1,776 results on '"Liston P"'
Search Results
2. Frontostriatal salience network expansion in individuals in depression
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Lynch, Charles J., Elbau, Immanuel G., Ng, Tommy, Ayaz, Aliza, Zhu, Shasha, Wolk, Danielle, Manfredi, Nicola, Johnson, Megan, Chang, Megan, Chou, Jolin, Summerville, Indira, Ho, Claire, Lueckel, Maximilian, Bukhari, Hussain, Buchanan, Derrick, Victoria, Lindsay W., Solomonov, Nili, Goldwaser, Eric, Moia, Stefano, Caballero-Gaudes, Cesar, Downar, Jonathan, Vila-Rodriguez, Fidel, Daskalakis, Zafiris J., Blumberger, Daniel M., Kay, Kendrick, Aloysi, Amy, Gordon, Evan M., Bhati, Mahendra T., Williams, Nolan, Power, Jonathan D., Zebley, Benjamin, Grosenick, Logan, Gunning, Faith M., and Liston, Conor
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- 2024
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3. Clinical features of fallers and non-fallers: finding best-performing combinations of physical performance measurements to discriminate physical impairments between fallers and non-fallers among older adults with and without osteoporosis
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Hirata, Rogerio Pessoto, Thomsen, Mikkel Jacobi, Liston, Matthew, Christensen, Merete Grothe, and Vestergaard, Peter
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- 2024
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4. Safety TransfEr Methodology (STEM): a structured methodology for transferring safety innovation across sectors
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Liston, Paul M., Silvagni, Sara, and Ducci, Marco
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- 2024
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5. Brain regulatory T cells
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Liston, Adrian, Pasciuto, Emanuela, Fitzgerald, Denise C., and Yshii, Lidia
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- 2024
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6. Los Angeles Urban Forest Equity Neighborhood Strategy: Sylmar
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Gibson, Pam, Duran, Xiomara, Carillo, Alyssa, Hillemeier, Mary, Liston, Rose, O'Leary, Rachel, de Guzman, Edith, Yang, Mateo, Nasr, Hala, Reed, Chris, Hellman, Dana, Shandas, Vivek, Chen, Cindy, and Yu, Krystle
- Abstract
This report serves as one of five individual documents developed over the course of Phase II of the Urban Forest Equity Collective. This document provides an overview of the Sylmar pilot neighborhood assessment, engagement, and tree planting implementation process. It is intended to provide a transparent view into the decisions, points of analysis and key themes derived over the course of this phase.
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- 2024
7. An Immature NK Cell Compartment in Functional DBF4 Deficiency
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Willemsen, Mathijs, De Visscher, Amber, Filtjens, Jessica, Meyts, Isabelle, Matthys, Patrick, Humblet-Baron, Stephanie, and Liston, Adrian
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- 2024
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8. Exploring the decision-making process in model development: focus on the Arctic snowpack
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C. B. Menard, S. Rasmus, I. Merkouriadi, G. Balsamo, A. Bartsch, C. Derksen, F. Domine, M. Dumont, D. Ehrich, R. Essery, B. C. Forbes, G. Krinner, D. Lawrence, G. Liston, H. Matthes, N. Rutter, M. Sandells, M. Schneebeli, and S. Stark
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Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
The Arctic poses many challenges for Earth system and snow physics models, which are commonly unable to simulate crucial Arctic snowpack processes,such as vapour gradients and rain-on-snow-induced ice layers. These limitations raise concerns about the current understanding of Arctic warming and its impact on biodiversity, livelihoods, permafrost, and the global carbon budget. Recognizing that models are shaped by human choices, 18 Arctic researchers were interviewed to delve into the decision-making process behind model construction. Although data availability, issues of scale, internal model consistency, and historical and numerical model legacies were cited as obstacles to developing an Arctic snowpack model, no opinion was unanimous. Divergences were not merely scientific disagreements about the Arctic snowpack but reflected the broader research context. Inadequate and insufficient resources, partly driven by short-term priorities dominating research landscapes, impeded progress. Nevertheless, modellers were found to be both adaptable to shifting strategic research priorities – an adaptability demonstrated by the fact that interdisciplinary collaborations were the key motivation for model development – and anchored in the past. This anchoring and non-epistemic values led to diverging opinions about whether existing models were “good enough” and whether investing time and effort to build a new model was a useful strategy when addressing pressing research challenges. Moving forward, we recommend that both stakeholders and modellers be involved in future snow model intercomparison projects in order to drive developments that address snow model limitations currently impeding progress in various disciplines. We also argue for more transparency about the contextual factors that shape research decisions. Otherwise, the reality of our scientific process will remain hidden, limiting the changes necessary to our research practice.
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- 2024
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9. Letter to editor: rebuttal to OSIN-D-24–01254 “RE: Clinical features of fallers and non-fallers: Finding best-performing combinations of physical performance measurements to discriminate physical impairments between fallers and non-fallers among older adults with and without osteoporosis”
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Hirata, Rogerio Pessoto, Thomsen, Mikkel Jacobi, Liston, Matthew, Christensen, Merete Grothe, and Vestergaard, Peter
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- 2024
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10. Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
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Llorián-Salvador, María, de la Fuente, Alerie G., McMurran, Christopher E., Dashwood, Amy, Dooley, James, Liston, Adrian, Penalva, Rosana, Dombrowski, Yvonne, Stitt, Alan W., and Fitzgerald, Denise C.
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- 2024
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11. Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination
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de la Fuente, Alerie Guzman, Dittmer, Marie, Heesbeen, Elise J., de la Vega Gallardo, Nira, White, Jessica A., Young, Andrew, McColgan, Tiree, Dashwood, Amy, Mayne, Katie, Cabeza-Fernández, Sonia, Falconer, John, Rodriguez-Baena, Francisco Javier, McMurran, Christopher E., Inayatullah, Mohammed, Rawji, Khalil S., Franklin, Robin J. M., Dooley, James, Liston, Adrian, Ingram, Rebecca J., Tiwari, Vijay K., Penalva, Rosana, Dombrowski, Yvonne, and Fitzgerald, Denise C.
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- 2024
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12. The Role of Higher Education in High School Math Reform
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Columbia University, Community College Research Center (CCRC), Education Strategy Group (ESG), Barnett, Elisabeth A., Fay, Maggie P., Liston, Cynthia, and Reyna, Ryan
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While there is interest in pathways-aligned high school math reform among secondary education stakeholders, change in high school math depends a great deal on policies, practices, and norms at the higher education level. This report focuses on the role of higher education in influencing (encouraging or deterring) secondary education math reform. To better understand this topic, researchers from the Community College Research Center (CCRC) and the Education Strategy Group (ESG) conducted interviews with representatives from national secondary math education organizations as well as individuals from each of three states participating in Launch Years-- Georgia, Texas, and Washington--who are engaged in efforts to reform high school math. This report first presents findings on the ways that higher education affects secondary math reform in broad terms, relying on data from these interviews. This is done by describing several domains of higher education practice identified by the interviewees that tend to present challenges to high school math reform. The report discusses potential solutions to these challenges and considers ways that higher education can facilitate high school reform efforts. The report then presents short case studies of secondary math reform efforts in three states (all of which have also undertaken math pathways reforms--at least to some extent--at the college level) with a focus on the influence of higher education in effecting change. The report concludes with a brief discussion of an overarching theme that appears to be central to much of this work: the importance of sustained conversation and collaboration between math educators and administrators from both sectors--higher education and K-12--in moving secondary math reform forward.
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- 2022
13. The potential of gene delivery for the treatment of traumatic brain injury
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James Dooley, Jasmine G. Hughes, Edward J. Needham, Katerina A. Palios, and Adrian Liston
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Gene delivery ,AAV ,Neuroimmunology ,TBI ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Therapeutics for traumatic brains injuries constitute a global unmet medical need. Despite the advances in neurocritical care, which have dramatically improved the survival rate for the ~ 70 million patients annually, few treatments have been developed to counter the long-term neuroinflammatory processes and accompanying cognitive impairments, frequent among patients. This review looks at gene delivery as a potential therapeutic development avenue for traumatic brain injury. We discuss the capacity of gene delivery to function in traumatic brain injury, by producing beneficial biologics within the brain. Gene delivery modalities, promising vectors and key delivery routes are discussed, along with the pathways that biological cargos could target to improve long-term outcomes for patients. Coupling blood-brain barrier crossing with sustained local production, gene delivery has the potential to convert proteins with useful biological properties, but poor pharmacodynamics, into effective therapeutics. Finally, we review the limitations and health economics of traumatic brain injury, and whether future gene delivery approaches will be viable for patients and health care systems.
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- 2024
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14. Parallel SnowModel (v1.0): a parallel implementation of a distributed snow-evolution modeling system (SnowModel)
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R. Mower, E. D. Gutmann, G. E. Liston, J. Lundquist, and S. Rasmussen
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Geology ,QE1-996.5 - Abstract
SnowModel, a spatially distributed snow-evolution modeling system, was parallelized using Coarray Fortran for high-performance computing architectures to allow high-resolution (1 m to hundreds of meters) simulations over large regional- to continental-scale domains. In the parallel algorithm, the model domain was split into smaller rectangular sub-domains that are distributed over multiple processor cores using one-dimensional decomposition. All the memory allocations from the original code were reduced to the size of the local sub-domains, allowing each core to perform fewer computations and requiring less memory for each process. Most of the subroutines in SnowModel were simple to parallelize; however, there were certain physical processes, including blowing snow redistribution and components within the solar radiation and wind models, that required non-trivial parallelization using halo-exchange patterns. To validate the parallel algorithm and assess parallel scaling characteristics, high-resolution (100 m grid) simulations were performed over several western United States domains and over the contiguous United States (CONUS) for a year. The CONUS scaling experiment had approximately 70 % parallel efficiency; runtime decreased by a factor of 1.9 running on 1800 cores relative to 648 cores (the minimum number of cores that could be used to run such a large domain because of memory and time limitations). CONUS 100 m simulations were performed for 21 years (2000–2021) using 46 238 and 28 260 grid cells in the x and y dimensions, respectively. Each year was simulated using 1800 cores and took approximately 5 h to run.
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- 2024
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15. Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence.
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Liu, Zhongle, Cowen, Leah, Hossain, Saif, Liston, Sean, Robbins, Nicole, Whitesell, Luke, Noble, Suzanne, and Basso, Pauline
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Humans ,Animals ,Mice ,Virulence ,Oxidoreductases ,Promoter Regions ,Genetic ,Transcription Factors ,Candida albicans ,Fungal Proteins - Abstract
Metabolic flexibility enables fungi to invade challenging host environments. In Candida albicans, a common cause of life-threatening infections in humans, an important contributor to flexibility is alternative oxidase (Aox) activity. Dramatic induction of this activity occurs under respiratory-stress conditions, which impair the classical electron transport chain (ETC). Here, we show that deletion of the inducible AOX2 gene cripples C. albicans virulence in mice by increasing immune recognition. To investigate further, we examined transcriptional regulation of AOX2 in molecular detail under host-relevant, ETC-inhibitory conditions. We found that multiple transcription factors, including Rtg1/Rtg3, Cwt1/Zcf11, and Zcf2, bind and regulate the AOX2 promoter, conferring thousand-fold levels of inducibility to AOX2 in response to distinct environmental stressors. Further dissection of this complex promoter revealed how integration of stimuli ranging from reactive species of oxygen, nitrogen, and sulfur to reduced copper availability is achieved at the transcriptional level to regulate AOX2 induction and enable pathogenesis.
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- 2023
16. A somato-cognitive action network alternates with effector regions in motor cortex.
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Gordon, Evan M, Chauvin, Roselyne J, Van, Andrew N, Rajesh, Aishwarya, Nielsen, Ashley, Newbold, Dillan J, Lynch, Charles J, Seider, Nicole A, Krimmel, Samuel R, Scheidter, Kristen M, Monk, Julia, Miller, Ryland L, Metoki, Athanasia, Montez, David F, Zheng, Annie, Elbau, Immanuel, Madison, Thomas, Nishino, Tomoyuki, Myers, Michael J, Kaplan, Sydney, Badke D'Andrea, Carolina, Demeter, Damion V, Feigelis, Matthew, Ramirez, Julian SB, Xu, Ting, Barch, Deanna M, Smyser, Christopher D, Rogers, Cynthia E, Zimmermann, Jan, Botteron, Kelly N, Pruett, John R, Willie, Jon T, Brunner, Peter, Shimony, Joshua S, Kay, Benjamin P, Marek, Scott, Norris, Scott A, Gratton, Caterina, Sylvester, Chad M, Power, Jonathan D, Liston, Conor, Greene, Deanna J, Roland, Jarod L, Petersen, Steven E, Raichle, Marcus E, Laumann, Timothy O, Fair, Damien A, and Dosenbach, Nico UF
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Foot ,Hand ,Mouth ,Motor Cortex ,Animals ,Macaca ,Humans ,Magnetic Resonance Imaging ,Brain Mapping ,Cognition ,Child ,Infant ,Infant ,Newborn ,Datasets as Topic ,Pediatric ,Neurosciences ,1.1 Normal biological development and functioning ,Underpinning research ,Neurological ,General Science & Technology - Abstract
Motor cortex (M1) has been thought to form a continuous somatotopic homunculus extending down the precentral gyrus from foot to face representations1,2, despite evidence for concentric functional zones3 and maps of complex actions4. Here, using precision functional magnetic resonance imaging (fMRI) methods, we find that the classic homunculus is interrupted by regions with distinct connectivity, structure and function, alternating with effector-specific (foot, hand and mouth) areas. These inter-effector regions exhibit decreased cortical thickness and strong functional connectivity to each other, as well as to the cingulo-opercular network (CON), critical for action5 and physiological control6, arousal7, errors8 and pain9. This interdigitation of action control-linked and motor effector regions was verified in the three largest fMRI datasets. Macaque and pediatric (newborn, infant and child) precision fMRI suggested cross-species homologues and developmental precursors of the inter-effector system. A battery of motor and action fMRI tasks documented concentric effector somatotopies, separated by the CON-linked inter-effector regions. The inter-effectors lacked movement specificity and co-activated during action planning (coordination of hands and feet) and axial body movement (such as of the abdomen or eyebrows). These results, together with previous studies demonstrating stimulation-evoked complex actions4 and connectivity to internal organs10 such as the adrenal medulla, suggest that M1 is punctuated by a system for whole-body action planning, the somato-cognitive action network (SCAN). In M1, two parallel systems intertwine, forming an integrate-isolate pattern: effector-specific regions (foot, hand and mouth) for isolating fine motor control and the SCAN for integrating goals, physiology and body movement.
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- 2023
17. Author Correction: Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons
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Hergenreder, Emiliano, Minotti, Andrew P., Zorina, Yana, Oberst, Polina, Zhao, Zeping, Munguba, Hermany, Calder, Elizabeth L., Baggiolini, Arianna, Walsh, Ryan M., Liston, Conor, Levitz, Joshua, Garippa, Ralph, Chen, Shuibing, Ciceri, Gabriele, and Studer, Lorenz
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- 2024
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18. Ultrafast Dynamics of the Topological Semimetal GdSb$_{x}$Te$_{2-x-\delta}$ In the Presence and Absence of a Charge Density Wave
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Kirby, Robert J., Montanaro, Angela, Giusti, Francesca, Koch-Liston, André, Lei, Shiming, Petrides, Ioannis, Narang, Prineha, Burch, Kenneth S., Fausti, Daniele, Scholes, Gregory D., and Schoop, Leslie M.
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Condensed Matter - Materials Science - Abstract
Time-resolved dynamics in charge-density-wave materials have revealed interesting out-of-equilibrium electronic responses. However these are typically only performed in a single material possessing a CDW. As such, it is challenging to separate subtle effects originating from the CDW. Here, we report on the ultrafast dynamics of the GdSb$_{x}$Te$_{2-x-\delta}$ series of materials where E$_{F}$ can be tuned, resulting in a change from an undistorted tetraganal phase to a CDW with a wavevector that depends on $x$. Using mid-infrared, near-infrared, and visible excitation, we find the dynamics are sensitive to both E$_{F}$ and the presence of the CDW. Specifically, as the Sb content of the compounds increases, transient spectral features shift to higher probe energies. In addition, we observe an enhanced lifetime and change in the sign of the transient signal upon removing the CDW with high Sb concentrations. Finally, we reveal fluence- and temperature-dependent photo-induced responses of the differential reflectivity, which provide evidence of transient charge density wave suppression in related telluride materials. Taken together our results provide a blueprint for future ultrafast studies of CDW systems.
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- 2023
19. Simple and Scalable Algorithms for Cluster-Aware Precision Medicine
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Buch, Amanda M., Liston, Conor, and Grosenick, Logan
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Computer Science - Machine Learning ,Quantitative Biology - Quantitative Methods ,Statistics - Machine Learning - Abstract
AI-enabled precision medicine promises a transformational improvement in healthcare outcomes by enabling data-driven personalized diagnosis, prognosis, and treatment. However, the well-known "curse of dimensionality" and the clustered structure of biomedical data together interact to present a joint challenge in the high dimensional, limited observation precision medicine regime. To overcome both issues simultaneously we propose a simple and scalable approach to joint clustering and embedding that combines standard embedding methods with a convex clustering penalty in a modular way. This novel, cluster-aware embedding approach overcomes the complexity and limitations of current joint embedding and clustering methods, which we show with straightforward implementations of hierarchically clustered principal component analysis (PCA), locally linear embedding (LLE), and canonical correlation analysis (CCA). Through both numerical experiments and real-world examples, we demonstrate that our approach outperforms traditional and contemporary clustering methods on highly underdetermined problems (e.g., with just tens of observations) as well as on large sample datasets. Importantly, our approach does not require the user to choose the desired number of clusters, but instead yields interpretable dendrograms of hierarchically clustered embeddings. Thus our approach improves significantly on existing methods for identifying patient subgroups in multiomics and neuroimaging data, enabling scalable and interpretable biomarkers for precision medicine., Comment: 15 pages, 3 figures, 3 tables
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- 2022
20. Nurturing a positive research culture within your laboratory [version 2; peer review: 2 approved]
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Adrian Liston and Denise C. Fitzgerald
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research ,academia ,research culture ,eng ,Medicine ,Science - Abstract
As a Principal Investigator leading a research team, creating a positive research culture for your team members is one of the best long-term investments you can make, for your research programme, for the sector and for society. A positive research environment is one where team members are empowered, recognised, have a clear career developmental pathway, can contribute to impactful and reproducible research and, ideally, propagate these effects. While these virtues can arise organically from a team built around kindness and integrity, they are also values that should be deliberately embedded within your lab. Here we provide advice on how to create a culture of integrity and a culture of belonging for your team members. We focus on thoughtful consideration of your key lab values, and the use of structure, language and your personal actions to make these values explicit. A holistic approach to integrating positive culture throughout every facet of your research team creates a system that can be self-sustaining in scientific integrity and more resilient to negative challenges. Starting on the pathway to self-improvement as a manager, recognising that this requires often uncomfortable self-reflection, provides both personal and professional reward.
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- 2024
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21. Genetics Navigator: protocol for a mixed methods randomized controlled trial evaluating a digital platform to deliver genomic services in Canadian pediatric and adult populations
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Trevor Jamieson, Kevin Thorpe, Francois Bernier, Melyssa Aronson, Marc Clausen, Rita Kodida, Emma Reble, June C Carroll, Jordan Lerner-Ellis, Yvonne Bombard, Matthew Osmond, Muhammad Mamdani, Ronald Cohn, Emily Seto, Hanna Faghfoury, Josh Silver, Maureen Smith, Lauren Chad, Jan M Friedman, Robin Z Hayeems, Michael Brudno, Gregory Costain, Quynh Pham, Anne-Marie Laberge, Christian Marshall, Cheryl Shuman, Rebekah Jobling, Irfan Dhalla, Serena Shastri-Estrada, Daniel Assamad, Stephanie Luca, Stacy Hewson, Eriskay Liston, Frank Rudzicz, Wendy Ungar, and Guylaine D'Amours
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Medicine - Abstract
Introduction Genetic testing is used across medical disciplines leading to unprecedented demand for genetic services. This has resulted in excessive waitlists and unsustainable pressure on the standard model of genetic healthcare. Alternative models are needed; e-health tools represent scalable and evidence-based solution. We aim to evaluate the effectiveness of the Genetics Navigator, an interactive patient-centred digital platform that supports the collection of medical and family history, provision of pregenetic and postgenetic counselling and return of genetic testing results across paediatric and adult settings.Methods and analysis We will evaluate the effectiveness of the Genetics Navigator combined with usual care by a genetics clinician (physician or counsellor) to usual care alone in a randomised controlled trial. One hundred and thirty participants (adults patients or parents of paediatric patients) eligible for genetic testing through standard of care will be recruited across Ontario genetics clinics. Participants randomised into the intervention arm will use the Genetics Navigator for pretest and post-test genetic counselling and results disclosure in conjunction with their clinician. Participants randomised into the control arm will receive usual care, that is, clinician-delivered pretest and post-test genetic counselling, and results disclosure. The primary outcome is participant distress 2 weeks after test results disclosure. Secondary outcomes include knowledge, decisional conflict, anxiety, empowerment, quality of life, satisfaction, acceptability, digital health literacy and health resource use. Quantitative data will be analysed using statistical hypothesis tests and regression models. A subset of participants will be interviewed to explore user experience; data will be analysed using interpretive description. A cost-effectiveness analysis will examine the incremental cost of the Navigator compared with usual care per unit reduction in distress or unit improvement in quality of life from public payer and societal perspectives.Ethics and dissemination This study was approved by Clinical Trials Ontario. Results will be shared through stakeholder workshops, national and international conferences and peer-reviewed journals.Trial registration number NCT06455384.
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- 2024
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22. Industry Review of Best Practices for Risk Management of Drug-Induced Liver Injury from Development to Real-World Use
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Marquez, Loreta, Raheja, Ritu, Chan-Liston, May, Marcinak, John, Estilo, Alvin, Pineda Salgado, Liliam, Jiang, Jason, Chang, Curtis, and Beninger, Paul
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- 2024
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23. Harnessing our lived experience for science communication
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Liston, Adrian
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- 2024
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24. Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
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María Llorián-Salvador, Alerie G. de la Fuente, Christopher E. McMurran, Amy Dashwood, James Dooley, Adrian Liston, Rosana Penalva, Yvonne Dombrowski, Alan W. Stitt, and Denise C. Fitzgerald
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Ageing ,Inflammation ,Neurodegeneration ,Regulatory T cells ,Retina ,Neurology. Diseases of the nervous system ,RC346-429 ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background Ageing is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the developed countries. These conditions include age-related macular degeneration or diabetic retinopathy. Regulatory T cells play a vital role in immunoregulation of the nervous system by limiting inflammation and tissue damage in health and disease. Because the retina was long-considered an immunoprivileged site, the precise contribution of regulatory T cells in retinal homeostasis and in age-related retinal diseases remains unknown. Methods Regulatory T cells were selectively depleted in both young (2–4 months) and aged (18–23 months) FoxP3-DTR mice. We evaluated neuroretinal degeneration, gliosis, subretinal space phagocyte infiltration, and retinal pigmented epithelium morphology through immunofluorescence analysis. Subsequently, aged Treg depleted animals underwent adoptive transfer of both young and aged regulatory T cells from wild-type mice, and the resulting impact on neurodegeneration was assessed. Statistical analyses employed included the U-Mann Whitney test, and for comparisons involving more than two groups, 1-way ANOVA analysis followed by Bonferroni’s post hoc test. Results Our study shows that regulatory T cell elimination leads to retinal pigment epithelium cell dysmorphology and accumulation of phagocytes in the subretinal space of young and aged mice. However, only aged mice experience retinal neurodegeneration and gliosis. Surprisingly, adoptive transfer of young but not aged regulatory T cells reverse these changes. Conclusion Our findings demonstrate an essential role for regulatory T cells in maintaining age retinal homeostasis and preventing age-related neurodegeneration. This previously undescribed role of regulatory T cells in limiting retinal inflammation, RPE/choroid epithelium damage and subsequently photoreceptor loss with age, opens novel avenues to explore regulatory T cell neuroprotective and anti-inflammatory properties as potential therapeutic approaches for age-related retinal diseases.
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- 2024
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25. Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination
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Alerie Guzman de la Fuente, Marie Dittmer, Elise J. Heesbeen, Nira de la Vega Gallardo, Jessica A. White, Andrew Young, Tiree McColgan, Amy Dashwood, Katie Mayne, Sonia Cabeza-Fernández, John Falconer, Francisco Javier Rodriguez-Baena, Christopher E. McMurran, Mohammed Inayatullah, Khalil S. Rawji, Robin J. M. Franklin, James Dooley, Adrian Liston, Rebecca J. Ingram, Vijay K. Tiwari, Rosana Penalva, Yvonne Dombrowski, and Denise C. Fitzgerald
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Science - Abstract
Abstract Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. Regulatory T cells (Treg) recently emerged as critical players in tissue regeneration, including remyelination. However, the effect of ageing on Treg-mediated regenerative processes is poorly understood. Here, we show that expansion of aged Treg does not rescue age-associated remyelination impairment due to an intrinsically diminished capacity of aged Treg to promote oligodendrocyte differentiation and myelination in male and female mice. This decline in regenerative Treg functions can be rescued by a young environment. We identified Melanoma Cell Adhesion Molecule 1 (MCAM1) and Integrin alpha 2 (ITGA2) as candidates of Treg-mediated oligodendrocyte differentiation that decrease with age. Our findings demonstrate that ageing limits the neuroregenerative capacity of Treg, likely limiting their remyelinating therapeutic potential in aged patients, and describe two mechanisms implicated in Treg-driven remyelination that may be targetable to overcome this limitation.
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- 2024
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26. Performance Analysis of Duct Vane Application on Patrol Boats Using Computational Fluid Dynamics
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Muhammad Arif Budiyanto, Fadhil Naufal, Gerry Liston Putra, Achmad Riadi, Dedy Triawan Suprayogi, Muhammad Iqbal, and Triwilaswandio Wuruk Pribadi
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duct vane ,hydrodynamics ,patrol boat ,Technology ,Technology (General) ,T1-995 - Abstract
Fast patrol boats are designed for high performance in surveillance and warfare missions. In terms of hull technology development, the fast patrol boat commonly uses a V-type hull with hard chine. A duct vane is an innovation developed to improve the performance of patrol boats by combining the principles of wake-equalizing duct and hydrofoil. The objective of this paper is to investigate the hydrodynamic effect of the application of duct vane on the patrol boat hull design. The investigation was carried out using computational fluid dynamics that was validated using experiment data. The result of the duct vane application can improve the ship speed performance and reduce the total resistance by 40% at Fn 0.6. The results of this study also provide an overview of the influence of the duct vane on the lift force of a hard chine hull-type.
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- 2024
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27. Enhancing hybrid genetic algorithm performance in reducing steel usage for shipbuilding through sensitivity analysis
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Jos Istiyanto, Gerry Liston Putra, and Muhammad Rifqi Ramadhan
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Material selection ,sensitivity analysis ,hybrid genetic algorithm ,computation time ,material cost ,Zhou Zude, Senior Editor, Wuhan University of Technology, China ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
AbstractIn ship construction, material costs constitute a substantial portion of the overall expenses. With the surging steel prices, the shipbuilding industry faces a pressing challenge. To counterbalance this issue, optimizing the structural components of ships has emerged as a viable solution. Genetic Algorithm (GA) methods, known for their application in structural optimization, have demonstrated their potential. However, the protracted computational time associated with GA remains a limiting factor. This research introduces a novel approach by merging GA with Finite Element Method (FEM) for optimizing plate sizes, resulting in a hybrid GA system. Moreover, the study incorporates sensitivity analysis (SA) due to its proven efficacy in enhancing optimization processes involving multiple variables. The SA component investigates plate interrelationships and effectively clusters them. After this grouping, the hybrid GA executes parallel optimization of plates that influence each other under tension. By integrating SA, the optimization process becomes faster and more time-efficient, while preserving optimal manufacturing costs. Remarkably, this methodology culminates in a substantial reduction in computational time when contrasted with the hybrid GA approach devoid of SA, all the while maintaining a parallel manufacturing cost trajectory. In conclusion, this study presents an innovative hybrid GA approach, supplemented with SA, as an effective strategy for mitigating the escalating steel costs in shipbuilding. The amalgamation of GA, FEM and SA synergistically simplifies the optimization process, ensuring optimal results in a faster way.
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- 2024
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28. Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships
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Fetcho, Robert N, Hall, Baila S, Estrin, David J, Walsh, Alexander P, Schuette, Peter J, Kaminsky, Jesse, Singh, Ashna, Roshgodal, Jacob, Bavley, Charlotte C, Nadkarni, Viraj, Antigua, Susan, Huynh, Thu N, Grosenick, Logan, Carthy, Camille, Komer, Lauren, Adhikari, Avishek, Lee, Francis S, Rajadhyaksha, Anjali M, and Liston, Conor
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Mental Health ,Behavioral and Social Science ,Neurosciences ,Basic Behavioral and Social Science ,Mice ,Animals ,Social Interaction ,Social Behavior ,Prefrontal Cortex ,Social Dominance ,Nucleus Accumbens - Abstract
Social hierarchies exert a powerful influence on behavior, but the neurobiological mechanisms that detect and regulate hierarchical interactions are not well understood, especially at the level of neural circuits. Here, we use fiber photometry and chemogenetic tools to record and manipulate the activity of nucleus accumbens-projecting cells in the ventromedial prefrontal cortex (vmPFC-NAcSh) during tube test social competitions. We show that vmPFC-NAcSh projections signal learned hierarchical relationships, and are selectively recruited by subordinate mice when they initiate effortful social dominance behavior during encounters with a dominant competitor from an established hierarchy. After repeated bouts of social defeat stress, this circuit is preferentially activated during social interactions initiated by stress resilient individuals, and plays a necessary role in supporting social approach behavior in subordinated mice. These results define a necessary role for vmPFC-NAcSh cells in the adaptive regulation of social interaction behavior based on prior hierarchical interactions.
- Published
- 2023
29. Nurturing a positive research culture within your laboratory [version 1; peer review: 2 approved]
- Author
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Adrian Liston and Denise C. Fitzgerald
- Subjects
research ,academia ,research culture ,eng ,Medicine ,Science - Abstract
As a Principal Investigator leading a research team, creating a positive research culture for your team members is one of the best long-term investments you can make, for your research programme, for the sector and for society. A positive research environment is one where team members are empowered, recognised, have a clear career developmental pathway, can contribute to impactful and reproducible research and, ideally, propagate these effects. While these virtues can arise organically from a team built around kindness and integrity, they are also values that should be deliberately embedded within your lab. Here we provide advice on how to create a culture of integrity and a culture of belonging for your team members. We focus on thoughtful consideration of your key lab values, and the use of structure, language and your personal actions to make these values explicit. A holistic approach to integrating positive culture throughout every facet of your research team creates a system that can be self-sustaining in scientific integrity and more resilient to negative challenges. Starting on the pathway to self-improvement as a manager, recognising that this requires often uncomfortable self-reflection, provides both personal and professional reward.
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- 2024
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30. Investigating the effects of radiation, T cell depletion, and bone marrow transplantation on murine gut microbiota
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Jakub Kreisinger, James Dooley, Kailash Singh, Dagmar Čížková, Lucie Schmiedová, Barbora Bendová, Adrian Liston, and Alena Moudra
- Subjects
HSC ,T cell depleted ,BM transplantation ,T cell replete ,microbiome and dysbiosis ,Microbiology ,QR1-502 - Abstract
Microbiome research has gained much attention in recent years as the importance of gut microbiota in regulating host health becomes increasingly evident. However, the impact of radiation on the microbiota in the murine bone marrow transplantation model is still poorly understood. In this paper, we present key findings from our study on how radiation, followed by bone marrow transplantation with or without T cell depletion, impacts the microbiota in the ileum and caecum. Our findings show that radiation has different effects on the microbiota of the two intestinal regions, with the caecum showing increased interindividual variation, suggesting an impaired ability of the host to regulate microbial symbionts, consistent with the Anna Karenina principle. Additionally, we observed changes in the ileum composition, including an increase in bacterial taxa that are important modulators of host health, such as Akkermansia and Faecalibaculum. In contrast, radiation in the caecum was associated with an increased abundance of several common commensal taxa in the gut, including Lachnospiraceae and Bacteroides. Finally, we found that high doses of radiation had more substantial effects on the caecal microbiota of the T-cell-depleted group than that of the non-T-cell-depleted group. Overall, our results contribute to a better understanding of the complex relationship between radiation and the gut microbiota in the context of bone marrow transplantation and highlight the importance of considering different intestinal regions when studying microbiome responses to environmental stressors.
- Published
- 2024
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31. Letter from the Editors
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Joe Pellegrino, Delores Liston, and Delena Gatch
- Subjects
Theory and practice of education ,LB5-3640 - Abstract
This letter introduces the first issue of volume 18. It addresses the most recent findings on student perceptions of higher education in the United States, based on a two-year study funded by the Gates Foundation.
- Published
- 2024
- Full Text
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32. OTULIN haploinsufficiency predisposes to environmentally directed inflammation
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Frederik Staels, Leoni Bücken, Leana De Vuyst, Mathijs Willemsen, Erika Van Nieuwenhove, Margaux Gerbaux, Julika Neumann, Vanshika Malviya, Lize Van Meerbeeck, Jeason Haughton, Laura Seldeslachts, Mieke Gouwy, Kimberly Martinod, Greetje Vande Velde, Paul Proost, Lidia Yshii, Susan Schlenner, Rik Schrijvers, Adrian Liston, and Stephanie Humblet-Baron
- Subjects
OTULIN deficiency ,inflammation ,inborn errors in immunity ,OTULIN-related autoinflammatory syndrome ,OTULIN ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Recently, OTULIN haploinsufficiency was linked to enhanced susceptibility to Staphylococcus aureus infections accompanied by local necrosis and systemic inflammation. The pathogenesis observed in haploinsufficient patients differs from the hyperinflammation seen in classical OTULIN-related autoinflammatory syndrome (ORAS) patients and is characterized by increased susceptibility of dermal fibroblasts to S. aureus alpha toxin-inflicted cytotoxic damage. Immunological abnormalities were not observed in OTULIN haploinsufficient patients, suggesting a non-hematopoietic basis. In this research report, we investigated an Otulin+/− mouse model after in vivo provocation with lipopolysaccharide (LPS) to explore the potential role of hematopoietic-driven inflammation in OTULIN haploinsufficiency. We observed a hyperinflammatory signature in LPS-provoked Otulin+/− mice, which was driven by CD64+ monocytes and macrophages. Bone marrow-derived macrophages (BMDMs) of Otulin+/− mice demonstrated higher proinflammatory cytokine secretion after in vitro stimulation with LPS or polyinosinic:polycytidylic acid (Poly(I:C)). Our experiments in full and mixed bone marrow chimeric mice suggest that, in contrast to humans, the observed inflammation was mainly driven by the hematopoietic compartment with cell-extrinsic effects likely contributing to inflammatory outcomes. Using an OTULIN haploinsufficient mouse model, we validated the role of OTULIN in the regulation of environmentally directed inflammation.
- Published
- 2024
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33. Evaluating the Evidence for Water World Populations using Mixture Models
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Neil, Andrew R., Liston, Jessica, and Rogers, Leslie A.
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
Water worlds have been hypothesized as an alternative to photo-evaporation in order to explain the gap in the radius distribution of Kepler exoplanets. We explore water worlds within the framework of a joint mass-radius-period distribution of planets fit to a sample of transiting Kepler exoplanets, a subset of which have radial velocity mass measurements. We employ hierarchical Bayesian modeling to create a range of ten mixture models that include multiple compositional subpopulations of exoplanets. We model these subpopulations - including planets with gaseous envelopes, evaporated rocky cores, evaporated icy cores, intrinsically rocky planets, and intrinsically icy planets - in different combinations in order to assess which combinations are most favored by the data. Using cross-validation, we evaluate the support for models that include planets with icy compositions compared to the support for models that do not, finding broad support for both. We find significant population-level degeneracies between subpopulations of water worlds and planets with primordial envelopes. Among models that include one or more icy-core subpopulations, we find a wide range for the fraction of planets with icy compositions, with a rough upper limit of 50%. Improved datasets or alternative modeling approaches may better be able to distinguish between these subpopulations of planets., Comment: 31 pages, 10 figures, accepted for publication in ApJ
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- 2022
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34. Multimedia Open Educational Resource Materials for Teaching-Online Diversity and Leadership: Aligning Bloom's Taxonomy and Studio Habits of Mind
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Johnston, Elizabeth, Burleigh, Cheryl, Rasmusson, Xeno, Turner, Patrick, Valentine, Drena, and Bailey, Liston
- Abstract
Objective: The purpose of this study was to explore, develop, test, and refine processes to incorporate meaningful and equitable use of open educational resources (OER) in online classrooms. Method: The intent of this qualitative study was to use an action research process of interactive discussions between higher education practitioners to shape collective understanding of how to teach in an online learning environment using OER. Results: The study resulted in the identification six exemplar learning opportunities which could be incorporated into the blended pedagogical model. Each exemplar OER included all four types of knowledge as defined by Bloom's taxonomy and required skills of observe and envision as defined in the Studio Habits of Mind (SHoM). A second criteria for our purposive selection was that each exemplar could be used to teach in multiple contexts for multiple purposes across a spectrum of higher education online courses. Conclusion: This study reminds us that educators need a new mindset to work with multimedia and visual resources. The blended pedagogical model provides scaffold teaching and learning opportunities that were not visible in either Bloom's taxonomy or SHoM alone. This blended pedagogical model scaffolds the "how" when using a visual approach to curriculum development that may enrich the learning experiences of students when presented in online higher education classrooms. Implication for Practice: Educators might replicate this study or transfer findings for purposes of comparing and testing further the use of OER in their online higher education classes to further engage student learning. Applying new understanding in a project that is shared with the larger learning group is essential as students understand and begin to own new skills and insights. The blended pedagogical model presented in this paper could be helpful to educators to maximize the benefits from the integration of technology and OERs to support online higher education.
- Published
- 2021
35. Teacher Awareness of Trauma Informed Practice: Raising Awareness in Southeast Georgia
- Author
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Rahimi, Regina, liston, delores d., Adkins, Amee, and Nourzad, Jamie
- Abstract
While the concept of trauma-informed care has been developed in other fields, its development within the field of Education is relatively new (Thomas, Crosby, & Vanderhaar, 2019), However, as the educational field is becoming more and more aware of this approach, we recognize there is a critical need for teachers and other educational professionals to recognize the symptoms of trauma in students, the associated behaviors of trauma-affected students, and instructional and environmental strategies for addressing these to support student success (trauma informed pedagogy). This paper outlines a study examining the extent to which teachers in the region of southeast Georgia are aware of trauma-informed strategies, the theory undergirding the approach, and the resources available to them for addressing issues related to adverse childhood experiences. With participation from over 500 educators in our study, it is clear that there is a strong need to support teachers and provide resources to support trauma-informed practice.
- Published
- 2021
36. TORREFACTION OF RICE HUSK AS PREPARATION OF COAL-BIOMASS CO-FIRING AND ITS PROPENSITY ON ASH DEPOSITION
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Datin Fatia Umar, Zulfahmi Zulfahmi, Liston Setiawan, Gunawan Gunawan, Agus Prakosa, Truman Wijaya, and Edwin Akhdiat Daranin
- Subjects
torrefaction ,temperature ,residence time ,alkali ,ash deposition ,Mining engineering. Metallurgy ,TN1-997 ,Geology ,QE1-996.5 - Abstract
The most extensive use of coal in Indonesia is for electricity generation. Due to increasing concerns about climate change and the need to reduce emissions caused by burning coal, biomass-based fuels are becoming more competitive. The biomass carbonization process, or torrefaction, to produce solid fuel has been introduced elsewhere. This research uses sub-bituminous coal and rice husks, considering Indonesia’s large potential for both. The primary objective of this research was to determine the optimal temperature and residence time for the rice husk torrefaction process, intending to reduce the alkali oxide content that led to ash deposition. This was necessary due to the limited information available, particularly for local rice husks from Indonesia. We carried out the rice husk torrefaction at 300, 350, and 400°C temperatures for 30, 60, and 90 minutes. The results show that a temperature of 350°C and a residence time of 60 minutes were the optimal conditions. In these conditions, the potassium and sodium oxides decreased, and the calorific value increased. To get a coal-rice husk blending with a calorific value greater than 5,000 cal/g (ADB), the proportion of coal to rice husk should be 90 and 10%, respectively. The rice husk torrefaction process did not have much influence on the occurrence of ash deposition. However, the torrefaction process increased the calorific value, reduced transportation costs due to the lower moisture content, and improved grindability so that it was easy to blend with coal.
- Published
- 2024
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37. TWO-STAGE PALM KERNEL SHELL WASHING WITH WATER AND ACETIC ACID AS PREPARATION OF CO-FIRING SYSTEM WITH COAL
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Datin Fatia Umar, Zulfahmi Zulfahmi, Suganal Suganal, Nendaryono Madiutomo, Truman Wijaya, Miftahul Huda, Liston Setiawan, Edwin Akhdiat Daranin, Gunawan Gunawan, and Ika Monika
- Subjects
washing ,torrefaction ,slagging ,fouling ,ash fusion temperature ,Mining engineering. Metallurgy ,TN1-997 ,Geology ,QE1-996.5 - Abstract
Palm kernel shells (PKS) were washed with water and glacial acetic acid (CH3COOH) gradually to prepare them for co-firing with coal. They were then torrefied at 450ºC for one hour. Washing was done to reduce the concentration of ash and alkaline oxides, which would reduce the chance of slagging and fouling. The research was conducted considering that information about washing the PKS with acetic acid and then having them torrefied is very limited and unclear. The results showed that washed and torrefied PKS had better characteristics than those of raw PKS or PKS washed with water. PKS that is washed with acid, torrefied and then blended with coal has low slagging and medium fouling tendencies. However, based on ash fusion temperature, the inclination towards slagging and fouling is high under reducing conditions and medium under oxidation conditions.
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- 2024
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38. How do representatives from sporting organisations understand primary prevention of violence against women?
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Liston, Ruth, Hamilton, Gemma, and McCook, Sarah
- Published
- 2023
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39. CTLA4-Ig Effectively Controls Clinical Deterioration and Immune Condition in a Murine Model of Foxp3 Deficiency
- Author
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Gerbaux, Margaux, Roos, Evelyne, Willemsen, Mathijs, Staels, Frederik, Neumann, Julika, Bücken, Leoni, Haughton, Jeason, Yshii, Lidia, Dooley, James, Schlenner, Susan, Humblet-Baron, Stephanie, and Liston, Adrian
- Published
- 2023
- Full Text
- View/download PDF
40. Letter from the Editors
- Author
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Joe Pellegrino, Nikki DiGregorio, Delores E. Liston, and Delena Bell Gatch
- Subjects
Theory and practice of education ,LB5-3640 - Abstract
This letter introduces issue 2 of volume 17. It discusses institutional accreditation, academic program assessment, the rigor necessary to have confidence in our curricular decisions, and how the scholarship of teaching and learning fits into this picture.
- Published
- 2023
- Full Text
- View/download PDF
41. Techno-economic analysis of natural gas distribution using a small-scale liquefied natural gas carrier
- Author
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Muhammad Arif Budiyanto, Gerry Liston Putra, Achmad Riadi, Gunawan, Apri Melianes Febri, and Gerasimos Theotokatos
- Subjects
Medicine ,Science - Abstract
Abstract The design of the gas distribution for small-demand power plants located on remote islands is logistically challenging. The use of small-scale liquefied natural gas (LNG) vessels can be an option for these logistic problems. This paper aims to conduct a techno-economic analysis of using small-scale LNG vessels for gas distribution to the power plants that are spread across different islands. Route optimisation has been conducted using the capacitated vehicle routing problem method. The ship’s principal dimensions were determined using the aspect ratio from a linear regression of existing small-scale LNG vessels. As a case study, the gas demands for a gas power plant in eastern Indonesia were analysed into four distribution clusters. The results of the techno-economic analysis showed that the four distribution clusters have different characteristics regarding the LNG requirements, location characteristics and ship specifications. The capacity of small-scale LNG vessels feasible in terms of technical aspects varies from 2500, 5000, to > 10,000 m3 with variations in the ship speed depending on the location of the power plants. The amount of cargo requested and the shipping distance was affected to the cost of LNG transportation. The economic assessment proposes that the feasible investment by considering small-scale LNG cargo distribution, from the case study shows that with a ship capacity of 5000 m3 feasible margin rate is ≥ 3 USD/metric million British thermal units with an internal rate of return of 10% and estimated payback period is less than 15 years.
- Published
- 2023
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42. Conhecimentos provenientes das epistemologias antirracistas postos em circulação nos currículos por professores negros
- Author
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Rose Cristiani Franco Seco Liston and José Licínio Backes
- Subjects
epistemologias antirracistas ,professores negros ,currículo ,Education (General) ,L7-991 - Abstract
O artigo tem como objetivo analisar como conhecimentos provenientes de epistemologias antirracistas têm sido colocados em circulação nos currículos por professores negros. A discussão teórica pauta-se nos estudos étnico-raciais, destacando-se a crítica à epistemologia moderna/ocidental/colonial e a potência das epistemologias antirracistas. A pesquisa de campo foi realizada por meio de entrevistas semiestruturadas com professores negros militantes que atuam na educação básica. Com base na análise qualitativa efetuada, pode-se concluir que vários conhecimentos provenientes das epistemologias antirracistas estão nos currículos, com destaque para o questionamento do racismo estrutural, da forma como os alunos negros têm sido tratados nas escolas e das práticas racistas ainda existentes e com ênfase na defesa da cultura e identidade negra.
- Published
- 2023
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43. A Cross Entropy test allows quantitative statistical comparison of t-SNE and UMAP representations
- Author
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Roca1, Carlos P., Burton, Oliver T., Neumann, Julika, Tareen, Samar, Whyte, Carly E., Humblet-Baron, Stéphanie, and Liston, Adrian
- Subjects
Quantitative Biology - Quantitative Methods ,92C37 - Abstract
The advent of high dimensional single cell data in the biomedical sciences has necessitated the development of dimensionality-reduction tools. t-SNE and UMAP are the two most frequently used approaches, allowing clear visualisation of highly complex single cell datasets. Despite the ubiquity of these approaches and the clear need for quantitative comparison of single cell datasets, t-SNE and UMAP have largely remained data visualisation tools due to the lack of robust statistical approaches available. Here, we have derived a statistical test for evaluating the difference between dimensionality-reduced datasets, using the Kolmogorov-Smirnov test on the distributions of cross entropy of single cells within each dataset. As the approach uses the interrelationship of single cells for comparison, the resulting statistic is robust and capable of distinguishing between true biological variation and rotational symmetry generation during dimensionality reduction. Further, the test provides a valid distance between single cell datasets, allowing the organisation of multiple samples into a dendrogram for quantitative comparison of complex datasets. These results demonstrate the largely untapped potential of dimensionality-reduction tools for biomedical data analysis beyond visualisation., Comment: 26 pages, 5 figures
- Published
- 2021
44. Original Research By Young Twinkle Students (ORBYTS): Ephemeris Refinement of Transiting Exoplanets III
- Author
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Edwards, Billy, Ho, Cynthia S. K., Osborne, Hannah L. M., Deen, Nabeeha, Hathorn, Ellie, Johnson, Solomon, Patel, Jiya, Vogireddy, Varun, Waddon, Ansh, Ahmed, Ayuub, Bham, Muhammad, Campbell, Nathan, Chummun, Zahra, Crossley, Nicholas, Dunsdon, Reggie, Hayes, Robert, Malik, Haroon, Marsden, Frank, Mayfield, Lois, Mitchell, Liston, Prosser, Agnes, Rabrenovic, Valentina, Smith, Emma, Thomas, Rico, Kokori, Anastasia, Tsiaras, Angelos, Tessenyi, Marcell, Tinetti, Giovanna, and Tennyson, Jonathan
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
We report photometric follow-up observations of thirteen exoplanets (HATS-1 b, HATS2 b, HATS-3 b, HAT-P-18 b, HAT-P-27 b, HAT-P-30 b, HAT-P-55 b, KELT-4A b, WASP-25 b, WASP-42 b, WASP-57 b, WASP-61 b and WASP-123 b), as part of the Original Research By Young Twinkle Students (ORBYTS) programme. All these planets are potentially viable targets for atmospheric characterisation and our data, which were taken using the LCOGT network of ground-based telescopes, will be combined with observations from other users of ExoClock to ensure that the transit times of these planets continue to be well-known, far into the future., Comment: Accepted for publication in the Astronomy Theory, Observations and Methods Journal. Secondary school students (16-17 y/o) performed the majority of the analysis, as well as writing much of the paper, as part of the ORBYTS programme
- Published
- 2021
- Full Text
- View/download PDF
45. Making College Work for Students and the Economy: A State Policy Roadmap
- Author
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Jobs for the Future, Altstadt, David, Lima, Ashley Bliss, and Liston, Cynthia
- Abstract
The rapidly changing economy is raising the stakes on states to address the skilled workforce needs of employers and to expand economic opportunity to more people and places. To guide the policy actions of states, Jobs for the Future (JFF) designed a comprehensive policy agenda for increasing attainment of postsecondary credentials valued in the labor market and analyzed the extent to which the recommended policies have taken hold in a representative sample of states. Detailed in this report, JFF research finds that states have made progress in adopting several essential policy elements, but critical gaps remain that are undercutting talent development aims and contributing to persistent disparities in education and employment outcomes. Through this research, the authors identified three key findings that highlight critical gaps and areas for improvement, as well as achievements to build upon: (1) States are data rich, but information poor; (2) Expanding access is not enough; and (3) Better align systems to maximize impact. This report provides a road map for state leaders to tackle the tough work ahead and achieve lasting impact for learners, workers, employers, communities, and regional economies.
- Published
- 2019
46. Techno-economic analysis of natural gas distribution using a small-scale liquefied natural gas carrier
- Author
-
Budiyanto, Muhammad Arif, Putra, Gerry Liston, Riadi, Achmad, Gunawan, Febri, Apri Melianes, and Theotokatos, Gerasimos
- Published
- 2023
- Full Text
- View/download PDF
47. Primary school mobile dental program in New South Wales, Australia: protocol for the evaluation of a state government oral health initiative
- Author
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Balasubramanian, M, Ghanbarzadegan, A, Sohn, W, Killedar, A, Sivaprakash, P, Holden, A, Norris, S, Wilson, A, Pogson, B, Liston, G, Chor, L, Yaacoub, A, Masoe, A, Clarke, K, Chen, R, Milat, A, and Schneider C, Carmen Huckel
- Published
- 2023
- Full Text
- View/download PDF
48. Mapping Potential Timing of Ice Algal Blooms From Satellite
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J. C. Stroeve, G. Veyssiere, C. Nab, B. Light, D. Perovich, J. Laliberté, K. Campbell, J. Landy, R. Mallett, A. Barrett, G. E. Liston, A. Haddon, and J. Wilkinson
- Subjects
Sea ice ,snow cover ,under‐ice light ,ice algae ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract As Arctic sea ice and its overlying snow cover thin, more light penetrates into the ice and upper ocean, shifting the phenology of algal growth within the bottom of sea ice, with cascading impacts on higher trophic levels of the Arctic marine ecosystem. While field data or autonomous observatories provide direct measurements of the coupled sea ice‐algal system, they are limited in space and time. Satellite observations of key sea ice variables that control the amount of light penetrating through sea ice offer the possibility to map the under‐ice light field across the entire Arctic basin. This study provides the first satellite‐based estimates of potential sea ice‐associated algal bloom onset dates since the launch of CryoSat‐2 and explores how a changing snowpack may have shifted bloom onset timings over the last four decades.
- Published
- 2024
- Full Text
- View/download PDF
49. Stress urinary incontinence prevalence and risk factors in female rugby players: a common health problem across four nations
- Author
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Kari Bø, Isabel S Moore, Patrick O'Halloran, Joanna Perkins, Gráinne M Donnelly, Mairéad Liston, Molly McCarthy-Ryan, Karina Leahy, and Yeomans Caithriona
- Subjects
Medicine (General) ,R5-920 - Abstract
Objectives Female athletes engaging in high-impact sports have a higher prevalence of experiencing stress urinary incontinence (SUI). However, the prevalence of sport-specific SUI and associated risk factors in female rugby players is relatively unknown. We aimed to determine the prevalence of general and rugby-related SUI and identify associated risk factors and inciting events in female rugby players.Methods Observational, cross-sectional study of 396 female rugby players (age 28±8 years, mass 80±18 kg, height 1.90±0.19 m, playing years 7±6 years) participating in rugby across UK and Ireland completed an electronic questionnaire regardless of SUI status.Results 63 to 88% of players had SUI, and 43% had rugby-related SUI. There was an association with players reporting a change in incontinence status due to playing rugby (p
- Published
- 2024
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50. Gene–brain–behavior mechanisms underlying autism spectrum disorder: implications for precision psychiatry
- Author
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Buch, Amanda M. and Liston, Conor
- Published
- 2024
- Full Text
- View/download PDF
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