1. DALI: Vitamin D and lifestyle intervention for gestational diabetes mellitus (GDM) prevention: An European multicentre, randomised trial - study protocol
- Author
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Gernot Desoye, Dirk Timmerman, Peter Damm, Jürgen Harreiter, Liselotte Sigh Andersen, Alessandra Bertolotto, Ewa Wender-Oegowska, Sander Galjaard, Agnieszka Zawiejska, Fidelma Dunne, Judith G. M. Jelsma, Annunziata Lapolla, David Simmons, Roland Devlieger, Rosa Corcoy, Frank J. Snoek, Goele Jans, P. Rebollo, Mireille N M van Poppel, Dorte Møller Jensen, Kinga Blumska, David Hill, André Van Assche, Graziano Di Cianni, Elisabeth R. Mathiesen, Alexandra Kautzky-Willer, Public and occupational health, Medical psychology, EMGO - Lifestyle, overweight and diabetes, and Academic Medical Center
- Subjects
Blood Glucose ,Lifestyle intervention ,endocrine system diseases ,Overweight ,skinfold measurements ,Weight Gain ,Gestational diabetes mellitus ,law.invention ,Study Protocol ,0302 clinical medicine ,Randomized controlled trial ,law ,Pregnancy ,Obstetrics and Gynaecology ,030212 general & internal medicine ,Vitamin D ,obese pregnant-women ,physical-activity ,Randomised controlled trial ,Obstetrics ,Motivational interviewing ,Obstetrics and Gynecology ,Vitamins ,female genital diseases and pregnancy complications ,Gestational diabetes ,Europe ,Research Design ,Healthy eating ,Female ,medicine.symptom ,Adult ,medicine.medical_specialty ,Adolescent ,Birth weight ,weight-gain ,growth ,030209 endocrinology & metabolism ,Motivational Interviewing ,Motor Activity ,Placebo ,venous doppler ,insulin-resistance ,03 medical and health sciences ,Young Adult ,Insulin resistance ,Patient Education as Topic ,lean mass ,medicine ,Vitamin D and neurology ,Humans ,Life Style ,business.industry ,Physical activity ,Prevention ,fetal liver length ,nutritional and metabolic diseases ,medicine.disease ,Diet ,Diabetes, Gestational ,Dietary Supplements ,Physical therapy ,Insulin Resistance ,business ,Weight gain ,neonatal body-composition - Abstract
Background Gestational diabetes mellitus (GDM) is an increasing problem world-wide. Lifestyle interventions and/or vitamin D supplementation might help prevent GDM in some women. Methods/design Pregnant women at risk of GDM (BMI≥29 (kg/m2)) from 9 European countries will be invited to participate and consent obtained before 19+6 weeks of gestation. After giving informed consent, women without GDM will be included (based on IADPSG criteria: fasting glucose Discussion DALI is a unique Europe-wide randomised controlled trial, which will gain insight into preventive measures against the development of GDM in overweight and obese women. Trial registration ISRCTN70595832
- Published
- 2013