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1,018 results on '"Liquid chromatography -- Methods"'

1. Data from University of Amsterdam Provide New Insights into Urinary Antiinfectives (A Quantitative Method for the Analysis of Total and Unbound Concentrations of Amoxicillin, Ampicillin, Ceftazidime, Ceftriaxone, Ertapenem, Fosfomycin and ...)

Subjects
Mass spectrometry -- Methods, Penicillin -- Methods, Liquid chromatography -- Methods, Fosfomycin -- Methods, Ceftazidime -- Methods, Physical fitness -- Methods, Ceftriaxone -- Methods, Ceftriaxone sodium -- Methods, Health, University of Amsterdam
Abstract

2024 SEP 7 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Drugs and Therapies - Urinary Antiinfectives. According [...]

Published
2024

2. Reports Summarize Calcium Channel Blocking Agents Study Results from King Saud University [Development and Validation of Ultra-performance Liquid Chromatography (Uplc) Method for Simultaneous Quantification of Hydrochlorothiazide, Amlodipine ...]

Subjects
Drug therapy, Combination -- Methods, Liquid chromatography -- Methods, Valsartan -- Methods, Calcium channels -- Methods, Physical fitness -- Methods, Amlodipine -- Methods, Hydrochlorothiazide -- Methods, Health, King Saud University
Abstract

2024 JUL 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Drugs and Therapies - Calcium Channel Blocking [...]

Published
2024

3. Profiling Detection and Validation of Six Sartan Substances in Human Urine by LC-MS/MS

Author

Hong, Yu, He, Genye, Lu, Jianghai, and Xu, Youxuan

Subjects
Urine -- Analysis, Angiotensin II receptor blockers -- Measurement, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Chemistry
Abstract

Six sartan substances including telmisartan, losartan, valsartan, irbesartan, olmesartan, and candesartan were selected in this work. A simple and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated to simutaniously detect six drugs. Linearity, LOD, and LOQ were satisfied for routine quantitative and qualitative detection. The linearity ranged from 2 to 1000 ng/mL with the determination coefficient more than 0.98. The intra-day and inter-day precisions were all below 27.5%. All the recoveries were above 80%, and matrix effects were between 25 and 120%. Profiling detection of six sartan substances in human urine was also developed after administration. Irbesartan urinary metabolic pathway was firstly investigated by liquid chromatography quadruple time-of-flight mass spectrometry using full scan and targeted tandem mass spectrometry techniques. Fifteen urinary metabolites of irbesartan were identified and characterized, and ten of them were firstly reported., Author(s): Yu Hong [sup.1] [sup.2] , Genye He [sup.3] , Jianghai Lu [sup.1] , Youxuan Xu [sup.1] Author Affiliations: (1) https://ror.org/03nxed310, grid.506888.b, 0000 0004 6004 1007, Drug and food anti-doping [...]

Published
2023
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4. Novel Adsorbents for the Determination of Amino Acids in Soil Extracts by Hydrophilic Interaction Liquid Chromatography with Mass Spectrometric Detection

Author

Chikurova, N. Yu., Gorbovskaia, A. V., Stavrianidi, A. N., Fedorova, E. S., Shemyakina, A. O., Buryak, A. K., and Uzhel, A. S.

Subjects
Soil chemistry -- Research, Chemical research, Mass spectrometry -- Methods, Adsorbents -- Usage, Amino acids -- Measurement -- Chemical properties, Liquid chromatography -- Methods, Chemistry
Abstract

Adsorbents based on various substrates-silica and a copolymer of styrene with divinylbenzene-are developed for the determination of amino acids by hydrophilic interaction liquid chromatography-mass spectrometry. The optimal version of the structure of the functional layer in two series of the obtained stationary phases was chosen, which provides the best hydrophilization for each substrate. Retention mechanisms were studied and the conditions for the mass-spectrometric detection, separation, and determination of 16 amino acids were chosen. The applicability of the obtained adsorbents and a method for determining amino acids for the analysis of soil extracts were estimated., Author(s): N. Yu. Chikurova [sup.1] , A. V. Gorbovskaia [sup.1] , A. N. Stavrianidi [sup.1] [sup.2] , E. S. Fedorova [sup.2] , A. O. Shemyakina [sup.1] , A. K. Buryak [...]

Published
2023
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5. Development of an UPLC-QTOF-MS Method for the Simultaneous Estimation of Dronedarone and its Unlisted Pharmacopoeial Impurities

Author

Thangaraj, Menaka, Ramya Kuber B., and Karthika, Anoop

Subjects
Time-of-flight mass spectrometry -- Methods, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Chemistry
Abstract

For the first time, an UPLC-QTOF-MS method was developed and validated to simultaneously estimate dronedarone (DDN) and its four unlisted pharmacopoeial impurities: DDN impurities A, B, C, and D. UPLC separation was performed for 6 min on a BEH C18 (50 x 2.1 mm, 1.7 [micro]m) columnwith 0.1% formic acid in water (A) and acetonitrile (B) as mobile phase delivered in gradient at a constant flow rate of 0.6 mL/min. Mass spectrometric detection was performed in ESI-QTOF-MS. The LOD and LOQ values for the analytes ranged from 0.5 to 10 and 0.8 to 75 ng/mL, respectively. The method was found to be linear for all analyte ranges with r.sup.2 values [greater than or equal to]0.9998. The method was precise with %RSD values [less than or equal to]6.5% and overall analyte recovery was found to be 99.8 ± 1.0%. A novel, sensitive, selective, specific, linear, and accurate UPLC-QTOF-MS method was developed and validated to simultaneously estimate DDN and its impurities which are not listed in the pharmacopoeia., Author(s): Menaka Thangaraj [sup.1] Ramya Kuber B. [sup.2] , Anoop Karthika [sup.3] Author Affiliations: (1) Department of Pharmaceutical Chemistry, Mallige College of Pharmacy, , Bengaluru, India (2) grid.444735.5, 0000 0000 [...]

Published
2023
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6. 2D-LC-MS Approaches for the Analysis of In-Process Samples and for the Characterization of mAbs in a Regulated Environment

Author

Butre, Claire I. and Delobel, Arnaud

Subjects
Liquid chromatography -- Methods, Adalimumab -- Methods, Enzymes -- Methods, Chemistry, Science and technology
Abstract

Biologics, and in particular monoclonal antibodies (mAbs), are an important class of therapeutics, and their market share keeps growing. The production of antibodies is a complex and lengthy process. In-process characterization of the mAb would help in optimizing the production steps. Efficiency in mAb characterization can be obtained by automating analysis and reducing hands-on time. Although mass spectrometry (MS) is an essential technique for detailed characterization of biomolecules, its use is limited to purified samples. However, the hyphenation of an MS system to two-dimensional liquid chromatography (2D-LC) allows for the analysis of more complex samples. The first dimension of a 2D-LC system can be used to purify the sample from its matrix or separate compounds using mobile phases that are not MS-compatible, whereas the second dimension coupled to MS can be used to desalt or separate the different variants or species obtained on the first dimension. A 2D-LC-MS system installed in a full good manufacturing practice (GMP)-complianl environment using validated software was used for the characterization of mAbs in complex mixtures at the intact and subunit levels using a Protein A affinity column with no sample preparation steps. In the second application, MS characterization of mAb subunits was made possible by digestion of the mAb online by an immobilized IdeS enzyme. The addition of a disulfide bridge reduction step online led to analyzing smaller molecules to access fine characterization., Monoclonal antibodies (mAbs) represent a large part of pharmaceuticals currently under development (1). Monoclonal antibodies are 150 kDa molecules consisting of two heavy chains of ~50 kDa and two light [...]

Published
2023

7. Anomalous Retention Prediction Using Modelling Software in Gradient Reversed-Phase Liquid Chromatography: Why it Can Occur and How to Prevent It

Author

Field, Jennifer K., Berry, Stuart N., Hogbin, James, McKoy, Earl, Paget, Veronica, Petersson, Patrik, Wong, Raymond, and Euerby, Melvin R.

Subjects
Liquid chromatography -- Methods, Chemistry, Science and technology
Abstract

This article presents the benefits of screening column and mobile phase combinations that generate differing chromatographic selectivities in reversed-phase gradient ultrahigh-pressure liquid chromatographic (UHPLC) method development strategies. Photodiode array (PDA) and mass spectrophotometric (MS) detection was necessary to facilitate peak tracking or identification of components in the sample mixture to build retention models. Retention time prediction accuracies of < 0.3% were obtained from a two-dimensional gradient time vs. temperature model when the initial gradient conditions were maintained. However, anomalous retention predictions were observed when higher %B initial gradient conditions were employed. Polar analytes in the sample mixture that started to migrate down the column in the dwell volume of the UHPLC system produced inaccurate retention time predictions if an inappropriate dwell volume was used in the retention model. An iterative dwell volume estimation was demonstrated to generate more accurate retention time predictions than when a practically determined dwell volume was used. However, to obtain good predictions the analyst should endeavour to use initial chromatographic conditions that promote focusing of all analytes on top of the column (that is, retention factor > 10)., A popular strategy in reversed-phase liquid chromatographic (RPLC) method development for small-molecular-weight active pharmaceutical ingredients (APIs) is to screen various stationary and mobile phase combinations using a fixed %B/min gradient [...]

Published
2023

8. Researchers from Mashhad University of Medical Sciences Provide Details of New Studies and Findings in the Area of Analytical Chemistry (Polycyclic Aromatic Hydrocarbons, Mycotoxins, and Pesticides Residues In Coffee: a Probabilistic Assessment ...)

Subjects
Gas chromatography -- Methods, Pesticides -- Identification and classification -- Health aspects, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Mycotoxins -- Identification and classification -- Health aspects, Polycyclic aromatic hydrocarbons -- Identification and classification -- Health aspects, Learning models (Stochastic processes) -- Methods, Health
Abstract

2024 MAY 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Chemistry - Analytical Chemistry is now available. According [...]

Published
2024

9. Investigators from University of Orebro Release New Data on Hematology (Assessing the Performance of a Targeted Absolute Quantification Isotope Dilution Liquid Chromatography Tandem Mass Spectrometry Assay Versus a Commercial Nontargeted ...)

Subjects
Medical research, Medicine, Experimental, Mass spectrometry -- Methods, Blood -- Analysis and chemistry, Liquid chromatography -- Methods, Health
Abstract

2024 FEB 24 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Hematology. According to news reporting from Orebro, [...]

Published
2024

10. New Findings from Tokyo University of Science in the Area of Hormone Replacement Therapy Described (Derivatization Procedure of Estradiol With a Combination of Mpdnp-f and 4-dimethylaminopyridine To Generate Product Ion Containing ...)

Subjects
Estradiol -- Health aspects -- Measurement, Pyridine -- Usage -- Chemical properties, Mass spectrometry -- Methods, Serodiagnosis -- Methods, Liquid chromatography -- Methods, Pharmaceutical research, Iodides -- Usage -- Chemical properties, Health
Abstract

2024 JAN 20 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Drugs and Therapies - Hormone Replacement Therapy are presented [...]

Published
2024

11. Researchers Submit Patent Application, 'Dual-Column Lc-Ms System And Methods Of Use Thereof', for Approval (USPTO 20230393141)

Subjects
Mass spectrometry -- Methods, Amino acids -- Intellectual property -- Methods, Liquid chromatography -- Methods, Monoclonal antibodies -- Methods, Physical fitness -- Methods, Health
Abstract

2023 DEC 30 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- From Washington, D.C., NewsRx journalists report that a patent application by the [...]

Published
2023

12. Data from Shanghai University of Traditional Chinese Medicine Broaden Understanding of Esophageal Cancer (DMMIC derivatization-assisted liquid chromatography-mass spectrometry method for metabolite profiling of the glutathione anabolic pathway ...)

Subjects
Medicine, Chinese -- Methods, Mass spectrometry -- Methods, Metabolites -- Methods, Liquid chromatography -- Methods, Physical fitness -- Methods, Esophageal cancer -- Methods, Health
Abstract

2023 DEC 30 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on esophageal cancer have been published. According to news [...]

Published
2023

13. Findings from School of Sciences Update Knowledge of Sodium-Glucose Transporter 2 Inhibitors [A Sensitive Ultra-performance Liquid Chromatography-tandem Mass Spectrometry Method for the Simultaneous Quantification of Assay and Trace-level ...]

Subjects
Dextrose -- Methods, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Glucose -- Methods, Physical fitness -- Methods, Health
Abstract

2023 DEC 16 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Drugs and Therapies - Sodium-Glucose Transporter 2 [...]

Published
2023

14. Data from Ankara University Provide New Insights into Guaifenesin Therapy (A Chemometric Strategy In the Development of a Rp-uplc Method for the Quantitative Resolution of a Two-component Syrup Formulation)

Subjects
Guaiacol glyceryl ether -- Methods, Liquid chromatography -- Methods, Physical fitness -- Methods, Health, Ankara University
Abstract

2023 DEC 2 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Drugs and Therapies - Guaifenesin Therapy. According [...]

Published
2023

15. Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder

Author

Zhu, Jiang, Hua, Xueying, Yang, Ting, Guo, Min, Li, Qiu, Xiao, Lu, and Li, Ling

Subjects
Amino acid metabolism -- Health aspects, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Autistic children -- Care and treatment, Metabolomics -- Analysis, Health
Abstract

Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism., Author(s): Jiang Zhu [sup.1] [sup.2] , Xueying Hua [sup.1] [sup.3] , Ting Yang [sup.1] [sup.2] , Min Guo [sup.1] [sup.2] , Qiu Li [sup.1] [sup.2] , Lu Xiao [sup.1] [sup.2] [...]

Published
2022
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17. Study Findings from University of Nebraska Medical Center Provide New Insights into Antiretrovirals (Quantification of Nine Antiretroviral Drugs In Cerebrospinal Fluid: an Approach To Overcome Sample Collection Tube Adsorption)

Subjects
Antiviral agents -- Identification and classification, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Cerebrospinal fluid -- Analysis, Health
Abstract

2023 SEP 16 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Drugs and Therapies - Antiretrovirals. According to [...]

Published
2023

18. New Data from University of Mississippi Illuminate Findings in Obesity, Fitness and Wellness [Development of a Liquid Chromatography-tandem Mass Spectrometry (Lc-ms/ms) Method for Characterizing Pomegranate Extract Pharmacokinetics In Humans]

Subjects
Pharmacokinetics -- Research, Materia medica, Vegetable -- Chemical properties -- Health aspects, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Pomegranate -- Chemical properties -- Health aspects, Plant extracts -- Chemical properties -- Health aspects, Health
Abstract

2023 SEP 16 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Obesity, Fitness and Wellness is now available. According [...]

Published
2023

19. Study Data from Chungnam National University Update Understanding of Analytical Science and Technology (Liquid chromatography-tandem mass spectrometry for pharmacokinetics evaluation of AZD5305, a selective PARP1 inhibitor, in mice)

Subjects
Pharmacokinetics -- Research, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Proton pump inhibitors -- Testing, Health
Abstract

2023 SEP 2 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on analytical science and technology. According to news [...]

Published
2023

21. Researchers Submit Patent Application, 'Method For Adjusting Pressure Sensor And Liquid Chromatography Analyzer', for Approval (USPTO 20240183828)

Subjects
Sensors -- Intellectual property -- Methods, Liquid chromatography -- Methods, Analytical instruments -- Methods -- Intellectual property, Government, Political science
Abstract

2024 JUN 27 (VerticalNews) -- By a News Reporter-Staff News Editor at Politics & Government Week -- From Washington, D.C., VerticalNews journalists report that a patent application by the inventors [...]

Published
2024

23. New Acetic Acids Study Findings Have Been Reported from University of Cordoba (Implementation of a Novel Method for Processing Proteins from Acetic Acid Bacteria via Liquid Chromatography Coupled with Tandem Mass Spectrometry)

Subjects
Microbiota (Symbiotic organisms) -- Methods, Bacteria -- Methods, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Organic acids -- Methods, Acetic acid -- Methods, Biological sciences, Health
Abstract

2024 JUN 18 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on acetic acids have been presented. According to news reporting out of [...]

Published
2024

24. New Findings from Roland Institute of Pharmaceutical Sciences in the Area of BCR-ABL Tyrosine Kinase Inhibitors Described (A Validated Liquid Chromatographic Method for the Estimation of Imatinib Mesylate in Dosage Forms: Application to ...)

Subjects
Tyrosine -- Methods, Phenols -- Methods, Liquid chromatography -- Methods, Physical fitness -- Methods, Health
Abstract

2023 JUL 29 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in BCR-ABL tyrosine kinase inhibitors. According to news [...]

Published
2023

25. New Meloxicam Therapy Study Findings Recently Were Published by Researchers at University of Sao Paulo (Liquid Chromatography-Tandem Mass Spectrometry Method for Detection and Quantification of Meloxicam and 5'-Carboxymeloxicam in Oral Fluid ...)

Subjects
Mass spectrometry -- Methods, Liquid chromatography -- Methods, Meloxicam -- Properties -- Identification and classification, Health
Abstract

2023 JUL 15 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in meloxicam therapy. According to news originating from [...]

Published
2023

26. Study Results from University of Beira Interior in the Area of Gene Therapy Reported (Multimodal Ionic Liquid-based Chromatographic Supports for an Effective Rna Purification)

Subjects
Extraction (Chemistry) -- Methods, Chemical research, Liquid chromatography -- Methods, RNA -- Chemical properties, Health
Abstract

2023 JUN 24 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Biotechnology - Gene Therapy is now available. According [...]

Published
2023

27. Data on Neurologic Diseases and Conditions Described by Researchers at Johannes Gutenberg University of Mainz (Lipidomics and Transcriptomics In Neurological Diseases)

Subjects
Medical research, Medicine, Experimental, Membrane lipids -- Health aspects -- Identification and classification, RNA sequencing -- Methods, Nervous system diseases -- Causes of, Messenger RNA -- Identification and classification -- Health aspects, Liquid chromatography -- Methods, Health
Abstract

2023 MAR 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Neurologic Diseases and Conditions are discussed in a new [...]

Published
2023

28. China Academy of Chinese Medical Sciences Researchers Have Provided New Data on Pharmaceutical Research (Progress and prediction of multicomponent quantification in complex systems with practical LC-UV methods)

Subjects
Ultraviolet radiation -- Methods, Complex systems -- Analysis, Liquid chromatography -- Methods, Health
Abstract

2023 MAR 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on pharmaceutical research is now available. According to news [...]

Published
2023

29. Researcher at University of Salamanca Releases New Data on Antifungals (Validation and clinical evaluation of an ultra-performance liquid chromatography with ultraviolet detector method for plasma quantification of micafungin)

Subjects
Detectors -- Methods, Liquid chromatography -- Methods, Physical fitness -- Methods, Health
Abstract

2023 MAR 18 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New study results on antifungals have been published. According to news originating [...]

Published
2023

30. Research Findings from China Pharmaceutical University Update Understanding of Chemicals and Chemistry (Comprehensive chemical profiling and quantification of Shexiang Xintongning tablets by integrating liquid chromatography-mass spectrometry ...)

Subjects
Liquid chromatography -- Methods, Health
Abstract

2023 MAR 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in chemicals and chemistry. According to news originating [...]

Published
2023

31. Pfizer Worldwide Research and Development Researchers Further Understanding of Analytical Chemistry (Validation of a purity method for a Suzuki-Miyaura boronic ester by liquid chromatography with derivatization)

Subjects
Pfizer Inc., Liquid chromatography -- Methods, Industrial research -- Connecticut -- United States, Pharmaceutical industry -- Methods, Research and development, Business, Pharmaceuticals and cosmetics industries, Health
Abstract

2024 MAY 6 (NewsRx) -- By a News Reporter-Staff News Editor at Pharma Business Week -- Investigators discuss new findings in analytical chemistry. According to news reporting originating from Groton, [...]

Published
2024

32. Researchers from Merck & Company Describe Findings in Vaccines (A Targeted Liquid Chromatography Mass Spectrometry Method for Routine Monitoring of Cell Culture Media Components for Bioprocess Development)

Subjects
Merck & Company Inc., Biological products industry -- Methods, Medical research -- Methods, Medicine, Experimental -- Methods, Journalistic ethics -- Methods, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Vaccines -- Quality management, Pharmaceutical industry -- Methods, Health
Abstract

2024 MAR 20 (NewsRx) -- By a News Reporter-Staff News Editor at Vaccine Weekly -- Data detailed on Immunization - Vaccines have been presented. According to news reporting originating in [...]

Published
2024

33. New Data from Israel Institute for Biological Research Illuminate Research in Military and Defense (Monitoring Exposure to Five Chemical Warfare Agents Using the Dried Urine Spot Technique and Liquid Chromatography-Mass Spectrometry/Mass ...)

Subjects
Biological research -- Methods, Biology, Experimental -- Methods, Liquid chromatography -- Methods, Health, Social sciences
Abstract

2023 DEC 25 (NewsRx) -- By a News Reporter-Staff News Editor at Bioterrorism Week -- Current study results on military and defense have been published. According to news reporting out [...]

Published
2023

34. Modern Nontargeted Screening (NTS) Methods for Environmental Analysis

Author

Botcherby, Lewis

Subjects
Drinking water -- Methods, Mass spectrometry -- Methods, Leaching -- Methods, Liquid chromatography -- Methods, Plastic containers -- Methods, Sediments (Geology) -- Methods, Chemistry, Science and technology, University of Copenhagen
Abstract

LCGC Asia Pacific spoke to Selina Tisler and Jan H. Christensen from the University of Copenhagen in Denmark, about recent research projects focusing on nontargeted screening (NTS) approaches for important environmental monitoring applications, including the analysis of chemical leaching from plastic bottles using liquid chromatography tandem mass spectrometry (LC-MS/MS) and sediment analysis using comprehensive two-dimensional gas chromatography-high-resolution MS (GCXGC-HRMS)., Q. Your team recently investigated the leaching of chemicals from reusable plastic bottles into the drinking substances they hold (1). Why is this an issue and what are the possible [...]

Published
2022

35. Modern Nontargeted Screening (NTS) Methods for Environmental Analysis

Author

Botcherby, Lewis

Subjects
Drinking water -- Methods, Mass spectrometry -- Methods, Leaching -- Methods, Liquid chromatography -- Methods, Plastic containers -- Methods, Sediments (Geology) -- Methods, Chemistry, Science and technology, University of Copenhagen
Abstract

LCGC Europe spoke to Selina Tisler and Jan H. Christensen from the University of Copenhagen in Denmark, about recent research projects focusing on nontargeted screening (NTS) approaches for important environmental monitoring applications, including the analysis of chemical leaching from plastic bottles using liquid chromatography tandem mass spectrometry (LC--MS/MS) and sediment analysis using comprehensive two-dimensional gas chromatography--high-resolution MS (GCxGC--HRMS)., Q. Your team recently investigated the leaching of chemicals from reusable plastic bottles into the drinking substances they hold (1). Why is this an issue and what are the possible [...]

Published
2022

36. Research Results from King Saud University Update Understanding of Catecholamine Receptors (A Liquid Chromatography Tandem Mass Spectrometry Method for the Simultaneous Estimation of the Dopamine Receptor Antagonist LE300 and Its N-Methyl ...)

Subjects
Pharmacokinetics -- Analysis, Mass spectrometry -- Methods, Dopamine receptors -- Analysis, Liquid chromatography -- Methods, Catecholamines -- Composition, Health
Abstract

2023 FEB 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on catecholamine receptors is now available. According to news [...]

Published
2023

37. New Immunoglobulin Variable Region Findings from Merck & Company Outlined (Discovery and Control of Succinimide Formation and Accumulation At Aspartic Acid Residues In the Complementarity-determining Region of a Therapeutic Monoclonal Antibody)

Subjects
Immunoglobulins -- Composition, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Monoclonal antibodies -- Dosage and administration, Health
Abstract

2023 FEB 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Immunology - Immunoglobulin Variable Region are presented in a [...]

Published
2023

38. Studies from National Institute of Metrology Yield New Data on Kinase Inhibitors (Investigation on acquired palbociclib resistance by LC-MS based multi-omics analysis)

Subjects
Cell cycle -- Analysis, Drug resistance -- Prevention, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Health
Abstract

2023 FEB 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on kinase inhibitors is now available. According to news [...]

Published
2023

39. Studies Conducted at Mashhad University of Medical Sciences on Respiratory Inhalant Products Recently Published (Simultaneous determination of mometasone furoate and calcipotriol in a binary mixture by validated HPLC and chemometric-assisted UV ...)

Subjects
Mass spectrometry -- Methods, Calcipotriene -- Chemical properties, Liquid chromatography -- Methods, Mometasone -- Chemical properties, Health
Abstract

2023 JAN 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on respiratory inhalant products. According to news reporting [...]

Published
2023

40. Researchers at Fudan University Shanghai Cancer Center Publish New Study Findings on Liposarcomas (Lipidomics and Transcriptomics Differ Liposarcoma Differentiation Characteristics That Can Be Altered by Pentose Phosphate Pathway Intervention)

Subjects
Liposarcoma -- Diagnosis -- Care and treatment -- Genetic aspects, Carcinogenesis -- Health aspects, Sugars -- Composition, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Monosaccharides -- Composition, Fat cells -- Measurement -- Health aspects, Health
Abstract

2023 JAN 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on liposarcomas is the subject of a new report. According [...]

Published
2023

41. Findings from Fourth Hospital of Hebei Medical University Reveals New Findings on Central Nervous System Agents (A Validated Uhplc-ms/ms Method for Determination of Nalbuphine In Human Plasma and Application for Pharmacokinetic Study of ...)

Subjects
Pharmacokinetics -- Research, Pharmacology, Experimental, Mass spectrometry -- Usage, Liquid chromatography -- Methods, Nalbuphine -- Measurement -- Physiological aspects, General anesthesia -- Methods, Health
Abstract

2023 JAN 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Drugs and Therapies - Central Nervous System Agents are [...]

Published
2023

42. Researcher from Institut de medecine legale Publishes Findings in Codeine Therapy (Fingerprints: A New Specimen for Innovative Applications for the Detection of Xenobiotics)

Subjects
Mass spectrometry -- Methods, Codeine -- Dosage and administration, Liquid chromatography -- Methods, Physical fitness -- Identification and classification, Health
Abstract

2022 DEC 24 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on codeine therapy have been presented. According to news originating [...]

Published
2022

43. Studies from University of Sao Paulo in the Area of Naproxen Therapy Published (* * CYP2C9* * Polymorphism Influence in PK/PD Model of Naproxen and 6-O-Desmethylnaproxen in Oral Fluid)

Subjects
Nonsteroidal anti-inflammatory drugs -- Composition, Pharmacokinetics -- Analysis, Genetic polymorphisms -- Analysis, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Health
Abstract

2022 DEC 17 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New study results on naproxen therapy have been published. According to news [...]

Published
2022

44. Research from Second Affiliated Hospital of Zhejiang University Yields New Data on Artificial Neural Networks (Development and validation of a new LC-MS/MS method for the determination of mefatinib in human plasma and its first application in ...)

Subjects
Pharmacokinetics -- Analysis, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Neural networks -- Analysis, Neural network, Health
Abstract

2022 DEC 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on artificial neural networks have been published. According to [...]

Published
2022

45. New Pharmacology Study Results Reported from Universiti Malaysia Kelantan [LC-TOF-MS/MS and GC-MS based phytochemical profiling and evaluation of wound healing activity of Oroxylum Indicum (L.) Kurz (Beka)]

Subjects
Gas chromatography -- Methods, Wound healing -- Research, Pharmacology, Experimental, Mass spectrometry -- Methods, Liquid chromatography -- Methods, Medicinal plants -- Chemical properties, Phytochemicals -- Identification and classification -- Health aspects, Lamiales -- Chemical properties, Health
Abstract

2022 DEC 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on pharmacology have been published. According to news reporting [...]

Published
2022

46. New Findings on Clinical Oncology from Sri Sathya Sai Institute of Higher Learning Summarized (Optimized Lc-ms/ms Method for Simultaneous Determination of Endocrine Disruptors and Pahs Bound To Pm2.5: Sources and Health Risk In Indo-gangetic ...)

Subjects
Endocrine disruptors -- Identification and classification, Mass spectrometry -- Methods, Phthalates -- Identification and classification, Liquid chromatography -- Methods, Polycyclic aromatic hydrocarbons -- Identification and classification, Particles -- Health aspects, Health
Abstract

2022 DEC 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Clinical Oncology is now available. According to news [...]

Published
2022

47. Findings from Beni Suef University Provide New Insights into Phenothiazine Antipsychotics (Four Greenness Evaluations of Two Chromatographic Methods: Application To Fluphenazine Hcl and Nortriptyline Hcl Pharmaceutical Combination In Presence ...)

Subjects
Nortriptyline -- Chemical properties, Liquid chromatography -- Methods, Fluphenazine -- Chemical properties, Green chemistry -- Methods, Pharmaceutical research, Chemistry, Analytic -- Methods, Drug adulteration -- Research, Health
Abstract

2022 DEC 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on Drugs and Therapies - Phenothiazine Antipsychotics is the subject [...]

Published
2022

48. Findings from Xi'an University of Architecture and Technology Has Provided New Data on Obesity, Fitness and Wellness (Synergistic Degradation of Sulfamethoxazole Using Peroxymonosulfate Activated By Fe-mn-cu Hollow Spheres: Kinetics and ...)

Subjects
Catalysts -- Analysis, Mass spectrometry -- Analysis, Liquid chromatography -- Methods, Biodegradation -- Methods, Sulfamethoxazole -- Composition, Density functionals -- Analysis, Health
Abstract

2022 DEC 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Obesity, Fitness and Wellness are presented in a new [...]

Published
2022

49. New Findings Reported from China Pharmaceutical University Describe Advances in Clinical Oncology (Development and Validation of a Liquid Chromatography-tandem Mass Spectrometry Method for Cpul1, a Novel Antitumor Candidate Compound, and Its ...)

Subjects
Mass spectrometry -- Methods, Liquid chromatography -- Methods, Physical fitness -- Methods, Health
Abstract

2022 DEC 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Clinical Oncology. According to news originating from [...]

Published
2022

50. Applying Liquid Chromatography (LC) and Liquid ChromatographyMass Spectrometry (LC-MS) Methods to the Characterization and Analysis of rAAV

Author

Koza, Stephan M., Zhang, Ximo, Yang, Hua, and Chen, Weibin

Subjects
Waters Corp., Mass spectrometry -- Methods, Product development -- Methods, Liquid chromatography -- Methods, Instrument industry -- Methods, Time to market, Chemistry, Science and technology
Abstract

Because of advances in the fundamental understanding of gene therapy treatments and the 2017 regulatory approval of a recombinant adeno-associated viral (rAAV) therapy, interest in developing rAAV-based therapies has increased. However, for patients worldwide to truly benefit from these therapies, significant improvements in the efficacy and manufacturing efficiency of rAAV are essential. We have recently seen substantial increases of inquiries regarding liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) methods for the characterization and analysis of rAAV from scientists who are supporting advancements in product development. This edition of 'Column Watch' highlights selected LC and LC-MS methods that can be applied to the analysis of these complex products., Gene therapy involves altering of the genome of selected cells within a patient (1). Although CRISPR/Cas9 has received widespread attention because of the groundbreaking work done by Emmanuelle Charpentier and [...]

Published
2020

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