22 results on '"Lisa Coffey"'
Search Results
2. Genotype-by-environment interactions affecting heterosis in maize.
- Author
-
Zhi Li, Lisa Coffey, Jacob Garfin, Nathan D Miller, Michael R White, Edgar P Spalding, Natalia de Leon, Shawn M Kaeppler, Patrick S Schnable, Nathan M Springer, and Candice N Hirsch
- Subjects
Medicine ,Science - Abstract
The environment can influence heterosis, the phenomena in which the offspring of two inbred parents exhibits phenotypic performance beyond the inbred parents for specific traits. In this study we measured 25 traits in a set of 47 maize hybrids and their inbred parents grown in 16 different environments with varying levels of average productivity. By quantifying 25 vegetative and reproductive traits across the life cycle we were able to analyze interactions between the environment and multiple distinct instances of heterosis. The magnitude and rank among hybrids for better-parent heterosis (BPH) varied for the different traits and environments. Across the traits, a higher within plot variance was observed for inbred lines compared to hybrids. However, for most traits, variance across environments was not significantly different for inbred lines compared to hybrids. Further, for many traits the correlations of BPH to hybrid performance and BPH to better parent performance were of comparable magnitude. These results indicate that inbred lines and hybrids show similar trends in environmental response and both are contributing to observed genotype-by-environment interactions for heterosis. This study highlights the degree of heterosis is not an inherent trait of a specific hybrid, but varies depending on the trait measured and the environment where that trait is measured. Studies that attempt to correlate molecular processes with heterosis are hindered by the fact that heterosis is not a consistent attribute of a specific hybrid.
- Published
- 2018
- Full Text
- View/download PDF
3. The Holistic Approach to Academia: Traditional Classroom Instruction and Experiential Learning of Student-Athletes
- Author
-
Lisa Coffey and Armani Davis
- Subjects
student-athlete employ-ability ,experiential learning ,transferable skills ,career development ,competitive advantage ,Education - Abstract
National Collegiate Athletic Association (NCAA) student-athletes represent a unique subculture on college campuses, and the athlete must balance the rigors of coursework, athletics, and the non-traditional dynamics associated with being an athlete, which include “dumb jock” stereotypes, isolation, negative criticism, and the fear associated with athletic retirement. Unlike non-athletes, these students face increasing pressure from outside sources, including family, coaches, and fans, to be the best. However, participation in athletics gives student-athletes an opportunity to learn valuable skills and characteristics that are transferrable to the workplace. This mixed-method research extracted descriptive data to identify the characteristics learned through athletics, the skill-sets potential employers value the most, and how those skills are transferable to the workplace. Those characteristics include refined leadership, communication skills, and an ability to multi-task with a laser-sharp focus. Student-athletes are assertive, driven, understand the concept of teamwork, and handle constructive criticism without adverse reactions. The results show that when student-athletes engage in the classroom and absorb the learning opportunities provided through athletics, student-athletes can have a competitive advantage in the job marketplace.
- Published
- 2019
- Full Text
- View/download PDF
4. Towards Autonomous Crop Monitoring: Inserting Sensors in Cluttered Environments.
- Author
-
Moonyoung Lee, Aaron Berger, Dominic Guri, Kevin Zhang 0002, Lisa Coffey, George Kantor, and Oliver Kroemer
- Published
- 2024
- Full Text
- View/download PDF
5. Erratum to: Relative utility of agronomic, phenological, and morphological traits for assessing genotype‐by‐environment interaction in maize inbreds
- Author
-
Celeste M. Falcon, Shawn M. Kaeppler, Edgar P. Spalding, Nathan D. Miller, Nicholas Haase, Naser AlKhalifah, Martin Bohn, Edward S. Buckler, Darwin A. Campbell, Ignacio Ciampitti, Lisa Coffey, Jode Edwards, David Ertl, Sherry Flint‐Garcia, Michael A. Gore, Christopher Graham, Candice N. Hirsch, James B. Holland, Diego Jarquín, Joseph Knoll, Nick Lauter, Carolyn J. Lawrence‐Dill, Elizabeth C. Lee, Aaron Lorenz, Jonathan P. Lynch, Seth C. Murray, Rebecca Nelson, M. Cinta Romay, Torbert Rocheford, Patrick S. Schnable, Brian Scully, Margaret Smith, Nathan Springer, Mitchell R. Tuinstra, Renee Walton, Teclemariam Weldekidan, Randall J. Wisser, Wenwei Xu, and Natalia de Leon
- Subjects
Agronomy and Crop Science - Published
- 2022
6. Characterizing introgression-by-environment interactions using maize near isogenic lines
- Author
-
Sara B. Tirado, Shawn M. Kaeppler, Nathan M. Springer, Dnyaneshwar C. Kadam, Zhi Li, Nathan D. Miller, Candice N. Hirsch, Aaron J. Lorenz, Patrick S. Schnable, Edgar P. Spalding, Natalia de Leon, and Lisa Coffey
- Subjects
0106 biological sciences ,Phenotypic plasticity ,Range (biology) ,fungi ,food and beverages ,Introgression ,General Medicine ,Quantitative trait locus ,Biology ,equipment and supplies ,complex mixtures ,01 natural sciences ,Genome ,Phenotype ,Evolutionary biology ,Genetics ,bacteria ,Gene–environment interaction ,Agronomy and Crop Science ,Gene ,010606 plant biology & botany ,Biotechnology - Abstract
Significant introgression-by-environment interactions are observed for traits throughout development from small introgressed segments of the genome. Relatively small genomic introgressions containing quantitative trait loci can have significant impacts on the phenotype of an individual plant. However, the magnitude of phenotypic effects for the same introgression can vary quite substantially in different environments due to introgression-by-environment interactions. To study potential patterns of introgression-by-environment interactions, fifteen near-isogenic lines (NILs) with > 90% B73 genetic background and multiple Mo17 introgressions were grown in 16 different environments. These environments included five geographical locations with multiple planting dates and multiple planting densities. The phenotypic impact of the introgressions was evaluated for up to 26 traits that span different growth stages in each environment to assess introgression-by-environment interactions. Results from this study showed that small portions of the genome can drive significant genotype-by-environment interaction across a wide range of vegetative and reproductive traits, and the magnitude of the introgression-by-environment interaction varies across traits. Some introgressed segments were more prone to introgression-by-environment interaction than others when evaluating the interaction on a whole plant basis throughout developmental time, indicating variation in phenotypic plasticity throughout the genome. Understanding the profile of introgression-by-environment interaction in NILs is useful in consideration of how small introgressions of QTL or transgene containing regions might be expected to impact traits in diverse environments.
- Published
- 2020
7. Relative utility of agronomic, phenological, and morphological traits for assessing genotype‐by‐environment interaction in maize inbreds
- Author
-
Shawn M. Kaeppler, Torbert Rocheford, Nicholas J. Haase, Diego Jarquin, Renee Walton, Sherry Flint-Garcia, Randall J. Wisser, Nick Lauter, Margaret E. Smith, Martin O. Bohn, Celeste M. Falcon, Carolyn J. Lawrence-Dill, Aaron J. Lorenz, Jode W. Edwards, Jonathan P. Lynch, Natalia de Leon, M. Cinta Romay, Ignacio A. Ciampitti, David S. Ertl, James B. Holland, Elizabeth C. Lee, Nathan D. Miller, Lisa Coffey, Brian T. Scully, Seth C. Murray, Nathan M. Springer, Wenwei Xu, Rebecca Nelson, Edgar P. Spalding, Patrick S. Schnable, Mitchell R. Tuinstra, Edward S. Buckler, Christopher Graham, Darwin A. Campbell, Teclemariam Weldekidan, Naser Alkhalifah, Joseph E. Knoll, Michael A. Gore, and Candice N. Hirsch
- Subjects
0106 biological sciences ,Agronomy ,Relative utility ,Phenology ,040103 agronomy & agriculture ,0401 agriculture, forestry, and fisheries ,04 agricultural and veterinary sciences ,Biology ,Gene–environment interaction ,01 natural sciences ,Agronomy and Crop Science ,010606 plant biology & botany - Published
- 2020
8. Shared Genetic Control of Root System Architecture between Zea mays and Sorghum bicolor
- Author
-
Stefan Hey, Lisa Coffey, Frank Hochholdinger, Patrick S. Schnable, Yu Yang, James C. Schnable, Chenyong Miao, Baskar Ganapathysubramanian, Zihao Zheng, Brandi Sigmon, Huyu Liu, and Talukder Z. Jubery
- Subjects
0106 biological sciences ,Genetics ,biology ,Physiology ,food and beverages ,Population genetics ,Locus (genetics) ,Single-nucleotide polymorphism ,Plant Science ,Quantitative trait locus ,Sorghum ,biology.organism_classification ,01 natural sciences ,Genotype ,Gene ,010606 plant biology & botany ,Synteny - Abstract
Determining the genetic control of root system architecture (RSA) in plants via large-scale genome-wide association study (GWAS) requires high-throughput pipelines for root phenotyping. We developed Core Root Excavation using Compressed-air (CREAMD), a high-throughput pipeline for the cleaning of field-grown roots, and Core Root Feature Extraction (COFE), a semiautomated pipeline for the extraction of RSA traits from images. CREAMD-COFE was applied to diversity panels of maize (Zea mays) and sorghum (Sorghum bicolor), which consisted of 369 and 294 genotypes, respectively. Six RSA-traits were extracted from images collected from >3,300 maize roots and >1,470 sorghum roots. Single nucleotide polymorphism (SNP)-based GWAS identified 87 TAS (trait-associated SNPs) in maize, representing 77 genes and 115 TAS in sorghum. An additional 62 RSA-associated maize genes were identified via expression read depth GWAS. Among the 139 maize RSA-associated genes (or their homologs), 22 (16%) are known to affect RSA in maize or other species. In addition, 26 RSA-associated genes are coregulated with genes previously shown to affect RSA and 51 (37% of RSA-associated genes) are themselves transe–quantitative trait locus for another RSA-associated gene. Finally, the finding that RSA-associated genes from maize and sorghum included seven pairs of syntenic genes demonstrates the conservation of regulation of morphology across taxa.
- Published
- 2019
9. Validation of a model for identification of patients with compensated cirrhosis at high risk of decompensation
- Author
-
Rebecca Harris, Audrey Dillon, Imad Waked, Philip J. Johnson, David J. Harman, Stephen Stewart, Alessandro Cucchetti, Sarah Berhane, Guruprasad P. Aithal, Omar Elshaarawy, Lisa Coffey, Indra Neil Guha, Martin W. James, Guha I.N., Harris R., Berhane S., Dillon A., Coffey L., James M.W., Cucchetti A., Harman D.J., Aithal G.P., Elshaarawy O., Waked I., Stewart S., and Johnson P.J.
- Subjects
Liver Cirrhosis ,Alcohol-Associated Liver Disease Outcome ,Male ,medicine.medical_specialty ,Cirrhosis ,Prognosi ,Liver Cirrhosi ,liver failure, prognostic factor, alcohol-associated liver disease outcome, NAFLD prediction ,Predictive Value of Test ,Risk Assessment ,Severity of Illness Index ,Follow-Up Studie ,03 medical and health sciences ,Liver disease ,0302 clinical medicine ,Model for End-Stage Liver Disease ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Humans ,Decompensation ,Prospective Studies ,NAFLD Prediction ,Aged ,Framingham Risk Score ,Hepatology ,business.industry ,Prognostic Factor ,Risk Factor ,Hazard ratio ,Gastroenterology ,Middle Aged ,Prognosis ,medicine.disease ,Prospective Studie ,Liver ,030220 oncology & carcinogenesis ,Cohort ,Disease Progression ,Egypt ,Female ,030211 gastroenterology & hepatology ,Liver function ,business ,Ireland ,Liver Failure ,Follow-Up Studies ,Human - Abstract
Background & Aims It is important to rapidly identify patients with advanced liver disease. Routine tests to assess liver function and fibrosis provide data that can be used to determine patients’ prognoses. We tested the validated the ability of combined data from the ALBI and FIB-4 scoring systems to identify patients with compensated cirrhosis at highest risk for decompensation. Methods We collected data from 145 patients with compensated cirrhosis (91% Child A cirrhosis and median MELD scores below 8) from a cohort in Nottingham, United Kingdom, followed for a median 4.59 years (development cohort). We collected baseline clinical features and recorded decompensation events. We used these data to develop a model based on liver function (assessed by the ALBI score) and extent of fibrosis (assessed by the FIB-4 index) to determine risk of decompensation. We validated the model in 2 independent external cohorts (1 in Dublin, Ireland and 1 in Menoufia, Egypt) comprising 234 patients. Results In the development cohort, 19.3% of the patients developed decompensated cirrhosis. Using a combination of ALBI and FIB-4 scores, we developed a model that identified patients at low vs high risk of decompensation (hazard ratio [HR] for decompensation in patients with high risk score was 7.10). When we tested the scoring system in the validation cohorts, the HR for decompensation in patients with a high-risk score was 12.54 in the Ireland cohort and 5.10 in the Egypt cohort. Conclusion We developed scoring system, based on a combination of ALBI and FIB-4 scores, that identifies patients at risk for liver decompensation. We validated the scoring system in 2 independent international cohorts (Europe and the Middle East), so it appears to apply to diverse populations.
- Published
- 2019
10. Correction to: Characterizing introgression‑by‑environment interactions using maize near isogenic lines
- Author
-
Edgar P. Spalding, Zhi Li, Aaron J. Lorenz, Nathan D. Miller, Shawn M. Kaeppler, Patrick S. Schnable, Candice N. Hirsch, Natalia de Leon, Lisa Coffey, Sara B. Tirado, Nathan M. Springer, and Dnyaneshwar C. Kadam
- Subjects
Evolutionary biology ,Genetics ,Introgression ,General Medicine ,Biology ,Agronomy and Crop Science ,Biotechnology - Published
- 2021
11. Characterizing allele-by-environment interactions using maize introgression lines
- Author
-
Nathan M. Springer, Candice N. Hirsch, Patrick S. Schnable, Nathan D. Miller, Aaron J. Lorenz, Zhi Li, Edgar P. Spalding, Lisa Coffey, Dnyaneshwar C. Kadam, Sara B. Tirado, Shawn M. Kaeppler, and Natalia de Leon
- Subjects
Phenotypic plasticity ,Range (biology) ,fungi ,Introgression ,food and beverages ,Quantitative trait locus ,Biology ,equipment and supplies ,Phenotype ,Genome ,complex mixtures ,Evolutionary biology ,bacteria ,Allele - Abstract
Relatively small genomic introgressions containing quantitative trait loci can have significant impacts on the phenotype of an individual plant. However, the magnitude of phenotypic effects for the same introgression can vary quite substantially in different environments due to allele-by-environment interactions. To study potential patterns of allele-by-environment interactions, fifteen near-isogenic lines (NILs) with >90% B73 genetic background and multiple Mo17 introgressions were grown in 16 different environments. These environments included five geographical locations with multiple planting dates and multiple planting densities. The phenotypic impact of the introgressions was evaluated for up to 26 traits that span different growth stages in each environment to assess allele-by-environment interactions. Results from this study showed that small portions of the genome can drive significant genotype-by-environment interaction across a wide range of vegetative and reproductive traits, and the magnitude of the allele-by-environment interaction varies across traits. Some introgressed segments were more prone to genotype-by-environment interaction than others when evaluating the interaction on a whole plant basis throughout developmental time, indicating variation in phenotypic plasticity throughout the genome. Understanding the profile of allele-by-environment interaction is useful in considerations of how small introgressions of QTL or transgene containing regions might be expected to impact traits in diverse environments.Key MessageSignificant allele-by-environment interactions are observed for traits throughout development from small introgressed segments of the genome.
- Published
- 2019
- Full Text
- View/download PDF
12. Characterizing introgression-by-environment interactions using maize near isogenic lines
- Author
-
Zhi, Li, Sara B, Tirado, Dnyaneshwar C, Kadam, Lisa, Coffey, Nathan D, Miller, Edgar P, Spalding, Aaron J, Lorenz, Natalia, de Leon, Shawn M, Kaeppler, Patrick S, Schnable, Nathan M, Springer, and Candice N, Hirsch
- Subjects
Phenotype ,Genotype ,Quantitative Trait Loci ,Gene-Environment Interaction ,Environment ,Zea mays ,Genome, Plant - Abstract
Significant introgression-by-environment interactions are observed for traits throughout development from small introgressed segments of the genome. Relatively small genomic introgressions containing quantitative trait loci can have significant impacts on the phenotype of an individual plant. However, the magnitude of phenotypic effects for the same introgression can vary quite substantially in different environments due to introgression-by-environment interactions. To study potential patterns of introgression-by-environment interactions, fifteen near-isogenic lines (NILs) with 90% B73 genetic background and multiple Mo17 introgressions were grown in 16 different environments. These environments included five geographical locations with multiple planting dates and multiple planting densities. The phenotypic impact of the introgressions was evaluated for up to 26 traits that span different growth stages in each environment to assess introgression-by-environment interactions. Results from this study showed that small portions of the genome can drive significant genotype-by-environment interaction across a wide range of vegetative and reproductive traits, and the magnitude of the introgression-by-environment interaction varies across traits. Some introgressed segments were more prone to introgression-by-environment interaction than others when evaluating the interaction on a whole plant basis throughout developmental time, indicating variation in phenotypic plasticity throughout the genome. Understanding the profile of introgression-by-environment interaction in NILs is useful in consideration of how small introgressions of QTL or transgene containing regions might be expected to impact traits in diverse environments.
- Published
- 2019
13. Shared Genetic Control of Root System Architecture between
- Author
-
Zihao, Zheng, Stefan, Hey, Talukder, Jubery, Huyu, Liu, Yu, Yang, Lisa, Coffey, Chenyong, Miao, Brandi, Sigmon, James C, Schnable, Frank, Hochholdinger, Baskar, Ganapathysubramanian, and Patrick S, Schnable
- Subjects
Genotype ,Quantitative Trait Loci ,food and beverages ,Plant Roots ,Polymorphism, Single Nucleotide ,Zea mays ,Phenotype ,Biological Variation, Population ,Databases, Genetic ,Image Processing, Computer-Assisted ,Gene Regulatory Networks ,Genetic Association Studies ,Software ,Sorghum ,Research Articles ,Genome-Wide Association Study - Abstract
Determining the genetic control of root system architecture (RSA) in plants via large-scale genome-wide association study (GWAS) requires high-throughput pipelines for root phenotyping. We developed Core Root Excavation using Compressed-air (CREAMD), a high-throughput pipeline for the cleaning of field-grown roots, and Core Root Feature Extraction (COFE), a semiautomated pipeline for the extraction of RSA traits from images. CREAMD-COFE was applied to diversity panels of maize (Zea mays) and sorghum (Sorghum bicolor), which consisted of 369 and 294 genotypes, respectively. Six RSA-traits were extracted from images collected from >3,300 maize roots and >1,470 sorghum roots. Single nucleotide polymorphism (SNP)-based GWAS identified 87 TAS (trait-associated SNPs) in maize, representing 77 genes and 115 TAS in sorghum. An additional 62 RSA-associated maize genes were identified via expression read depth GWAS. Among the 139 maize RSA-associated genes (or their homologs), 22 (16%) are known to affect RSA in maize or other species. In addition, 26 RSA-associated genes are coregulated with genes previously shown to affect RSA and 51 (37% of RSA-associated genes) are themselves transe–quantitative trait locus for another RSA-associated gene. Finally, the finding that RSA-associated genes from maize and sorghum included seven pairs of syntenic genes demonstrates the conservation of regulation of morphology across taxa.
- Published
- 2019
14. The Holistic Approach to Academia: Traditional Classroom Instruction and Experiential Learning of Student-Athletes
- Author
-
Armani Davis and Lisa Coffey
- Subjects
Public Administration ,media_common.quotation_subject ,Physical Therapy, Sports Therapy and Rehabilitation ,Leadership ,Experiential learning ,Competitive advantage ,career development ,Education ,Constructive criticism ,student-athlete employ-ability ,0502 economics and business ,Developmental and Educational Psychology ,Computer Science (miscellaneous) ,Transferable skills analysis ,media_common ,Medical education ,Teamwork ,experiential learning ,05 social sciences ,050301 education ,College athletics ,Computer Science Applications ,transferable skills ,Coursework ,competitive advantage ,lcsh:L ,Psychology ,0503 education ,050203 business & management ,lcsh:Education - Abstract
National Collegiate Athletic Association (NCAA) student-athletes represent a unique subculture on college campuses, and the athlete must balance the rigors of coursework, athletics, and the non-traditional dynamics associated with being an athlete, which include &ldquo, dumb jock&rdquo, stereotypes, isolation, negative criticism, and the fear associated with athletic retirement. Unlike non-athletes, these students face increasing pressure from outside sources, including family, coaches, and fans, to be the best. However, participation in athletics gives student-athletes an opportunity to learn valuable skills and characteristics that are transferrable to the workplace. This mixed-method research extracted descriptive data to identify the characteristics learned through athletics, the skill-sets potential employers value the most, and how those skills are transferable to the workplace. Those characteristics include refined leadership, communication skills, and an ability to multi-task with a laser-sharp focus. Student-athletes are assertive, driven, understand the concept of teamwork, and handle constructive criticism without adverse reactions. The results show that when student-athletes engage in the classroom and absorb the learning opportunities provided through athletics, student-athletes can have a competitive advantage in the job marketplace.
- Published
- 2019
- Full Text
- View/download PDF
15. Genotype-by-Environment Interactions Affecting Heterosis in Maize
- Author
-
Patrick S. Schnable, Michael R. White, Natalia de Leon, Nathan M. Springer, Edgar P. Spalding, Lisa Coffey, Zhi Li, Shawn M. Kaeppler, Candice N. Hirsch, Jacob Garfin, and Nathan D. Miller
- Subjects
0106 biological sciences ,0301 basic medicine ,Leaves ,Heredity ,Genotype ,Heterosis ,Inbred Strains ,lcsh:Medicine ,Plant Science ,Biology ,Research and Analysis Methods ,Zea mays ,01 natural sciences ,03 medical and health sciences ,Model Organisms ,Inbred strain ,Plant and Algal Models ,Genetics ,Hybrid Vigor ,Inbreeding ,Grasses ,Plant breeding ,Gene–environment interaction ,lcsh:Science ,Flowering Plants ,Hybrid ,Multidisciplinary ,Plant Anatomy ,lcsh:R ,Organisms ,Biology and Life Sciences ,Eukaryota ,Correction ,Plants ,Maize ,Phenotypes ,030104 developmental biology ,Experimental Organism Systems ,Plant Physiology ,Trait ,Gene-Environment Interaction ,lcsh:Q ,Research Article ,010606 plant biology & botany - Abstract
The environment can influence heterosis, the phenomena in which the offspring of two inbred parents exhibits phenotypic performance beyond the inbred parents for specific traits. In this study we measured 25 traits in a set of 47 maize hybrids and their inbred parents grown in 16 different environments, and each had varying levels of average productivity. By quantifying 25 vegetative and reproductive traits across the life cycle we were able to analyze interactions between the environment and multiple distinct instances of heterosis. The magnitude and rank among hybrids of better-parent heterosis (BPH) varied for the different traits and environments. Across the traits, a higher within plot variance was observed for inbred lines compared to hybrids. However, for most traits, variance across environments was not significantly different for inbred lines compared to hybrids. Further, for many traits the correlations of BPH to hybrid performance and BPH to better parent performance were of comparable magnitude. These results indicate that inbreds and hybrids are showing similar trends in environmental response and are both contribute to genotype-by-environment interactions for heterosis. This study highlights that degree of heterosis is not an inherent trait of a specific hybrid, but varies depending on the trait measured and the environment where that trait is measured. Studies that attempt to correlate molecular processes with heterosis are hindered by the fact that heterosis is not a consistent attribute of a specific hybrid.
- Published
- 2017
16. Correction: Genotype-by-environment interactions affecting heterosis in maize
- Author
-
Nathan M. Springer, Michael R. H. White, Candice N. Hirsch, Zhi Li, Natalia de Leon, Patrick S. Schnable, Jacob Garfin, Nathan D. Miller, Shawn M. Kaeppler, Edgar P. Spalding, and Lisa Coffey
- Subjects
Multidisciplinary ,business.industry ,Heterosis ,lcsh:R ,Genotype ,lcsh:Medicine ,lcsh:Q ,Biology ,lcsh:Science ,business ,Biotechnology - Abstract
[This corrects the article DOI: 10.1371/journal.pone.0191321.].
- Published
- 2019
17. Sa1567 – Fibroscan Predicts Five Year Liver Outcomes
- Author
-
Stewart Stephen, Paul R. Armstrong, Jennifer Russell, and Lisa Coffey
- Subjects
Hepatology ,Gastroenterology - Published
- 2019
18. Nightly Home Hemodialysis in Lynchburg, Virginia: Economic and Logistic Considerations
- Author
-
Helen Anderson, Robert S. Lockridge, Lesley McPhatter, Floyd M. Jennings, Maureen Spencer, Viola Craft, Angela Swafford, and Lisa Coffey
- Subjects
Nephrology ,business.industry ,Home hemodialysis ,medicine ,Medical emergency ,medicine.disease ,business - Published
- 1999
19. Nightly Home Hemodialysis: Fifteen Months of Experience in Lynchburg, Virginia
- Author
-
Lesley McPhatter, Maureen Spencer, Floyd M. Jennings, Viola Craft, Helen Anderson, Jeanette Albert, Robert S. Lockridge, Terry Barger, Lisa Coffey, and Angela Swafford
- Subjects
Nephrology ,medicine.medical_specialty ,business.industry ,Anemia ,Mortality rate ,medicine.medical_treatment ,Home hemodialysis ,Epoetin alfa ,General Medicine ,medicine.disease ,Surgery ,Blood pressure ,Anesthesia ,Internal medicine ,medicine ,Hemodialysis ,business ,Dialysis ,medicine.drug - Abstract
What constitutes adequate dialysis has been debated in the nephrology literature over the past eight years. The mortality rate of patients on dialysis in the United States is about 20% per year. We believed that short and infrequent dialysis sessions contributed to poor outcomes. To improve the results, Lynchburg Nephrology started the nightly home hemodialysis (NHHD) program in September 1997. Ten patients were trained in the first 15 months of the program. Patients dialyzed 7 - 9 hours, 6 nights/week, using the Fresenius 2008H machine. A standard dialysis solution with 2.0 mEq/L potassium, calcium concentration of 3.0 - 3.5 mEq/L was used. Dialysis solution flow rates were 200 - 300 mL/min. Serum phosphate levels were maintained above 2.5 mg/dL by adding 0 - 45 mL Fleet's Phosphosoda to the bicarbonate bath. Patients had marked improvement in quality of life as measured with the SF-36. Blood pressure was better controlled with fewer medications. All phosphate binders were eliminated. Caloric intake and protein intake increased to normal levels as measured by three-day dietary histories pre-NHHD, and at 3, 6, and 12 months on NHHD. Epoetin alfa dosages were reduced by about 50%. Nightly home hemodialysis should be considered as a valuable modality option for end-stage renal disease patients; it is potentially superior to conventional thrice-weekly hemodialysis.
- Published
- 1999
20. Nightly home hemodialysis: improvement in nutrition and quality of life
- Author
-
Floyd M. Jennings, Helen Anderson, Robert S. Lockridge, Maureen Spencer, Jeanette Albert, Lisa Coffey, Terry Barger, Angela Swafford, Viola Craft, and Lesley McPhatter
- Subjects
Program evaluation ,Gerontology ,Adult ,Male ,medicine.medical_specialty ,Night Care ,Calorie ,medicine.medical_treatment ,Peritoneal dialysis ,End stage renal disease ,Blood Urea Nitrogen ,Patient satisfaction ,Quality of life ,Renal Dialysis ,medicine ,Humans ,Aged ,Dialysis adequacy ,business.industry ,Home hemodialysis ,Phosphorus ,Sodium, Dietary ,Middle Aged ,Health Surveys ,Nutrition Assessment ,Nephrology ,Patient Satisfaction ,Physical therapy ,Quality of Life ,Kidney Failure, Chronic ,Female ,business ,Energy Intake ,Peritoneal Dialysis ,Program Evaluation - Abstract
In September, 1997, we began a Nightly Home Hemodialysis Program modeled after a program in Toronto, Canada. We have assessed nutritional parameters and quality of life indicators before initiation of the program, and at 3, 6, 12, and 18 months. Data suggest that patients have improved overall quality of life as measured by the CHOICE Health Experience Questionnaire. Three-day dietary recalls at 0, 3, 6, 12, and 18 months also show patients are eating healthy and maintaining adequate kilocalorie and protein intakes, as well as maintaining adequate dry weight and protein stores.
- Published
- 1999
21. Power expert says it may be time for solar energy in Bay Area
- Author
-
Mahoney, Lisa Coffey
- Abstract
WALNUT CREEK, Calif. _ The skyrocketing cost of electricity is forcing communities like San Francisco to reconsider their energy options, national power expert Paul Fenn said last week at a […]
- Published
- 2001
22. Educational Technology Leadership Conference Helps Digital Immigrants Understand Digital Natives.
- Author
-
Mahoney, Lisa Coffey
- Subjects
CONFERENCES & conventions ,EDUCATIONAL technology conferences ,EDUCATIONAL innovations - Abstract
The article presents information on the Educational Technology Leadership Conference held at the Bishop O'Dowd High School in Oakland, California on October 28, 2006. The conference was planned by an association of technology leaders and heads of various schools. Writer Marc Prensky, in his keynote speech, encouraged educators to engage students electronically. A group discussion about technologies that can be used in education was also included in the conference.
- Published
- 2007
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