22 results on '"Lisa Marie Knowlton"'
Search Results
2. Small bowel obstruction due to a migrated pyloric stent
- Author
-
Lisa Marie Knowlton, Simeng Wang, James Paul Agolia, Andrea Fisher, and Jaimie L Bryan
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2024
- Full Text
- View/download PDF
3. Taking action to achieve health equity and eliminate healthcare disparities within acute care surgery
- Author
-
Lillian S Kao, Brandon Bruns, Tanya L Zakrison, Lisa Marie Knowlton, Cherisse Berry, Marta L McCrum, and Kathie-Ann Joseph
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Addressing disparities is crucial for enhancing population health, ensuring health security, and fostering resilient health systems. Disparities in acute care surgery (trauma, emergency general surgery, and surgical critical care) have been well documented and the magnitude of inequities demand an intentional, organized, and effective response. As part of its commitment to achieve high-quality, equitable care in all aspects of acute care surgery, the American Association for the Surgery of Trauma convened an expert panel at its eigty-second annual meeting in September 2023 to discuss how to take action to work towards health equity in acute care surgery practice. The panel discussion framed contemporary disparities in the context of historic and political injustices, then identified targets for interventions and potential action items in health system structure, health policy, the surgical workforce, institutional operations and quality efforts. We offer a four-pronged approach to address health inequities: identify, reduce, eliminate, and heal disparities, with the goal of building a healthcare system that achieves equity and justice for all.
- Published
- 2024
- Full Text
- View/download PDF
4. Large uterine fibroids causing a closed loop small bowel obstruction following uterine fibroid embolization
- Author
-
Lisa Marie Knowlton, Amanda C Antono, Julie Najar, Sunnie Y W Wong, and Justin Junn
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2024
- Full Text
- View/download PDF
5. Weight-based enoxaparin thromboprophylaxis in young trauma patients: analysis of the CLOTT-1 registry
- Author
-
Sarah Lombardo, Ram Nirula, Elliott R Haut, Scott Brakenridge, Brandon Bruns, Charles E Wade, M Margaret Knudson, Thomas Scalea, Todd W Costantini, Lisa Marie Knowlton, David Spain, Ernest E Moore, Michelle K McNutt, Matthew J Martin, Andrew J Kerwin, George C Velmahos, Bruce Crookes, Marta McCrum, Lucy Kornblith, Mark D Cipolle, Laszlo N Kiraly, David J Milia, Alicia Mohr, Frederick Rogers, Sherry Sixta, and Jade Nunez
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Introduction Optimal venous thromboembolism (VTE) enoxaparin prophylaxis dosing remains elusive. Weight-based (WB) dosing safely increases anti-factor Xa levels without the need for routine monitoring but it is unclear if it leads to lower VTE risk. We hypothesized that WB dosing would decrease VTE risk compared with standard fixed dosing (SFD).Methods Patients from the prospective, observational CLOTT-1 registry receiving prophylactic enoxaparin (n=5539) were categorized as WB (0.45–0.55 mg/kg two times per day) or SFD (30 mg two times per day, 40 mg once a day). Multivariate logistic regression was used to generate a predicted probability of VTE for WB and SFD patients.Results Of 4360 patients analyzed, 1065 (24.4%) were WB and 3295 (75.6%) were SFD. WB patients were younger, female, more severely injured, and underwent major operation or major venous repair at a higher rate than individuals in the SFD group. Obesity was more common among the SFD group. Unadjusted VTE rates were comparable (WB 3.1% vs. SFD 3.9%; p=0.221). Early prophylaxis was associated with lower VTE rate (1.4% vs. 5.0%; p=0.001) and deep vein thrombosis (0.9% vs. 4.4%; p
- Published
- 2024
- Full Text
- View/download PDF
6. Managing career transitions in the profession of acute care surgery
- Author
-
Kimberly A Davis, Lisa Marie Knowlton, Ryan Peter Dumas, Michael W Cripps, Jennifer M Gurney, and Caitlin Anne Fitzgerald
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Career shifts are a naturally occurring part of the trauma and acute care surgeon’s profession. These transitions may occur at various timepoints throughout a surgeon’s career and each has their own specific challenges. Finding a good fit for your first job is critical for ensuring success as an early career surgeon. Equally, understanding how to navigate promotions or a change in job location mid-career can be fraught with uncertainty. As one progresses in their career, knowing when to take on a leadership position is oftentimes difficult as it may mean a change in priorities. Finally, navigating your path towards a fulfilling retirement is a complex discussion that is different for each surgeon. The American Association for the Surgery of Trauma (AAST) convened an expert panel of acute care surgeons in a virtual grand rounds session in August 2023 to address the aforementioned career transitions and highlight strategies for successfully navigating each shift. This was a collaboration between the AAST Associate Member Council (consisting of surgical resident, fellow and junior faculty members), the AAST Military Liaison Committee and the AAST Healthcare Economics Committee. Led by two moderators, the panel consisted of early, mid-career and senior surgeons, and recommendations are summarized below and in figure 1.
- Published
- 2024
- Full Text
- View/download PDF
7. Cholecystocolonic fistula: an unusual presentation of large bowel obstruction
- Author
-
Lakshika Tennakoon, Lisa Marie Knowlton, Ariel W Knight, and Ruoxue Wu
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2024
- Full Text
- View/download PDF
8. Power of mentorship for civilian and military acute care surgeons: identifying and leveraging opportunities for longitudinal professional development
- Author
-
Brandon Bruns, Jonathan P Meizoso, Lisa Marie Knowlton, Ryan Peter Dumas, Deborah M. Stein, Matthew J Martin, Haytham M A Kaafarani, Nicholas Namias, Kristan L Staudenmayer, William Jason Butler, Brittany K Bankhead, Jan-Michael Van Gent, Matthew D Tadlock, R Shayn Martin, and Jennifer M Gurney
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Across disciplines, mentorship has been recognized as a key to success. Acute care surgeons, focused on the care of trauma surgery, emergency general surgery and surgical critical care, practice in a wide variety of settings and have unique mentorship needs across all phases of their career. Recognizing the need for robust mentorship and professional development, the American Association for the Surgery of Trauma (AAST) convened an expert panel entitled ‘The Power of Mentorship’ at the 81st annual meeting in September 2022 (Chicago, Illinois). This was a collaboration between the AAST Associate Member Council (consisting of surgical resident, fellow and junior faculty members), the AAST Military Liaison Committee, and the AAST Healthcare Economics Committee. Led by two moderators, the panel consisted of five real-life mentor-mentee pairs. They addressed the following realms of mentorship: clinical, research, executive leadership and career development, mentorship through professional societies, and mentorship for military-trained surgeons. Recommendations, as well as pearls and pitfalls, are summarized below.
- Published
- 2023
- Full Text
- View/download PDF
9. Organ donation in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document
- Author
-
Deborah M Stein, Krista L Kaups, Christopher P Michetti, Lisa Marie Knowlton, Joseph Rappold, Matthew E Kutcher, Joseph Cuschieri, Abhijit Pathak, Anupamaa Seshadri, Tanya Rinderknecht, and Jason Young
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2023
- Full Text
- View/download PDF
10. Amyand hernia: considerations for operative approach and surgical repair
- Author
-
Lisa Marie Knowlton, Joshua D Jaramillo, Joseph M Garagliano, and Kimberly E Kopecky
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2020
- Full Text
- View/download PDF
11. Creation and implementation of a novel clinical workflow based on the AAST uniform anatomic severity grading system for emergency general surgery conditions
- Author
-
Lisa Marie Knowlton, Jeff Choi, David Spain, Sylvia Bereknyei Merrell, Kovi E Bessoff, and Aussama Khalaf Nassar
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Objective Emergency general surgery (EGS) conditions encompass a variety of diseases treated by acute care surgeons. The heterogeneity of these diseases limits infrastructure to facilitate EGS-specific quality improvement (QI) and research. A uniform anatomic severity grading system for EGS conditions was recently developed to fill this need. We integrated this system into our clinical workflow and examined its impact on research, surgical training, communication, and patient care.Methods The grading system was integrated into our clinical workflow in a phased fashion through formal education and a written handbook. A documentation template was also deployed in our electronic medical record to prospectively assign severity scores at the time of patient evaluation. Mixed methods including a quantitative survey and qualitative interviews of trainees and attending surgeons were used to evaluate the impact of the new workflow and to identify obstacles to its adoption.Results We identified 2291 patients presenting with EGS conditions during our study period. The most common diagnoses were small bowel obstruction (n=470, 20.5%), acute cholecystitis (n=384, 16.8%), and appendicitis (n=370, 16.1%). A total of 21 qualitative interviews were conducted. Twenty interviewees (95.2%) had a positive impression of the clinical workflow, citing enhanced patient care and research opportunities. Fifteen interviewees (75.0%) reported the severity grading system was a useful framework for clinical management, with five participants (25.0%) indicating the system was useful to facilitate clinical communication. Participants identified solutions to overcome barriers to adoption of the clinical workflow.Conclusions The uniform anatomic severity grading system can be readily integrated into a clinical workflow to facilitate prospective data collection for QI and research. The system is perceived as valuable by users. Educational initiatives that focus on increasing familiarity with the system and its benefits will likely improve adoption of the classification system and the clinical workflow that uses it.Level of evidence Level III.
- Published
- 2020
- Full Text
- View/download PDF
12. Iatrogenic gallbladder perforation secondary to Veress needle placement: a complication of robotic nephrectomy
- Author
-
Lisa Marie Knowlton, Joshua D Jaramillo, and Andrew J Sun
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2020
- Full Text
- View/download PDF
13. Mucormycosis emboli: a rare cause of segmental bowel ischemia
- Author
-
Ioana Baiu and Lisa Marie Knowlton
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
The patient is a 34-year-old man with a history of primary refractory acute myeloblastic leukemia diagnosed 1 year prior, with multiple relapses. As rescue treatment, he underwent allogeneic bone marrow transplant from cord blood 27 days prior to surgical consult. His post-transplant course has been notable for delayed engraftment, prolonged severe neutropenia, resulting in vancomycin-resistant Enterococcus, Streptococcus viridans and Streptococcus mitis bacteremia for which he treated with tedizolid, cefepime, Flagyl and daptomycin per guidance from the Infectious Disease team. On the day of consultation, he developed acute abdominal pain, he was on filgrastim to promote hematopoiesis, and prophylaxis with acyclovir, Bactrim, and caspofungin as well as the above antibiotics for bacteremia. A second antifungal was not started due to the potential toxicity and data from prior infections that he had. On surgical evaluation, his examination was notable for fever to 38.2°C, tachycardia to 155 basic metabolic panel, hypotension to 99/81 and tachypnea to 36; he was ill appearing with a distended abdomen and localized peritonitis. His white cell count was 0.2 x 109 /L with an absolute neutrophil count (ANC) of zero. Additionally, he was anemic with a hemoglobin of 7 g/L, thrombocytopenic with a platelet count of 10 x 109 /L, and a lactic acid of 3.1 mmol/L. His CT scan earlier in the morning revealed segmental ischemia of the small bowel (figure 1).Figure 1CT scan or initial presentation showing lack of wall enhancement of a discrete segment of small bowel.What would you do? Offer non-operative management with broad spectrum antibiotics.Transition to comfort care.Perform a small bowel resection with primary anastomosis.Perform a small bowel resection with end ileostomy.
- Published
- 2019
- Full Text
- View/download PDF
14. Data resources for evaluating the economic and financial consequences of surgical care in the United States
- Author
-
John W, Scott, Patricia, Ayoung-Chee, Erica L W, Lester, Brandon R, Bruns, Kimberly A, Davis, Amy, Gore, Lisa Marie, Knowlton, Charles, Liu, R Shayn, Martin, Esther Jiin, Oh, Samuel Wade, Ross, Michael, Wandling, Joseph P, Minei, and Kristan, Staudenmayer
- Subjects
Health Policy ,Humans ,Surgery ,Health Services Research ,Critical Care and Intensive Care Medicine ,Delivery of Health Care ,Hospitals ,Patient Discharge ,United States - Abstract
Evaluating the relationship between health care costs and quality is paramount in the current health care economic climate, as an understanding of value is needed to drive policy decisions. While many policy analyses are focused on the larger health care system, there is a pressing need for surgically focused economic analyses. Surgical care is costly, and innovative technology is constantly introduced into the operating room, and surgical care impacts patients' short- and long-term physical and economic well-being. Unfortunately, significant knowledge gaps exist regarding the relationship between cost, value, and economic impact of surgical interventions. Despite the plethora of health care data available in the forms of claims databases, discharge databases, and national surveys, no single source of data contains all the information needed for every policy-relevant analysis of surgical care. For this reason, it is important to understand which data are available and what can be accomplished with each of the data sets. In this article, we provide an overview of databases commonly used in surgical health services research. We focus our review on the following five categories of data: governmental claims databases, commercial claims databases, hospital-based clinical databases, state and national discharge databases, and national surveys. For each, we present a summary of the database sampling frame, clinically relevant variables, variables relevant to economic analyses, strengths, weaknesses, and examples of surgically relevant analyses. This review is intended to improve understanding of the current landscape of data available, as well as stimulate novel analyses among surgical populations. Ongoing debates over national health policy reforms may shape the delivery of surgical care for decades to come. Appropriate use of available data resources can improve our understanding of the economic impact of surgical care on our health care system and our patients.Regular Review, Level V.
- Published
- 2022
- Full Text
- View/download PDF
15. Firearm-Related Injuries and the US Opioid Epidemic: A Nationwide Evaluation of Emergency Department Encounters
- Author
-
Lakshika D Tennakoon, Aussama K Nassar, Jennifer A Wanberg, and Lisa Marie Knowlton
- Subjects
Surgery - Published
- 2022
- Full Text
- View/download PDF
16. Difference-In-Difference Techniques and Causal Inference
- Author
-
Sue Fu, Katherine Arnow, Amber Trickey, and Lisa Marie Knowlton
- Published
- 2022
- Full Text
- View/download PDF
17. Evaluating the Impact of the Covid-19 Pandemic on Emergency Medicaid Programs: Have Insurance Rates Improved among Trauma Patients?
- Author
-
Thomas J Handley, Ana Carolina Boncompagni, Katherine D Arnow, Marzena Sasnal, Amber W Trickey, Arden M Morris, and Lisa Marie Knowlton
- Subjects
Surgery - Published
- 2022
- Full Text
- View/download PDF
18. Faculty Lead Coaching as a Method to Enhance Feedback Culture and Communication Skills Development in Surgical Education-Needs Assessment (Study in Progress)
- Author
-
Aussama Nassar, Marzena Sasnal, Jamie Tung, Ara Ko, Micaela Esquivel, and Lisa Marie Knowlton
- Subjects
Surgery - Published
- 2022
- Full Text
- View/download PDF
19. Surgical Critical Care of Special Populations (Pregnant, Geriatric, Pediatric)
- Author
-
Kristan Staudenmayer, Chad M. Thorson, Lisa Marie Knowlton, and Stephanie D. Chao
- Subjects
Surgical critical care ,medicine.medical_specialty ,Special populations ,business.industry ,medicine ,Intensive care medicine ,business - Abstract
This review covers the specialized care of populations who present different management challenges when critically injured. The text is divided into three sections: pregnant, geriatric, and pediatric patients. For each population, the discussion focuses on the unique diagnostic and treatment algorithms that the surgical intensivist must consider. In addition to management of trauma in these special populations, other common diagnoses warranting surgical intensive care unit (ICU) admission are reviewed. Current guidelines on diagnostic imaging and medication safety are outlined. Injury prevention and outcomes improvement are an essential component of optimizing trauma care. The epidemiology of traumatic injury within each specialized population is included in this review. Outcomes are discussed in depth, particularly with respect to the geriatric ICU patient, including a section on barriers to disposition, decision-making capacity, and end-of-life care in the surgical ICU. This review contains 2 figures, 4 tables, and 72 references. Key words: end of life in the ICU, geriatric trauma, injury prevention, pediatric trauma, pregnancy
- Published
- 2017
- Full Text
- View/download PDF
20. The American College of Surgeons Needs-Based Assessment of Trauma Systems: Estimates for the State of California
- Author
-
Tarsicio Uribe-Leitz, Micaela M. Esquivel, David A. Spain, Feng Lin, Renee Y. Hsia, Kristan Staudenmayer, David Ciesla, Robert J. Winchell, and Lisa Marie Knowlton
- Subjects
Gerontology ,medicine.medical_specialty ,Physical Injury - Accidents and Adverse Effects ,media_common.quotation_subject ,Clinical Sciences ,MEDLINE ,Traumatology ,Rural Health ,Nursing ,Needs-Based Assessment of Trauma Systems (NBATS) tool ,Cardiorespiratory Medicine and Haematology ,Critical Care and Intensive Care Medicine ,Emergency Care ,California ,Article ,03 medical and health sciences ,trauma centers ,0302 clinical medicine ,State (polity) ,Trauma Centers ,Medical ,Surveys and Questionnaires ,trauma service area ,medicine ,Humans ,Societies, Medical ,media_common ,Medical education ,business.industry ,Extramural ,Consensus conference ,030208 emergency & critical care medicine ,trauma system ,Emergency & Critical Care Medicine ,030220 oncology & carcinogenesis ,Needs assessment ,Surgery ,Societies ,American College of Surgeons Committee on Trauma ,business ,Needs Assessment - Abstract
BackgroundIn 2015, the American College of Surgeons Committee on Trauma convened a consensus conference to develop the Needs-Based Assessment of Trauma Systems (NBATS) tool to assist in determining the number of trauma centers required for a region. We tested the performance of NBATS with respect to the optimal number of trauma centers needed by region in California.MethodsTrauma center data were obtained from the California Emergency Services Authority Information Systems (CEMSIS). Numbers of admitted trauma patients (ISS > 15) were obtained using statewide nonpublic admissions data from the California Office of Statewide Health Planning and Development (OSHPD), CEMSIS, and data from local emergency medical service agency (LEMSA) directors who agreed to participate in a telephone survey. Population estimates per county for 2014 were obtained from the U.S. Census. NBATS criteria used included population, transport time, community support, and number of discharges for severely injured patients (ISS > 15) at nontrauma centers and trauma centers. Estimates for the number of trauma centers per region were created for each of the three data sources and compared to the number of existing centers.ResultsA total of 62 state-designated trauma centers were identified for California: 13 (21%) Level I, 36 (58%) Level II, and 13 (11%) Level III. NBATS estimates for the total number of trauma centers in California were 27% to 47% lower compared to the number of trauma centers in existence, but this varied based on urban/rural status. NBATS estimates were lower than the current state in 70% of urban areas but were higher in almost 90% of rural areas. All data sources (OSHPD, CEMSIS, local data) produced similar results.ConclusionEstimates from the NBATS tool are different from what is currently in existence in California, and differences exist based on whether the region is rural or urban. Findings from the current study can help inform future iterations of the NBATS tool.Level of evidenceEconomic, level V.
- Published
- 2017
21. A Multinational Evaluation of Timely Access to Basic Surgical Services Using Geospatial Analyses
- Author
-
Tiffany E. Chao, Lisa-Marie Knowlton, Smita Chackungal, Thomas G. Weiser, David A. Spain, Tarsicio Uribe-Leitz, Micaela M. Esquivel, Kelly McQueen, and Drake G. LeBrun
- Subjects
Knowledge management ,Geospatial analysis ,business.industry ,Multinational corporation ,Medicine ,Surgery ,business ,computer.software_genre ,computer - Published
- 2016
- Full Text
- View/download PDF
22. Common values in assessing health outcomes from disease and injury : Disability weights measurement study for the Global Burden of Disease Study 2010
- Author
-
Joshua A Salomon, Theo Vos, Daniel R Hogan, Michael Gagnon, Mohsen Naghavi, Ali Mokdad, Nazma Begum, Razibuzzaman Shah, Muhammad Karyana, Soewarta Kosen, Mario Reyna Farje, Gilberto Moncada, Arup Dutta, Sunil Sazawal, Andrew Dyer, Jason Seiler, Victor Aboyans, Lesley Baker, Amanda Baxter, Emelia J Benjamin, Kavi Bhalla, Aref Bin Abdulhak, Fiona Blyth, Rupert Bourne, Tasanee Braithwaite, Peter Brooks, Traolach S Brugha, Claire Bryan-Hancock, Rachelle Buchbinder, Peter Burney, Bianca Calabria, Honglei Chen, Sumeet S Chugh, Rebecca Cooley, Michael H Criqui, Marita Cross, Kaustubh C Dabhadkar, Nabila Dahodwala, Adrian Davis, Louisa Degenhardt, Cesar Díaz-Torné, E Ray Dorsey, Tim Driscoll, Karen Edmond, Alexis Elbaz, Majid Ezzati, Valery Feigin, Cleusa P Ferri, Abraham D Flaxman, Louise Flood, Marlene Fransen, Kana Fuse, Belinda J Gabbe, Richard F Gillum, Juanita Haagsma, James E Harrison, Rasmus Havmoeller, Roderick J Hay, Abdullah Hel-Baqui, Hans W Hoek, Howard Hoffman, Emily Hogeland, Damian Hoy, Deborah Jarvis, Jost B Jonas, Ganesan Karthikeyan, Lisa Marie Knowlton, Tim Lathlean, Janet L Leasher, Stephen S Lim, Steven E Lipshultz, Alan D Lopez, Rafael Lozano, Ronan Lyons, Reza Malekzadeh, Wagner Marcenes, Lyn March, David J Margolis, Neil McGill, John McGrath, George A Mensah, Ana-Claire Meyer, Catherine Michaud, Andrew Moran, Rintaro Mori, Michele E Murdoch, Luigi Naldi, Charles R Newton, Rosana Norman, Saad B Omer, Richard Osborne, Neil Pearce, Fernando Perez-Ruiz, Norberto Perico, Konrad Pesudovs, David Phillips, Farshad Pourmalek, Martin Prince, Jürgen T Rehm, Guiseppe Remuzzi, Kathryn Richardson, Robin Room, Sukanta Saha, Uchechukwu Sampson, Lidia Sanchez-Riera, Maria Segui-Gomez, Saeid Shahraz, Kenji Shibuya, David Singh, Karen Sliwa, Emma Smith, Isabelle Soerjomataram, Timothy Steiner, Wilma A Stolk, Lars Jacob Stovner, Christopher Sudfeld, Hugh R Taylor, Imad M Tleyjeh, Marieke J van der Werf, Wendy L Watson, David J Weatherall, Robert Weintraub, Marc G Weisskopf, Harvey Whiteford, James D Wilkinson, Anthony D Woolf, Zhi-Jie Zheng, Christopher JL Murray, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Respiratory Epidemiology and Public Health, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute [UK], Neuroépidémiologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Respiratory Epidemiology and Public Health Group, Imperial College London-National Heart and Lung Institute [UK], Tehran University of Medical Sciences, Anaesthetics, Southampton University Hospital, Department of dermatology, Milano University-Azienda Ospedaleria Ospedali Riuniti di Bergamo, Massey University, centre for photomolecular science, Imperial College London, Department of Radiology, Weill Medical College of Cornell University [New York], Department of Public Health, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Harvard School of Public Health, The Weatherall Institute of Molecular Medicine, University of Oxford [Oxford], Cardiothoracic Surgery, Public Health, Cell biology, and University of Oxford
- Subjects
Gerontology ,Male ,Health Status ,Poison control ,Empirical Research ,Suicide prevention ,Tanzania ,Occupational safety and health ,Disability Evaluation ,0302 clinical medicine ,MESH: Health Surveys ,Peru ,Medicine ,030212 general & internal medicine ,10. No inequality ,MESH: Empirical Research ,MESH: Health Status ,MESH: Aged ,education.field_of_study ,Bangladesh ,MESH: Middle Aged ,MESH: Disability Evaluation ,General Medicine ,Middle Aged ,3. Good health ,MESH: Quality-Adjusted Life Years ,MESH: Internet ,MESH: Young Adult ,Female ,Quality-Adjusted Life Years ,MESH: Bangladesh ,Adult ,Adolescent ,Population ,Population health ,MESH: Indonesia ,03 medical and health sciences ,Young Adult ,MESH: Tanzania ,Injury prevention ,MESH: United States ,Disability-adjusted life year ,Humans ,education ,MESH: Peru ,Aged ,MESH: Adolescent ,Internet ,MESH: Humans ,business.industry ,MESH: Adult ,Health Surveys ,MESH: Male ,United States ,Quality-adjusted life year ,MESH: Wounds and Injuries ,Indonesia ,Wounds and Injuries ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,MESH: Female ,030217 neurology & neurosurgery ,Demography - Abstract
International audience; BACKGROUND: Measurement of the global burden of disease with disability-adjusted life-years (DALYs) requires disability weights that quantify health losses for all non-fatal consequences of disease and injury. There has been extensive debate about a range of conceptual and methodological issues concerning the definition and measurement of these weights. Our primary objective was a comprehensive re-estimation of disability weights for the Global Burden of Disease Study 2010 through a large-scale empirical investigation in which judgments about health losses associated with many causes of disease and injury were elicited from the general public in diverse communities through a new, standardised approach. METHODS: We surveyed respondents in two ways: household surveys of adults aged 18 years or older (face-to-face interviews in Bangladesh, Indonesia, Peru, and Tanzania; telephone interviews in the USA) between Oct 28, 2009, and June 23, 2010; and an open-access web-based survey between July 26, 2010, and May 16, 2011. The surveys used paired comparison questions, in which respondents considered two hypothetical individuals with different, randomly selected health states and indicated which person they regarded as healthier. The web survey added questions about population health equivalence, which compared the overall health benefits of different life-saving or disease-prevention programmes. We analysed paired comparison responses with probit regression analysis on all 220 unique states in the study. We used results from the population health equivalence responses to anchor the results from the paired comparisons on the disability weight scale from 0 (implying no loss of health) to 1 (implying a health loss equivalent to death). Additionally, we compared new disability weights with those used in WHO's most recent update of the Global Burden of Disease Study for 2004. FINDINGS: 13,902 individuals participated in household surveys and 16,328 in the web survey. Analysis of paired comparison responses indicated a high degree of consistency across surveys: correlations between individual survey results and results from analysis of the pooled dataset were 0*9 or higher in all surveys except in Bangladesh (r=0*75). Most of the 220 disability weights were located on the mild end of the severity scale, with 58 (26%) having weights below 0*05. Five (11%) states had weights below 0*01, such as mild anaemia, mild hearing or vision loss, and secondary infertility. The health states with the highest disability weights were acute schizophrenia (0*76) and severe multiple sclerosis (0*71). We identified a broad pattern of agreement between the old and new weights (r=0*70), particularly in the moderate-to-severe range. However, in the mild range below 0*2, many states had significantly lower weights in our study than previously. INTERPRETATION: This study represents the most extensive empirical effort as yet to measure disability weights. By contrast with the popular hypothesis that disability assessments vary widely across samples with different cultural environments, we have reported strong evidence of highly consistent results. FUNDING: Bill & Melinda Gates Foundation.
- Published
- 2012
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.