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Liver fibrosis is the initial step of hepatocellular carcinoma (HCC). Liver fibrosis can be triggered by metabolic perturbation, viral infection, and harmful chemical exposure. This in vivo study aims to investigate the potential of Moringa oleifera leaf powder (MOLP) from Madura Island as the future candidate for antifibrosis and hepatoprotective agent. The study was conducted to evaluate the alteration of circulating levels of liver injury marker-linked liver fibrosis development, Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST). The animal model was prepared using Balb-c mice age 6-8 weeks treated by intraperitoneal injection of carbon tetrachloride (CCl4) dose 1 µL/g of BW for six weeks to induce liver fibrosis. The experimental groups were received green materials Moringa oleifera leaf powder solution with a serial dosage by peroral administration for six weeks. Interestingly, our animal model's preliminary study shows that the administration of green materials MOLP can alleviate the increase of ALT and AST. MOLP treatment can also prevent significant changes in liver weight, morphology, and even histological feature-associated liver injury and fibrosis. Hence, MOLP Madura Island may become the future green materials source for cancer herbal drug development.

Moringa oleifera is an endemic plant in East Java Province spreading over several districts in this region. Moringa oleifera is not only the potential and miracle natural resources in Indonesia but also the crucial alternative solution combating malnutrition linked to micro-macro elements deficiency. This study was conducted using Moringa oleifera leaf powder (MOLP) from Madura Island and the other four districts. The basic profile of micro and macro elements was quantified by X-ray fluorescence spectroscopy (XRF) analysis. Importantly, the higher level of Phosphor, Sulfur, and Potassium was found in the MOLP Malang area, while the lowest one was discovered in the Madura sample. By contrast, a considerable amount of Calcium, Manganese, Ferrum, and Molybdenum was dominantly found in the Madura sample. This data imply that Moringa oleifera leaf powder in East Java regions has a potential ingredient in the development of green halal materials synthesis and application, biomedical resources, and other applications. To sum up, the exploration and application of MOLP from Madura variety for future clinical and non-clinical administration may become an alternative solution for combating metabolic distribution-related diseases. Thus, further expanding research is urgently required to establish the application of MOLP for medical and biomedical engineering linked advanced bionanotechnology.