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Your search keyword '"Lipner, Ettie M."' showing total 36 results
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36 results on '"Lipner, Ettie M."'

10. Genomic Epidemiology ofMycobacterium abscessusat an Adult Cystic Fibrosis Program Reveals Low Potential for Healthcare-Associated Transmission

Author

Gross, Jane E., primary, Finklea, James D., additional, Caceres, Silvia M., additional, Poch, Katie R., additional, Hasan, Nabeeh A., additional, Jia, Fan, additional, Epperson, L. Elaine, additional, Lipner, Ettie M., additional, Vang, Charmie K., additional, Honda, Jennifer R., additional, Strand, Matthew J., additional, Nogueira de Moura, Vinicius Calado, additional, Daley, Charles L., additional, Strong, Michael, additional, and Nick, Jerry A., additional

Published
2024
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11. Prefiltered component‐based greedy (PreCoG) scan method.

Author

French, Joshua P., Meysami, Mohammad, and Lipner, Ettie M.

Subjects
DISEASE clusters, INFECTIOUS disease transmission, RESEARCH personnel, PUBLIC health, ALGORITHMS
Abstract

The spatial distribution of disease cases can provide important insights into disease spread and its potential risk factors. Identifying disease clusters correctly can help us discover new risk factors and inform interventions to control and prevent the spread of disease as quickly as possible. In this study, we propose a novel scan method, the Prefiltered Component‐based Greedy (PreCoG) scan method, which efficiently and accurately detects irregularly shaped clusters using a prefiltered component‐based algorithm. The PreCoG scan method's flexibility allows it to perform well in detecting both regularly and irregularly‐shaped clusters. Additionally, it is fast to apply while providing high power, sensitivity, and positive predictive value for the detected clusters compared to other scan methods. To confirm the effectiveness of the PreCoG method, we compare its performance to many other scan methods. Additionally, we have implemented this method in the smerc R package to make it publicly available to other researchers. Our proposed PreCoG scan method presents a unique and innovative process for detecting disease clusters and can improve the accuracy of disease surveillance systems. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Prospective healthcare-associated links in transmission of nontuberculous mycobacteria among people with cystic fibrosis (pHALT NTM) study: Rationale and study design

Author

Gross, Jane E., primary, Caceres, Silvia, additional, Poch, Katie, additional, Epperson, L. Elaine, additional, Hasan, Nabeeh A., additional, Jia, Fan, additional, Calado Nogueira de Moura, Vinicius, additional, Strand, Matthew, additional, Lipner, Ettie M., additional, Honda, Jennifer R., additional, Strong, Michael, additional, Davidson, Rebecca M., additional, Daley, Charles L., additional, and Nick, Jerry A., additional

Published
2023
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17. Molecular Epidemiologic Investigation of Mycobacterium intracellulare subspecies chimaera Lung Infections at an Adult Cystic Fibrosis Program

Author

Gross, Jane E., primary, Teneback, Charlotte C., additional, Sweet, Julie G., additional, Caceres, Silvia M, additional, Poch, Katie R, additional, Hasan, Nabeeh A, additional, Jia, Fan, additional, Epperson, L Elaine, additional, Lipner, Ettie M., additional, Vang, Charmie K, additional, Honda, Jennifer R., additional, Strand, Matthew J, additional, Calado Nogueira de Moura, Vinicius, additional, Daley, Charles L., additional, Strong, Michael, additional, Davidson, Rebecca M, additional, and Nick, Jerry A, additional

Published
2023
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24. A randomized trial of doxycycline for mansonella perstans infection

Author

Coulibaly, Yaya I., Dembele, Benoit, Diallo, Abdallah A., Lipner, Ettie M., Doumbia, Salif S., Coulibaly, Siaka Y., Konate, Siaka, Diallo, Dapa A., Yalcouye, Daniel, Kubofcik, Joseph, Doumbo, Ogobara K., Traore, Sekou F., Keita, Adama D., Fay, Michael P., Nutman, Thomas B., and Kilion, Amy D.

Subjects
Doxycycline -- Usage, Roundworm infections -- Care and treatment
Abstract

A study was conducted to evaluate the efficacy of doxycycline in the treatment of mansonella perstans infection. Results indicated that doxycycline was found to be an effective treatment option for the ailment, and also that mansonella perstans infection does contain bacterial endosymbionts.

Published
2009

28. Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015)

Author

Ries, Stefan J., Brandts, Christian H., Chung, Alicia S., Biederer, Carola H., Hann, Byron C., Lipner, Ettie M., McCormick, Frank, and Michael Korn, W.

Subjects
Control, Genetic aspects, Research, Health aspects, Apoptosis -- Health aspects -- Research -- Genetic aspects, Cancer genetics -- Research -- Genetic aspects, Tumor suppressor genes -- Health aspects -- Research -- Genetic aspects, Virus replication -- Control -- Research -- Genetic aspects -- Health aspects, Adenoviruses -- Health aspects -- Genetic aspects -- Research, Cancer -- Genetic aspects
Abstract

Author(s): Stefan J. Ries [1]; Christian H. Brandts [1]; Alicia S. Chung [1]; Carola H. Biederer [1]; Byron C. Hann [1]; Ettie M. Lipner [1]; Frank McCormick [1]; W. Michael [...]

Published
2000
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32. A Randomized Trial of Doxycycline forMansonella perstansInfection

Author

Coulibaly, Yaya I., primary, Dembele, Benoit, additional, Diallo, Abdallah A., additional, Lipner, Ettie M., additional, Doumbia, Salif S., additional, Coulibaly, Siaka Y., additional, Konate, Siaka, additional, Diallo, Dapa A., additional, Yalcouye, Daniel, additional, Kubofcik, Joseph, additional, Doumbo, Ogobara K., additional, Traore, Abdel K., additional, Keita, Adama D., additional, Fay, Michael P., additional, Traore, Sekou F., additional, Nutman, Thomas B., additional, and Klion, Amy D., additional

Published
2009
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33. COINCIDENT FILARIAL, INTESTINAL HELMINTH, AND MYCOBACTERIAL INFECTION: HELMINTHS FAIL TO INFLUENCE TUBERCULIN REACTIVITY, BUT BCG INFLUENCES HOOKWORM PREVALENCE

Author

LIPNER, ETTIE M., primary, KUMARASWAMI, V., additional, NARAYANAN, P. R., additional, KUMARAN, PAUL, additional, SUBRAMANI, R., additional, NUTMAN, THOMAS B., additional, PREVOTS, D. REBECCA, additional, KOLAPPAN, C., additional, SADACHARAM, K., additional, and GOPI, P. G., additional

Published
2006
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35. Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

Author

Ries, Stefan J., Brandts, Christian H., Chung, Alicia S., Biederer, Carola H., Hann, Byron C., Lipner, Ettie M., McCormick, Frank, and Michael Korn, W.

Subjects
ADENOVIRUSES, TUMOR treatment
Abstract

The adenovirus mutant dl1520 (ONYX-015) does not express the E1B-55K protein that binds and inactivates p53. This virus replicates in tumor cells with mutant p53, but not in normal cells with functional p53. Although intra-tumoral injection of dl1520 shows promising responses in patients with solid tumors, previous in vitro studies have not established a close correlation between p53 status and dl1520 replication. Here we identify loss of p14[sup ARF] as a mechanism that allows dl1520 replication in tumor cells retaining wild-type p53. We demonstrate that the re-introduction of p14[sup ARF] into tumor cells with wild-type p53 suppresses replication of dl1520 in a p53-dependent manner. Our study supports the therapeutic use of dl1520 in tumors with lesions within the p53 pathway other than mutation of p53. [ABSTRACT FROM AUTHOR]

Published
2000
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36. The Rise and Fall and Rise of Linkage Analysis as a Technique for Finding and Characterizing Inherited Influences on Disease Expression.

Author

Lipner EM and Greenberg DA

Subjects
Animals, Genetic Diseases, Inborn metabolism, Humans, Gene Expression Regulation, Genetic Diseases, Inborn genetics, Genetic Linkage, Genotyping Techniques methods
Abstract

For many years, family-based studies using linkage analysis represented the primary approach for identifying disease genes. This strategy is responsible for the identification of the greatest number of genes proven to cause human disease. However, technical advancements in next generation sequencing and high throughput genotyping, coupled with the apparent simplicity of association testing, led to the rejection of family-based studies and of linkage analysis. At present, genetic association methods, using case-control comparisons, have become the exclusive approach for detecting disease-related genes, particularly those underlying common, complex diseases. In this chapter, we present a historical overview of linkage analysis, including a description of how the approach works, as well as its strengths and weaknesses. We discuss how the transition from family-based studies to population comparison association studies led to a critical loss of information with respect to genetic etiology and inheritance, and we present historical and contemporary examples of linkage analysis "success stories" in identifying genes contributing to the development of human disease. Currently, linkage analysis is re-emerging as a useful approach for identifying disease genes, determining genetic parameters, and resolving genetic heterogeneity. We posit that the combination of linkage analysis, association testing, and high throughput sequencing provides a powerful approach for identifying disease-causing genes.

Published
2018
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