendyl, additional, O'Brien, Terence, additional, Seneviratne, Udaya, additional, Robinson, Martin, additional, Bozinov, Plamen, additional, Milanov, Ivan, additional, Titianova, Ekaterina, additional, Zahariev, Zahari, additional, Wu, Liwen, additional, Wang, Xuefeng, additional, Zhou, Dong, additional, Buresova, Jindriska, additional, Hadac, Jan, additional, Marusic, Petr, additional, Oslejskova, Hana, additional, Haldre, Sulev, additional, Pajos, Ain, additional, Sander, Valentin, additional, Talvik, Inga, additional, Arnold, Stephan, additional, Hufnagel, Andreas, additional, Kerling, Frank, additional, Lerche, Holger, additional, Noachtar, Soheyl, additional, Rosenow, Felix, additional, Springub, Joachim, additional, Steinhoff, Bernhard J, additional, Werhahn, Konrad J, additional, Cheung, Raymond T, additional, Kwan, Patrick, additional, Ng, Ping Wing, additional, Chan, John, additional, Balogh, Attila, additional, Kondákor, István, additional, Neuwirth, Magdolna, additional, Rajna, Péter, additional, Rásonyi, György, additional, Desai, Joy, additional, Kothari, Sudhir, additional, Sattaluri, Sita, additional, Sharma, Bhawna, additional, Yardi, Nandan, additional, Murthy, Jagarlapudi, additional, Mehndiratta, Manmohan, additional, Venkateshwaralu, Kolichana, additional, Franceschetti, Silvana, additional, Karelis, Guntis, additional, Rozentals, Guntis, additional, Uskane, Baiba, additional, Mameniskiene, Ruta, additional, Virketiene, Irena, additional, Aziz, Zariah Abdul, additional, Seang Lim, Kheng, additional, Tai, Mei-Ling Sharon, additional, Collantes, Maria Epifania, additional, Gosiengfiao, Katerina Tanya, additional, Czlonkowska, Anna, additional, Drozdowski, Wieslaw, additional, Fryze, Waldemar, additional, Gawlowicz, Jacek, additional, Mazurkiewicz-Beldzinska, Maria, additional, Motta, Ewa, additional, Bentes, Carla, additional, Cunha, Luis, additional, de Sousa, Georgine, additional, Lopes Lima, Jose Manuel, additional, Mindruta, Ioana Raluca, additional, Nagy, Dezso, additional, Nica, Sanda Maria, additional, Belousova, Elena, additional, Kalinin, Vladimir, additional, Levitina, Elena, additional, Perunova, Natalya, additional, Pizova, Natalya, additional, Poverennova, Irina, additional, Vlasov, Pavel, additional, Sokic, Dragoslav, additional, Bozic, Ksenija, additional, Jovic, Nebojsa, additional, Martinovic, Zarko, additional, Spasic, Mirjana, additional, Hong, Seung-Bong, additional, Kang, Joong Koo, additional, Kim, Sang Ho, additional, Kim, Sung Eun, additional, Lee, Byung-In, additional, Lee, Sang Kun, additional, Cho, Yong Won, additional, Barriga Hernández, Francisco Javier, additional, Becerra, Juan Luis, additional, Escartín Siquier, Antonio, additional, Morales, Irene García, additional, López-Trigo, Javier, additional, Santasusana, Antonio Valls, additional, Sánchez Alvarez, Juan Carlos, additional, Desudchit, Tayard, additional, Likasitwattanakul, Surachai, additional, Nabangchang, Charcrin, additional, Tiamkao, Somsak, additional, Tiyapun, Nantaporn, additional, Tsai, Jing-Jane, additional, Hsieh, Pei-Yuan F., additional, Tseng, Yu-Lung, additional, Wu, Yu-Li, additional, Kharchuk, Sergii, additional, Litovchenko, Tetyana, additional, Lutskyy, Igor, additional, Makedonska, Iryna, additional, Martyniuk, Volodymyr, additional, Mar'yenko, Lidiya, additional, Smolanka, Volodymyr, additional, Voloshyn, Petro, additional, and Yevtushenko, Stanislav, additional

Published
2012
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18. Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

Author

Montalban, Xavier, Hauser, Stephen L., Kappos, Ludwig, Arnold, Douglas L., Bar-Or, Amit, Comi, Giancarlo, Seze, Jérôme, Giovannoni, Gavin, Hartung, Hans-Peter, Hemmer, Bernhard, Lublin, Fred, Rammohan, Kottil W., Selmaj, Krzysztof, Traboulsee, Anthony, Sauter, Annette, Masterman, Donna, Fontoura, Paulo, Belachew, Shibeshih, Garren, Hideki, Mairon, Nicole, Chin, Peter, Wolinsky, Jerry S., Oratorio, Clinical Investigators, Reingold, Stephen C., Sandberg-Wollheim, Magnhild, Barkhof, Frederik, Dörner, Thomas, Evans, Scott, Mcfarland, Henry F., Steiner, Israel, Yaldizli, Özgür, D Souza, Marcus, Andelova, Michaela, Rust, Heiko, Sedal, Leslie, Taylor, Bruce, Assar, Hamid, Auff, Eduard, Berger, Thomas, Guger, Michael, Pilz, Georg, Wipfler, Peter, Bartholomé, Emmanuel, Decoo, Danny, Becker, Jefferson, Da Silva Filho, Irenio, Diniz, Denise, Gomes Neto, Antônio, Leon, Soniza, Haralanov, Lyubomir, Milanov, Ivan, Bar-Or, Amir, Freedman, Mark, Grand Maison, François, Marriott, James, O Connor, Paul, Selchen, Daniel, Yeung, Michael, Benesova, Yvonne, Krasulova, Eva, Vachova, Marta, Airas, Laura, Elovaara, Irina, Färkkilä, Markus, Korpela, Jaana, Sumelahti, Marja-Liisa, Brassat, David, Brochet, Bruno, Camu, William, Castelnovo, Giovanni, Clanet, Michel, Clavelou, Pierre, Debouverie, Marc, Defer, Giles, Gout, Olivier, Heinzlef, Olivier, Laplaud, David, Lebrun-Frenay, Christine, Papeix, Caroline, Pelletier, Jean, Tourbah, Ayman, Vermersch, Patrick, Vukusic, Sandra, Angstwurm, Klemens, Berghoff, Martin, Förch, Christian, Goebels, Norbert, Haas, Judith, Harms, Lutz, Kleiter, Ingo, Koehler, Jürgen, Lensch, Eckard, Limmroth, Volker, Meuth, Sven, Oschmann, Patrick, Platten, Michael, Then Bergh, Florian, Tumani, Hayrettin, Ziemann, Ulf, Ziemssen, Tjalf, Afradou, Theodora, Fakas, Nikolaos, Tsounis, Stefanos, Vlaikidis, Nikolaos, Jakab, Gábor, Komoly, Sámuel, Rózsa, Csilla, Sátori, Mária, Szabó, Gyöngyi, Vécsei, László, Achiron, Anat, Hellmann, Mark, Karni, Arnon, Karussis, Dimitrios, Milo, Ron, Shahien, Radi, Bertolotto, Antonio, Marrosu, Maria Giovanna, Uccelli, Antonio, Malciene, Lina, Rastenyte, Daiva, Sceponaviciute, Sigla, Castro Farfan, Freddy, Duriez Sotelo, Eduardo, Flores-Rivera, Jose, Reyes Morales, Sarug, Hintzen, Rogier, Hupperts, Raymond, Lynch, Christopher, Mossman, Stuart, Gulowsen Celius, Elisabeth, Gavidia Chucan, Jorge, Perez Villegas, Julio, Pretell Alva, Edwin, Bielecki, Dariusz, Brola, Waldemar, Kochanowicz, Jan, Maciejowski, Maciej, Stelmasiak, Zbigniew, Zbrojkiewicz, Janusz, Cunha, Luis, Gonçalves, José, Mendes, Irene, Sá, João, Salgado, Vasco, Silva, Ana, Balasa, Rodica, Manescu, Silviu, Panea, Cristina Aura, Simu, Mihaela Adriana, Yakupov, Eduard, Álvarez Cermeño, José, Álvarez Cermeño, Carlos, Arroyo, Rafael, Escartín Siquier, Antonio, Fernández, Oscar, Izquierdo Ayuso, Guillermo, Martinez Rodríguez, José Enrique, Fernandez Sanchez, Victoria, Olascoaga Urtaza, Francisco Javier, Meca, Virginia, Olascoaga, Javier, Oreja-Guevara, Celia, Perez Sempere, Angel, Prieto González, José María, Ramió Torrentá, Lluis, Rodríguez-Antigüeda, Alfredo, Saiz, Albert, Gobbi, Claudio, Kuhle, Jens, Galusha, Anatoliy, Goloborodko, Alla, Litovchenko, Tetyana, Moroz, Olena, Sergii Moskovko, Nehrych, Tetyana, Pashkovskyy, Valeriy, Shkolnyk, Valerii, Shulga, Olga, Sokolova, Larysa, Voloshyna, Nataliya, Brex, Peter, Constantinescu, Cris, Duddy, Martin, Schmierer, Klaus, Young, Carolyn, Agius, Mark, Ash, Paul, Bandari, Daniel, Belkin, Martin, Bernitsas, Evanthia, Bowen, James, Cahill, Jonathan, Carpenter, Adam, Carter, Jonathan, Cerghet, Mirela, Conway, Jill, Cooper, Joanna, Coyle, Patricia, Cross, Anne, Ford, Corey, Fox, Edward, Freedman, S. Mitchell, Frohman, Elliot, Gitt, Jeffrey, Gottesman, Malcolm, Gudesblatt, Mark, Hendin, Barry, Hutton, George, Klineova, Sylvia, Krupp, Lauren, Lynch, Sharon, Markowitz, Clyde, Mattson, David, Miller, Aaron, Miravalle, Augusto, Muley, Suraj, Nealon, Nancy, Pardo, Gabriel, Picone, Mary Ann, Racke, Michael, Rizvi, Syed, Rossman, Howard, Rowe, Vernon, Schulman, Alan, Shafer, Stuart, William, Sheremata, Stein, Lee, and Waubant, Emmanuelle

19. DIFFERENTIAL DIAGNOSIS OF PAROXYSMAL STATES: LITERATURE REVIEW AND ANALYSIS OF A CLINICAL CASE ON THE EXAMPLEOF CLOCCS-SYNDROME IN A YOUNG MAN.

Author

Voitiuk AA, Litovchenko TA, Borodai ON, and Rudkivska NA

Subjects
Adult, Diagnosis, Differential, Humans, Male, Seizures diagnosis, Syndrome, Electroencephalography, Epilepsy diagnosis
Abstract

Diagnosis of paroxysmal conditions in neurology is one of the most difficult problems. Particular difficulties are caused by differential diagnosis of epileptic and non-epileptic paroxysmal states. There are no absolutely pathognomonic signs of epileptic and non-epileptic seizures. False positive diagnosis of epilepsy occurs in 2-71% of cases. Diagnosis of paroxysmal conditions requires an integrated approach to the problem and includes not only a clinical examination, but also a thorough history taking, neurophysiological, neuroimaging, laboratory research methods, involves the involvement of other specialists. The article presents a clinical case of 27-year-old young man who was initially misdiagnosed. Using the methods of functional and laboratory diagnostics, the patient was diagnosed correctly. Instead of idiopathic epilepsy, he was diagnosed with cytotoxic lesions of the corpus callosum (CLOCCs-syndrome associated with an infectious process) with motor paroxysms of non-epileptic genesis. Thus, using the example of this clinical case, it has been shown that the differential diagnosis of epileptic and non-epileptic paroxysmal states presents significant difficulties for a practicing neurologist.

Published
2022
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