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19. Prognostic Significance of the Microenvironment in Human Papillomavirus Oropharyngeal Carcinoma: A Systematic Review.

Author

Baudouin, R., Hans, S., Lisan, Q., Morin, B., Adimi, Y., Martin, J., Lechien, J. R., Tartour, E., and Badoual, C.

Abstract

Objective: The immune microenvironment of HPV‐associated (HPV+) oropharyngeal squamous cell carcinomas (OPSCCs) (HPV+OPSCCs) differs from that of HPV‐independent oropharyngeal cancers (HPV‐independent OPSCCs). The literature on the subject is very abundant, demanding an organized synthesis of this wealth of information to evaluate the hypothesis associating the favorable prognosis of HPV+OPSCC patients with a different immune microenvironment. A systematic review of the literature was conducted regarding the microenvironment of HPV+OPSCCs. Data Source: MEDLINE/PubMed, Embase, and Cochrane Library databases. Review Methods: A literature search was performed following PRISMA guidelines (Moher D. PLoS Med. 2009). The PEO (Population, Exposure, and Outcome) framework is detailed as follows: P: patients with oropharyngeal squamous cell carcinomas, E: human papillomavirus (HPV), and O: histological and immunological composition of the tumoral microenvironment (TME). No meta‐analysis was performed. Results: From 1,202 studies that were screened, 58 studies were included (n = 6,474 patients; n = 3,581 (55%) HPV+OPSCCs and n = 2,861(45%) HPV‐independent OPSCCs). The presence of tumor‐infiltrating lymphocytes (TIL), CD3+ in 1,733 patients, CD4+ in 520 patients, and CD8+ (cytotoxic T lymphocytes (CTL)) in 3,104 patients, and high levels of PD‐L1 expression in 1,222 patients is strongly correlated with an improved clinical outcome in HPV+OPSCCs. Conclusion: This systematic review provides the most comprehensive information on the immune microenvironment of HPV+OPSCCs to date. Tumor‐infiltrating lymphocytes and PD‐L1 expression are associated with a favorable prognosis. B, CD8+ and resident memory cells densities are higher in HPV+OPSCCs. The importance of myeloid lineages is still a matter of debate and research. Level of Evidence: NA Laryngoscope, 134:1507–1516, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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20. Writing in the European Annals of Otorhinolaryngology Head & Neck Diseases. Dos and Don’ts!

Author

Righini, C., primary, Laccourreye, O., additional, Fakhry, N., additional, Franco-Vidal, V., additional, Leboulanger, N., additional, Lisan, Q., additional, Radulesco, T., additional, Rumeau, C., additional, Schmerber, S., additional, Simon, F., additional, Thaï Van, H., additional, Vergez, S., additional, Vincent, C., additional, and Jankowski, R., additional

Published
2023
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31. Les clefs d’une publication réussie dans les Eur Ann Otorhinolaryngol Head Neck Dis : analyse STROBE de la relecture des articles scientifiques soumis en 2020–2021

Author

Laccourreye, O., primary, Lisan, Q., additional, Vincent, C., additional, Righini, C., additional, Leboulanger, N., additional, Franco-Vidal, V., additional, Radulesco, T., additional, Rumeau, C., additional, Schmerber, S., additional, Simon, F., additional, Van, H.T., additional, Vergez, S., additional, Fakhry, N., additional, and Jankowski, R., additional

Published
2023
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37. Keys for successful publication in Eur Ann Otorhinolaryngol Head Neck Dis: A STROBE analysis of peer reviews of articles submitted in 2020–2021

Author

Laccourreye, O., primary, Lisan, Q., additional, Vincent, C., additional, Righini, C., additional, Leboulanger, N., additional, Franco-Vidal, V., additional, Radulesco, T., additional, Rumeau, C., additional, Schmerber, S., additional, Simon, F., additional, Van, H.T., additional, Vergez, S., additional, Fakhry, N., additional, and Jankowski, R., additional

Published
2022
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41. Sleep Apnea is Associated With Accelerated Vascular Aging: Results From 2 European Community-Based Cohort Studies

Author

Lisan, Q., van Sloten, T., Boutouyrie, P., Laurent, S., Danchin, N., Thomas, F., Guibout, C., Perier, M.C., Dagnelie, P., Henry, R.M., Schram, M.T., Heinzer, R., Marques-Vidal, P., van der Kallen, C.J., Crijns, H.J., van Greevenbroek, M., Reesink, K., Köhler, S., Sastry, M., Jouven, X., Stehouwer, CDA, Empana, J.P., Interne Geneeskunde, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: HVC Pieken Maastricht Studie (9), Biomedische Technologie, RS: Carim - H07 Cardiovascular System Dynamics, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), and MUMC+: MA Interne Geneeskunde (3)

Subjects
Male, Aging, Epidemiology, POSITIVE AIRWAY PRESSURE, Carotid Intima-Media Thickness, Risk Assessment, INTIMA-MEDIA THICKNESS, DISEASE, PULSE-WAVE, Vascular Stiffness, community‐based study, sleep apnea, vascular aging, Prevalence, Humans, Correlation of Data, Ultrasonography, Original Research, RISK, Sleep Apnea, Obstructive, AORTIC STIFFNESS, Middle Aged, community-based study, EARLY SIGNS, Europe, ATHEROSCLEROSIS, Cardiovascular Diseases, Heart Disease Risk Factors, Carotid-Femoral Pulse Wave Velocity, Female, BERLIN QUESTIONNAIRE, FOLLOW-UP
Abstract

Background The mechanisms underlying the association between obstructive sleep apnea (OSA) and cardiovascular disease may include accelerated vascular aging. The aim was to compare the magnitude of vascular aging in patients with high versus low risk of OSA. Methods and Results In 2 community-based studies, the PPS3 (Paris Prospective Study 3) and the Maastricht Study, high risk of OSA was determined with the Berlin questionnaire (a screening questionnaire for OSA). We assessed carotid artery properties (carotid intima-media thickness, Young's elastic modulus, carotid-femoral pulse wave velocity, carotid pulse wave velocity, carotid diameter using high precision ultrasound echography), and carotid-femoral pulse wave velocity (in the Maastricht Study only). Regression coefficients were estimated on pooled data using multivariate linear regression. A total of 8615 participants without prior cardiovascular disease were included (6840 from PPS3, 62% men, mean age 59.5 +/- 6.2 years, and 1775 from the Maastricht Study, 51% men, 58.9 +/- 8.1 years). Overall, high risk of OSA prevalence was 16.8% (n=1150) in PPS3 and 23.8% (n=423) in the Maastricht Study. A high risk of OSA was associated with greater carotid intima-media thickness (beta=0.21; 0.17-0.26), Young's elastic modulus (beta=0.21; 0.17-0.25), carotid-femoral pulse wave velocity (beta=0.24; 0.14-0.34), carotid pulse wave velocity (beta=0.31; 0.26-0.35), and carotid diameter (beta=0.43; 0.38-0.48), after adjustment for age, sex, total cholesterol, smoking, education level, diabetes mellitus, heart rate, and study site. Consistent associations were observed after additional adjustments for mean blood pressure, body mass index, or antihypertensive medications. Conclusions These data lend support for accelerated vascular aging in individuals with high risk of OSA. This may, at least in part, underlie the association between OSA and cardiovascular disease.

Published
2021

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