1. Use of Proton Pump Inhibitors and the Risk of Listeriosis: A Nationwide Registry-based Case-Control Study
- Author
-
Jacob Simonsen, Steen Ethelberg, and Anne Jensen
- Subjects
Microbiology (medical) ,Male ,Risk ,medicine.medical_specialty ,Time Factors ,Proton pump inhibitors ,Listeria ,Denmark ,Case-control studies ,Comorbidity ,Proton Pump Inhibitors/adverse effects ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Journal Article ,Odds Ratio ,Humans ,Listeriosis ,030212 general & internal medicine ,Registries ,Medical prescription ,Aged ,Aged, 80 and over ,business.industry ,Incidence ,Confounding ,Case-control study ,Proton Pump Inhibitors ,Odds ratio ,Middle Aged ,medicine.disease ,Listeriosis/epidemiology ,Confidence interval ,Surgery ,Infectious Diseases ,Case-Control Studies ,Population Surveillance ,030211 gastroenterology & hepatology ,Registry data ,Female ,business ,Comorbidity index - Abstract
Background. Recent studies suggest that proton pump inhibitors (PPIs) may increase the risk for listeriosis. We investigated a potential association in cases of nonpregnancy-associated listeriosis using registry data. Methods. We conducted a population-based, case-control study using Danish health registries. Cases (n = 721) were defined as patients aged ≥45 years notified with listeriosis from July 1994 to December 2012. We selected 34 800 controls using risk-set sampling. Controls were individually matched for age, sex, and municipality. Data on use of PPIs and other drugs and hospitalization diagnoses over a 5-year period were extracted from nationwide health registries. A comorbidity index (CMI) was constructed. We calculated the association between use of PPIs and related drugs within 30 days (current use) and other time windows before the index date. Using conditional logistic regression, matched odds ratios (ORs) adjusted for CMI and confounders were estimated. Results. The adjusted OR for current use of PPIs and development of listeriosis was 2.81 (95% confidence interval [CI], 2.14-3.69). PPI usage up to 90 days before the index date remained statistically significant. Subgroup analyses revealed increasing ORs with decreasing age and level of comorbidity and an increased OR for concurrent glucocorticoid treatment (OR, 4.61; 95% CI, 3.01-7.06). No significant association was found for current use of histamine-2-receptor antagonists (adjusted OR, 1.82; 95% CI, 0.89-3.71). Conclusions. Prescribed PPIs were associated with increased risk of listeriosis. The risk waned with time since last prescription redemption. PPIs may have unwanted side effects in vulnerable populations.
- Published
- 2016