Search

Your search keyword '"Lisitskiy, Vladimir A."' showing total 7 results
Start Over Author "Lisitskiy, Vladimir A."
7 results on '"Lisitskiy, Vladimir A."'

1. Homocystamide Conjugates of Human Serum Albumin as a Platform to Prepare Bimodal Multidrug Delivery Systems for Boron Neutron Capture Therapy

Author

Popova, Tatyana, primary, Dymova, Maya A., additional, Koroleva, Ludmila S., additional, Zakharova, Olga D., additional, Lisitskiy, Vladimir A., additional, Raskolupova, Valeria I., additional, Sycheva, Tatiana, additional, Taskaev, Sergei, additional, Silnikov, Vladimir N., additional, and Godovikova, Tatyana S., additional

Published
2021
Full Text
View/download PDF

3. Protein modification by thiolactone homocysteine chemistry: a multifunctionalized human serum albumin theranostic

Author

Popova, Tatyana V., primary, Krumkacheva, Olesya A., additional, Burmakova, Anna S., additional, Spitsyna, Anna S., additional, Zakharova, Olga D., additional, Lisitskiy, Vladimir A., additional, Kirilyuk, Igor A., additional, Silnikov, Vladimir N., additional, Bowman, Michael K., additional, Bagryanskaya, Elena G., additional, and Godovikova, Tatyana S., additional

Published
2020
Full Text
View/download PDF

5. Protein modification by thiolactone homocysteine chemistry: a multifunctionalized human serum albumin theranosticElectronic supplementary information (ESI) available: Spectroscopic materials and methods, additional spectra (UV-vis absorption, fluorescence, NMR), preparation of HSA modified by sulfo-Cy5 dye (HSA-Cy5), size exclusion chromatography (SEC), and in vitrocytotoxicity assay. See DOI: 10.1039/c9md00516a

Author

Popova, Tatyana V., Krumkacheva, Olesya A., Burmakova, Anna S., Spitsyna, Anna S., Zakharova, Olga D., Lisitskiy, Vladimir A., Kirilyuk, Igor A., Silnikov, Vladimir N., Bowman, Michael K., Bagryanskaya, Elena G., and Godovikova, Tatyana S.

Abstract

As the most abundant protein with a variety of physiological functions, albumin has been used extensively for the delivery of therapeutic molecules. Thiolactone chemistry provides a powerful tool to prepare spin-labeled albumin-based multimodal imaging probes and therapeutic agents. We report the synthesis of a tamoxifen homocysteine thiolactone derivative and its use in thiol-‘click’ chemistry to prepare multi-functionalized serum albumin. The released sulfhydryl group of the homocysteine functional handle was labeled with a nitroxide reagent to prepare a spin-labeled albumin–tamoxifen conjugate confirmed by MALDI-TOF-MS, EPR spectroscopy, UV-vis and fluorescent emission spectra. This is the basis for a novel multimodal tamoxifen–albumin theranostic with a significant (dose-dependent) inhibitory effect on the proliferation of malignant cells. The response of human glioblastoma multiforme T98G cells and breast cancer MCF-7 cells to tamoxifen and its albumin conjugates was different in tumor cells with different expression level of ERα in our experiments. These results provide further impetus to develop a serum protein for delivery of tamoxifen to cancer cells.

Published
2020
Full Text
View/download PDF

6. Ligand-Directed Acid-Sensitive Amidophosphate 5-Trifluoromethyl-2′-Deoxyuridine Conjugate as a Potential Theranostic Agent

Author

Godovikova, Tatyana S., primary, Lisitskiy, Vladimir A., additional, Antonova, Natalya M., additional, Popova, Tatyana V., additional, Zakharova, Olga D., additional, Chubarov, Alexey S., additional, Koptyug, Igor V., additional, Sagdeev, Renad Z., additional, Kaptein, Robert, additional, Akulov, Andrey E., additional, Kaledin, Vassily I., additional, Nikolin, Valeriy P., additional, Baiborodin, Sergei I., additional, Koroleva, Ludmila S., additional, and Silnikov, Vladimir N., additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results