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Aims Methods and Results Conclusion Ossifying fibromyxoid tumour is a rare mesenchymal neoplasm predominantly affecting adults characterised by a multinodular growth pattern and the presence of a fibrous pseudocapsule with areas of ossification. Prompted by the recognition of a non‐ossifying ossifying fibromyxoid tumour with lipomatous differentiation which caused diagnostic difficulty, we sought to further explore cases of ossifying fibromyxoid tumour with non‐osseous heterologous elements.A search of our institutional and consultation archives revealed three additional cases that demonstrated lipomatous components and two cases with cartilaginous differentiation. RNA‐sequencing revealed fusions involving PHF1 (n = 4) or EPC1 (n = 1) in all (five of five) cases tested, including EPC1::PHC1 and JAZF1::PHF1 fusions, which have not been reported before in ossifying fibromyxoid tumour.These six cases expand the histomorphological spectrum of ossifying fibromyxoid tumour, introducing lipomatous differentiation as a hitherto undocumented feature. Awareness of these rare variants will ensure appropriate diagnosis and clinical management. [ABSTRACT FROM AUTHOR]

This article describes a case of a supratentorial ependymoma with lipomatous differentiation in a young adult. The patient presented with headaches and imaging revealed a left parietal mass. Surgical excision was performed, and the patient remained disease-free for 25 years. Histopathological examination showed a neoplasm with lipomatous differentiation, and additional immunostains and molecular analyses confirmed the diagnosis of supratentorial ependymoma, ZFTA fusion-positive. The article discusses the rarity of lipomatous differentiation in supratentorial ependymomas and the prognostic implications. The patient's case represents a remarkable example of excellent outcome. [Extracted from the article]

Pleomorphic adenoma is the most common benign salivary gland neoplasm principally affecting the parotid gland of the salivary gland and the palate of the minor salivary gland. The term pleomorphic is assigned due to its varied histopathological presentation. We hereby describe a rare case of pleomorphic adenoma in a male patient in his 7th decade of life complaining of swelling in the hard palate for the past 3 years. This case report emphasizes the unique representation of squamous and lipomatous differentiation which was erroneously diagnosed as OSCC or mucoepidermoid carcinoma. We have also included a literature search of such cases that exhibited lipomatous and squamous differentiation in PA listed from the last 10 years.

Phyllodes tumors are uncommon neoplasms of the breast. Lipomatous differentiation of malignant phyllodes tumor is a rare stromal alteration of this fibroepithelial tumor, demonstrated as a fat-containing mass on imaging. We present the case of a 46-year-old woman who was diagnosed with a malignant phyllodes tumor of the breast that demonstrated extensive lipomatous differentiation.

Pleomorphic adenoma (PA) is reported to be commonest benign neoplasm of salivary glands in Pakistan constituting 80-90% of all benign salivary gland tumours. Owing to the high prevalence and scarcity of local data in relation to the spectrum of its histological features, this study was designed to describe the various morphological patterns of this tumour with potential diagnostic pitfalls. This descriptive study was conducted at the Department of Morbid Anatomy and Histopathology/Oral Pathology, University of Health Sciences Lahore, Pakistan. Paraffin embedded blocks and detailed clinical data of 63 cases of pleomorphic adenoma reported at local tertiary care hospitals from Jan. 2013 to Sep. 2015 was retrieved. The histologic diagnosis was made on Hematoxylin and Eosin staining. The tumours were classified into classic, cell-rich and stroma-rich subtypes. The tumoral parenchyma was observed according to the presence of cuboidal, spindle, stellate, plasmacytoid & squamous. The epithelial architectural pattern was studied with respect to the ducts, trabeculae, solid nests while mesenchymal component was divided into myxoid, chondroid and chondromyxoid elements. Unusual epithelial and /or stromal differentiations were observed and reported accordingly. The most frequently observed age group of the patients was the 2nd and 3rd decades (43%) with mean age of 35.57 (± 16.993). Females reported more frequently (69.9%) than males (30.1%) (F: M ratio= 2.3:1). Parotid gland (62%) was the commonest site involved followed by submandibular gland (19%) and palate (12.6%). Histologically, classic variant (46%) was the commonest subtype followed by cell-rich (32%) and stroma-rich (22%) types. Cuboidal (81%) and spindle (62%) cells dominated most cases. Ducts (92%) and trabeculae (22.2%) were the most common epithelial patterns seen while myxoid (90%) and chondroid (55.5%) were the most frequently encountered mesenchymal patterns. Unusual patterns of lipomatous (6.3%), osteoid (17.4%) and extensive squamous differentiation with keratin pearl formation were also observed (20.6%). Pleomorphic adenoma occurs in a younger age group in Pakistani population with a female predilection. The most favoured site for PA is the parotid gland while the commonest minor salivary gland site is palate. Classic variant of PA is the commonest subtype followed by cell-rich variant. A variety of histological patterns can be encountered in pleomorphic adenoma which may cause diagnostic pitfalls and thus have serious therapeutic and prognostic implications. Hence there is a dire need for meticulous approach in reporting these lesions. [ABSTRACT FROM AUTHOR]

The reported liponeurocytoma of the left lateral ventricle in a 35-year-old man represents the fifth recorded case of a supratentoral intraventricular liponuerocytoma. In this location, liponeurocytomas are very exceptional, whereas it is the typical site for classic central neurocytomas. Conversely, neurocytomas of the cerebellum are predominantly liponeurocytomas with until now more than 25 reported cases. Thus, cerebellar liponeurocytoma is the most frequent neuroepithelial CNS tumor with adipose-like cells followed by ependymomas with a lipid component and supratentorial intraventricular liponeurocytoma. Adipose-like cells in neurocytomas may originate by lipidization of tumor cells, metaplastic transformation of neuroectodermal cells into fat cells or by true adipocytic differentiation. The present case showed also focal glial differentiation with GFAp-positivity of some cells as often seen in cerebellar liponeurocytomas but much rarer in central neurocytomas. Pathogenetic and noslogic implications of supratentorial intraventricular liponeurocytomas are discussed. Future WHO tumor classification should consider that liponeurocytomas are not restricted to the cerebellum. Reports on cerebellar liponeurocytomas with a less favorable clinical course suggest a WHO grade II for liponeurocytomas. [ABSTRACT FROM AUTHOR]

We report a case of astroblastoma with unusual signet-ring-like cell components. A 33-year-old-woman presented with occasional partial seizures of the face. Radiological studies revealed an enhanced frontal mass lesion. At surgery, a gray, soft, well-circumscribed mass was seen and shelled out. Histologically, the tumor showed a perivascular arrangement and papillary-like patterns with compact cellularity. The tumor cells radiating from the hyalinized vessels showed broader, shorter, less tapered processes. A part of each tumor cell displayed prominent islands of signet-ring-like cells. Glial fibrillary acidic protein reaction revealed strongly positive staining of tumor cells and signet-ring-like cells. Eight years after the operation the patient remains well with no tumor recurrence. It remains to be determined whether, in this astroblastoma, the unusual signet-ring-like cell components were related to benign biological characteristics or to the tumor's low-grade form with incidental signet-ring-like cell appearance. [ABSTRACT FROM AUTHOR]

Liponeurocytoma has been recognized recently as a distinct clinicopathological entity by the World Health Organization. Although there are few cases described in the literature it has been accepted as a benign lesion. Here we present a 55-year-old woman with a supratentorial intraventricular liponeurocytoma of the left lateral ventricle. [ABSTRACT FROM AUTHOR]