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1. Stereotactic radiosurgery (SRS) for patients with brainstem cerebral cavernous malformations (CCMs): an international, multicentric study

Author

Dayawansa, Sam, Dumot, Chloe, Mantziaris, Georgios, Xu, Zhiyuan, Pikis, Stylianos, Peker, Selcuk, Samanci, Yavuz, Ardor, Gokce D., Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Abdelkarim, Khaled, El-Shehaby, Amr M. N., Eldin, Reem M. Emad, Elazzazi, Ahmed H., Moreno, Nuria Martínez, Álvarez, Roberto Martínez, Liscak, Roman, May, Jaromir, Mathieu, David, Tourigny, Jean-Nicolas, Tripathi, Manjul, Rajput, Akshay, Kumar, Narendra, Kaur, Rupinder, Picozzi, Piero, Franzini, Andrea, Speckter, Herwin, Hernandez, Wenceslao, Brito, Anderson, Warnick, Ronald E., Alzate, Juan, Kondziolka, Douglas, Bowden, Greg N., Patel, Samir, and Sheehan, Jason P.

Published
2024
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2. Comparative analysis of stereotactic radiosurgery outcomes for supratentorial hemangioblastomas in von hippel-lindau disease and sporadic cases: A multi-center international study

Author

Tos, Salem M., Hajikarimloo, Bardia, Mantziaris, Georgios, Shaaban, Ahmed, Pham, Duy, Dayawansa, Sam, Wei, Zhishuo, McKendrick, Lindsay M., Niranjan, Ajay, Lunsford, L Dade, Peker, Selcuk, Samanci, Yavuz, Liscak, Roman, May, Jaromir, Mathieu, David, Picozzi, Piero, Franzini, Andrea, Warnick, Ronald E., Schoenhals, Jonathan E., Palmer, Joshua D., Xu, Zhiyuan, and Sheehan, Jason P.

Published
2024
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3. Epilepsy associated with cerebral cavernous malformations managed with stereotactic radiosurgery: an international, multicenter study

Author

Dumot, Chloe, Mantziaris, Georgios, Pikis, Stylianos, Dayawansa, Sam, Xu, Zhiyuan, Samanci, Yavuz, Ardor, Gokce D., Peker, Selcuk, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Abdel Karim, Khaled, El-Shehaby, Amr M. N., Eldin, Reem M. Emad, Elazzazi, Ahmed H., Moreno, Nuria Martínez, Álvarez, Roberto Martínez, Liscak, Roman, May, Jaromir, Mathieu, David, Tourigny, Jean-Nicolas, Tripathi, Manjul, Rajput, Akshay, Kumar, Narendra, Kaur, Rupinder, Picozzi, Piero, Franzini, Andrea, Speckter, Herwin, Hernandez, Wenceslao, Brito, Anderson, Warnick, Ronald E., Alzate, Juan, Kondziolka, Douglas, Bowden, Greg N., Patel, Samir, and Sheehan, Jason P.

Published
2023
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4. Reirradiation With Stereotactic Radiosurgery After Local or Marginal Recurrence of Brain Metastases From Previous Radiosurgery

Author

Kowalchuk, Roman O., Niranjan, Ajay, Lee, Cheng-chia, Yang, Huai-che, Liscak, Roman, Guseynova, Khumar, Tripathi, Manjul, Kumar, Narendra, Peker, Selcuk, Samanci, Yavuz, Hess, Judith, Chiang, Veronica, Iorio-Morin, Christian, Mathieu, David, Pikis, Stylianos, Wei, Zhishuo, Lunsford, L. Dade, Trifiletti, Daniel M., and Sheehan, Jason P.

Published
2022
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5. Long-term radiographic and endocrinological outcomes of stereotactic radiosurgery for recurrent or residual nonfunctioning pituitary adenomas.

Author

Shaaban, Ahmed, Dumot, Chloé, Mantziaris, Georgios, Dayawansa, Sam, Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Karim, Khaled Abdel, El-Shehaby, Amr M. N., Eldin, Reem M. Emad, Abdelsalam, Ahmed Ragab, Liscak, Roman, May, Jaromir, Mashiach, Elad, Vasconcellos, Fernando De Nigris, Bernstein, Kenneth, Kondziolka, Douglas, and Speckter, Herwin

Published
2024
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6. Stereotactic radiosurgery versus active surveillance for asymptomatic, skull-based meningiomas: an international, multicenter matched cohort study

Author

Mantziaris, Georgios, Pikis, Stylianos, Samanci, Yavuz, Peker, Selcuk, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., El-Shehaby, Amr M. N., Abdelkarim, Khaled, Emad, Reem M., Delabar, Violaine, Mathieu, David, Lee, Cheng-chia, Yang, Huai-che, Liscak, Roman, Hanuska, Jaromir, Alvarez, Roberto Martinez, Moreno, Nuria Martinez, Tripathi, Manjul, Speckter, Herwin, Albert, Camilo, Benveniste, Ronald J., Bowden, Greg N., Patel, Dev N., Kondziolka, Douglas, Bernstein, Kenneth, Lunsford, L. Dade, Jenkinson, Michael D., Islim, Abdurrahman I., and Sheehan, Jason

Published
2022
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7. Stereotactic radiosurgery for asymptomatic petroclival region meningiomas: a focused analysis from the IMPASSE study

Author

Mantziaris, Georgios, Pikis, Stylianos, Bunevicius, Adomas, Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., El-Shehaby, Amr M. N., Abdelkarim, Khaled, Emad, Reem M., Delabar, Violaine, Mathieu, David, Lee, Cheng-chia, Yang, Huai-che, Liscak, Roman, Hanuska, Jaromir, Alvarez, Roberto Martinez, Moreno, Nuria Martinez, Tripathi, Manjul, Speckter, Herwin, Albert, Camilo, Bowden, Greg N., Benveniste, Ronald J., Patel, Dev N., Kondziolka, Douglas, Bernstein, Kenneth, Lunsford, L. Dade, and Sheehan, Jason

Published
2022
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8. Hypopituitarism after Gamma Knife radiosurgery for pituitary adenomas: a multicenter, international study

Author

Cordeiro, Diogo, Xu, Zhiyuan, Mehta, Gautam, Ding, Dale, Vance, Mary Lee, Kano, Hideyuki, Sisterson, Nathaniel, Yang, Huai-che, Kondziolka, Douglas, Lunsford, L Dade, Mathieu, David, Barnett, Gene, Chiang, Veronica, Lee, John, Sneed, Penny, Su, Yan-Hua, Lee, Cheng-chia, Krsek, Michal, Liscak, Roman, Nabeel, Ahmed, El-Shehaby, Amr, Karim, Khaled, Reda, Wael, Martinez-Moreno, Nuria, Martinez-Alvarez, Roberto, Blas, Kevin, Grills, Inga, Lee, Kuei, Kosak, Mikulas, Cifarelli, Christopher, Katsevman, Gennadiy, and Sheehan, Jason

Subjects
Paediatrics, Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Rare Diseases, hypopituitarism, pituitary adenoma, Cushing's disease, acromegaly, stereotactic radiosurgery, Cushing’s disease, Neurosciences, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveRecurrent or residual adenomas are frequently treated with Gamma Knife radiosurgery (GKRS). The most common complication after GKRS for pituitary adenomas is hypopituitarism. In the current study, the authors detail the timing and types of hypopituitarism in a multicenter, international cohort of pituitary adenoma patients treated with GKRS.MethodsSeventeen institutions pooled clinical data obtained from pituitary adenoma patients who were treated with GKRS from 1988 to 2016. Patients who had undergone prior radiotherapy were excluded. A total of 1023 patients met the study inclusion criteria. The treated lesions included 410 nonfunctioning pituitary adenomas (NFPAs), 262 cases of Cushing’s disease (CD), and 251 cases of acromegaly. The median follow-up was 51 months (range 6–246 months). Statistical analysis was performed using a Cox proportional hazards model to evaluate factors associated with the development of new-onset hypopituitarism.ResultsAt last follow-up, 248 patients had developed new pituitary hormone deficiency (86 with NFPA, 66 with CD, and 96 with acromegaly). Among these patients, 150 (60.5%) had single and 98 (39.5%) had multiple hormone deficiencies. New hormonal changes included 82 cortisol (21.6%), 135 thyrotropin (35.6%), 92 gonadotropin (24.3%), 59 growth hormone (15.6%), and 11 vasopressin (2.9%) deficiencies. The actuarial 1-year, 3-year, 5-year, 7-year, and 10-year rates of hypopituitarism were 7.8%, 16.2%, 22.4%, 27.5%, and 31.3%, respectively. The median time to hypopituitarism onset was 39 months.In univariate analyses, an increased rate of new-onset hypopituitarism was significantly associated with a lower isodose line (p = 0.006, HR = 8.695), whole sellar targeting (p = 0.033, HR = 1.452), and treatment of a functional pituitary adenoma as compared with an NFPA (p = 0.008, HR = 1.510). In multivariate analyses, only a lower isodose line was found to be an independent predictor of new-onset hypopituitarism (p = 0.001, HR = 1.38).ConclusionsHypopituitarism remains the most common unintended effect of GKRS for a pituitary adenoma. Treating the target volume at an isodose line of 50% or greater and avoiding whole-sellar radiosurgery, unless necessary, will likely mitigate the risk of post-GKRS hypopituitarism. Follow-up of these patients is required to detect and treat latent endocrinopathies.

Published
2018

9. Local control and survival after stereotactic radiosurgery for colorectal cancer brain metastases: an international multicenter analysis

Author

Bin-Alamer, Othman, primary, Abou-Al-Shaar, Hussam, additional, Singh, Raj, additional, Mallela, Arka N., additional, Legarreta, Andrew, additional, Bowden, Greg, additional, Mathieu, David, additional, Perlow, Haley K., additional, Palmer, Joshua D., additional, Elhamdani, Shahed, additional, Shepard, Matthew, additional, Liang, Yun, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M. N., additional, Emad Eldin, Reem, additional, Elazzazi, Ahmed Hesham, additional, Warnick, Ronald E., additional, Gozal, Yair M., additional, Daly, Megan, additional, McShane, Brendan, additional, Addis-Jackson, Marcel, additional, Karthikeyan, Gokul, additional, Smith, Sian, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Kaisman-Elbaz, Tehila, additional, Yang, Huai-che, additional, Hess, Judith, additional, Templeton, Kelsey, additional, Zhang, Xiaoran, additional, Wei, Zhishuo, additional, Pikis, Stylianos, additional, Mantziaris, Georgios, additional, Simonova, Gabriela, additional, Liscak, Roman, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Chiang, Veronica, additional, Kersh, Charles R., additional, Lee, Cheng-Chia, additional, Trifiletti, Daniel M., additional, Niranjan, Ajay, additional, Hadjipanayis, Constantinos G., additional, Lunsford, L. Dade, additional, and Sheehan, Jason P., additional

Published
2024
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10. Stereotactic Radiosurgery for WHO Grade 2 and 3 Oligodendroglioma: An International Multicenter Study

Author

Langlois, Anne-Marie, primary, Iorio-Morin, Christian, additional, Kallos, Justiss, additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Park, David J., additional, Barnett, Gene H., additional, Liscak, Roman, additional, Simonova, Gabriela, additional, Sheehan, Jason P., additional, Pikis, Stylianos, additional, Mantziaris, Georgios, additional, Lee, Cheng-Chia, additional, Yang, Huai-Che, additional, Bowden, Gregory N., additional, and Mathieu, David, additional

Published
2024
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11. 499 Silent Corticotroph Staining Pituitary Neuroendocrine Tumors: Prognostic Significance in Radiosurgery

Author

Maragkos, Georgios A., primary, Mantziaris, Georgios, additional, Pikis, Stylianos, additional, Chytka, Tomas, additional, Liscak, Roman, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Bindal, Shray, additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Kaur, Rupinder, additional, Tripathi, Manjul, additional, Pangal, Dhiraj J., additional, Strickland, Ben Allen, additional, Zada, Gabriel, additional, Langlois, Anne-Marie, additional, Mathieu, David, additional, Warnick, Ronald E., additional, Patel, Samir, additional, Minier, Zayda, additional, Speckter, Herwin, additional, Kondziolka, Douglas S., additional, Lee, Cheng-chia, additional, Lee Vance, Mary, additional, and Sheehan, Jason P., additional

Published
2024
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12. 220 Outcome Evaluation of Repeat Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations

Author

Mantziaris, Georgios, primary, Dumot, Chloe, additional, Liscak, Roman, additional, Lee, Cheng-Chia, additional, Lunsford, L. Dade, additional, Niranjan, Ajay, additional, Peker, Selcuk, additional, Mathieu, David, additional, Kondziolka, Douglas S., additional, Tripathi, Manjul, additional, Palmer, Joshua, additional, Zada, Gabriel, additional, Cifarelli, Christopher Paul, additional, Pikis, Stylianos, additional, Dayawansa, Sam, additional, and Sheehan, Jason P., additional

Published
2024
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13. Stereotactic radiosurgery (SRS) for patients with brainstem cerebral cavernous malformations (CCMs): An International, Multicentric Study

Author

Dayawansa, Sam, primary, Dumot, Chloe, additional, Mantziaris, Georgios, additional, Xu, Zhiyuan, additional, Pikis, Stylianos, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Ardor, Gokce D, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M. N., additional, Eldin, Reem M Emad, additional, Elazzazi, Ahmed H, additional, Moreno, Nuria Martínez, additional, Álvarez, Roberto Martínez, additional, Liscak, Roman, additional, May, Jaromir, additional, Mathieu, David, additional, Tourigny, Jean-Nicolas, additional, Tripathi, Manjul, additional, Rajput, Akshay, additional, Kumar, Narendra, additional, Kaur, Rupinder, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Brito, Anderson, additional, Warnick, Ronald E., additional, Alzate, Juan, additional, Kondziolka, Douglas, additional, Bowden, Greg N., additional, Patel, Samir, additional, and sheehan, jason, additional

Published
2024
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14. Stereotactic radiosurgery for clinoid meningiomas: a multi-institutional study

Author

Bunevicius, Adomas, Pikis, Stylianos, Anand, Rithika Kormath, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Abdelkarim, Khaled, El-Shehaby, Amr M. N., Emad, Reem M., Chytka, Tomas, Liscak, Roman, Caceres, Marco Perez, Mathieu, David, Lee, Cheng-chia, Yang, Huai-che, Picozzi, Piero, Franzini, Andrea, Attuati, Luca, Speckter, Herwin, Olivo, Jeremy, Patel, Samir, Cifarelli, Christopher P., Cifarelli, Daniel T., Hack, Joshua D., Strickland, Ben A., Zada, Gabriel, Chang, Eric L., Fakhoury, Kareem R., Rusthoven, Chad G., Warnick, Ronald E., and Sheehan, Jason

Published
2021
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15. Treatment of WHO Grade 2 Meningiomas With Stereotactic Radiosurgery: Identification of an Optimal Group for SRS Using RPA

Author

Kowalchuk, Roman O., Shepard, Matthew J., Sheehan, Kimball, Sheehan, Darrah, Faramand, Andrew, Niranjan, Ajay, Kano, Hideyuki, Gurewitz, Jason, Bernstein, Kenneth, Liscak, Roman, Guseynova, Khumar, Grills, Inga S., Parzen, Jacob S., Cifarelli, Christopher P., Rehman, Azeem A., Atik, Ahmet, Bakhsheshian, Joshua, Zada, Gabriel, Chang, Eric, Giannotta, Steven, Speckter, Herwin, Wu, Hsiu-mei, Kondziolka, Douglas, Mathieu, David, Lee, Cheng-chia, Warnick, Ronald E., Lunsford, L. Dade, Trifiletti, Daniel M., and Sheehan, Jason P.

Published
2021
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17. Third Stereotactic Radiosurgery for Residual Arteriovenous Malformations: A Retrospective Multicenter Study.

Author

Pikis, Stylianos, Mantziaris, Georgios, Dumot, Chloe, Shaaban, Ahmed, Protopapa, Maria, Zhiyuan Xu, Niranjan, Ajay, Zhishuo Wei, Srinivasan, Priyanka, Tang, Lilly W., Liscak, Roman, May, Jaromir, Martinez Moreno, Nuria, Martinez Álvarez, Roberto, Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., and Abdelkarim, Khaled

Published
2024
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19. Stereotactic radiosurgery for nonfunctioning pituitary tumor: A multicenter study of new pituitary hormone deficiency

Author

Dumot, Chloe, primary, Mantziaris, Georgios, additional, Dayawansa, Sam, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Nabeel, Ahmed M, additional, Reda, Wael A, additional, Tawadros, Sameh R, additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M N, additional, Emad, Reem M, additional, Abdelsalam, Ahmed Ragab, additional, Liscak, Roman, additional, May, Jaromir, additional, Mashiach, Elad, additional, De Nigris Vasconcellos, Fernando, additional, Bernstein, Kenneth, additional, Kondziolka, Douglas, additional, Speckter, Herwin, additional, Mota, Ruben, additional, Brito, Anderson, additional, Bindal, Shray Kumar, additional, Niranjan, Ajay, additional, Lunsford, Dade L, additional, Benjamin, Carolina Gesteira, additional, Abrantes de Lacerda Almeida, Timoteo, additional, Mao, Jennifer, additional, Mathieu, David, additional, Tourigny, Jean-Nicolas, additional, Tripathi, Manjul, additional, Palmer, Joshua David, additional, Matsui, Jennifer, additional, Crooks, Joe, additional, Wegner, Rodney E, additional, Shepard, Matthew J, additional, Vance, Mary Lee, additional, and Sheehan, Jason P, additional

Published
2023
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20. Clinical outcomes following stereotactic radiosurgery for cerebral cavernous malformations of the basal ganglia and thalamus

Author

Singh, Raj, primary, Dumot, Chloe, additional, Mantziaris, Georgios, additional, Dayawansa, Sam, additional, Xu, Zhiyuan, additional, Pikis, Stylianos, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Ardor, Gokce D., additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdel Karim, Khaled, additional, El-Shehaby, Amr M. N., additional, Emad Eldin, Reem M., additional, Sheehan, Darrah, additional, Sheehan, Kimball, additional, Elazzazi, Ahmed H., additional, Martínez Moreno, Nuria, additional, Martínez Álvarez, Roberto, additional, Liscak, Roman, additional, May, Jaromir, additional, Mathieu, David, additional, Tourigny, Jean-Nicolas, additional, Tripathi, Manjul, additional, Rajput, Akshay, additional, Kumar, Narendra, additional, Kaur, Rupinder, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Brito, Anderson, additional, Warnick, Ronald E., additional, Alzate, Juan Diego, additional, Kondziolka, Douglas, additional, Bowden, Greg N., additional, Patel, Samir, additional, and Sheehan, Jason P., additional

Published
2023
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21. Effect of cerebral arteriovenous malformation location on outcomes of repeat, single-fraction stereotactic radiosurgery: a matched-cohort analysis

Author

Mantziaris, Georgios, primary, Pikis, Stylianos, additional, Dumot, Chloe, additional, Dayawansa, Sam, additional, Liscak, Roman, additional, May, Jaromir, additional, Lee, Cheng-Chia, additional, Yang, Huai-Che, additional, Martínez Moreno, Nuria, additional, Martinez Álvarez, Roberto, additional, Lunsford, L. Dade, additional, Niranjan, Ajay, additional, Wei, Zhishuo, additional, Srinivasan, Priyanka, additional, Tang, Lilly W., additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdel Karim, Khaled, additional, El-Shehaby, Amr M. N., additional, Emad Eldin, Reem M., additional, Elazzazi, Ahmed Hesham, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Padmanaban, Varun, additional, Jareczek, Francis J., additional, McInerney, James, additional, Cockroft, Kevin M., additional, Mathieu, David, additional, Aldakhil, Salman, additional, Alzate, Juan Diego, additional, Kondziolka, Douglas, additional, Tripathi, Manjul, additional, Palmer, Joshua D., additional, Upadhyay, Rituraj, additional, Lin, Michelle, additional, Zada, Gabriel, additional, Yu, Cheng, additional, Cifarelli, Christopher P., additional, Cifarelli, Daniel T., additional, Shaaban, Ahmed, additional, Xu, Zhiyuan, additional, and Sheehan, Jason P., additional

Published
2023
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22. Stereotactic radiosurgery for nonfunctioning pituitary tumor: A multicenter study of new pituitary hormone deficiency.

Author

Dumot, Chloe, Mantziaris, Georgios, Dayawansa, Sam, Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M, Reda, Wael A, Tawadros, Sameh R, Abdelkarim, Khaled, El-Shehaby, Amr M N, Emad, Reem M, Abdelsalam, Ahmed Ragab, Liscak, Roman, May, Jaromir, Mashiach, Elad, Vasconcellos, Fernando De Nigris, Bernstein, Kenneth, Kondziolka, Douglas, Speckter, Herwin, and Mota, Ruben

Published
2024
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23. Repeat stereotactic radiosurgery for persistent cerebral arteriovenous malformations in pediatric patients.

Author

Garcia, Gracie, Mantziaris, Georgios, Pikis, Stylianos, Dumot, Chloe, Lunsford, L. Dade, Niranjan, Ajay, Zhishuo Wei, Srinivasan, Priyanka, Tang, Lilly W., Liscak, Roman, May, Jaromir, Cheng-Chia Lee, Huai-Che Yang, Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Karim, Khaled Abdel, and El-Shehaby, Amr M. N.

Published
2024
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24. Pediatric cerebral cavernous malformations and stereotactic radiosurgery: an analysis of 50 cases from a multicentric study.

Author

Mantziaris, Georgios, Dumot, Chloe, Pikis, Stylianos, Peker, Selcuk, Samanci, Yavuz, Ardor, Gokce D., Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Karim, Khaled Abdel, El-Shehaby, Amr M. N., Emad Eldin, Reem M., Elazzazi, Ahmed H., Sheehan, Darrah, Sheehan, Kimball, Martínez Moreno, Nuria, Martínez Álvarez, Roberto, Liscak, Roman, May, Jaromir, and Tripathi, Manjul

Published
2024
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25. Technique of Whole-Sellar Stereotactic Radiosurgery for Cushing Disease: Results from a Multicenter, International Cohort Study

Author

Shepard, Matthew J., Mehta, Gautam U., Xu, Zhiyuan, Kano, Hideyuki, Sisterson, Nathaniel, Su, Yan-Hua, Krsek, Michal, Nabeel, Ahmed M., El-Shehaby, Amr, Kareem, Khaled A., Martinez-Moreno, Nuria, Mathieu, David, McShane, Brendan J., Blas, Kevin, Kondziolka, Douglas, Grills, Inga, Lee, John Y., Martinez-Alvarez, Roberto, Reda, Wael A., Liscak, Roman, Lee, Cheng-Chia, Lunsford, L. Dade, Lee Vance, Mary, and Sheehan, Jason P.

Published
2018
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28. Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation: a multi-institutional, retrospective study

Author

Dumot, Chloe, primary, Mantziaris, Georgios, additional, Dayawansa, Sam, additional, Xu, Zhiyuan, additional, Pikis, Stylianos, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Ardor, Gokce D, additional, Nabeel, Ahmed M, additional, Reda, Wael A, additional, Tawadros, Sameh R, additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M N, additional, Emad Eldin, Reem M, additional, Elazzazi, Ahmed H, additional, Moreno, Nuria Martínez, additional, Martínez Álvarez, Roberto, additional, Liscak, Roman, additional, May, Jaromir, additional, Mathieu, David, additional, Tourigny, Jean-Nicolas, additional, Tripathi, Manjul, additional, Rajput, Akshay, additional, Kumar, Narendra, additional, Kaur, Rupinder, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Brito, Anderson, additional, Warnick, Ronald E, additional, Alzate, Juan, additional, Kondziolka, Douglas, additional, Bowden, Greg N, additional, Patel, Samir, additional, and Sheehan, Jason, additional

Published
2023
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29. Intratumoral Hemorrhage in Vestibular Schwannomas After Stereotactic Radiosurgery: Multi-Institutional Study

Author

Bin-Alamer, Othman, primary, Abou-Al-Shaar, Hussam, additional, Mallela, Arka N., additional, Kallos, Justiss A., additional, Deng, Hansen, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M. N., additional, Emad, Reem M., additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Mathieu, David, additional, Tripathi, Manjul, additional, Mantziaris, Georgios, additional, Mullapudi, Abhishek, additional, Urgosik, Dusan, additional, Liscak, Roman, additional, Bowden, Greg N., additional, Zaki, Peter, additional, Wegner, Rodney E., additional, Shepard, Matthew J., additional, Sheehan, Jason P., additional, Niranjan, Ajay, additional, Hadjipanayis, Constantinos G., additional, and Lunsford, L. Dade, additional

Published
2023
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30. Clinical and Imaging Outcomes After Trigeminal Schwannoma Radiosurgery: Results From a Multicenter, International Cohort Study

Author

Niranjan, Ajay, primary, Faramand, Andrew, additional, Raju, Sudesh S., additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Nabeel, Ahmed M., additional, Tawadros, Sameh R., additional, El-Shehaby, Amr M. N., additional, Abdelkarim, Khaled, additional, Emad, Reem M., additional, Reda, Wael A., additional, Álvarez, Roberto Martínez, additional, Moreno, Nuria E. Martínez, additional, Liscak, Roman, additional, May, Jaromir, additional, Mathieu, David, additional, Langlois, Anne-Marie, additional, Snyder, M. Harrison, additional, Shepard, Matthew J., additional, Sheehan, Jason, additional, Muhsen, Baha'eddin A., additional, Borghei-Razavi, Hamid, additional, Barnett, Gene, additional, Kondziolka, Douglas, additional, Golfinos, John G., additional, Attuati, Luca, additional, Picozzi, Piero, additional, McInerney, James, additional, Daggubati, Lekhaj Chand, additional, Warnick, Ronald E., additional, Feliciano, Caleb E., additional, Carro, Eric, additional, McCarthy, David, additional, Starke, Robert M., additional, Landy, Howard J., additional, Cifarelli, Christopher P., additional, Vargo, John A., additional, Flickinger, John, additional, and Lunsford, L. Dade, additional

Published
2023
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31. Silent Corticotroph Staining Pituitary Neuroendocrine Tumors: Prognostic Significance in Radiosurgery

Author

Maragkos, Georgios A., primary, Mantziaris, Georgios, additional, Pikis, Stylianos, additional, Chytka, Tomas, additional, Liscak, Roman, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Bindal, Shray K., additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Kaur, Rupinder, additional, Madan, Renu, additional, Tripathi, Manjul, additional, Pangal, Dhiraj J., additional, Strickland, Ben A., additional, Zada, Gabriel, additional, Langlois, Anne-Marie, additional, Mathieu, David, additional, Warnick, Ronald E., additional, Patel, Samir, additional, Minier, Zayda, additional, Speckter, Herwin, additional, Kondziolka, Douglas, additional, Lee, Cheng-chia, additional, Vance, Mary Lee, additional, and Sheehan, Jason P., additional

Published
2023
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33. Facial Nerve Schwannoma Treatment with Stereotactic Radiosurgery (SRS) versus Resection followed by SRS: Outcomes and a Management Protocol.

Author

Dayawansa, Sam, Dumot, Chloe, Mantziaris, Georgios, Mehta, Gautam U., Lekovic, Gregory P., Kondziolka, Douglas, Mathieu, David, Reda, Wael A., Liscak, Roman, Cheng-chia, Lee, Kaufmann, Anthony M., Barnet, Gene, Trifiletti, Daniel M., Lunsford, L Dade, and Sheehan, Jason

Subjects
STEREOTACTIC radiosurgery, VESTIBULAR nerve, FACIAL nerve, RADIATION doses, CANCER invasiveness, SCHWANNOMAS
Abstract

Background Stereotactic radiosurgery (SRS) and resection are treatment options for patients with facial nerve schwannomas without mass effect. Objective This article evaluates outcomes of patients treated with SRS versus resection + SRS. Method We retrospectively compared 43 patients treated with SRS to 12 patients treated with resection + SRS. The primary study outcome was unfavorable combined endpoint, defined as worsening or new clinical symptoms, and/or tumor radiological progression. SRS (38.81 ± 5.3) and resection + SRS (67.14 ± 11.8) groups had similar clinical follow-ups. Results At the time of SRS, the tumor volumes of SRS (mean ± standard error; 1.83 ± 0.35 mL) and resection + SRS (2.51 ± 0.75 mL) groups were similar. SRS (12.15 ± 0.08 Gy) and resection + SRS (12.16 ± 0.14 Gy) groups received similar radiation doses. SRS group (42/43, 98%) had better local tumor control than the resection + SRS group (10/12, 83%, p = 0.04). Most of SRS (32/43, 74%) and resection + SRS (10/12, 83%) group patients reached a favorable combined endpoint following SRS (p = 0.52). Considering surgical associated side effects, only 2/10 patients of the resection + SRS group reached a favorable endpoint (p < 0.001). Patients of SRS group, who are > 34 years old (p = 0.02), have larger tumors (> 4 mL, 0.04), internal auditory canal (IAC) segment tumor involvement (p = 0.01) were more likely to reach an unfavorable endpoint. Resection + SRS group patients did not show such a difference. Conclusion While resection is still needed for larger tumors, SRS offers better clinical and radiological outcomes compared to resection followed by SRS for facial schwannomas. Younger age, smaller tumors, and non-IAC situated tumors are factors that portend a favorable outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Ocular and Orbital Lesions

Author

Li, Yan Michael, Šimonová, Gabriela, Lisčák, Roman, Novotný, Josef, Jr., Singla, Amit, Chin, Lawrence S., Chin, Lawrence S., editor, and Regine, William F., editor

Published
2015
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36. Adjuvant Stereotactic Radiosurgery With or Without Postresection Fractionated Radiation Therapy for the Management of Clival Chordomas in Adults: An International Multicenter Case Series

Author

Bin-Alamer, Othman, primary, Pikis, Stylianos, additional, Mantziaris, Georgios, additional, Abdulbaki, Arif, additional, Mallela, Arka N., additional, Lu, Victor M., additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, El-Shehaby, Amr M. N., additional, Abdelkarim, Khaled, additional, Emad Eldin, Reem M., additional, Sheehan, Darrah, additional, Sheehan, Kimball, additional, Liscak, Roman, additional, Chytka, Tomas, additional, Tripathi, Manjul, additional, Madan, Renu, additional, Speckter, Herwin, additional, Hernández, Wenceslao, additional, Barnett, Gene H., additional, Hori, Yusuke S., additional, Dabhi, Nisha, additional, Aldakhil, Salman, additional, Mathieu, David, additional, Kondziolka, Douglas, additional, Bernstein, Kenneth, additional, Wei, Zhishuo, additional, Niranjan, Ajay, additional, Kersh, Charles R., additional, Lunsford, L. Dade, additional, Sheehan, Jason P., additional, and Abou-Al-Shaar, Hussam, additional

Published
2023
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37. 477 Stereotactic Radiosurgery With Versus Without Prior Onyx Embolization for Brain Arteriovenous Malformations

Author

Chen, Ching-Jen, primary, Ding, Dale, additional, Lee, Cheng-chia, additional, Kearns, Kathryn, additional, Pomeraniec, Isaac Jonathan, additional, Cifarelli, Christopher Paul, additional, Liscak, Roman, additional, May, Jaromir, additional, Williams, Brian Jeremy, additional, Ironside, Natasha, additional, Burke, Rebecca M., additional, Warnick, Ronald E., additional, Trifiletti, Daniel M., additional, Mathieu, David, additional, Kondziolka, Douglas, additional, Feliciano, Caleb E., additional, Rodriguez-Mercado, Rafael, additional, Cockroft, Kevin M., additional, Simon, Scott Douglas, additional, Lee, John Y.K., additional, and Sheehan, Jason P., additional

Published
2023
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38. Local Control and Survival Outcomes After Stereotactic Radiosurgery for Brain Metastases From Gastrointestinal Primaries: An International Multicenter Analysis

Author

Singh, Raj, primary, Bowden, Greg, additional, Mathieu, David, additional, Perlow, Haley K., additional, Palmer, Joshua D., additional, Elhamdani, Shahed, additional, Shepard, Matthew, additional, Liang, Yun, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R, additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M.N., additional, Emad, Reem M, additional, Elazzazi, Ahmed Hesham, additional, Warnick, Ronald E., additional, Gozal, Yair M., additional, Daly, Megan, additional, McShane, Brendan, additional, Addis-Jackson, Marcel, additional, Karthikeyan, Gokul, additional, Smith, Sian, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Kaisman-Elbaz, Tehila, additional, Yang, Huai-che, additional, Wei, Zhishuo, additional, Legarreta, Andrew, additional, Hess, Judith, additional, Templeton, Kelsey, additional, Pikis, Stylianos, additional, Mantziaris, Georgios, additional, Simonova, Gabriela, additional, Liscak, Roman, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Chiang, Veronica, additional, Niranjan, Ajay, additional, Kersh, Charles R., additional, Lee, Cheng-Chia, additional, Trifiletti, Daniel M., additional, Lunsford, L. Dade, additional, and Sheehan, Jason P., additional

Published
2023
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39. Stereotactic Radiosurgery for Vestibular Schwannoma in Neurofibromatosis Type 2: An International Multicenter Case Series of Response and Malignant Transformation Risk

Author

Bin-Alamer, Othman, primary, Faramand, Andrew, additional, Alarifi, Norah A., additional, Wei, Zhishuo, additional, Mallela, Arka N., additional, Lu, Victor M., additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M.N., additional, Emad, Reem M., additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Delabar, Violaine, additional, Mathieu, David, additional, Tripathi, Manjul, additional, Kearns, Kathryn Nicole, additional, Bunevicius, Adomas, additional, Sheehan, Jason P., additional, Chytka, Tomas, additional, Liscak, Roman, additional, Moreno, Nuria Martínez, additional, Álvarez, Roberto Martínez, additional, Grills, Inga S., additional, Parzen, Jacob S., additional, Cifarelli, Christopher P., additional, Rehman, Azeem A., additional, Speckter, Herwin, additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, and Abou-Al-Shaar, Hussam, additional

Published
2023
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40. Stereotactic radiosurgery for vestibular schwannoma in neurofibromatosis type 2: an international multicenter case series of response and malignant transformation risk

Author

Peker, Selçuk (ORCID 0000-0003-3057-3355 & YÖK ID 11480); Samancı, Mustafa Yavuz (ORCID 0000-0001-8952-6866 & YÖK ID 275252), Bin-Alamer, Othman; Faramand, Andrew; Alarifi, Norah A.; Wei, Zhishuo; Mallela, Arka N.; Lu, Victor M.; Nabeel, Ahmed M.; Reda, Wael A.; Tawadros, Sameh R.; Abdelkarim, Khaled; El-Shehaby, Amr M. N.; Emad, Reem M.; Lee, Cheng-chia; Yang, Huai-che; Delabar, Violaine; Mathieu, David; Tripathi, Manjul; Kearns, Kathryn Nicole; Bunevicius, Adomas; Sheehan, Jason P.; Chytka, Tomas; Liscak, Roman; Moreno, Nuria Martinez; Alvarez, Roberto Martinez; Grills, Inga S.; Parzen, Jacob S.; Cifarelli, Christopher P.; Rehman, Azeem A.; Speckter, Herwin; Niranjan, Ajay; Lunsford, L. Dade; Abou-Al-Shaar, Hussam, School of Medicine, Peker, Selçuk (ORCID 0000-0003-3057-3355 & YÖK ID 11480); Samancı, Mustafa Yavuz (ORCID 0000-0001-8952-6866 & YÖK ID 275252), Bin-Alamer, Othman; Faramand, Andrew; Alarifi, Norah A.; Wei, Zhishuo; Mallela, Arka N.; Lu, Victor M.; Nabeel, Ahmed M.; Reda, Wael A.; Tawadros, Sameh R.; Abdelkarim, Khaled; El-Shehaby, Amr M. N.; Emad, Reem M.; Lee, Cheng-chia; Yang, Huai-che; Delabar, Violaine; Mathieu, David; Tripathi, Manjul; Kearns, Kathryn Nicole; Bunevicius, Adomas; Sheehan, Jason P.; Chytka, Tomas; Liscak, Roman; Moreno, Nuria Martinez; Alvarez, Roberto Martinez; Grills, Inga S.; Parzen, Jacob S.; Cifarelli, Christopher P.; Rehman, Azeem A.; Speckter, Herwin; Niranjan, Ajay; Lunsford, L. Dade; Abou-Al-Shaar, Hussam, and School of Medicine

Abstract

BACKGROUND: Vestibular schwannomas (VSs) related to neurofibromatosis type 2 (NF2) are challenging tumors. The increasing use of stereotactic radiosurgery (SRS) necessitates further investigations of its role and safety. OBJECTIVE: To evaluate tumor control, freedom from additional treatment (FFAT), serviceable hearing preservation, and radiation-related risks of patients with NF2 after SRS for VS.METHODS: We performed a retrospective study of 267 patients with NF2 (328 VSs) who underwent single-session SRS at 12 centers participating in the International Radiosurgery Research Foundation. The median patient age was 31 years (IQR, 21-45 years), and 52% were male. RESULTS: A total of 328 tumors underwent SRS during a median follow-up time of 59 months (IQR, 23-112 months). At 10 and 15 years, the tumor control rates were 77% (95% CI: 69%-84%) and 52% (95% CI: 40%-64%), respectively, and the FFAT rate were 85% (95% CI: 79%-90%) and 75% (95% CI: 65%-86%), respectively. At 5 and 10 years, the serviceable hearing preservation rates were 64% (95% CI: 55%-75%) and 35% (95% CI: 25%-54%), respectively. In the multivariate analysis, age (hazards ratio: 1.03 [95% CI: 1.01-1.05]; P= .02) and bilateral VSs (hazards ratio: 4.56 [95% CI: 1.05-19.78]; P= .04) were predictors for serviceable hearing loss. Neither radiation-induced tumors nor malignant transformation were encountered in this cohort. CONCLUSION: Although the absolute volumetric tumor progression rate was 48% at 15 years, the rate of FFAT related to VS was 75% at 15 years after SRS. None of the patients with NF2-related VS developed a new radiation-related neoplasm or malignant transformation after SRS., NA

Published
2023

41. Stereotactic Radiosurgery for Brainstem Metastases: An International Cooperative Study to Define Response and Toxicity

Author

Trifiletti, Daniel M., Lee, Cheng-Chia, Kano, Hideyuki, Cohen, Jonathan, Janopaul-Naylor, James, Alonso-Basanta, Michelle, Lee, John Y.K., Simonova, Gabriela, Liscak, Roman, Wolf, Amparo, Kvint, Svetlana, Grills, Inga S., Johnson, Matthew, Liu, Kang-Du, Lin, Chung-Jung, Mathieu, David, Héroux, France, Silva, Danilo, Sharma, Mayur, Cifarelli, Christopher P., Watson, Christopher N., Hack, Joshua D., Golfinos, John G., Kondziolka, Douglas, Barnett, Gene, Lunsford, L. Dade, and Sheehan, Jason P.

Published
2016
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42. Effects of Neuroanatomic Structural Distances on Pituitary Function After Stereotactic Radiosurgery: A Multicenter Study

Author

Ironside, Natasha, primary, Chen, Ching-Jen, additional, Xu, Zhiyuan, additional, Schlesinger, David, additional, Lee Vance, Mary, additional, Hong, Gregory K., additional, Jane, John A., additional, Patel, Samir, additional, Bindal, Shray K., additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Liscak, Roman, additional, Chytka, Thomas, additional, Jezkova, Jana, additional, Saifi, Omran, additional, Trifiletti, Daniel M., additional, Berger, Assaf, additional, Alzate, Juan, additional, Bernstein, Kenneth, additional, Kondziolka, Douglas, additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Lazo, Erwin, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Zacharia, Brad E., additional, Mau, Christine, additional, Wegner, Rodney E., additional, Shepard, Matthew J., additional, Mathieu, David, additional, Maillet, Michel, additional, and Sheehan, Jason P., additional

Published
2023
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45. Stereotactic Radiosurgery for Intraventricular Metastases: A Multicenter Study

Author

Mantziaris, Georgios, primary, Pikis, Stylianos, additional, Xu, Zhiyuan, additional, Mullen, Reed, additional, Alzate, Juan, additional, Bernstein, Kenneth, additional, Kondziolka, Douglas, additional, Wei, Zhishuo, additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Liscak, Roman, additional, May, Jaromir, additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Coupé, François-Louis, additional, Mathieu, David, additional, Sheehan, Kimball, additional, Sheehan, Darrah, additional, Palmer, Joshua D., additional, Perlow, Haley K., additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Peterson, Jennifer, additional, Trifiletti, Daniel M., additional, Shepard, Matthew J., additional, Elhamdani, Shahed, additional, Wegner, Rodney E., additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Warnick, Ronald E., additional, and Sheehan, Jason, additional

Published
2022
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46. European consensus conference on unruptured brain AVMs treatment (Supported by EANS, ESMINT, EGKS, and SINCH)

Author

Cenzato, Marco, Boccardi, Edoardo, Beghi, Ettore, Vajkoczy, Peter, Szikora, Istvan, Motti, Enrico, Regli, Luca, Raabe, Andreas, Eliava, Shalva, Gruber, Andreas, Meling, Torstein R., Niemela, Mika, Pasqualin, Alberto, Golanov, Andrey, Karlsson, Bengt, Kemeny, Andras, Liscak, Roman, Lippitz, Bodo, Radatz, Matthias, La Camera, Alessandro, Chapot, René, Islak, Civan, Spelle, Laurent, Debernardi, Alberto, Agostoni, Elio, Revay, Martina, and Morgan, Michael K.

Published
2017
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48. Facial Nerve Schwannoma Treatment with Stereotactic Radiosurgery (SRS) versus Resection followed by SRS: Outcomes and a Management Protocol

Author

Dayawansa, Sam, additional, Dumot, Chloe, additional, Mantziaris, Georgios, additional, Mehta, Gautam U., additional, Lekovic, Gregory P., additional, Kondziolka, Douglas, additional, Mathieu, David, additional, Reda, Wael A., additional, Liscak, Roman, additional, Cheng-chia, Lee, additional, Kaufmann, Anthony M., additional, Barnet, Gene, additional, Trifiletti, Daniel M., additional, Lunsford, L Dade, additional, and Sheehan, Jason, additional

Published
2022
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49. Chronic Encapsulated Expanding Hematomas After Stereotactic Radiosurgery for Intracranial Arteriovenous Malformations: An International Multicenter Case Series

Author

Abou-Al-Shaar, Hussam, primary, Patel, Aneek, additional, Mallela, Arka N., additional, Bin-Alamer, Othman, additional, Niranjan, Ajay, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Liscak, Roman, additional, May, Jaromir, additional, Kumar, Jeyan Sathia, additional, Sheehan, Jason P., additional, and Lunsford, L. Dade, additional

Published
2022
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50. Stereotactic radiosurgery for intracranial chordomas: an international multiinstitutional study

Author

Pikis, Stylianos, primary, Mantziaris, Georgios, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, El-Shehaby, Amr M. N., additional, Abdelkarim, Khaled, additional, Eldin, Reem M. Emad, additional, Sheehan, Darrah, additional, Sheehan, Kimball, additional, Liscak, Roman, additional, Chytka, Tomas, additional, Tripathi, Manjul, additional, Madan, Renu, additional, Speckter, Herwin, additional, Hernández, Wenceslao, additional, Barnett, Gene H., additional, Hori, Yusuke S., additional, Dabhi, Nisha, additional, Aldakhil, Salman, additional, Mathieu, David, additional, Kondziolka, Douglas, additional, Bernstein, Kenneth, additional, Wei, Zhishuo, additional, Niranjan, Ajay, additional, Kersh, Charles R., additional, Lunsford, L. Dade, additional, and Sheehan, Jason P., additional

Published
2022
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