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34 results on '"Lissauer, Matthew E."'

1. Predictors of Mortality, Withdrawal of Life-Sustaining Measures, and Discharge Disposition in Octogenarians with Subdural Hematomas

Author

Ghneim, Mira, Albrecht, Jennifer S., Brasel, Karen, Livaris, Anna, Watras, Jill B., Michetti, Christopher P., Haan, James M., Lightwine, Kelly, Winfield, Robert D., Adams, Sasha D., Podbielski, Jeanette M., Armen, Scott B., Zacko, J. Christopher, Nasrallah, Fady S., Schaffer, Kathryn B., Dunn, Julie, Widdel, Lars, Schroeppel, Thomas J., Stillman, Zachery, Cooper, Zara, Stein, Deborah, Adams, Charles, Lueckel, Stephanie, Murry, Jason, Patel, Nikita, Hsu, Cindy, Bhatti, Umer F., Lissauer, Matthew E., LaFonte, Marc, Najafi, Kaveh, Lewandowski, Karen, Mukherjee, Kaushik, Imperio-Lagabon, Kristelle J., Martin, Niels D., Hirsch, Kathleen, Berry, Cherisse, Freitas, Derek, Cullinane, Daniel, Ramawi, Roshini, Truitt, Michael, Pearcy, Chris, Hashimi, Habiba, Kaups, Krista, Claridge, Jeffrey, Hartwell, Jennifer L., Ballou, Jessica, Croce, Martin, Markle, Stephanie, Osserwaarde, Sally, Posluszny, Joseph, Stocker, Benjamin, Hranjec, Tjasa, Solomon, Rachele, Martinek, Lucy, Gupta, Alok, Grabo, Daniel J., Khan, Uzer, Tatum, Danielle, Jacome, Tomas, Gates, Jonathan, Jawani, Alisha, Berndtson, Allison E., Curry, Terry G., Bala, Miklosh, Dultz, Linda A., Houshmand, Natasha N., Pieri, Paola, Zielinski, Martin D., Hughes, Joy D., Hartwell, Jennifer, Malhotra, Ajai K., Lee, Tim, Petrone, Patrizio, Joseph, D'andrea, Marshall, Gary T., Carrick, Matthew M., Pathak, Abhijit, Van Zandt, Andrea, Glass, Nina, Livingston, David, Gregg, Shea, Webb, Travis, Drumheller, Byron, Kozar, Rosemary, Barraco, Robert, Joseph, Bellal, Kashkoush, Ahmed, Petitt, Jordan C., Ladhani, Husayn, Ho, Vanessa P., and Kelly, Michael L.

Published
2022
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2. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury

Author

Kashani, Kianoush, Al-Khafaji, Ali, Ardiles, Thomas, Artigas, Antonio, Bagshaw, Sean M, Bell, Max, Bihorac, Azra, Birkhahn, Robert, Cely, Cynthia M, Chawla, Lakhmir S, Davison, Danielle L, Feldkamp, Thorsten, Forni, Lui G, Gong, Michelle, Gunnerson, Kyle J, Haase, Michael, Hackett, James, Honore, Patrick M, Hoste, Eric AJ, Joannes-Boyau, Olivier, Joannidis, Michael, Kim, Patrick, Koyner, Jay L, Laskowitz, Daniel T, Lissauer, Matthew E, Marx, Gernot, McCullough, Peter A, Mullaney, Scott, Ostermann, Marlies, Rimmelé, Thomas, Shapiro, Nathan I, Shaw, Andrew D, Shi, Jing, Sprague, Amy M, Vincent, Jean-Louis, Vinsonneau, Christophe, Wagner, Ludwig, Walker, Michael G, Wilkerson, R Gentry, Zacharowski, Kai, and Kellum, John A

Abstract

Abstract Introduction Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely to provide benefit. Identifying early markers of kidney damage has been difficult due to the complex nature of human AKI, in which multiple etiologies exist. The objective of this study was to identify and validate novel biomarkers of AKI. Methods We performed two multicenter observational studies in critically ill patients at risk for AKI - discovery and validation. The top two markers from discovery were validated in a second study (Sapphire) and compared to a number of previously described biomarkers. In the discovery phase, we enrolled 522 adults in three distinct cohorts including patients with sepsis, shock, major surgery, and trauma and examined over 300 markers. In the Sapphire validation study, we enrolled 744 adult subjects with critical illness and without evidence of AKI at enrollment; the final analysis cohort was a heterogeneous sample of 728 critically ill patients. The primary endpoint was moderate to severe AKI (KDIGO stage 2 to 3) within 12 hours of sample collection. Results Moderate to severe AKI occurred in 14% of Sapphire subjects. The two top biomarkers from discovery were validated. Urine insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2), both inducers of G1 cell cycle arrest, a key mechanism implicated in AKI, together demonstrated an AUC of 0.80 (0.76 and 0.79 alone). Urine [TIMP-2]·[IGFBP7] was significantly superior to all previously described markers of AKI (P 0.72. Furthermore, [TIMP-2]·[IGFBP7] significantly improved risk stratification when added to a nine-variable clinical model when analyzed using Cox proportional hazards model, generalized estimating equation, integrated discrimination improvement or net reclassification improvement. Finally, in sensitivity analyses [TIMP-2]·[IGFBP7] remained significant and superior to all other markers regardless of changes in reference creatinine method. Conclusions Two novel markers for AKI have been identified and validated in independent multicenter cohorts. Both markers are superior to existing markers, provide additional information over clinical variables and add mechanistic insight into AKI. Trial registration ClinicalTrials.gov number NCT01209169.

Published
2013

13. Predictors of Mortality, Withdrawal of Life-Sustaining Measures, and Discharge Disposition in Octogenarians with Subdural Hematomas

Author

Kashkoush, Ahmed, primary, Petitt, Jordan C., additional, Ladhani, Husayn, additional, Ho, Vanessa P., additional, Kelly, Michael L., additional, Ghneim, Mira, additional, Albrecht, Jennifer S., additional, Brasel, Karen, additional, Livaris, Anna, additional, Watras, Jill B., additional, Michetti, Christopher P., additional, Haan, James M., additional, Lightwine, Kelly, additional, Winfield, Robert D., additional, Adams, Sasha D., additional, Podbielski, Jeanette M., additional, Armen, Scott B., additional, Zacko, J. Christopher, additional, Nasrallah, Fady S., additional, Schaffer, Kathryn B., additional, Dunn, Julie, additional, Widdel, Lars, additional, Schroeppel, Thomas J., additional, Stillman, Zachery, additional, Cooper, Zara, additional, Stein, Deborah, additional, Adams, Charles, additional, Lueckel, Stephanie, additional, Murry, Jason, additional, Patel, Nikita, additional, Hsu, Cindy, additional, Bhatti, Umer F., additional, Lissauer, Matthew E., additional, LaFonte, Marc, additional, Najafi, Kaveh, additional, Lewandowski, Karen, additional, Mukherjee, Kaushik, additional, Imperio-Lagabon, Kristelle J., additional, Martin, Niels D., additional, Hirsch, Kathleen, additional, Berry, Cherisse, additional, Freitas, Derek, additional, Cullinane, Daniel, additional, Ramawi, Roshini, additional, Truitt, Michael, additional, Pearcy, Chris, additional, Hashimi, Habiba, additional, Kaups, Krista, additional, Claridge, Jeffrey, additional, Hartwell, Jennifer L., additional, Ballou, Jessica, additional, Croce, Martin, additional, Markle, Stephanie, additional, Osserwaarde, Sally, additional, Posluszny, Joseph, additional, Stocker, Benjamin, additional, Hranjec, Tjasa, additional, Solomon, Rachele, additional, Martinek, Lucy, additional, Gupta, Alok, additional, Grabo, Daniel J., additional, Khan, Uzer, additional, Tatum, Danielle, additional, Jacome, Tomas, additional, Gates, Jonathan, additional, Jawani, Alisha, additional, Berndtson, Allison E., additional, Curry, Terry G., additional, Bala, Miklosh, additional, Dultz, Linda A., additional, Houshmand, Natasha N., additional, Pieri, Paola, additional, Zielinski, Martin D., additional, Hughes, Joy D., additional, Hartwell, Jennifer, additional, Malhotra, Ajai K., additional, Lee, Tim, additional, Petrone, Patrizio, additional, Joseph, D'andrea, additional, Marshall, Gary T., additional, Carrick, Matthew M., additional, Pathak, Abhijit, additional, Van Zandt, Andrea, additional, Glass, Nina, additional, Livingston, David, additional, Gregg, Shea, additional, Webb, Travis, additional, Drumheller, Byron, additional, Kozar, Rosemary, additional, Barraco, Robert, additional, and Joseph, Bellal, additional

Published
2022
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15. The Correlation of Respiratory System Compliance and Mortality in COVID-19 Acute Respiratory Distress Syndrome: Do Phenotypes Really Exist?

Author

Choron, Rachel L., primary, Iacono, Stephen A., additional, Cong, Alexander, additional, Bargoud, Christopher G., additional, Teichman, Amanda L., additional, Krumrei, Nicole J., additional, Manderski, Michelle T. Bover, additional, Rodricks, Michael B, additional, Gupta, Rajan, additional, and Lissauer, Matthew E., additional

Published
2021
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16. Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial

Author

Harris, Anthony D., Pineles, Lisa, Belton, Beverly, Johnson, Kristie J., Shardell, Michelle, Loeb, Mark, Newhouse, Robin, Dembry, Louise, Braun, Barbara, Perencevich, Eli N., Hall, Kendall K., Morgan, Daniel J., Shahryar, Syed K., Price, Connie S., Gadbaw, Joseph J., Drees, Marci, Kett, Daniel H., Muñoz-Price, Silvia L., Jacob, Jesse T., Herwaldt, Loreen A., Sulis, Carol A., Yokoe, Deborah S., Maragakis, Lisa, Lissauer, Matthew E., Zervos, Marcus J., Warren, David K., Carver, Robin L., Anderson, Deverick J., Calfee, David P., Bowling, Jason E., and Safdar, Nasia

Published
2013
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19. Surgical management of pancreatic necrosis

Author

Mowery, Nathan T., primary, Bruns, Brandon R., additional, MacNew, Heather G., additional, Agarwal, Suresh, additional, Enniss, Toby M., additional, Khan, Mansoor, additional, Guo, Weidun Alan, additional, Cannon, Jeremy W., additional, Lissauer, Matthew E., additional, Duane, Therese M., additional, Hildreth, Amy N., additional, Pappas, Peter A., additional, Gries, Lynn M., additional, Kaiser, Meghann, additional, and Robinson, Bryce R.H., additional

Published
2017
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20. Multimodality Monitoring in Neurocritical Care: Decision-Making Utilizing Direct And Indirect Surrogate Markers.

Author

Al-Mufti, Fawaz, Lander, Megan, Smith, Brendan, Morris, Nicholas A., Nuoman, Rolla, Gupta, Rajan, Lissauer, Matthew E., Gupta, Gaurav, and Lee, Kiwon

Subjects
BRAIN metabolism, BIOMARKERS, CEREBRAL hemorrhage, BRAIN injuries, CEREBRAL circulation, CEREBRAL ischemia, CRITICAL care medicine, DECISION making, INTRACRANIAL pressure, PATIENT monitoring, SYSTEMATIC reviews
Abstract

Substantial progress has been made to create innovative technology that can monitor the different physiological characteristics that precede the onset of secondary brain injury, with the ultimate goal of intervening prior to the onset of irreversible neurological damage. One of the goals of neurocritical care is to recognize and preemptively manage secondary neurological injury by analyzing physiologic markers of ischemia and brain injury prior to the development of irreversible damage. This is helpful in a multitude of neurological conditions, whereby secondary neurological injury could present including but not limited to traumatic intracranial hemorrhage and, specifically, subarachnoid hemorrhage, which has the potential of progressing to delayed cerebral ischemia and monitoring postneurosurgical interventions. In this study, we examine the utilization of direct and indirect surrogate physiologic markers of ongoing neurologic injury, including intracranial pressure, cerebral blood flow, and brain metabolism. [ABSTRACT FROM AUTHOR]

Published
2019
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33. DIFFERENTIAL EXPRESSION OF TOLL-LIKE RECEPTOR GENES

Author

Lissauer, Matthew E., primary, Johnson, Steven B., additional, Bochicchio, Grant V., additional, Feild, Carinda J., additional, Cross, Alan S., additional, Hasday, Jeffrey D., additional, Whiteford, Craig C., additional, Nussbaumer, William A., additional, Towns, Michael, additional, and Scalea, Thomas M., additional

Published
2009
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