1. Myocardial infarction with a preserved ejection fraction—the impaired function of the cardio-renal baroreflex
- Author
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Lisa Pickny, Martin Hindermann, Tilmann Ditting, Karl F. Hilgers, Peter Linz, Christian Ott, Roland E. Schmieder, Mario Schiffer, Kerstin Amann, Roland Veelken, and Kristina Rodionova
- Subjects
cardiac afferent neurons after myocardial infarction cardiac afferent innervation ,renal innervation ,neuronal cell culture ,myocardial infarction ,congestive heart failure ,preserved ejection fraction ,Physiology ,QP1-981 - Abstract
Introduction: In experimental myocardial infarction with reduced ejection fraction causing overt congestive heart failure, the control of renal sympathetic nerve activity (RSNA) by the cardio-renal baroreflex was impaired. The afferent vagal nerve activity under these experimental conditions had a lower frequency at saturation than that in controls. Hence, by investigating respective first neurons in the nodose ganglion (NG), we wanted to test the hypothesis that after myocardial infarction with still-preserved ejection fraction, the cardiac afferent nerve pathway is also already impaired.Material and methods: A myocardial infarction was induced by coronary artery ligature. After 21 days, nodose ganglion neurons with cardiac afferents from rats with myocardial infarction were cultured. A current clamp was used to characterize neurons as “tonic,” i.e., sustained action potential (AP) firing, or “phasic,” i.e.,
- Published
- 2023
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