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1. Technical Design Report for the LUXE experiment

Author

Abramowicz, H., Almanza Soto, M., Altarelli, M., Aßmann, R., Athanassiadis, A., Avoni, G., Behnke, T., Benettoni, M., Benhammou, Y., Bhatt, J., Blackburn, T., Blanch, C., Bonaldo, S., Boogert, S., Borysov, O., Borysova, M., Boudry, V., Breton, D., Brinkmann, R., Bruschi, M., Burkart, F., Büßer, K., Cavanagh, N., Dal Corso, F., Decking, W., Deniaud, M., Diner, O., Dosselli, U., Elad, M., Epshteyn, L., Esperante, D., Ferber, T., Firlej, M., Fiutowski, T., Fleck, K., Fuster-Martinez, N., Gadow, K., Gaede, F., Gallas, A., Garcia Cabrera, H., Gerstmayr, E., Ghenescu, V., Giorato, M., Golubeva, N., Grojean, C., Grutta, P., Grzelak, G., Hallford, J., Hartman, L., Heinemann, B., Heinzl, T., Helary, L., Hendriks, L., Hoffmann, M., Horn, D., Huang, S., Huang, X., Idzik, M., Irles, A., Jacobs, R., King, B., Klute, M., Kropf, A., Kroupp, E., Lahno, H., Lasagni Manghi, F., Lawhorn, J., Levanon, A., Levi, A., Levinson, L., Levy, A., Levy, I., Liberman, A., Liss, B., List, B., List, J., Lohmann, W., Maalmi, J., Madlener, T., Malka, V., Marsault, T., Mattiazzo, S., Meloni, F., Miron, D., Morandin, M., Moroń, J., Nanni, J., Neagu, A. T., Negodin, E., Paccagnella, A., Pantano, D., Pietruch, D., Pomerantz, I., Pöschl, R., Potlog, P. M., Prasad, R., Quishpe, R., Ranken, E., Ringwald, A., Roich, A., Salgado, F., Santra, A., Sarri, G., Sävert, A., Sbrizzi, A., Schmitt, S., Schulthess, I., Schuwalow, S., Seipt, D., Simi, G., Soreq, Y., Spataro, D., Streeter, M., Swientek, K., Tal Hod, N., Teter, T., Thiebault, A., Thoden, D., Trevisani, N., Urmanov, R., Vasiukov, S., Walker, S., Warren, M., Wing, M., Yap, Y. C., Zadok, N., Zanetti, M., Żarnecki, A. F., Zbińkowski, P., Zembaczyński, K., Zepf, M., Zerwas, D., Ziegler, W., and Zuffa, M.

Published
2024
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2. Technical Design Report for the LUXE Experiment

Author

Abramowicz, H., Soto, M. Almanza, Altarelli, M., Aßmann, R., Athanassiadis, A., Avoni, G., Behnke, T., Benettoni, M., Benhammou, Y., Bhatt, J., Blackburn, T., Blanch, C., Bonaldo, S., Boogert, S., Borysov, O., Borysova, M., Boudry, V., Breton, D., Brinkmann, R., Bruschi, M., Burkart, F., Büßer, K., Cavanagh, N., Corso, F. Dal, Decking, W., Deniaud, M., Diner, O., Dosselli, U., Elad, M., Epshteyn, L., Esperante, D., Ferber, T., Firlej, M., Fiutowski, T., Fleck, K., Fuster-Martinez, N., Gadow, K., Gaede, F., Gallas, A., Cabrera, H. Garcia, Gerstmayr, E., Ghenescu, V., Giorato, M., Golubeva, N., Grojean, C., Grutta, P., Grzelak, G., Hallford, J., Hartman, L., Heinemann, B., Heinzl, T., Helary, L., Hendriks, L., Hoffmann, M., Horn, D., Huang, S., Huang, X., Idzik, M., Irles, A., Jacobs, R., King, B., Klute, M., Kropf, A., Kroupp, E., Lahno, H., Manghi, F. Lasagni, Lawhorn, J., Levanon, A., Levi, A., Levinson, L., Levy, A., Levy, I., Liberman, A., Liss, B., List, B., List, J., Lohmann, W., Maalmi, J., Madlener, T., Malka, V., Marsault, T., Mattiazzo, S., Meloni, F., Miron, D., Morandin, M., Moroń, J., Nanni, J., Neagu, A. T., Negodin, E., Paccagnella, A., Pantano, D., Pietruch, D., Pomerantz, I., Pöschl, R., Potlog, P. M., Prasad, R., Quishpe, R., Ranken, E., Ringwald, A., Roich, A., Salgado, F., Santra, A., Sarri, G., Sävert, A., Sbrizzi, A., Schmitt, S., Schulthess, I., Schuwalow, S., Seipt, D., Simi, G., Soreq, Y., Spataro, D., Streeter, M., Swientek, K., Hod, N. Tal, Teter, T., Thiebault, A., Thoden, D., Trevisani, N., Urmanov, R., Vasiukov, S., Walker, S., Warren, M., Wing, M., Yap, Y. C., Zadok, N., Zanetti, M., Żarnecki, A. F., Zbińkowski, P., Zembaczyński, K., Zepf, M., Zerwas, D., Ziegler, W., and Zuffa, M.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

This Technical Design Report presents a detailed description of all aspects of the LUXE (Laser Und XFEL Experiment), an experiment that will combine the high-quality and high-energy electron beam of the European XFEL with a high-intensity laser, to explore the uncharted terrain of strong-field quantum electrodynamics characterised by both high energy and high intensity, reaching the Schwinger field and beyond. The further implications for the search of physics beyond the Standard Model are also discussed.

Published
2023

3. Kleinhirn

Author

Liss, B., Kätzel, D., Brandes, Ralf, editor, Lang, Florian, editor, and Schmidt, Robert F., editor

Published
2019
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4. At-Risk World Heritage, Cyber, and Marine Archaeology: The Kastrouli–Antikyra Bay Land and Sea Project, Phokis, Greece

Author

Levy, Thomas E., Sideris, T., Howland, M., Liss, B., Tsokas, G., Stambolidis, A., Fikos, E., Vargemezis, G., Tsourlos, P., Georgopoulos, A., Papatheodorou, G., Garaga, M., Christodoulou, D., Norris, R., Rivera-Collazo, I., Liritzis, I., Pyburn, K. Anne, Series editor, Badran, Arwa, Series editor, Levy, Thomas E., editor, and Jones, Ian W. N., editor

Published
2018
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5. Anti-infective vaccination strategies in patients with hematologic malignancies or solid tumors—Guideline of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO)

Author

Rieger, C.T., Liss, B., Mellinghoff, S., Buchheidt, D., Cornely, O.A., Egerer, G., Heinz, W.J., Hentrich, M., Maschmeyer, G., Mayer, K., Sandherr, M., Silling, G., Ullmann, A., Vehreschild, M.J.G.T., von Lilienfeld-Toal, M., Wolf, H.H., and Lehners, N.

Published
2018
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8. At-Risk World Heritage, Cyber, and Marine Archaeology: The Kastrouli–Antikyra Bay Land and Sea Project, Phokis, Greece

Author

Levy, Thomas E., primary, Sideris, T., additional, Howland, M., additional, Liss, B., additional, Tsokas, G., additional, Stambolidis, A., additional, Fikos, E., additional, Vargemezis, G., additional, Tsourlos, P., additional, Georgopoulos, A., additional, Papatheodorou, G., additional, Garaga, M., additional, Christodoulou, D., additional, Norris, R., additional, Rivera-Collazo, I., additional, and Liritzis, I., additional

Published
2017
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12. Control of impulsivity by G(i)-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex

Author

van der Veen, B, Kapanaiah, SKT, Kilonzo, K, Steele-Perkins, P, Jendryka, MM, Schulz, S, Tasic, B, Yao, Z, Zeng, H, Akam, T, Nicholson, JR, Liss, B, Nissen, W, Pekcec, A, and Kätzel, D

Subjects
Receptors, G-protein-coupled, QH301-705.5, DEFICIT HYPERACTIVITY DISORDER, MICE LACKING, Neural circuits, Gyrus Cinguli, G-Protein gekoppelter Rezeptor, GENETIC ASSOCIATION, POSITIVE ALLOSTERIC MODULATOR, Target identification, Verhaltensstörung, Verhaltensst��rung, ddc:610, INHIBITORY CONTROL, Biology (General), REACTION-TIME-TASK, Neurons, Nervenkrankheit, Neurokinin, Receptors, Neurokinin-1, Nervous system diseases, Receptors, Glutamate, Cognitive control, NK1 RECEPTORS, GLUTAMATE-RECEPTOR AGONIST, DDC 610 / Medicine & health, COGNITIVE FLEXIBILITY, Disruptive, Impulse control, and conduct disorders
Abstract

Pathological impulsivity is a debilitating symptom of multiple psychiatric diseases with few effective treatment options. To identify druggable receptors with anti-impulsive action we developed a systematic target discovery approach combining behavioural chemogenetics and gene expression analysis. Spatially restricted inhibition of three subdivisions of the prefrontal cortex of mice revealed that the anterior cingulate cortex (ACC) regulates premature responding, a form of motor impulsivity. Probing three G-protein cascades with designer receptors, we found that the activation of Gi-signalling in layer-5 pyramidal cells (L5-PCs) of the ACC strongly, reproducibly, and selectively decreased challenge-induced impulsivity. Differential gene expression analysis across murine ACC cell-types and 402 GPCRs revealed that - among Gi-coupled receptor-encoding genes - Grm2 is the most selectively expressed in L5-PCs while alternative targets were scarce. Validating our approach, we confirmed that mGluR2 activation reduced premature responding. These results suggest Gi-coupled receptors in ACC L5-PCs as therapeutic targets for impulse control disorders., publishedVersion

Published
2021

16. Digital monitoring and management of patients with advanced or metastatic non-small cell lung cancer treated with cancer immunotherapy and its impact on quality of clinical care:interview and survey study among health care professionals and patients

Author

Schmalz, O. (Oliver), Jacob, C. (Christine), Ammann, J. (Johannes), Liss, B. (Blasius), Iivanainen, S. (Sanna), Kammermann, M. (Manuel), Koivunen, J. (Jussi), Klein, A. (Alexander), and Popescu, R. A. (Razvan Andrei)

Subjects
cancer immunotherapy, mHealth, quality of patient care, advanced or metastatic non-small cell lung cancer, patient-reported outcomes, user experience, drug- and indication-specific cancer immunotherapy module, eHealth, digital patient monitoring, real-time symptom reporting
Abstract

Background: Cancer immunotherapy (CIT), as a monotherapy or in combination with chemotherapy, has been shown to extend overall survival in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). However, patients experience treatment-related symptoms that they are required to recall between hospital visits. Digital patient monitoring and management (DPMM) tools may improve clinical practice by allowing real-time symptom reporting. Objective: This proof-of-concept pilot study assessed patient and health care professional (HCP) adoption of our DPMM tool, which was designed specifically for patients with advanced or metastatic NSCLC treated with CIT, and the tool’s impact on clinical care. Methods: Four advisory boards were assembled in order to co-develop a drug- and indication-specific CIT (CIT+) module, based on a generic CIT DPMM tool from Kaiku Health, Helsinki, Finland. A total of 45 patients treated with second-line single-agent CIT (ie, atezolizumab or otherwise) for advanced or metastatic NSCLC, as well as HCPs, whose exact number was decided by the clinics, were recruited from 10 clinics in Germany, Finland, and Switzerland between February and May 2019. All clinics were provided with the Kaiku Health generic CIT DPMM tool, including our CIT+ module. Data on user experience, overall satisfaction, and impact of the tool on clinical practice were collected using anonymized surveys—answers ranged from 1 (low agreement) to 5 (high agreement)—and HCP interviews; surveys and interviews consisted of closed-ended Likert scales and open-ended questions, respectively. The first survey was conducted after 2 months of DPMM use, and a second survey and HCP interviews were conducted at study end (ie, after ≥3 months of DPMM use); only a subgroup of HCPs from each clinic responded to the surveys and interviews. Survey data were analyzed quantitatively; interviews were recorded, transcribed verbatim, and translated into English, where applicable, for coding and qualitative thematic analysis. Results: Among interim survey respondents (N=51: 13 [25%] nurses, 11 [22%] physicians, and 27 [53%] patients), mean rankings of the tool’s seven usability attributes ranged from 3.2 to 4.4 (nurses), 3.7 to 4.5 (physicians), and 3.7 to 4.2 (patients). At the end-of-study survey (N=48: 19 [40%] nurses, 8 [17%] physicians, and 21 [44%] patients), most respondents agreed that the tool facilitated more efficient and focused discussions between patients and HCPs (nurses and patients: mean rating 4.2, SD 0.8; physicians: mean rating 4.4, SD 0.8) and allowed HCPs to tailor discussions with patients (mean rating 4.35, SD 0.65). The standalone tool was well integrated into HCP daily clinical workflow (mean rating 3.80, SD 0.75), enabled workflow optimization between physicians and nurses (mean rating 3.75, SD 0.80), and saved time by decreasing phone consultations (mean rating 3.75, SD 1.00) and patient visits (mean rating 3.45, SD 1.20). Workload was the most common challenge of tool use among respondents (12/19, 63%). Conclusions: Our results demonstrate high user satisfaction and acceptance of DPMM tools by HCPs and patients, and highlight the improvements to clinical care in patients with advanced or metastatic NSCLC treated with CIT monotherapy. However, further integration of the tool into the clinical information technology data flow is required. Future studies or registries using our DPMM tool may provide insights into significant effects on patient quality of life or health-economic benefits.

Published
2020

20. Anti-infective vaccination strategies in patients with hematologic malignancies or solid tumors-Guideline of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO)

Author

Rieger, C. T., Liss, B., Mellinghoff, S., Buchheidt, D., Cornely, O. A., Egerer, G., Heinz, W. J., Hentrich, M., Maschmeyer, G., Mayer, K., Sandherr, M., Silling, G., Ullmann, A., Vehreschild, M. J. G. T., von Lilienfeld-Toal, M., Wolf, H. H., Lehners, N., Rieger, C. T., Liss, B., Mellinghoff, S., Buchheidt, D., Cornely, O. A., Egerer, G., Heinz, W. J., Hentrich, M., Maschmeyer, G., Mayer, K., Sandherr, M., Silling, G., Ullmann, A., Vehreschild, M. J. G. T., von Lilienfeld-Toal, M., Wolf, H. H., and Lehners, N.

Abstract

Infectious complications are a significant cause of morbidity and mortality in patients with malignancies specifically when receiving anticancer treatments. Prevention of infection through vaccines is an important aspect of clinical care of cancer patients. Immunocompromising effects of the underlying disease as well as of antineoplastic therapies need to be considered when devising vaccination strategies. This guideline provides clinical recommendations on vaccine use in cancer patients including autologous stem cell transplant recipients, while allogeneic stem cell transplantation is subject of a separate guideline. The document was prepared by the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) by reviewing currently available data and applying evidence-based medicine criteria.

Published
2018

21. Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger

Author

Denis Burdakov, Liss, B., and Ashcroft, F. M.

Subjects
nervous system, digestive, oral, and skin physiology, mental disorders, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes
Abstract

The neuropeptides orexins/hypocretins are essential for normal wakefulness and energy balance, and disruption of their function causes narcolepsy and obesity. Although much is known of the role of orexins in sleep/wake behavior, it remains unclear how they stimulate feeding and metabolism. One of the main targets of orexinergic neurons is the arcuate nucleus (ARC) of the hypothalamus, which plays a key role in feeding and energy homeostasis. By combining patch-clamp and RT-multiplex PCR analysis of individual neurons in mouse brain slices, we show that an electrophysiologically distinct subset of ARC neurons coexpress orexin receptors and glutamate decarboxylase-67 and are excited by orexin. Acting on postsynaptic orexin type 2 receptors, orexin activates a sodium-calcium exchange current, thereby depolarizing the cell and increasing its firing frequency. Because GABA is a potent stimulus for feeding, in both the ARC and its main projection site, these results suggest a mechanism for how orexin may control appetite.

Published
2016

24. 1,3-ss-D-glucan concentrations in blood products predict false positive post-transfusion results

Author

Liss, B., Cornely, O. A., Hoffmann, D., Dimitriou, V., Wisplinghoff, H., Liss, B., Cornely, O. A., Hoffmann, D., Dimitriou, V., and Wisplinghoff, H.

Abstract

1,3-ss-D-glucan (BDG) is increasingly used to diagnose invasive fungal infections (IFI), although false positive results are a concern. To evaluate the potential interaction of blood products with the BDG assay, human albumin (HA), fresh frozen plasma (FFP), undiluted platelet transfusion (UPT) and packed red blood cells (PRBC) were tested for their BDG content using two different b-D-glucan tests. UPTs tested negative, FFP, PBRC and HA tested positive for BDG. In serial dilution, BDG concentration correlated with blood product concentration. To investigate the clinical impact of blood product transfusions, we measured BDG levels before and after the transfusion in three patients (2 PRBC, 1 HA). In the patients receiving PRBC transfusions, BDG values increased from 13 and 17pgml(-1) to 183 and 361pgml(-1), the HA transfusion increased the serum level from 42 to 58pgml(-1). BDG concentrations measured in blood products can be used to predict false positive BDG results.

Published
2016

26. 1,3-beta-d-Glucan contamination of common antimicrobials

Author

Liss, B., Cornely, O. A., Hoffmann, D., Dimitriou, V., Wisplinghoff, H., Liss, B., Cornely, O. A., Hoffmann, D., Dimitriou, V., and Wisplinghoff, H.

Abstract

1,3-beta-d-Glucan (BDG) is a fungal cell wall constituent used in the diagnosis of invasive fungal infections. BDG testing, although endorsed by the European Organization for Research and Treatment of Cancer, suffers from limited specificity. False-positive results have been linked to haemodialysis membranes, blood products, antineoplastic agents and antimicrobial use. The aim of this study was to determine whether false-positive BDG results in the context of antimicrobial use are caused by BDG present in infusion solutions. We obtained 35 antimicrobial drugs (30 antibiotics and 5 antifungals) and analysed their BDG content using two different assays. Twenty-five antimicrobials (20 antibiotics and all the tested antifungals) contained enough BDG to trigger a positive test. Depending on the substance, BDG varied between 9 and 2818 pg/mL. A majority of the available antimicrobial substances contained BDG, potentially limiting the utility of BDG testing in the context of prior exposure to these drugs. As the cumulative effects of repeated BDG exposure are unknown, efforts to reduce contamination should be considered.

Published
2016

27. Domestic mould exposure and invasive aspergillosis-air sampling of Aspergillus spp. spores in homes of hematological patients, a pilot study

Author

Schweer, K. E., Jakob, B., Liss, B., Christ, H., Fischer, G., Vehreschild, M. J. G. T., Cornely, O. A., Vehreschild, J. J., Schweer, K. E., Jakob, B., Liss, B., Christ, H., Fischer, G., Vehreschild, M. J. G. T., Cornely, O. A., and Vehreschild, J. J.

Abstract

Aspergillus spp.-related morbidity and mortality remains a major challenge in the management of neutropenic patients. Little is known about the impact of domestic Aspergillus spp. exposure. In this controlled prospective study, fungal spores were collected from homes of neutropenic patients. Cases were defined as patients with probable or proven controls as patients with no invasive pulmonary aspergillosis, while patients with possible disease were evaluated as a third group. Forty patients were enrolled and returned questionnaires on high-risk activities and mould exposure. A. fumigatus was detected in concentrations of 0 to 76 cfu/m(3) in every home. A. terreus was detected in nine (18%) homes. Mean Aspergillus spp. cfu/m(3) according to EORTC criteria were: proven/probable IA (15 patients) - 36; possible IA (12 patients) - 42; no IA (13 patients) - 42. Of the seven patients with self-reported moulded walls at home, four had probable and three had possible aspergillosis; the risk ratio of developing IA was 1.65 (95% CI: 1.25-2.17). In conclusion self-reported domestic mould exposure was associated with a high incidence of IA and may be a feasible tool for identifying high-risk patients. There was no correlation between domestic ambient-air spore counts and IA.

Published
2016

28. FungiScope (TM) - Global Registry for rare invasive Fungal Infections

Author

Seidel, D., Graeff, L. Duran, Vehreschild, M. J. G., Liss, B., Koehler, P., Mueller, F., Wisplinghoff, H., Vehreschild, J. J., Cornely, O., Seidel, D., Graeff, L. Duran, Vehreschild, M. J. G., Liss, B., Koehler, P., Mueller, F., Wisplinghoff, H., Vehreschild, J. J., and Cornely, O.

Published
2016

34. TriReg - study of trichosporonosis

Author

Seidel, D., Wahlers, K., Vehreschild, M. J. G. T., Koehler, P., Liss, B., Mueller, F., Wisplinghoff, H., Floerl, Lass C., Comely, O. A., Seidel, D., Wahlers, K., Vehreschild, M. J. G. T., Koehler, P., Liss, B., Mueller, F., Wisplinghoff, H., Floerl, Lass C., and Comely, O. A.

Published
2015

37. p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

Author

Begus-Nahrmann, Y., Lechel, A., Obenauf, A.C., Nalapareddy, K., Peit, E., Hoffmann, E., Schlaudraff, F., Liss, B., Schirmacher, P., Kestler, H., Danenberg, E.M., Barker, N., Clevers, H., Speicher, M.R., Rudolph, K.L., Begus-Nahrmann, Y., Lechel, A., Obenauf, A.C., Nalapareddy, K., Peit, E., Hoffmann, E., Schlaudraff, F., Liss, B., Schirmacher, P., Kestler, H., Danenberg, E.M., Barker, N., Clevers, H., Speicher, M.R., and Rudolph, K.L.

Abstract

Telomere dysfunction limits the proliferative capacity of human cells and induces organismal aging by activation of p53 and p21. Although deletion of p21 elongates the lifespan of telomere-dysfunctional mice, a direct analysis of p53 in telomere-related aging has been hampered by early tumor formation in p53 knockout mice. Here we analyzed the functional consequences of conditional p53 deletion. Intestinal deletion of p53 shortened the lifespan of telomere-dysfunctional mice without inducing tumor formation. In contrast to p21 deletion, the deletion of p53 impaired the depletion of chromosomal-instable intestinal stem cells in aging telomere-dysfunctional mice. These instable stem cells contributed to epithelial regeneration leading to an accumulation of chromosomal instability, increased apoptosis, altered epithelial cell differentiation and premature intestinal failure. Together, these results provide the first experimental evidence for an organ system in which p53-dependent mechanisms prevent tissue destruction in response to telomere dysfunction by depleting genetically instable stem cells., Telomere dysfunction limits the proliferative capacity of human cells and induces organismal aging by activation of p53 and p21. Although deletion of p21 elongates the lifespan of telomere-dysfunctional mice, a direct analysis of p53 in telomere-related aging has been hampered by early tumor formation in p53 knockout mice. Here we analyzed the functional consequences of conditional p53 deletion. Intestinal deletion of p53 shortened the lifespan of telomere-dysfunctional mice without inducing tumor formation. In contrast to p21 deletion, the deletion of p53 impaired the depletion of chromosomal-instable intestinal stem cells in aging telomere-dysfunctional mice. These instable stem cells contributed to epithelial regeneration leading to an accumulation of chromosomal instability, increased apoptosis, altered epithelial cell differentiation and premature intestinal failure. Together, these results provide the first experimental evidence for an organ system in which p53-dependent mechanisms prevent tissue destruction in response to telomere dysfunction by depleting genetically instable stem cells.

Published
2009

39. 3.119 STRIATAL LONG-TERM DEPRESSION AND DOPAMINE SIGNALING IMPAIRMENT IN A53T-ALPHA-SYNUCLEIN OVEREXPRESSING MICE

Author

Auburger, G., primary, Kurz, A., additional, Double, K.L., additional, Lastres-Becker, I., additional, Tozzi, A., additional, Tantucci, M., additional, Bockhart, V., additional, Bonin, M., additional, Garcia-Arencibia, M., additional, Nuber, S., additional, Schlaudraff, F., additional, Liss, B., additional, Fernandez-Ruiz, J., additional, Gerlach, M., additional, Wuellner, U., additional, Lueddens, H., additional, Calabresi, P., additional, and Gispert, S., additional

Published
2012
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46. Digital Monitoring and Management of Patients With Advanced or Metastatic Non-Small Cell Lung Cancer Treated With Cancer Immunotherapy and Its Impact on Quality of Clinical Care: Interview and Survey Study Among Health Care Professionals and Patients

Author

Schmalz, Oliver, Jacob, Christine, Ammann, Johannes, Liss, Blasius, Iivanainen, Sanna, Kammermann, Manuel, Koivunen, Jussi, Klein, Alexander, and Popescu, Razvan Andrei

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundCancer immunotherapy (CIT), as a monotherapy or in combination with chemotherapy, has been shown to extend overall survival in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). However, patients experience treatment-related symptoms that they are required to recall between hospital visits. Digital patient monitoring and management (DPMM) tools may improve clinical practice by allowing real-time symptom reporting. ObjectiveThis proof-of-concept pilot study assessed patient and health care professional (HCP) adoption of our DPMM tool, which was designed specifically for patients with advanced or metastatic NSCLC treated with CIT, and the tool’s impact on clinical care. MethodsFour advisory boards were assembled in order to co-develop a drug- and indication-specific CIT (CIT+) module, based on a generic CIT DPMM tool from Kaiku Health, Helsinki, Finland. A total of 45 patients treated with second-line single-agent CIT (ie, atezolizumab or otherwise) for advanced or metastatic NSCLC, as well as HCPs, whose exact number was decided by the clinics, were recruited from 10 clinics in Germany, Finland, and Switzerland between February and May 2019. All clinics were provided with the Kaiku Health generic CIT DPMM tool, including our CIT+ module. Data on user experience, overall satisfaction, and impact of the tool on clinical practice were collected using anonymized surveys—answers ranged from 1 (low agreement) to 5 (high agreement)—and HCP interviews; surveys and interviews consisted of closed-ended Likert scales and open-ended questions, respectively. The first survey was conducted after 2 months of DPMM use, and a second survey and HCP interviews were conducted at study end (ie, after ≥3 months of DPMM use); only a subgroup of HCPs from each clinic responded to the surveys and interviews. Survey data were analyzed quantitatively; interviews were recorded, transcribed verbatim, and translated into English, where applicable, for coding and qualitative thematic analysis. ResultsAmong interim survey respondents (N=51: 13 [25%] nurses, 11 [22%] physicians, and 27 [53%] patients), mean rankings of the tool’s seven usability attributes ranged from 3.2 to 4.4 (nurses), 3.7 to 4.5 (physicians), and 3.7 to 4.2 (patients). At the end-of-study survey (N=48: 19 [40%] nurses, 8 [17%] physicians, and 21 [44%] patients), most respondents agreed that the tool facilitated more efficient and focused discussions between patients and HCPs (nurses and patients: mean rating 4.2, SD 0.8; physicians: mean rating 4.4, SD 0.8) and allowed HCPs to tailor discussions with patients (mean rating 4.35, SD 0.65). The standalone tool was well integrated into HCP daily clinical workflow (mean rating 3.80, SD 0.75), enabled workflow optimization between physicians and nurses (mean rating 3.75, SD 0.80), and saved time by decreasing phone consultations (mean rating 3.75, SD 1.00) and patient visits (mean rating 3.45, SD 1.20). Workload was the most common challenge of tool use among respondents (12/19, 63%). ConclusionsOur results demonstrate high user satisfaction and acceptance of DPMM tools by HCPs and patients, and highlight the improvements to clinical care in patients with advanced or metastatic NSCLC treated with CIT monotherapy. However, further integration of the tool into the clinical information technology data flow is required. Future studies or registries using our DPMM tool may provide insights into significant effects on patient quality of life or health-economic benefits.

Published
2020
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49. The H1 detector at HERA

Author

Abt, I., primary, Ahmed, T., additional, Aid, S., additional, Andreev, V., additional, Andrieu, B., additional, Appuhn, R.D., additional, Arnault, C., additional, Arpagaus, M., additional, Babaev, A., additional, Bärwolff, H., additional, Bán, J., additional, Banas, E., additional, Baranov, P., additional, Barrelet, E., additional, Bartel, W., additional, Barth, M., additional, Bassler, U., additional, Basti, F., additional, Baynham, D.E., additional, Baze, J.-M., additional, Beck, G.A., additional, Beck, H.P., additional, Bederede, D., additional, Behrend, H.-J., additional, Beigbeder, C., additional, Belousov, A., additional, Berger, Ch., additional, Bergstein, H., additional, Bernard, R., additional, Bernardi, G., additional, Bernet, R., additional, Bernier, R., additional, Berthon, U., additional, Bertrand-Coremans, G., additional, Besançon, M., additional, Beyer, R., additional, Biasci, J.-C., additional, Biddulph, P., additional, Bidoli, V., additional, Binder, E., additional, Binko, P., additional, Bizot, J.-C., additional, Blobel, V., additional, Blouzon, F., additional, Blume, H., additional, Borras, K., additional, Boudry, V., additional, Bourdarios, C., additional, Brasse, F., additional, Braunschweig, W., additional, Breton, D., additional, Brettel, H., additional, Brisson, V., additional, Bruncko, D., additional, Brune, C., additional, Buchner, U., additional, Büngener, L., additional, Bürger, J., additional, Büsser, F.W., additional, Buniatian, A., additional, Burke, S., additional, Burmeister, P., additional, Busata, A., additional, Buschhorn, G., additional, Campbell, A.J., additional, Carli, T., additional, Charles, F., additional, Charlet, M., additional, Chase, R., additional, Clarke, D., additional, Clegg, A.B., additional, Colombo, M., additional, Commichau, V., additional, Connolly, J.F., additional, Cornett, U., additional, Coughlan, J.A., additional, Courau, A., additional, Cousinou, M.-C., additional, Coutures, Ch., additional, Coville, A., additional, Cozzika, G., additional, Cragg, D.A., additional, Criegee, L., additional, Cronström, H.I., additional, Cunliffe, N.H., additional, Cvach, J., additional, Cyz, A., additional, Dagoret, S., additional, Dainton, J.B., additional, Danilov, M., additional, Dann, A.W.E., additional, Darvill, D., additional, Dau, W.D., additional, David, J., additional, David, M., additional, Day, R.J., additional, Deffur, E., additional, Delcourt, B., additional, Del Buono, L., additional, Descamps, F., additional, Devel, M., additional, Dewulf, J.P., additional, De Roeck, A., additional, Dingus, P., additional, Djidi, K., additional, Dollfus, C., additional, Dowell, J.D., additional, Dreis, H.B., additional, Drescher, A., additional, Dretzler, U., additional, Duboc, J., additional, Ducorps, A., additional, Düllmann, D., additional, Dünger, O., additional, Duhm, H., additional, Dulny, B., additional, Dupont, F., additional, Ebbinghaus, R., additional, Eberle, M., additional, Ebert, J., additional, Ebert, T.R., additional, Eckerlin, G., additional, Edwards, B.W.H., additional, Efremenko, V., additional, Egli, S., additional, Eichenberger, S., additional, Eichler, R., additional, Eisele, F., additional, Eisenhandler, E., additional, Ellis, N.N., additional, Ellison, R.J., additional, Elsen, E., additional, Epifantsev, A., additional, Erdmann, M., additional, Erdmann, W., additional, Ernst, G., additional, Evrard, E., additional, Falley, G., additional, Favart, L., additional, Fedotov, A., additional, Feeken, D., additional, Felst, R., additional, Feltesse, J., additional, Feng, Z.Y., additional, Fensome, I.F., additional, Fent, J., additional, Ferencei, J., additional, Ferrarotto, F., additional, Finke, K., additional, Flamm, K., additional, Flauger, W., additional, Fleischer, M., additional, Flieser, M., additional, Flower, P.S., additional, Flügge, G., additional, Fomenko, A., additional, Fominykh, B., additional, Forbush, M., additional, Formánek, J., additional, Foster, J.M., additional, Franke, G., additional, Fretwurst, E., additional, Fröchtenicht, W., additional, Fuhrmann, P., additional, Gabathuler, E., additional, Gabathuler, K., additional, Gadow, K., additional, Gamerdinger, K., additional, Garvey, J., additional, Gayler, J., additional, Gažo, E., additional, Gellrich, A., additional, Gennis, M., additional, Gensch, U., additional, Genzel, H., additional, Gerhards, R., additional, Geske, K., additional, Giesgen, I., additional, Gillespie, D., additional, Glasgow, W., additional, Godfrey, L., additional, Godlewski, J., additional, Goerlach, U., additional, Goerlich, L., additional, Gogitidze, N., additional, Goldberg, M., additional, Goodall, A.M., additional, Gorelov, I., additional, Goritchev, P., additional, Gosset, L., additional, Grab, C., additional, Grässler, H., additional, Grässler, R., additional, Greenshaw, T., additional, Gregory, C., additional, Greif, H., additional, Grewe, M., additional, Grindhammer, G., additional, Gruber, A., additional, Gruber, C., additional, Günther, S., additional, Haack, J., additional, Haguenauer, M., additional, Haidt, D., additional, Hajduk, L., additional, Hammer, D., additional, Hamon, O., additional, Hampel, M., additional, Handschuh, D., additional, Hangarter, K., additional, Hanlon, E.M., additional, Hapke, M., additional, Harder, U., additional, Harjes, J., additional, Hartz, P., additional, Hatton, P.E., additional, Haydar, R., additional, Haynes, W.J., additional, Heatherington, J., additional, Hedberg, V., additional, Hedgecock, C.R., additional, Heinzelmann, G., additional, Henderson, R.C.W., additional, Henschel, H., additional, Herma, R., additional, Herynek, I., additional, Hildesheim, W., additional, Hill, P., additional, Hill, D.L., additional, Hilton, C.D., additional, Hladký, J., additional, Hoeger, K.C., additional, Hopes, R.B., additional, Horisberger, R., additional, Hrisoho, A., additional, Huber, J., additional, Huet, Ph., additional, Hufnagel, H., additional, Huot, N., additional, Huppert, J.-F., additional, Ibbotson, M., additional, Imbault, D., additional, Itterbeck, H., additional, Jabiol, M.-A., additional, Jacholkowska, A., additional, Jacobsson, C., additional, Jaffré, M., additional, Jansen, T., additional, Jean, P., additional, Jeanjean, J., additional, Jönsson, L., additional, Johannsen, K., additional, Johnson, D.P., additional, Johnson, L., additional, Jovanovic, P., additional, Jung, H., additional, Kalmus, P.I.P., additional, Kant, D., additional, Kantel, G., additional, Karstensen, S., additional, Kasarian, S., additional, Kaschowitz, R., additional, Kasselmann, P., additional, Kathage, U., additional, Kaufmann, H.H., additional, Kemmerling, G., additional, Kenyon, I.R., additional, Kermiche, S., additional, Keuker, C., additional, Kiesling, C., additional, Klein, M., additional, Kleinwort, C., additional, Knies, G., additional, Ko, W., additional, Kobler, T., additional, Koch, J., additional, Köhler, T., additional, Köhne, J., additional, Kolander, M., additional, Kolanoski, H., additional, Kole, F., additional, Koll, J., additional, Kolya, S.D., additional, Koppitz, B., additional, Korbel, V., additional, Korn, M., additional, Kostka, P., additional, Kotelnikov, S.K., additional, Krasny, M.W., additional, Krehbiel, H., additional, Krivan, F., additional, Krücker, D., additional, Krüger, U., additional, Krüner-Marquis, U., additional, Kubantsev, M., additional, Kubenka, J.P., additional, Külper, T., additional, Küsel, H.-J., additional, Küster, H., additional, Kuhlen, M., additional, Kurča, T., additional, Kurzhöfer, J., additional, Kuznik, B., additional, Laforge, B., additional, Lamarche, F., additional, Lander, R., additional, Landon, M.P.J., additional, Lange, W., additional, Langkau, R., additional, Lanius, P., additional, Laporte, J.-F., additional, Laptin, L., additional, Laskus, H., additional, Lebedev, A., additional, Lemler, M., additional, Lenhardt, U., additional, Leuschner, A., additional, Leverenz, C., additional, Levonian, S., additional, Lewin, D., additional, Ley, Ch., additional, Lindner, A., additional, Lindström, G., additional, Linsel, F., additional, Lipinski, J., additional, Liss, B., additional, Loch, P., additional, Lodge, A.B., additional, Lohmander, H., additional, Lopez, G.C., additional, Lottin, J.-P., additional, Lubimov, V., additional, Ludwig, K., additional, Lüers, D., additional, Lugetski, N., additional, Lundberg, B., additional, Maeshima, K., additional, Magnussen, N., additional, Malinovski, E., additional, Mani, S., additional, Marage, P., additional, Marks, J., additional, Marshall, R., additional, Martens, J., additional, Martin, F., additional, Martin, G., additional, Martin, R., additional, Martyn, H.-U., additional, Martyniak, J., additional, Masbender, V., additional, Masson, S., additional, Mavroidis, A., additional, Maxfield, S.J., additional, McMahon, S.J., additional, Mehta, A., additional, Meier, K., additional, Meissner, J., additional, Mercer, D., additional, Merz, T., additional, Meyer, C.A., additional, Meyer, H., additional, Meyer, J., additional, Mikocki, S., additional, Mills, J.L., additional, Milone, V., additional, Möck, J., additional, Monnier, E., additional, Montés, B., additional, Moreau, F., additional, Moreels, J., additional, Morgan, B., additional, Morris, J.V., additional, Morton, J.M., additional, Müller, K., additional, Murín, P., additional, Murray, S.A., additional, Nagovizin, V., additional, Naroska, B., additional, Naumann, Th., additional, Nayman, P., additional, Nepeipivo, A., additional, Newman, P., additional, Newman-Coburn, D., additional, Newton, D., additional, Neyret, D., additional, Nguyen, H.K., additional, Niebergall, F., additional, Niebuhr, C., additional, Nisius, R., additional, Novák, T., additional, Nováková, H., additional, Nowak, G., additional, Noyes, G.W., additional, Nyberg, M., additional, Oberlack, H., additional, Obrock, U., additional, Olsson, J.E., additional, Olszowska, J., additional, Orenstein, S., additional, Ould-Saada, F., additional, Pailler, P., additional, Palanque, S., additional, Panaro, E., additional, Panitch, A., additional, Parey, J.-Y., additional, Pascaud, C., additional, Patel, G.D., additional, Patoux, A., additional, Paulot, C., additional, Pein, U., additional, Peppel, E., additional, Perez, E., additional, Perrodo, P., additional, Perus, A., additional, Peters, S., additional, Pharabod, J.-P., additional, Phillips, H.T., additional, Phillips, J.P., additional, Pichler, Ch., additional, Pieuchot, A., additional, Pimpl, W., additional, Pitzl, D., additional, Porrovecchio, A., additional, Prell, S., additional, Prosi, R., additional, Quehl, H., additional, Rädel, G., additional, Raupach, F., additional, Rauschnabel, K., additional, Reboux, A., additional, Reimer, P., additional, Reinmuth, G., additional, Reinshagen, S., additional, Ribarics, P., additional, Riech, V., additional, Riedlberger, J., additional, Riege, H., additional, Riess, S., additional, Rietz, M., additional, Robertson, S.M., additional, Robmann, P., additional, Röpnack, P., additional, Roosen, R., additional, Rosenbauer, K., additional, Rostovtsev, A., additional, Royon, C., additional, Rudge, A., additional, Rüter, K., additional, Rudowicz, M., additional, Ruffer, M., additional, Rusakov, S., additional, Rusinov, V., additional, Rybicki, K., additional, Sacton, J., additional, Sahlmann, N., additional, Sanchez, E., additional, Sankey, D.P.C., additional, Savitski, M., additional, Schacht, P., additional, Schiek, S., additional, Schirm, N., additional, Schleif, S., additional, Schleper, P., additional, von Schlippe, W., additional, Schmidt, C., additional, Schmidt, D., additional, Schmidt, G., additional, Schmitz, W., additional, Schmücker, H., additional, Schröder, V., additional, Schütt, J., additional, Schuhmann, E., additional, Schulz, M., additional, Schwind, A., additional, Scobel, W., additional, Seehausen, U., additional, Sefkow, F., additional, Sell, R., additional, Seman, M., additional, Semenov, A., additional, Shatalov, P., additional, Shekelyan, V., additional, Sheviakov, I., additional, Shooshtari, H., additional, Shtarkov, L.N., additional, Siegmon, G., additional, Siewert, U., additional, Sirois, Y., additional, Sirous, A., additional, Skillicorn, I.O., additional, Škvařil, P., additional, Smirnov, P., additional, Smith, J.R., additional, Smolik, L., additional, Sole, D., additional, Soloviev, Y., additional, Špalek, J., additional, Spitzer, H., additional, von Staa, R., additional, Staeck, J., additional, Staroba, P., additional, Šťastný, J., additional, Steenbock, M., additional, Štefan, P., additional, Steffen, P., additional, Steinberg, R., additional, Steiner, H., additional, Stella, B., additional, Stephens, K., additional, Stier, J., additional, Stiewe, J., additional, Stösslein, U., additional, Strachota, J., additional, Straumann, U., additional, Strowbridge, A., additional, Struczinski, W., additional, Sutton, J.P., additional, Szkutnik, Z., additional, Tappern, G., additional, Tapprogge, S., additional, Taylor, R.E., additional, Tchernyshov, V., additional, Tchudakov, V., additional, Thiebaux, C., additional, Thiele, K., additional, Thompson, G., additional, Thompson, R.J., additional, Tichomirov, I., additional, Trenkel, C., additional, Tribanek, W., additional, Tröger, K., additional, Truöl, P., additional, Turiot, M., additional, Turnau, J., additional, Tutas, J., additional, Urban, L., additional, Urban, M., additional, Usik, A., additional, Valkár, Š., additional, Valkárová, A., additional, Vallée, C., additional, Van Beek, G., additional, Vanderkelen, M., additional, Van Lancker, L., additional, Van Mechelen, P., additional, Vartapetian, A., additional, Vazdik, Y., additional, Vecko, M., additional, Verrecchia, P., additional, Vick, R., additional, Villet, G., additional, Vogel, E., additional, Wacker, K., additional, Wagener, M., additional, Walker, I.W., additional, Walther, A., additional, Weber, G., additional, Wegener, D., additional, Wegner, A., additional, Weissbach, P., additional, Wellisch, H.P., additional, West, L., additional, White, D., additional, Willard, S., additional, Winde, M., additional, Winter, G.-G., additional, Wolff, Th., additional, Womersley, L.A., additional, Wright, A.E., additional, Wünsch, E., additional, Wulff, N., additional, Wyborn, B.E., additional, Yiou, T.P., additional, Žáček, J., additional, Zarbock, D., additional, Závada, P., additional, Zeitnitz, C., additional, Zhang, Z., additional, Ziaeepour, H., additional, Zimmer, M., additional, Zimmermann, W., additional, Zomer, F., additional, and Zuber, K., additional

Published
1997
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50. The tracking, calorimeter and muon detectors of the H1 experiment at HERA

Author

Abt, I., primary, Ahmed, T., additional, Aid, S., additional, Andreev, V., additional, Andrieu, B., additional, Appuhn, R.-D., additional, Arnault, C., additional, Arpagaus, M., additional, Babaev, A., additional, Bärwolff, H., additional, Bán, J., additional, Banas, E., additional, Baranov, P., additional, Barrelet, E., additional, Bartel, W., additional, Barth, M., additional, Bassler, U., additional, Basti, F., additional, Baynham, D.E., additional, Baze, J.-M., additional, Beck, G.A., additional, Beck, H.P., additional, Bederede, D., additional, Behrend, H.-J., additional, Beigbeder, C., additional, Belousov, A., additional, Berger, Ch., additional, Bergstein, H., additional, Bernard, R., additional, Bernardi, G., additional, Bernet, R., additional, Bernier, R., additional, Berthon, U., additional, Bertrand-Coremans, G., additional, Besançon, M., additional, Beyer, R., additional, Biasci, J.-C., additional, Biddulph, P., additional, Bidoli, V., additional, Binder, E., additional, Binko, P., additional, Bizot, J.-C., additional, Blobel, V., additional, Blouzon, F., additional, Blume, H., additional, Borras, K., additional, Boudry, V., additional, Bourdarios, C., additional, Brasse, F., additional, Braunschweig, W., additional, Breton, D., additional, Brettel, H., additional, Brisson, V., additional, Bruncko, D., additional, Brune, C., additional, Buchner, U., additional, Büngener, L., additional, Bürger, J., additional, Büsser, F.W., additional, Buniatian, A., additional, Burke, S., additional, Burmeister, P., additional, Busata, A., additional, Buschhorn, G., additional, Campbell, A.J., additional, Carli, T., additional, Charles, F., additional, Charlet, M., additional, Chase, R., additional, Clarke, D., additional, Clegg, A.B., additional, Colombo, M., additional, Commichau, V., additional, Connolly, J.F., additional, Cornett, U., additional, Coughlan, J.A., additional, Courau, A., additional, Cousinou, M.-C., additional, Coutures, Ch., additional, Coville, A., additional, Cozzika, G., additional, Cragg, D.A., additional, Criegee, L., additional, Cronström, H.I., additional, Cunliffe, N.H., additional, Cvach, J., additional, Cyz, A., additional, Dagoret, S., additional, Dainton, J.B., additional, Danilov, M., additional, Dann, A.W.E., additional, Darvill, D., additional, Dau, W.D., additional, David, J., additional, David, M., additional, Day, R.J., additional, Deffur, E., additional, Delcourt, B., additional, Del Buono, L., additional, Descamps, F., additional, Devel, M., additional, Dewulf, J.P., additional, De Roeck, A., additional, Dingus, P., additional, Djiki, K., additional, Dollfus, C., additional, Dowell, J.D., additional, Dreis, H.B., additional, Drescher, A., additional, Dretzler, U., additional, Duboc, J., additional, Ducorps, A., additional, Düllmann, D., additional, Dünger, O., additional, Duhm, H., additional, Dulny, B., additional, Dupont, F., additional, Ebbinghaus, R., additional, Eberle, M., additional, Ebert, J., additional, Ebert, T.R., additional, Eckerlin, G., additional, Edwards, B.W.H., additional, Efremenko, V., additional, Egli, S., additional, Eichenberger, S., additional, Eichler, R., additional, Eisele, F., additional, Eisenhandler, E., additional, Ellis, N.N., additional, Ellison, R.J., additional, Elsen, E., additional, Epifantsev, A., additional, Erdmann, M., additional, Erdmann, W., additional, Ernst, G., additional, Evrard, E., additional, Falley, G., additional, Favart, L., additional, Fedotov, A., additional, Feeken, D., additional, Felst, R., additional, Feltesse, J., additional, Feng, Z.Y., additional, Fensome, I.F., additional, Fent, J., additional, Ferencei, J., additional, Ferrarotto, F., additional, Finke, K., additional, Flamm, K., additional, Flauger, W., additional, Fleischer, M., additional, Flieser, M., additional, Flower, P.S., additional, Flügge, G., additional, Fomenko, A., additional, Fominykh, B., additional, Forbush, M., additional, Formánek, J., additional, Foster, J.M., additional, Franke, G., additional, Fretwurst, E., additional, Fröchtenicht, W., additional, Fuhrmann, P., additional, Gabathuler, E., additional, Gabathuler, K., additional, Gadow, K., additional, Gamerdinger, K., additional, Garvey, J., additional, Gayler, J., additional, Gažo, E., additional, Gellrich, A., additional, Gennis, M., additional, Gensch, U., additional, Genzel, H., additional, Gerhards, R., additional, Geske, K., additional, Giesgen, I., additional, Gillespie, D., additional, Glasgow, W., additional, Godfrey, L., additional, Godlewski, J., additional, Goerlach, U., additional, Goerlich, L., additional, Gogitidze, N., additional, Goldberg, M., additional, Goodall, A.M., additional, Gorelov, I., additional, Goritchev, P., additional, Gosset, L., additional, Grab, C., additional, Grässler, H., additional, Grässler, R., additional, Greenshaw, T., additional, Gregory, C., additional, Greif, H., additional, Grewe, M., additional, Grindhammer, G., additional, Gruber, A., additional, Gruber, C., additional, Günther, S., additional, Haack, J., additional, Haguenauer, M., additional, Haidt, D., additional, Hajduk, L., additional, Hammer, D., additional, Hamon, O., additional, Hampel, M., additional, Handschuh, D., additional, Hangarter, K., additional, Hanlon, E.M., additional, Hapke, M., additional, Harder, U., additional, Harjes, J., additional, Hartz, P., additional, Hatton, P.E., additional, Haydar, R., additional, Haynes, W.J., additional, Heatherington, J., additional, Hedberg, V., additional, Hedgecock, C.R., additional, Heinzelmann, G., additional, Henderson, R.C.W., additional, Henschel, H., additional, Herma, R., additional, Herynek, I., additional, Hildesheim, W., additional, Hill, P., additional, Hill, D.L., additional, Hilton, C.D., additional, Hladký, J., additional, Hoeger, K.C., additional, Hopes, R.B., additional, Horisberger, R., additional, Hrisoho, A., additional, Huber, J., additional, Huet, Ph., additional, Hufnagel, H., additional, Huot, N., additional, Huppert, J.-F., additional, Ibbotson, M., additional, Imbault, D., additional, Itterbeck, H., additional, Jabiol, M.-A., additional, Jacholkowska, A., additional, Jacobsson, C., additional, Jaffré, M., additional, Janoth, J., additional, Jansen, T., additional, Jean, P., additional, Jeanjean, J., additional, Jönsson, L., additional, Johannsen, K., additional, Johnson, D.P., additional, Johnson, L., additional, Jovanovic, P., additional, Jung, H., additional, Kalmus, P.I.P., additional, Kant, D., additional, Kantel, G., additional, Karstensen, S., additional, Kasarian, S., additional, Kaschowitz, R., additional, Kasselmann, P., additional, Kathage, U., additional, Kaufmann, H.H., additional, Kemmerling, G., additional, Kenyon, I.R., additional, Kermiche, S., additional, Keuker, C., additional, Kiesling, C., additional, Klein, M., additional, Kleinwort, C., additional, Knies, G., additional, Ko, W., additional, Kobler, T., additional, Koch, J., additional, Köhler, T., additional, Köhne, J., additional, Kolander, M., additional, Kolanoski, H., additional, Kole, F., additional, Koll, J., additional, Kolya, S.D., additional, Koppitz, B., additional, Korbel, V., additional, Korn, M., additional, Kostka, P., additional, Kotelnikov, S.K., additional, Krasny, M.W., additional, Krehbiel, H., additional, Krivan, F., additional, Krücker, D., additional, Krüger, U., additional, Krüner-Marquis, U., additional, Kubantsev, M., additional, Kubenka, J.P., additional, Külper, T., additional, Küsel, H.-J., additional, Küster, H., additional, Kuhlen, M., additional, Kurča, T., additional, Kurzhöfer, J., additional, Kuznik, B., additional, Laforge, B., additional, Lamarche, F., additional, Lander, R., additional, Landon, M.P.J., additional, Lange, W., additional, Langkau, R., additional, Lanius, P., additional, Laporte, J.-F., additional, Laptin, L., additional, Laskus, H., additional, Lebedev, A., additional, Lemler, M., additional, Lenhardt, U., additional, Leuschner, A., additional, Leverenz, C., additional, Levonian, S., additional, Lewin, D., additional, Ley, Ch., additional, Lindner, A., additional, Lindström, G., additional, Linsel, F., additional, Lipinski, J., additional, Liss, B., additional, Loch, P., additional, Lodge, A.B., additional, Lohmander, H., additional, Lopez, G.C., additional, Lottin, J.-P., additional, Lubimov, V., additional, Ludwig, K., additional, Lüers, D., additional, Lugetski, N., additional, Lundberg, B., additional, Maeshima, K., additional, Magnussen, N., additional, Malinovski, E., additional, Mani, S., additional, Marage, P., additional, Marks, J., additional, Marshall, R., additional, Martens, J., additional, Martin, F., additional, Martin, G., additional, Martin, R., additional, Martyn, H.-U., additional, Martyniak, J., additional, Masbender, V., additional, Masson, S., additional, Mavroidis, A., additional, Maxfield, S.J., additional, McMahon, S.J., additional, Mehta, A., additional, Meier, K., additional, Meissner, J., additional, Mercer, D., additional, Merz, T., additional, Meyer, C.A., additional, Meyer, H., additional, Meyer, J., additional, Mikocki, S., additional, Mills, J.L., additional, Milone, V., additional, Möck, J., additional, Monnier, E., additional, Montés, B., additional, Moreau, F., additional, Moreels, J., additional, Morgan, B., additional, Morris, J.V., additional, Morton, J.M., additional, Müller, K., additional, Murín, P., additional, Murray, S.A., additional, Nagovizin, V., additional, Naroska, B., additional, Naumann, Th., additional, Nayman, P., additional, Nepeipivo, A., additional, Newman, P., additional, Newman-Coburn, D., additional, Newton, D., additional, Neyret, D., additional, Nguyen, H.K., additional, Niebergall, F., additional, Niebuhr, C., additional, Nisius, R., additional, Novák, T., additional, Nováková, H., additional, Nowak, G., additional, Noyes, G.W., additional, Nyberg, M., additional, Oberlack, H., additional, Obrock, U., additional, Olsson, J.E., additional, Olszowska, J., additional, Orenstein, S., additional, Ould-Saada, F., additional, Pailler, P., additional, Palanque, S., additional, Panaro, E., additional, Panitch, A., additional, Parey, J.-Y., additional, Pascaud, C., additional, Patel, G.D., additional, Patoux, A., additional, Paulot, C., additional, Pein, U., additional, Peppel, E., additional, Perez, E., additional, Perrodo, P., additional, Perus, A., additional, Peters, S., additional, Pharabod, J.-P., additional, Phillips, H.T., additional, Phillips, J.P., additional, Pichler, Ch., additional, Pieuchot, A., additional, Pimpl, W., additional, Pitzl, D., additional, Porrovecchio, A., additional, Prell, S., additional, Prosi, R., additional, Quehl, H., additional, Rädel, G., additional, Raupach, F., additional, Rauschnabel, K., additional, Reboux, A., additional, Reimer, P., additional, Reinmuth, G., additional, Reinshagen, S., additional, Ribarics, P., additional, Riech, V., additional, 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additional, Seehausen, U., additional, Sefkow, F., additional, Sell, R., additional, Seman, M., additional, Semenov, A., additional, Shatalov, P., additional, Shekelyan, V., additional, Sheviakov, I., additional, Shooshtari, H., additional, Shtarkov, L.N., additional, Siegmon, G., additional, Siewert, U., additional, Sirois, Y., additional, Sirous, A., additional, Skillicorn, I.O., additional, Škvařil, P., additional, Smirnov, P., additional, Smith, J.R., additional, Smolik, L., additional, Sole, D., additional, Soloviev, Y., additional, Špalek, J., additional, Spitzer, H., additional, von Staa, R., additional, Staeck, J., additional, Staroba, P., additional, Šťastný, J., additional, Steenbock, M., additional, Štefan, P., additional, Steffen, P., additional, Steinberg, R., additional, Steiner, H., additional, Stella, B., additional, Stephens, K., additional, Stier, J., additional, Stiewe, J., additional, Stösslein, U., additional, Strachota, J., additional, Straumann, U., additional, 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Wagener, M., additional, Walker, I.W., additional, Walther, A., additional, Weber, G., additional, Wegener, D., additional, Wegner, A., additional, Weissbach, P., additional, Wellisch, H.P., additional, West, L., additional, White, D., additional, Willard, S., additional, Winde, M., additional, Winter, G.-G., additional, Wolff, Th., additional, Womersley, L.A., additional, Wright, A.E., additional, Wünsch, E., additional, Wulff, N., additional, Wyborn, B.E., additional, Yiou, T.P., additional, Žáček, J., additional, Zarbock, D., additional, Závada, P., additional, Zeitnitz, C., additional, Zhang, Z., additional, Ziaeepour, H., additional, Zimmer, M., additional, Zimmermann, W., additional, Zomer, F., additional, and Zuber, K., additional

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1997
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