34 results on '"Lishmanov, Y B"'
Search Results
2. Effect of Chronic Continuous Normobaric Hypoxia on Functional State of Cardiac Mitochondria and Tolerance of Isolated Rat Heart to Ischemia and Reperfusion: Role of μ and δ2 Opioid Receptors.
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PROKUDINA, E. S., NARYZHNAYA, N. V., MUKHOMEDZYANOV, A. V., GORBUNOV, A. S., ZHANG, Y., JAGGI, A. S., TSIBULNIKOV, S. Y., NESTEROV, E. A., LISHMANOV, Y. B., SULEIMAN, M. S., OELTGEN, P. R., and MASLOV, L. N.
- Subjects
OPIOID receptors ,MYOCARDIAL reperfusion ,REPERFUSION ,RESPIRATION ,MEMBRANE potential ,MITOCHONDRIA ,ISCHEMIA - Abstract
Chronic continuous normobaric hypoxia (CNH) increases cardiac tolerance to ischemia/reperfusion injury in vivo and this effect is mediated via µ and δ
2 opioid receptors (ORs) activation. CNH has also been shown to be cardioprotective in isolated rat heart. In this study, we hypothesize that this cardioprotective effect of CNH is mediated by activation of µ and δ2 ORs and preservation of mitochondrial function. Hearts from rats adapted to CNH (12% oxygen) for 3 weeks were extracted, perfused in the Langendorff mode and subjected to 45 min of global ischemia and 30 min of reperfusion. Intervention groups were pretreated for 10 min with antagonists for different OR types: naloxone (300 nmol/l), the selective d OR antagonist TIPP(ψ) (30 nmol/l), the selective d1 OR antagonist BNTX (1 nmol/l), the selective δ2 OR antagonist naltriben (1 nmol/l), the selective peptide µ OR antagonist CTAP (100 nmol/l) and the selective δ OR antagonist nor-binaltorphimine (3 nmol/l). Creatine kinase activity in coronary effluent and cardiac contractile function were monitored to assess cardiac injury and functional impairment. Additionally, cardiac tissue was collected to measure ATP and to isolate mitochondria to measure respiration rate and calcium retention capacity. Adaptation to CNH decreased myocardial creatine kinase release during reperfusion and improved the postischemic recovery of contractile function. Additionally, CNH improved mitochondrial state 3 and uncoupled respiration rates, ADP/O, mitochondrial transmembrane potential and calcium retention capacity and myocardial ATP level during reperfusion compared to the normoxic group. These protective effects were completely abolished by naloxone, TIPP(ψ), naltriben, CTAP but not BNTX or nor-binaltorphimine. These results suggest that cardioprotection associated with adaptation to CNH is mediated by µ and δ2 opioid receptors activation and preservation of mitochondrial function. [ABSTRACT FROM AUTHOR]- Published
- 2019
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3. Role of protein kinase C, PI3 kinase, tyrosine kinases, NO-synthase, KATP channels and MPT pore in the signaling pathway of the cardioprotective effect of chronic continuous hypoxia
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Tsibulnikov, S. Y., primary, Maslov, L. N., additional, Naryzhnaya, N. V., additional, Ma, H., additional, Lishmanov, Y. B., additional, Oeltgen, P. R., additional, and Garlid, K., additional
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- 2018
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4. Cardioprotective Properties of Opioid Receptor Agonists in Rats With Stress-Induced Cardiac Injury.
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PROKUDINA, E. S., MASLOV, L. N., NARYZHNAYA, N. V., TSIBULNIKOV, S. YU., LISHMANOV, Y. B., MADIAS, J. E., and OELTGEN, P. R.
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OPIOID receptors ,OPIOID peptides ,IMMOBILIZATION stress ,BLOOD-brain barrier ,RATS ,BROMOMETHANE ,THIAMIN pyrophosphate - Abstract
The objectives of this study were to investigate the role of endogenous opioids in the mediation of stress-induced cardiomyopathy (SIC), and to evaluate which opioid receptors regulate heart resistance to immobilization stress. Wistar rats were subjected to 24 h immobilization stress. Stress-induced heart injury was assessed by
99m Tc-pyrophosphate accumulation in the heart. The opioid receptor (OR) antagonists (naltrexone, NxMB - naltrexone methyl bromide, MR 2266, ICI 174.864) and agonists (DALDA, DAMGO, DSLET, U-50,488) were administered intraperitoneally prior to immobilization and 12 h after the start of stress. In addition, the selective μ OR agonists PL017 and DAMGO were administered intracerebroventricularly prior to stress. Finally pretreatment with guanethidine was used. Naltrexone did not alter the cardiac99m Tc-PP accumulation in stressed rats. NxMB aggravated stress-induced cardiomyopathy (P=0.005) (SIC). The selective μ OR agonist DALDA, which does not cross the blood-brain barrier, completely prevented (P=0.006) SIC. The μ OR agonist DAMGO exhibited weaker effect than DALDA. The selective δ ligand (DSLET) and κ OR ligand (U-50,488) did not alter stress-induced99m Tc-pyrophosphate accumulation in the heart. Intracerebroventricular administration of the μ OR agonists aggravated SIC. Pretreatment with guanethidine abolished this effect (P=0.01). Guanethidine alone exhibited cardioprotective properties. A stimulation of central μ OR promotes an appearance of SIC. In contrast, stimulation of peripheral μ OR contributes to an increase in cardiac tolerance to stress. [ABSTRACT FROM AUTHOR]- Published
- 2019
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5. Participation of Opioid Receptors in the Cytoprotective Effect of Chronic Normobaric Hypoxia.
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NARYZHNAYA, N. V., KHALIULIN, I., LISHMANOV, Y. B., SAADEH SULEIMAN, M., TSIBULNIKOV, S. Y., KOLAR, F., and MASLOV, L. N.
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OPIOID receptors ,CYTOPROTECTION ,HYPOXEMIA ,LACTATE dehydrogenase ,CELL death ,RAT control - Abstract
We studied the role of the δ, μ, and к opioid receptor (OR) subtypes in the cardioprotective effect of chronic continuous normobaric hypoxia (CNH) in the model of acuteanoxia/ reoxygenation of isolated cardiomyocytes. Adaptation of rats to CNH was performed by their exposure to atmosphere containing 12 % of O2 for 21 days. Anoxia/reoxygenation of cardiomyocytes isolated from normoxic control rats caused the death of 51 % of cells and lactate dehydrogenase (LDH) release. Adaptation of rats to CNH resulted in the anoxia/reoxygenation-induced cardiomyocyte death of only 38 %, and reduced the LDH release. Pre-incubation of the cells with either the non-selective OR blocker naloxone (300 nM/l), the δ OR antagonist TIPP(Ψ (30 nM/l), the selective δ2 OR antagonist naltriben (1 nM/l) or the μ OR antagonist CTAP (100 nM/l) for 25 minutes before anoxia abolished the reduction of cell death and LDH release afforded by CNH. The antagonist of δ1 OR BNTX (1 nM/l) or the κ OR antagonist nor-binaltorphimine (3 nM/l) did not influence the cytoprotective effects of CNH. Taken together, the cytoprotective effect of CNH is associated with the activation of the δ2 and μ OR localized on cardiomyocytes. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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6. Poster Session 2 : Monday 4 May 2015, 08
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Bouyoucef, S E, Uusitalo, V, Kamperidis, V, De Graaf, M A, Maaniitty, T, Stenstrom, I, Broersen, A, Scholte, A J, Saraste, A, Bax, J J, Knuuti, J, Furuhashi, T, Moroi, M, Awaya, T, Masai, H, Minakawa, M, Kunimasa, T, Fukuda, H, Sugi, K, Berezin, A, Kremzer, A, Clerc, O F, Kaufmann, B, Possner, M, Liga, R, Vontobel, J, Mikulicic, F, Graeni, C, Benz, D C, Kaufmann, P A, Buechel, R B, Ferreira, Mjv, Cunha, M J, Albuquerque, A, Ramos, D, Costa, G, Lima, J, Pego, M, Peix, A, Cisneros, L, Cabrera, L O, Padron, K, Rodriguez, L, Heres, F, Carrillo, R, Mena, E, Fernandez, Y, Huizing, E D, Van Dijk, J D, Van Dalen, J A, Timmer, J R, Ottervanger, J P, Slump, C H, Jager, P L, Venuraju, S, Jeevarethinam, A, Yerramasu, A, Atwal, S, Mehta, V S, Lahiri, A, Arjonilla Lopez, A, Calero Rueda, M J, Gallardo, G, Fernandez-Cuadrado, J, Hernandez Aceituno, D, Sanchez Hernandez, J, Yoshida, H, Mizukami, A, Matsumura, A, Smettei, O, Abazid, R, Sayed, S, Mlynarska, A, Mlynarski, R, Golba, K, Sosnowski, M, Winther, S, Svensson, M, Jorgensen, H S, Bouchelouche, K, Gormsen, L C, Holm, N R, Botker, H E, Ivarsen, P R, Bottcher, M, Cortes, C M, Aramayo G, E N, Daicz, M, Casuscelli, J F, Alaguibe, E D, Neira Sepulveda, A, Cerda, M, Ganum, G E, Embon, M, Vigne, J, Enilorac, B, Lebasnier, A, Valancogne, L, Peyronnet, D, Manrique, A, Agostini, D, Menendez, D, Rajpal, S, Kocherla, C, Acharya, M, Reddy, P, Sazonova, I, Ilushenkova, Yun, Batalov, R E, Rogovskaya, Y V, Lishmanov, Y B, Popov, S V, Varlamova, N V, Prado Diaz, S, Jimenez Rubio, C, Gemma, D, Refoyo Salicio, E, Valbuena Lopez, S C, Moreno Yanguela, M, Torres, M, Fernandez-Velilla, M, Lopez-Sendon, J L, Guzman Martinez, G, Puente, A, Rosales, S, Martinez, C, Cabada, M, Melendez, G M, Ferreira, R, Gonzaga, A, Santos, J, Vijayan, S, Smith, Smg, Smith, M, Muthusamy, R, Takeishi, Y, Oikawa, M, Goral, J L, Napoli, J, Montana, O R, Damico, A C, Quiroz, M C, Damico, A E, Forcada, P J, Schmidberg, J M, Zucchiatti, N E, Olivieri, D B, Dumo, A, Ruano, S, Rakhit, R, Davar, J, Nair, D, Cohen, M, Darko, D, Yokota, S, Maas, Ahe, Mouden, M, Knollema, S, Sanja Mazic, S M, Lazovic, B, Marina Djelic, Mdj, Jelena Suzic Lazic, J S, Tijana Acimovic, T A, Milica Deleva, M D, Vesnina, Z H, Zafrir, N, Bental, T, Mats, I, Solodky, A, Gutstein, A, Hasid, Y, Belzer, D, Kornowski, R, Ben Said, Rim, Ben Mansour, N, Ibn Haj Amor, H, Chourabi, C, Hagui, A, Fehri, W, Hawala, H, Shugushev, Z, Patrikeev, A, Maximkin, D, Chepurnoy, A, Kallianpur, V, Mambetov, A, Dokshokov, G, Teresinska, A, Wozniak, O, Maciag, A, Wnuk, J, Dabrowski, A, Czerwiec, A, Jezierski, J, Biernacka, K, Robinson, J, Prosser, J, Cheung, Gsm, Allan, S, Mcmaster, G, Reid, S, Tarbuck, A, Martin, W, Queiroz, R C, Falcao, A, Giorgi, McP, Imada, R, Nogueira, S A, Chalela, W A, Kalil Filho, R, Meneghetti, W A, Matveev, V V, Bubyenov, A S, Podzolkov, V I, Baranovich, V, Faibushevich, A, Kolzhecova, Y, Volkova, O, Fernandez, J, Lopez, G, Dondi, M, Paez, D, Butcher, Cjt, Reyes, E, Al-Housni, M B, Green, R, Santiago, H, Ghiotto, F, Hinton-Taylor, S, Pottle, A, Mason, M, Underwood, S R, Casans Tormo, I, Diaz-Exposito, R, Plancha-Burguera, E, Elsaban, K, Alsakhri, Hijji, Yoshinaga, K, Ochi, N, Tomiyama, Y, Katoh, C, Inoue, M, Nishida, M, Suzuki, E, Manabe, O, Ito, Y M, Tamaki, N, Tahilyani, A, Jafary, Fahim, Ho Hee Hwa, H H, Ozdemir, S, Kirilmaz, B, Barutcu, A, Tan, Y Z, Celik, F, Sakgoz, S, Cabada Gamboa, M, Puente Barragan, A, Morales Vitorino, N, Medina Servin, M A, Hindorf, C, Akil, S, Hedeer, F, Jogi, J, Engblom, H, Martire, V D, Pis Diez, E R, Martire, M V, Portillo, D O, Hoff, C M, Balche, A, Majgaard, J, Tolbod, L P, Harms, H J, Soerensen, J, Froekiaer, J, Nudi, F, Neri, G, Procaccini, E, Pinto, A, Vetere, M, Biondi-Zoccai, G, Soares, J, Do Val, R, Oliveira, M A, Meneghetti, J C, Tekabe, Y, Anthony, T, Li, Q, Schmidt, A M, Johnson, L, Groenman, M, Tarkia, M, Kakela, M, Halonen, P, Kiviniemi, T, Pietila, M, Yla-Herttuala, S, Roivainen, A, Nekolla, S, Swirzek, S, Higuchi, T, Reder, S, Schachoff, S, Bschorner, M, Laitinen, I, Robinson, S, Yousefi, B, Schwaiger, M, Kero, Tanja, Lindsjo, L, Antoni, Gunnar, Westermark, P, Carlson, K, Wikstrom, G, Sörensen, Jens, Lubberink, Mark, Rouzet, F, Cognet, T, Guedj, K, Morvan, M, El Shoukr, F, Louedec, L, Choqueux, C, Nicoletti, A, Le Guludec, D, Jimenez-Heffernan, A, Munoz-Beamud, F, Sanchez De Mora, E, Borrachero, C, Salgado, C, Ramos-Font, C, Lopez-Martin, J, Hidalgo, M L, Lopez-Aguilar, R, Soriano, E, Okizaki, A, Nakayama, M, Ishitoya, S, Sato, J, Takahashi, K, Burchert, I, Caobelli, F, Wollenweber, T, Nierada, M, Fulsche, J, Dieckmann, C, Bengel, F M, Shuaib, S, Mahlum, D, Port, S, Refoyo, E, Cuesta, E, Guzman, G, Lopez, T, Valbuena, S, Del Prado, S, Moreno, M, Harbinson, M, Donnelly, L, Einstein, A J, Johnson, L L, Deluca, A J, Kontak, A C, Groves, D W, Stant, J, Pozniakoff, T, Cheng, B, Rabbani, L E, Bokhari, S, Schuetze, C, Aguade-Bruix, S, Pizzi, M N, Romero-Farina, G, Terricabras, M, Villasboas, D, Castell-Conesa, J, Candell-Riera, J, Brunner, S, Gross, L, Todica, A, Lehner, S, Di Palo, A, Niccoli Asabella, A, Magarelli, C, Notaristefano, A, Ferrari, C, Rubini, G, Sellem, A, Melki, S, Elajmi, W, Hammami, H, Ziadi, M C, Montero, J, Ameriso, J L, Villavicencio, R L, Benito Gonzalez, T F, Mayorga Bajo, A, Gutierrez Caro, R, Rodriguez Santamarta, M, Alvarez Roy, L, Martinez Paz, E, Barinaga Martin, C, Martin Fernandez, J, Alonso Rodriguez, D, Iglesias Garriz, I, Rosillo, S, Taleb, S, Cherkaoui Salhi, G, Regbaoui, Y, Ait Idir, M, Guensi, A, Martin Lopez, C E, Castano Ruiz, M, Bouyoucef, S E, Uusitalo, V, Kamperidis, V, De Graaf, M A, Maaniitty, T, Stenstrom, I, Broersen, A, Scholte, A J, Saraste, A, Bax, J J, Knuuti, J, Furuhashi, T, Moroi, M, Awaya, T, Masai, H, Minakawa, M, Kunimasa, T, Fukuda, H, Sugi, K, Berezin, A, Kremzer, A, Clerc, O F, Kaufmann, B, Possner, M, Liga, R, Vontobel, J, Mikulicic, F, Graeni, C, Benz, D C, Kaufmann, P A, Buechel, R B, Ferreira, Mjv, Cunha, M J, Albuquerque, A, Ramos, D, Costa, G, Lima, J, Pego, M, Peix, A, Cisneros, L, Cabrera, L O, Padron, K, Rodriguez, L, Heres, F, Carrillo, R, Mena, E, Fernandez, Y, Huizing, E D, Van Dijk, J D, Van Dalen, J A, Timmer, J R, Ottervanger, J P, Slump, C H, Jager, P L, Venuraju, S, Jeevarethinam, A, Yerramasu, A, Atwal, S, Mehta, V S, Lahiri, A, Arjonilla Lopez, A, Calero Rueda, M J, Gallardo, G, Fernandez-Cuadrado, J, Hernandez Aceituno, D, Sanchez Hernandez, J, Yoshida, H, Mizukami, A, Matsumura, A, Smettei, O, Abazid, R, Sayed, S, Mlynarska, A, Mlynarski, R, Golba, K, Sosnowski, M, Winther, S, Svensson, M, Jorgensen, H S, Bouchelouche, K, Gormsen, L C, Holm, N R, Botker, H E, Ivarsen, P R, Bottcher, M, Cortes, C M, Aramayo G, E N, Daicz, M, Casuscelli, J F, Alaguibe, E D, Neira Sepulveda, A, Cerda, M, Ganum, G E, Embon, M, Vigne, J, Enilorac, B, Lebasnier, A, Valancogne, L, Peyronnet, D, Manrique, A, Agostini, D, Menendez, D, Rajpal, S, Kocherla, C, Acharya, M, Reddy, P, Sazonova, I, Ilushenkova, Yun, Batalov, R E, Rogovskaya, Y V, Lishmanov, Y B, Popov, S V, Varlamova, N V, Prado Diaz, S, Jimenez Rubio, C, Gemma, D, Refoyo Salicio, E, Valbuena Lopez, S C, Moreno Yanguela, M, Torres, M, Fernandez-Velilla, M, Lopez-Sendon, J L, Guzman Martinez, G, Puente, A, Rosales, S, Martinez, C, Cabada, M, Melendez, G M, Ferreira, R, Gonzaga, A, Santos, J, Vijayan, S, Smith, Smg, Smith, M, Muthusamy, R, Takeishi, Y, Oikawa, M, Goral, J L, Napoli, J, Montana, O R, Damico, A C, Quiroz, M C, Damico, A E, Forcada, P J, Schmidberg, J M, Zucchiatti, N E, Olivieri, D B, Dumo, A, Ruano, S, Rakhit, R, Davar, J, Nair, D, Cohen, M, Darko, D, Yokota, S, Maas, Ahe, Mouden, M, Knollema, S, Sanja Mazic, S M, Lazovic, B, Marina Djelic, Mdj, Jelena Suzic Lazic, J S, Tijana Acimovic, T A, Milica Deleva, M D, Vesnina, Z H, Zafrir, N, Bental, T, Mats, I, Solodky, A, Gutstein, A, Hasid, Y, Belzer, D, Kornowski, R, Ben Said, Rim, Ben Mansour, N, Ibn Haj Amor, H, Chourabi, C, Hagui, A, Fehri, W, Hawala, H, Shugushev, Z, Patrikeev, A, Maximkin, D, Chepurnoy, A, Kallianpur, V, Mambetov, A, Dokshokov, G, Teresinska, A, Wozniak, O, Maciag, A, Wnuk, J, Dabrowski, A, Czerwiec, A, Jezierski, J, Biernacka, K, Robinson, J, Prosser, J, Cheung, Gsm, Allan, S, Mcmaster, G, Reid, S, Tarbuck, A, Martin, W, Queiroz, R C, Falcao, A, Giorgi, McP, Imada, R, Nogueira, S A, Chalela, W A, Kalil Filho, R, Meneghetti, W A, Matveev, V V, Bubyenov, A S, Podzolkov, V I, Baranovich, V, Faibushevich, A, Kolzhecova, Y, Volkova, O, Fernandez, J, Lopez, G, Dondi, M, Paez, D, Butcher, Cjt, Reyes, E, Al-Housni, M B, Green, R, Santiago, H, Ghiotto, F, Hinton-Taylor, S, Pottle, A, Mason, M, Underwood, S R, Casans Tormo, I, Diaz-Exposito, R, Plancha-Burguera, E, Elsaban, K, Alsakhri, Hijji, Yoshinaga, K, Ochi, N, Tomiyama, Y, Katoh, C, Inoue, M, Nishida, M, Suzuki, E, Manabe, O, Ito, Y M, Tamaki, N, Tahilyani, A, Jafary, Fahim, Ho Hee Hwa, H H, Ozdemir, S, Kirilmaz, B, Barutcu, A, Tan, Y Z, Celik, F, Sakgoz, S, Cabada Gamboa, M, Puente Barragan, A, Morales Vitorino, N, Medina Servin, M A, Hindorf, C, Akil, S, Hedeer, F, Jogi, J, Engblom, H, Martire, V D, Pis Diez, E R, Martire, M V, Portillo, D O, Hoff, C M, Balche, A, Majgaard, J, Tolbod, L P, Harms, H J, Soerensen, J, Froekiaer, J, Nudi, F, Neri, G, Procaccini, E, Pinto, A, Vetere, M, Biondi-Zoccai, G, Soares, J, Do Val, R, Oliveira, M A, Meneghetti, J C, Tekabe, Y, Anthony, T, Li, Q, Schmidt, A M, Johnson, L, Groenman, M, Tarkia, M, Kakela, M, Halonen, P, Kiviniemi, T, Pietila, M, Yla-Herttuala, S, Roivainen, A, Nekolla, S, Swirzek, S, Higuchi, T, Reder, S, Schachoff, S, Bschorner, M, Laitinen, I, Robinson, S, Yousefi, B, Schwaiger, M, Kero, Tanja, Lindsjo, L, Antoni, Gunnar, Westermark, P, Carlson, K, Wikstrom, G, Sörensen, Jens, Lubberink, Mark, Rouzet, F, Cognet, T, Guedj, K, Morvan, M, El Shoukr, F, Louedec, L, Choqueux, C, Nicoletti, A, Le Guludec, D, Jimenez-Heffernan, A, Munoz-Beamud, F, Sanchez De Mora, E, Borrachero, C, Salgado, C, Ramos-Font, C, Lopez-Martin, J, Hidalgo, M L, Lopez-Aguilar, R, Soriano, E, Okizaki, A, Nakayama, M, Ishitoya, S, Sato, J, Takahashi, K, Burchert, I, Caobelli, F, Wollenweber, T, Nierada, M, Fulsche, J, Dieckmann, C, Bengel, F M, Shuaib, S, Mahlum, D, Port, S, Refoyo, E, Cuesta, E, Guzman, G, Lopez, T, Valbuena, S, Del Prado, S, Moreno, M, Harbinson, M, Donnelly, L, Einstein, A J, Johnson, L L, Deluca, A J, Kontak, A C, Groves, D W, Stant, J, Pozniakoff, T, Cheng, B, Rabbani, L E, Bokhari, S, Schuetze, C, Aguade-Bruix, S, Pizzi, M N, Romero-Farina, G, Terricabras, M, Villasboas, D, Castell-Conesa, J, Candell-Riera, J, Brunner, S, Gross, L, Todica, A, Lehner, S, Di Palo, A, Niccoli Asabella, A, Magarelli, C, Notaristefano, A, Ferrari, C, Rubini, G, Sellem, A, Melki, S, Elajmi, W, Hammami, H, Ziadi, M C, Montero, J, Ameriso, J L, Villavicencio, R L, Benito Gonzalez, T F, Mayorga Bajo, A, Gutierrez Caro, R, Rodriguez Santamarta, M, Alvarez Roy, L, Martinez Paz, E, Barinaga Martin, C, Martin Fernandez, J, Alonso Rodriguez, D, Iglesias Garriz, I, Rosillo, S, Taleb, S, Cherkaoui Salhi, G, Regbaoui, Y, Ait Idir, M, Guensi, A, Martin Lopez, C E, and Castano Ruiz, M
- Published
- 2015
- Full Text
- View/download PDF
7. Poster Session 1: Sunday 3 May 2015, 08:30-18:00 * Room: Poster Area
- Author
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Taniguchi, Y., primary, Takahashi, Y., additional, Toba, T., additional, Yamada, S., additional, Yokoi, K., additional, Kobayashi, S., additional, Okajima, S., additional, Shimane, A., additional, Kawai, H., additional, Yasaka, Y., additional, Smanio, P., additional, Oliveira, M. A., additional, Machado, L., additional, Cestari, P., additional, Medeiros, E., additional, Fukuzawa, S., additional, Okino, S., additional, Ikeda, A., additional, Maekawa, J., additional, Ichikawa, S., additional, Kuroiwa, N., additional, Yamanaka, K., additional, Igarashi, A., additional, Inagaki, M., additional, Patel, K., additional, Mahan, M., additional, Ananthasubramaniam, K., additional, Mouden, M., additional, Yokota, S., additional, Ottervanger, J., additional, Knollema, S., additional, Timmer, J., additional, Jager, P., additional, Padron, K., additional, Peix, A., additional, Cabrera, L., additional, Pena Bofill, V., additional, Valera, D., additional, Rodriguez Nande, L., additional, Carrillo Hernandez, R., additional, Mena Esnard, E., additional, Fernandez Columbie, Y., additional, Bertella, E., additional, Baggiano, A., additional, Mushtaq, S., additional, Segurini, C., additional, Loguercio, M., additional, Conte, E., additional, Beltrama, V., additional, Petulla', M., additional, Andreini, D., additional, Pontone, G., additional, Guzic Salobir, B., additional, Dolenc Novak, M., additional, Jug, B., additional, Kacjan, B., additional, Novak, Z., additional, Vrtovec, M., additional, Volpato, V., additional, Formenti, A., additional, Pepi, M., additional, Ajanovic, R., additional, Husic-Selimovic, A., additional, Zujovic-Ajanovic, A., additional, Mlynarski, R., additional, Mlynarska, A., additional, Golba, K., additional, Sosnowski, M., additional, Ameta, D., additional, Goyal, M., additional, Kumar, D., additional, Chandra, S., additional, Sethi, R., additional, Puri, A., additional, Dwivedi, S. K., additional, Narain, V. S., additional, Saran, R. K., additional, Nekolla, S., additional, Rischpler, C., additional, Nicolosi, S., additional, Langwieser, N., additional, Dirschinger, R., additional, Laugwitz, K., additional, Schwaiger, M., additional, Goral, J. L., additional, Napoli, J., additional, Forcada, P., additional, Zucchiatti, N., additional, Damico, A., additional, Olivieri, D., additional, Lavorato, M., additional, Dubesarsky, E., additional, Montana, O., additional, Salgado, C., additional, Jimenez-Heffernan, A., additional, Ramos-Font, C., additional, Lopez-Martin, J., additional, Sanchez De Mora, E., additional, Lopez-Aguilar, R., additional, Manovel, A., additional, Martinez, A., additional, Rivera, F., additional, Soriano, E., additional, Maroz-Vadalazhskaya, N., additional, Trisvetova, E., additional, Vrublevskaya, O., additional, Abazid, R., additional, Kattea, M., additional, Saqqah, H., additional, Sayed, S., additional, Smettei, O., additional, Winther, S., additional, Svensson, M., additional, Birn, H., additional, Jorgensen, H., additional, Botker, H., additional, Ivarsen, P., additional, Bottcher, M., additional, Maaniitty, T., additional, Stenstrom, I., additional, Saraste, A., additional, Pikkarainen, E., additional, Uusitalo, V., additional, Ukkonen, H., additional, Kajander, S., additional, Bax, J., additional, Knuuti, J., additional, Choi, T., additional, Park, H., additional, Lee, C., additional, Lee, J., additional, Seo, Y., additional, Cho, Y., additional, Hwang, E., additional, Cho, D., additional, Sanchez Enrique, C., additional, Ferrera, C., additional, Olmos, C., additional, Jimenez - Ballve, A., additional, Perez - Castejon, M. 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V., additional, Bruin, V. S., additional, Pan, X. B., additional, Declerck, J. M., additional, Van Der Zant, F. M., additional, Knol, R. J. J., additional, Juarez-Orozco, L. E., additional, Alexanderson, E., additional, Slart, R., additional, Tio, R., additional, Dierckx, R., additional, Zeebregts, C., additional, Boersma, H., additional, Hillege, H., additional, Martinez-Aguilar, M., additional, Jordan-Rios, A., additional, Christensen, T. E., additional, Ahtarovski, K. A., additional, Bang, L. E., additional, Holmvang, L., additional, Soeholm, H., additional, Ghotbi, A. A., additional, Andersson, H., additional, Ihlemann, N., additional, Kjaer, A., additional, Hasbak, P., additional, Gulya, M., additional, Lishmanov, Y. B., additional, Zavadovskii, K., additional, Lebedev, D., additional, Stahle, M., additional, Hellberg, S., additional, Liljenback, H., additional, Virta, J., additional, Metsala, O., additional, Yla-Herttuala, S., additional, Saukko, P., additional, Roivainen, A., additional, Thackeray, J., additional, Wang, Y., additional, Bankstahl, J., additional, Wollert, K., additional, Bengel, F., additional, Saushkina, Y., additional, Evtushenko, V., additional, Minin, S., additional, Efimova, I., additional, Evtushenko, A., additional, Smishlyaev, K., additional, Lishmanov, Y., additional, Maslov, L., additional, Kirihara, Y., additional, Sugino, S., additional, Taki, J., additional, Ahmadian, A., additional, Berman, J., additional, Govender, P., additional, Ruberg, F., additional, Miller, E., additional, Piriou, N., additional, Pallardy, A., additional, Valette, F., additional, Cahouch, Z., additional, Mathieu, C., additional, Warin-Fresse, K., additional, Gueffet, J., additional, Serfaty, J., additional, Trochu, J., additional, Kraeber-Bodere, F., additional, Van Dijk, J., additional, Van Dalen, J., additional, Ofrk, H., additional, Vaturi, M., additional, Hassid, Y., additional, Belzer, D., additional, Sagie, A., additional, Kaminek, M., additional, Metelkova, I., additional, Budikova, M., additional, Koranda, P., additional, Henzlova, L., additional, Sovova, E., additional, Kincl, V., additional, Drozdova, A., additional, Jordan, M., additional, Shahid, F., additional, Teoh, Y., additional, Thamen, R., additional, Hara, N., additional, Onoguchi, M., additional, Hojyo, O., additional, Kawaguchi, Y., additional, Murai, M., additional, Udaka, F., additional, Matsuzawa, Y., additional, Bulugahapitiya, D. S., additional, Avison, M., additional, Martin, J., additional, Liu, Y.-H., additional, Wu, J., additional, Liu, C., additional, Sinusas, A., additional, Daou, D., additional, Sabbah, R., additional, Bouladhour, H., additional, Coaguila, C., additional, Aguade-Bruix, S., additional, Pizzi, M., additional, Romero-Farina, G., additional, Candell-Riera, J., additional, Castell-Conesa, J., additional, Patchett, N., additional, Sverdlov, A., additional, Boulaamayl El Fatemi, S., additional, Sallam, L., additional, Snipelisky, D., additional, Park, J., additional, Ray, J., additional, Shapiro, B., additional, Kostkiewicz, M., additional, Szot, W., additional, Holcman, K., additional, Lesniak-Sobelga, A., additional, Podolec, P., additional, Clerc, O., additional, Possner, M., additional, Liga, R., additional, Vontobel, J., additional, Mikulicic, F., additional, Graeni, C., additional, Benz, D., additional, Herzog, B., additional, Gaemperli, O., additional, and Kaufmann, P., additional
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- 2015
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8. CHANGE IN OPIOID PEPTIDE LEVEL IN THE HEART AND BLOOD PLASMA DURING ACUTE MYOCARDIAL ISCHAEMIA COMPLICATED BY VENTRICULAR FIBRILLATION
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Maslov, L. N., primary and Lishmanov, Y. B., additional
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- 1995
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9. The utility of 99mTc-HMPAO leukocytes SPECT in diagnosis of latent myocarditis in patients with atrial fibrillation
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Sazonova, S., Ilyushenkova, Y. N., Batalov, R. E., Rogovskaya, Y. V., Lishmanov, Y. B., and Sergey Popov
10. Scintigraphic evaluation of renal protective effects of trimetazidine
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Vesnina Zhaneta, Vershinina, E. O., and Lishmanov, Y. B.
11. STRESS AND INFARCT LIMITING EFFECTS OF EARLY HYPOXIC PRECONDITIONING
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Lishmanov, Y. B., Maslov, L. N., Sementsov, A. S., Natalia Naryzhnaya, and Tsibulnikov, S. Y.
12. First-pass radionuclide angiography and multiple gated equilibrium blood pool scintigraphy in evaluation of chronic effect of cardiac resynchronization therapy
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Chernov, V. I., Minin, S. M., Makarova, E. V., Savenkova, G. M., Antonchenko, I. V., Sergey Popov, and Lishmanov, Y. B.
13. Cognitive Function and Cerebral Perfusion in off-pump and on-pump Coronary Artery Bypass Patients
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Chernov, V. I., Efimova, N. Y., Efimova, I. Y., Shamil Akhmedov, and Lishmanov, Y. B.
14. Metabolic scintigraphy with radiolabeled fatty acid in prognosis of cardiac resynchronization therapy in patients with dilated cardiomyopathy
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Lishmanov, Y. B., Marina Gulya, Zavadovsky, K. W., Sazonova, S. I., Lebedev, D. I., Skuridin, V. S., and Fillimonov, V. D.
15. PROBLEM OF END EFFECTOR OF ISCHEMIC POSTCONDITIONING OF THE HEART
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Leonid Maslov, Naryzhnaya, N. V., Pei, J. -M, Zhang, Y., Wang, H., Khaliulin, I. J., and Lishmanov, Y. B.
16. Tc-99m-tekhnetril (Tc-99m-MiBi) labeled with technetium-99m from extraction and sorption generators in scintigraphic diagnostics of coronary artery disease
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Lishmanov, Y. B., Chernov, V. I., Vesnina, Z. V., Krivonogov, N. G., Skuridin, V. S., and Garganeeva Alla
17. INVOLVEMENT OF NO-SYNTHASE IN THE INFARCT REDUCING EFFECT OF CONTINUOUS CHRONIC NORMOBARTC HYPOXTA
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Natalia Naryzhnaya, Maslov, L. N., Tsibulnikov, S. Y., Prokudina, E. S., and Lishmanov, Y. B.
18. [Intracellular mechanisms of cardioprotection during adaptation to hypoxia. Triggers and kinase cascades]
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Naryzhnaǐa, N. V., Lishmanov, Y. B., Frantisek Kolar, Maslov, L. N., Zhang, I., and Portnichenko, A. G.
19. Scintigraphic predictors of cardiac resynchronization therapy efficacy in patients with dilated cardiomyopathy
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Lishmanov, Y. B., Marina Gulya, Minin, S. M., Lebedev, D. I., and Zavadovsky, K. W.
20. Determination of the efficiency of single-photon emission computed tomography with 99mTc-HMPAO-labelled leukocytes in the diagnosis of myocarditis: Comparison of scintigraphic and histological data
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Sazonova, S. I., Il Yushenkova, Y. N., Batalov, R. E., Rogovskaya, Y. V., Lishmanov, Y. B., and Sergey Popov
21. The value of fist-pass radionuclide angiography and perfusion lung scintigraphy in prognosis of pulmonary hypertension in children with congenital systemic-to-pulmonary shunts
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Lishmanov, Y. B., Zavadovskiy, K. W., Ivanov, S. N., Nikolay Krivonogov, and Kondratjeva, T. P.
22. Alterations in pulmonary hemodynamics, assessed by first-pass radionuclide angiography, and nitric oxide production in congenital systemic-to-pulmonary shunt children
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Lishmanov, Y. B., Zavadovskiy, K. W., Ivanov, S. N., Suslova, T. E., Nikolay Krivonogov, and Kondratjeva, T. P.
23. Synthesis and experimental study of norfloxacin labeled with technecium-99m as a potential agent for infection imaging
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Sazonova, S. I., Lishmanov, Y. B., Varlamova, N. V., Skuridin, V. S., Ilushenkova, Y. N., Maria Karpova, and Nesterov, Y. A.
24. CHRONIC CONTINUOUS NOR-MOBARIC HYPOXIA AUGMENTS CELL TOLERANCE TO ANOXIA(REOXYGE-NATION: THE ROLE OF PROTEIN KINASES
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Natalia Naryzhnaya, Maslov, I. N., Khaliulin, I. G., Zhang, Y., Pei, J. M., Tsepokina, A. V., Khutornaya, M. V., Kutikhin, A. G., and Lishmanov, Y. B.
25. The value of radionuclide methods in patients with suspicious chronic myocarditis
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Chernov, V. I., Sazonova, S. I., Garganeeva Alla, Proskokova, I. Y., and Lishmanov, Y. B.
26. Possible causes of dissociation between pulmonary embolism volume and right ventricular dysfunction degree
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Lishmanov, Y. B., Pankova, A. N., and Konstantin Zavadovsky
- Subjects
pulmonary embolism ,RC666-701 ,Diseases of the circulatory (Cardiovascular) system ,gated blood pool spect ,right ventricle - Abstract
Aim. To study possible causes of the dissociation between pulmonary embolism volume and right ventricular (RV) dysfunction degree. Material and methods. The main group included 37 patients with pulmonary embolism (PE); the comparison group consisted of 15 patients with coronary heart disease (CHD) and NYHA functional class (FC) I–II heart failure (HF). All participants underwent ventilation-perfusion lung scintigraphy, gated blood pool single photon emission computed tomography (GBPS), and the measurement of plasma levels of stable NO metabolites, endotelin‑1, and 6‑keto-prostaglandin (Pg) F1α. Results. In PE patients, RV contractility parameters were significantly lower than those in the comparison group. Among patients with moderate PE volume (3–7 bronchopulmonary segments), no correlation was observed between the number of hypoperfused segments and RV dysfunction degree. In PE patients, compared to the comparison group, plasma levels of endotelin‑1, stable NO metabolites, and stable prostacyclin metabolite 6‑keto-Pg F1α were significantly higher. Conclusion. In PE patients, the most important GBPS parameters of RV dysfunction included reduced ejection fraction, stroke volume, peak ejection rate, and mean filling rate. The dissociation between PE volume and RV dysfunction degree could be caused by disturbed humoral regulation of pulmonary vascular tone.
27. The anti-arrhythmic effect of D-Ala 2, Leu 5, Arg 6-enkephalin and its possible mechanism
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Maslov, L. N. and Lishmanov, Y. B.
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- 1993
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28. Accelerated Communication: Participation of Central Kappa-opioid Receptor in Arrhythmogenesis
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Lishmanov, Y. B., Maslov, L. N., Ugdyzhekova, D. S., and Smagin, G. N.
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- 1997
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29. Effect of Chronic Continuous Normobaric Hypoxia on Functional State of Cardiac Mitochondria and Tolerance of Isolated Rat Heart to Ischemia and Reperfusion: Role of µ and delta2 Opioid Receptors.
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Prokudina ES, Naryzhnaya NV, Mukhomedzyanov AV, Gorbunov AS, Zhang Y, Yaggi AS, Tsibulnikov SY, Nesterov EA, Lishmanov YB, Suleiman MS, Oeltgen PR, and Maslov LN
- Subjects
- Animals, Male, Mitochondria, Heart drug effects, Myocardial Reperfusion Injury prevention & control, Narcotic Antagonists pharmacology, Organ Culture Techniques, Rats, Rats, Wistar, Receptors, Opioid, delta antagonists & inhibitors, Receptors, Opioid, mu antagonists & inhibitors, Hypoxia physiopathology, Mitochondria, Heart physiology, Myocardial Reperfusion Injury physiopathology, Receptors, Opioid, delta physiology, Receptors, Opioid, mu physiology
- Abstract
Chronic continuous normobaric hypoxia (CNH) increases cardiac tolerance to ischemia/reperfusion injury in vivo and this effect is mediated via µ and delta2 opioid receptors (ORs) activation. CNH has also been shown to be cardioprotective in isolated rat heart. In this study, we hypothesize that this cardioprotective effect of CNH is mediated by activation of µ and delta2 ORs and preservation of mitochondrial function. Hearts from rats adapted to CNH (12 % oxygen) for 3 weeks were extracted, perfused in the Langendorff mode and subjected to 45 min of global ischemia and 30 min of reperfusion. Intervention groups were pretreated for 10 min with antagonists for different OR types: naloxone (300 nmol/l), the selective delta OR antagonist TIPP(psi) (30 nmol/l), the selective delta1 OR antagonist BNTX (1 nmol/l), the selective delta2 OR antagonist naltriben (1 nmol/l), the selective peptide µ OR antagonist CTAP (100 nmol/l) and the selective delta OR antagonist nor-binaltorphimine (3 nmol/l). Creatine kinase activity in coronary effluent and cardiac contractile function were monitored to assess cardiac injury and functional impairment. Additionally, cardiac tissue was collected to measure ATP and to isolate mitochondria to measure respiration rate and calcium retention capacity. Adaptation to CNH decreased myocardial creatine kinase release during reperfusion and improved the postischemic recovery of contractile function. Additionally, CNH improved mitochondrial state 3 and uncoupled respiration rates, ADP/O, mitochondrial transmembrane potential and calcium retention capacity and myocardial ATP level during reperfusion compared to the normoxic group. These protective effects were completely abolished by naloxone, TIPP(psi), naltriben, CTAP but not BNTX or nor-binaltorphimine. These results suggest that cardioprotection associated with adaptation to CNH is mediated by µ and delta2 opioid receptors activation and preservation of mitochondrial function.
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- 2019
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30. [Perfusion-Metabolic Myocardial Scintigraphy in Prognosis of Left Ventricular Remodeling After Complex Surgical Treatment of Ischemic Cardiomyopathy].
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Lishmanov YB, Gulya MO, Zavadovsky KV, Andreev SL, and Alexandrova EA
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- Humans, Middle Aged, Prognosis, Stroke Volume, Treatment Outcome, Ventricular Remodeling, Cardiomyopathies diagnostic imaging, Myocardial Ischemia diagnostic imaging, Myocardial Perfusion Imaging, Ventricular Dysfunction, Left
- Abstract
Purpose: To study capabilities of perfusion-metabolic myocardial scintigraphy for prediction of the left ventricular (LV) reverse remodeling after comprehensive surgical treatment of ischemic cardiomyopathy (ICMP)., Methods: The study included ICMP patients aged 56±7 years (n=32) who underwent surgical correction of LV dysfunction (myocardial revascularization, LV reconstruction, and mitral valve restoration). Inclusion criteria were significant coronary artery disease; myocardial infarction; New York Heart Association (NYHA) class III-IV heart failure; LV ejection fraction (EF) ≤45%; LV end-systolic index (ESI) >60 mL/m2; and LV akinesia or dyskinesia according to echocardiography. Before surgery all patients were subjected to scintigraphy with 99mTc-MIBI (to assess perfusion) and with 123I-BMIPP (to assess myocardial metabolism). Scintigraphy results were expressed as median and lower; upper quartile (Me [lQ; hQ]). The clinical status and ventricular volume indicators were evaluated before surgery, in the early post-operative period (up to 4 weeks), and in the late post-operative period (12 months)., Results: At 12 months after intervention patients were divided into two groups: group 1 comprised patients (n=18) with beneficial outcome of the operation that stopped LV remodeling (ESI decreased, remained unchanged, or increased by.
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- 2017
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31. Myocardial perfusion and left ventricular function in long-term follow-up and prognosis of electrostimulation cardiomyoplasty.
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Lishmanov YB, Chernov VI, Vesnina JV, Ussov WY, Krylov AL, Pekarskaya MV, Akhmedov SD, Krivonogov NG, and Pekarsky V
- Abstract
Background: Twenty two patients with congestive cardiac failure treated surgically by dynamic cardiomyoplasty (CMP) with m. latissimus dorsi were examined. Myocardial perfusion was assessed with (199)TlCl scintigraphy combined with dipyridamole stress-test. In order to obtain direct evidence of myocardial perfusion from muscular flap we also injected a bolus of (99m)Tc into a. thoracodorsalis, with simultaneous blood sampling from coronary sinus. Haemodynamic parameters were assessed using radionuclide angiography., Methods: In a year of follow-up all the patients were assigned to one of two groups: eleven patients demonstrated improvement in clinical status (first group) and in another group comprising eleven persons no positive effect or deterioration were obvious (second group). The patients of the first group before operation revealed two times less persistent defect size than patients of the second group. Analysis of integral index of persistent defect revealed more expressive differences between groups. Before the surgical treatment the patients with improvement in clinical status after cardiomyoplasty demonstrated greater size of reversible defect in comparison with patients of the second group. In the second group coronary fraction of thallium accumulation was 1.4 times higher in comparison to the first group, as the result of myocardial hypertrophy in patients with bad prognosis. There were no significant differences between the two groups in Il/m level before cardiomyoplasty. Before the surgical treatment the patients with improvement in clinical status after cardiomyoplasty demonstrated greater ejection fraction in comparison with patients of the second group., Results: Cardiomyoplasty led to a decrease in the mean size of reversible defects due to indirect revascularisation. This hypothesis was testified to by the fact that in patients after cardiomyoplasty nuclide appeared in coronary sinus at 10-12th seconds after injection into artery thoracodorsalis through anastomoses between the latissimus dorsi muscle and the myocardium. The time of appearance of the second wave of rise gamma-counting in blood samples from coronary sinus reflects the repeated entry of radiopharmaceutical in myocardium after recirculation.
- Published
- 2000
32. Participation of central and peripheral kappa 1 and kappa 2 opioid receptors in arrhythmogenesis.
- Author
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Lishmanov YB, Maslov LN, and Ugdyzhekova DS
- Subjects
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer pharmacology, Animals, Antihypertensive Agents pharmacology, Dynorphins pharmacology, Male, Rats, Rats, Wistar, Receptors, Opioid, kappa physiology, Anti-Arrhythmia Agents therapeutic use, Arrhythmias, Cardiac etiology, Benzomorphans therapeutic use, Pyrrolidines therapeutic use, Receptors, Opioid, kappa drug effects
- Abstract
1. The kappa 1 and kappa 2 opioid receptor agonists U-62066 (8 mg/kg, i.p.) and (-)-bremazocine (0.7 mg/kg, i.v.), respectively, both exhibit anti-arrhythmic properties against adrenaline-induced dysrhythmias in rats. 2. In contrast, (+)-bremazocine has no effect on adrenaline-induced dysrhythmias. 3. The kappa 1 opioid receptor agonists U-50488 (110 nmol) and [D-Ala2]-dynorphin A (20 nmol) and the kappa 2 opioid receptor agonist (-)-bremazocine (30 nmol) exhibit pro-arrhythmic properties following intracerebroventricular administration. 4. Prior administration of the kappa opioid receptor antagonist nor-binaltorphimine doses i.c.v. (14 nmol), i.p. (10 mg/kg), completely abolishes the pro-arrhythmic (BNI, i.c.v., 14 nmol) as well as anti-arrhythmic (BNI, 10 mg/kg, i.p.) effects of the kappa opioid receptor agonists. 5. Neither hexamethonium (10 mg/kg, i.v.) nor atropine (1 mg/kg, i.v.) have any effect on the anti-arrhythmic actions of the kappa 1 opioid receptor agonist U-62066 following systemic administration. 6. It is suggested that the anti-arrhythmic effects of U-62066 and (-)-bremazocine are associated with the activation of peripheral kappa opioid receptors and do not depend on the activation of kappa opioid receptors in the autonomic nervous system.
- Published
- 1999
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33. Participation of central kappa-opioid receptor in arrhythmogenesis.
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Lishmanov YB, Maslov LN, Ugdyzhekova DS, and Smagin GN
- Subjects
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Animals, Dynorphins pharmacology, Epinephrine, Hexamethonium pharmacology, Male, Naloxone pharmacology, Naltrexone analogs & derivatives, Naltrexone pharmacology, Narcotic Antagonists pharmacology, Peptide Fragments pharmacology, Pyrrolidines pharmacology, Rats, Rats, Wistar, Receptors, Opioid, kappa agonists, Receptors, Opioid, kappa antagonists & inhibitors, Arrhythmias, Cardiac chemically induced, Receptors, Opioid, kappa physiology
- Abstract
The effect of kappa receptors agonists and antagonists was studied in the model of epinephrine induced arrhythmias. Kappa receptor agonists U-50,488 and [D-Ala2]-Dynorphin A (1-13) administered I.C.V. potentiate the arrhythmogenic effect of epinephrine. The effect of U-50,488 was completely blocked by kappa receptor antagonist, nor-binaltorphine. Administration of N-cholinergic receptor inhibitor, hexamethonium, prevented pro-arrhythmic effects of U-50,488 and [D-Ala2]-Dynorphin A (1-13). The data support the hypothesis that central kappa opioid receptors play an important role in the arrhythmogenesis.
- Published
- 1997
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34. Thallium-199: a new radiopharmaceutical for myocardial perfusion imaging.
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Chernov VI, Triss SV, Skuridin VS, and Lishmanov YB
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- Adult, Aged, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Radiation Dosage, Radionuclide Imaging, Sensitivity and Specificity, Heart diagnostic imaging, Radiopharmaceuticals, Thallium Radioisotopes
- Abstract
The efficacy of a new radionuclide, thallium-199 for myocardial scintigraphy was compared with conventional thallium-201 imaging. Owing to the short half-life of thallium-199 (7.4 hours), when the injected dose of thallium-199 was increased to 200 MBq, the total dose reaching the critical organs was 3.6-15.5 times lower than with conventional nuclide, thallium-201. Studies were performed in a total of 177 patients. The patients were divided into two groups(a) 17 patients with acute myocardial infarction and (b) 160 patients undergoing coronary angiography: 55 patients with no significant coronary artery disease and 105 patients with coronary disease. The sensitivity of the test was 92% with a specificity of 82% and overall predictive accuracy of 84%. Myocardial images obtained with low and high energy collimators have similar predictive accuracy. Perfusion defects were detected more frequently with increasing severity of angina. Myocardial infarction was characterized by persistent defects and myocardial ischaemia by redistribution of thallium. Thallium-199 myocardial scintigraphy performed at rest can be used for the diagnosis of acute myocardial infarction and for the determination of infarct site and extent. Thallium-199 is a new myocardial imaging agent, with a predictive accuracy for the diagnosis of coronary artery disease similar to thallium-201, but a significantly reduced total body dose permits repeat studies with a reduced radiation dose for the patient.
- Published
- 1996
- Full Text
- View/download PDF
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