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6. IntelliCage: the development and perspectives of a mouse- and user-friendly automated behavioral test system

Author

Lipp, Hans-Peter, Krackow, Sven, Turkes, Emir, Benner, Seico, Endo, Toshihiro, Russig, Holger, Lipp, Hans-Peter, Krackow, Sven, Turkes, Emir, Benner, Seico, Endo, Toshihiro, and Russig, Holger

Abstract

IntelliCage for mice is a rodent home-cage equipped with four corner structures harboring symmetrical double panels for operant conditioning at each of the two sides, either by reward (access to water) or by aversion (non-painful stimuli: air-puffs, LED lights). Corner visits, nose-pokes and actual licks at bottle-nipples are recorded individually using subcutaneously implanted transponders for RFID identification of up to 16 adult mice housed in the same home-cage. This allows for recording individual in-cage activity of mice and applying reward/punishment operant conditioning schemes in corners using workflows designed on a versatile graphic user interface. IntelliCage development had four roots: (i) dissatisfaction with standard approaches for analyzing mouse behavior, including standardization and reproducibility issues, (ii) response to handling and housing animal welfare issues, (iii) the increasing number of mouse models had produced a high work burden on classic manual behavioral phenotyping of single mice. and (iv), studies of transponder-chipped mice in outdoor settings revealed clear genetic behavioral differences in mouse models corresponding to those observed by classic testing in the laboratory. The latter observations were important for the development of home-cage testing in social groups, because they contradicted the traditional belief that animals must be tested under social isolation to prevent disturbance by other group members. The use of IntelliCages reduced indeed the amount of classic testing remarkably, while its flexibility was proved in a wide range of applications worldwide including transcontinental parallel testing. Essentially, two lines of testing emerged: sophisticated analysis of spontaneous behavior in the IntelliCage for screening of new genetic models, and hypothesis testing in many fields of behavioral neuroscience. Upcoming developments of the IntelliCage aim at improved stimulus presentation in the learning corners and videot

Published
2024

29. Virusinfektionen

Author

Lipp, Hans-Peter, Schneemann, Hubert, editor, Young, Lloyd Yee, editor, and Koda-Kimble, Mary Anne, editor

Published
2001
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30. Pilzinfektionen

Author

Lipp, Hans-Peter, Schneemann, Hubert, editor, Young, Lloyd Yee, editor, and Koda-Kimble, Mary Anne, editor

Published
2001
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31. Differential Involvement of the Central Amygdala in Appetitive versus Aversive Learning

Author

Lipp, Hans-Peter, Kaczmarek, Leszek, and Werka, Tomasz

Abstract

Understanding the function of the distinct amygdaloid nuclei in learning comprises a major challenge. In the two studies described herein, we used c-Fos immunolabeling to compare the engagement of various nuclei of the amygdala in appetitive and aversive instrumental training procedures. In the first experiment, rats that had already acquired a bar-pressing response to a partial food reinforcement were further trained to learn that an acoustic stimulus signaled either continuous food reinforcement (appetitive training) or a footshock (aversive training). The first training session of the presentation of the acoustic stimulus resulted in significant increases of c-Fos immunolabeling throughout the amygdala; however, the pattern of activation of the nuclei of the amygdala differed according to the valence of motivation. The medial part of the central amygdala (CE) responded, surprisingly, to the appetitive conditioning selectively. The second experiment was designed to extend the aversive versus appetitive conditioning to mice, trained either for place preference or place avoidance in an automated learning system (INTELLICAGE). Again, much more intense c-Fos expression was observed in the medial part of the CE after the appetitive training as compared to the aversive training. These data, obtained in two species and by means of novel experimental approaches balancing appetitive versus aversive conditioning, support the hypothesis that the central nucleus of the amygdala is particularly involved in appetitively motivated learning processes. (Contains 2 tables and 6 figures.)

Published
2006
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32. How to select a nanosimilar

Author

Astier, Alain, Barton Pai, Amy, Bissig, Marco, Crommelin, Daan J.A., Flühmann, Beat, Hecq, Jean‐Daniel, Knoeff, Josefien, Lipp, Hans‐Peter, Morell‐Baladrón, Alberto, and Mühlebach, Stefan

Published
2017
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