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7. To push or to pull? A clinical audit on the efficacy and safety of the pull and push percutaneous endoscopic gastrostomy techniques in oncological patients

Author

Kucha, Piotr, primary, Zorniak, Michal, additional, Szmit, Mateusz, additional, Lipczynski, Rafal, additional, Wieszczy‐Szczepanik, Paulina, additional, Kapala, Aleksandra, additional, Wojciechowska, Urszula, additional, Didkowska, Joanna, additional, Rupinski, Maciej, additional, Olesinski, Tomasz, additional, Maj, Tomasz, additional, Regula, Jaroslaw, additional, Kaminski, Michal F., additional, and Januszewicz, Wladyslaw, additional

Published
2023
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11. Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Author

Klimscha, Walter, Konecny, Regina, Luntzer, Robert, Morawk-Wintersperger, Ulrike, Neiger, Franz, Rustemeyer, Lydia, Breschan, Christian, Frey, Denise, Platzer, Manuela, Germann, Reinhard, Oeding, Joachim, Stoegermüller, Birgit, Ziegler, Bernhard, Brotatsch, Philipp, Gutmann, Anton, Mausser, Gerlinde, Messerer, Brigitte, Toller, Wolfgang, Vittinghoff, Maria, Zangl, Gregor, Seidel-Ahyai, Natascha, Hochhold, Christoph, Kroess, Ruth, Paal, Peter, Cnudde, Steven, Coucke, Patricia, Loveniers, Birgit, Mitchell, John, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Coppens, Marc, De Hert, Stefan, Heyse, Björn, Neckebroek, Martine, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Van Den Eynde, Nancy, Vanpeteghem, Caroline, Wyffels, Piet, Lalot, Michaël, Lechat, Jean-Paul, Stevens, France, Casaer, Sari, De Groote, Françoise, De Pooter, Françoise, De Villé, Andrée, Gerin, Marc, Magasich, Natalia, Sanchez Torres, Cristel, Van Deenen, Denise, Berghmans, Johan, Himpe, Dirk, Roofthooft, Eva, Joukes, Ellen, Smitz, Carine, Van Reeth, Veronique, Huygens, Christel, Lauweryns, Julie, De Smet, Karen, Najafi, Nadia, Poelaert, Jan, Van de Velde, Anne, Van Mossevelde, Veerle, Bekavac, Ivan, Butkovic, Diana, Heli Litvic, Dubravka, Kerovec Soric, Ivana, Maretic, Hrvoje, Moscatello, Djurdjica, Popovic, Ljiljana, Micici, Slobodan, Stuck Tus, Ivana, Kalagac Fabris, Lada, Simurina, Tatjana, Sulen, Nina, Kesic-Valpotic, Gordana, Djapic, Dajana, Žurek, Jirí, Jureckova, Lucie, Mackova, Iveta, Skacel, Monika, Weinlichova, Stanislava, Divák, Jan, Frelich, Michal, Urbanec, René, Biskupova, Vera, Mixa, Vladimir, Pavlickova, Jana, Afshari, Arash, Bøttger, Morten, Ellekvist, Marguerite B., Johansen, Mathias, Ingeborg Madsen, Birgitte, Christian Nilsson, Jens, Schousboe, Birgitte MB, Clausen, Nicola G., Hansen, Tom G., Phaff Steen, Nick, Ilmoja, Mari-Liis, Tonise, Virge, Karjagin, Juri, Kikas, Reet, Isohanni, Mika, Lyly, Anniina, Takala, Annika, Happo, Johanna, Kiviluoma, Kai, Martikainen, Kati, Aantaa, Riku, Manner, Tuula, Vilo, Sanna, Amory, Catherine, Ludot, Hugues, Lambotte, Patricia, Busche, René, Jacqmarcq, Olivier, Lejus, Corinne, Corouge, Julien, Erb, Christian, Garrigue, Delphine, Gillet, Patricia, Laffargue, Anne, Lambelin, Veronique, Le Freche, Hélène, Peresbota, Daliana, Richart, Pierre, Berton, Jerome, Chapotte, Catherine, Colbus, Laurent, Lehousse, Thierry, Monrigal, Jean, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Batoz, Hélène, Bordes, Maryline, Didier, Anne, Hamonic, Yann, Lagarde, Sylvaine, Nouette-Gaulain, Karine, Semjen, François, Zaghet, Brigitte, Dekens, Jacky, Delcuze, Axelle, Dupont, Hervé, Legrand, Aurélien, Raffoflandreur, Celine, Audren, Noémie, Camus, Blandine, Cartal, Marielle, Chazelet, Chantal, Davin, Isabelle, Guillier, Marion, Desjeux, Luc, Larcher, Claire, Grein, Elodie, Leclercq, Mickeal, Levitchi, Roxana, Rosu, Lilica, Simon, Dominique, Zang, Aurélien, Migeon, Anne, Gagey, Anne-Charlotte, Bourdaud, Nathalie, Carre, Anne-Charlotte, Duflo, Frédéric, Riche, Jean-Claude, Robert, Philippe, Druot, Emilie, Maupain, Olivier, Orliaguet, Gilles, Sabau, Lucie, Taright, Hanna, Uhrig, Lynn, Verchere-Montmayeur, Juliette, Debrabant, Lise, Pilla, Clotaire, Podvin, Alexandre, Roth, Benjamin, Dahmani, Souhayl, Julien-Marsollier, Florence, Sabourdin, Nada, Alexandri, Bogdan, Brezac, Gilles, de la Brière, Francois, Hayem, Catherine, Lhubat, Elizabeth, Paul Mission, Jean, Rémond, Charlotte, Dadure, Christophe, Maniora, Maud, Marie, Anais, Pirat, Philippe, Saour, Anne-Charlotte, Sola, Chrystelle, Ecoffey, Claude, Wodey, Eric, Adam, Christian, Standl, Thomas, Schindler, Ehrenfried, Yamamoto, Tomohiro, Brackhahn, Michael, Eich, Christoph Bernhard, Guericke, Holger, Kindermann, Petra, Laschat, Michael, Schink, Cornel, Wappler, Frank, Hoehne, Claudia, Skordou, Natalia, Ulrici, Johanna, Jetzek-Zader, Martin, Kienbaum, Peter, Meyer-Treschan, Tanja, Picker, Olaf, Schaefer, Maximilian S., Mielke, Golo, Baethge, Sabine, Ramminger, Axel, Bauer, Martin, Bollinger, Matthias, Hinz, José, Quintel, Michael, Russo, Sebastian G., Bauer, Michael, Geil, Dfominik, Kortgen, Andreas, Preussler, Niels-Peter, Hofmann, Ulrich, Raber, Manfred, Reindl, Doris, Becke, Karin, Oppenrieder, Karin, Schierlinger, Bettina, Roth, Jens, Funk, Wolfgang, Fischer, Thomas, Gernoth, Christian, Wiefelspütz, Christina, Volger, Hauke, Zederer, Nicole, Diers, Anja, Huber, Matthias, Schorer, Clemens, Weyland, Andreas, Schwarzkopf, Konrad, Grau, Catharina, Roth, Winfried, Holy, Rolf, Mader, Thomas, Peter, Laura, Supthut, Hauke, Kuehhirt, Thomas, Milde, Alexander, Fiedler, Fritz, Isselhorst, Carsten, Grundmann, Ulrich, Pattar, Alexander, Reinert, Jennifer, Ehm, Birgit, Fritzsche, Katrin, Gaebler, Ralf, Meybohm, Patrick, Hein, Maximilian, Guzman, Ines, Jokinen, Johanna, Kranke, Peter, Goebel, Ulrich, Harris, Sarah, Eisner, Christoph, Ochsenreiter, Miriam, Schoeler, Michael, Thil, Elke, Ellerkmann, Richard, Hoeft, Andreas, Neumann, Claudia, Weber, Stefan, Keilhauer, Julia, Kloessing, Jan, Schramm, Michael, Trieschmann, Uwe, Knauss, Kristina, Sinner, Barbara, Steinmann, Johannes, Koessler, Herbert, Kalliardou, Evagelia, Malisiova, Anna, Tsiotou, Adelais, Chloropoulou, Pelagia, Chrysi, Mpratzou, Iordanidou, Despoina, Ntavlis, Merkourios, Boda, Krisztina B, Guerin, Christilynn, Irwin, Janice, Magner, Claire, Nakhjavani, Solmaz, O'Hare, Brendan, Galvin, Deborah, Jamil, Yosry, Lesmes, Carlos, Barak, Yuri, Fisher, Haran, Kachko, Ludmyla, Katz, Jacob, Kirilov, Dmitry, Levinzon, Michael, Manevich, Yair, Nekrasov, Konstantin, Peled, Elia, Sanko, Elena, Schmain, Dmitri, Sheinkin, Olga, Simhi, Eliahu, Tarabikin, Alex, Trabkin, Evelina, Yagudaev, Irena, Zeitlin, Yelena, Zunser, Igor, Cerutti, Elisabetta, Maddalena Schellino, Maria, Valzan, Silvia, Lucia Pinciroli, Rosa, Bortone, Luciano, Cerati, Giorgia, Salici, Fabiana, Bussolin, Leonardo, Rizzo, Giuliana, Rossetti, Francesca, Marchesini, Laura, Tesoro, Simonetta, De Lorenzo, Brita, Guarracino, Fabio, Kuppers, Beate, Astuto, Marinella, Pitino, Sofia, Scalisi, Rita, Scordo, Lucia, D'Alessandro, Sandra, Dei Giudici, Luigi, Farinelli, Ivano, Lofino, Giuseppe, Marchetti, Giuliano, Giuseppe Picardo, Sergio, Reali, Simone, Vittori, Alessandro, Antonio Idone, Francesco, Sammartino, Maria, Sbaraglia, Fabio, Barbera, Cinzia, Bevilacqua, Michela, Cento, Valeria, Disma, Nicola, Kotzeva, Svetlana, Mameli, Leila, Montobbio, Giovanni, Passariello, Leandro, Punzo, Cinzia, Sileo, Rosanna, Viacava, Rosanna, Volpe, Claudia, Zanaboni, Clelia, Calderini, Edoardo, Genco, Daniele, Neri, Simona, Ottolina, Davide, Camporesi, Anna, Izzo, Francesca, Salvo, Ida, Wolfler, Andrea, Sanna, Andrea, Sciascia, Angela, Stoia, Paolo, Guddo, Annamaria, Lapi, Maria, Ivani, Giorgio, Longobardo, Annalisa, Mossetti, Valeria, Pedrotti, Dino, Grazzini, Maurizia, Meneghini, Luisa, Metrangolo, Salvatore, Michelon, Stefania, Minardi, Carmelo, Tognon, Costanza, Zadra, Nicola, Busi, Ilaria, Khotcholava, Magda, Guido Locatelli, Bruno, Sonzogni, Valter, Starita, Giusi, Almenrader, Nicole, Aurilio, Caterina, Sansone, Pasquale, Albarello, Raffaella, Bracci, Paolo, Cecini, Mariateresa, Cristina Mondardini, Maria, Pasini, Lorena, Vason, Milo, Zani, Gianluca, Zoppellari, Roberto, Pistidda, Laura, Cortegiani, Andrea, Maurizio Raineri, Santi, Hasani, Antigona, Hashimi, Medita, Ancupans, Agris, Barzdina, Arta, Straume, Zane, Zundane, Anda, Chlopin, Mikhail, Gestautaite, Dalia, Lukosiene, Laura, Paliokaite, Evelina, Razlevice, Ilona, Armoniene, Inesa, Bernotiene, Aurelija, Daugelavicius, Vidunas, Dockiene, Ilona, Gaidelyte, Lina, Saviciene, Nijole, Krikstaponiene, Jolita, Sidlovskaite-Baltake, Dominika, Stasevski, Vladyslav, Vaitoskaite, Agne, Gatt, David, Mifsud, Stephanie, Zammit, Simone, Allison, Celia, Aslami, Hamid, Eberl, Susanne, van Stijn, Mireille F M, Stevens, Markus F, Punt, Kees, van Osch, Rob, Bauwman, Arthur, Scholten, Harm, Svircevic, Vesna, Adriaens, Veronique, Dirckx, Maaike, Dogger, Jaap, Dons-Sinke, Ilse, Machotta, Andreas, Moors, Xavier, Rad, Mandana, Staals, Lonneke, van der Knijff - van Dortmont, Anouk, van der Marel, Caroline, Sieben, Anne, van der Zwan, Tim, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Vermeulen, Petronella M, Engel, Nicole, Vossen, Carine, Mahadewsing, Ravin, Meijer, Patrick, Gerling, Volker, van der Schatte Olivier, Roelof, van Doorn, Thea, Vons Mark Hendriks, Kristy, Lako, Sandra, jan Scheffer, Gert, Tielens, Luc, Voet, Marieke, Absalom, Anthony, Bergsma, Margot, Spanjer, Vera, Spanjersberg, Rob, van de Riet, Yvette, Volkers, Martin, de Graaff, Jurgen C., Hopman, Geranne A.J., Kappen, Teus H., Hannie, J., Megens, A.M., Numan, Sandra C., Schouten, Anton N.J., Turner, Nigel M., Van Der Werff, Désirée B.M., Wensing, Renee T.M., Ephraim, Erik, Nolte, Claire, Reikvam, Tore, Fredrik Lund, Ole, Skaaden, Lene, Marthe Ballovarre, Kari, Bakken Boerke, Wenche, Grindheim, Guro, Lindenskov, Pal H H, Beate Solas, Anne, Sponheim, Sjur, Ullensvang, Kyrre, Viken, Oddbjorn, Marie Drage, Inger, Gymoese Berthelsen, Kasper, Anders Kroken, Bjørn, Bergland, Unni, Pryzmont, Miroslaw, Talalaj, Mariola, Wasiluk, Malgorzata, Zalewska, Dorota, Damps, Maria, Siemek-Mitela, Jadzia, Wieczorek, Pawel, Juzwa, Magdalena, Rosada-Kurasinska, Jowita, Bartkowska-Sniatkowska, Alicja, Cettler, Maciej, Kopycinska, Renata, Rudewicz, Iwona, Sobczyk, Jaek, Wojciechowski, Dariusz, Baranowski, Artur, Basiewicz, Ewa, Mierzewska-Schmidt, Magdalena, Retka, Wlodzimierz, Sawicki, Piotr, Checinska, Magdalena, Zielinska, Marzena, Zurawska, Magdalena, Leal, Teresa, Mascarenhas, Catia, Pedro Pina, António, Joao Susano, Maria, Moniz, Antonio, Teresa Rocha, Maria, Calvao Santos, Carolina, Domingas Patuleia, M, Pereira, Ricardo, Roxo, Helena, Amaral, Rosa, Guedes, Isabel, Gomes, Cristina, Gonçalves, Marta, Salgado, Helena, Santos, Maria, Rodrigues, Sara, Sa, Angela, Machado, Elvira, Pé d'Arca, Sandra, Seabra, Manuel, Mihaela Gheorghe, Ligia, Ivascu, Constantin, Moraru-Draghici, Lucia, Suvejan, Mirela, Babici, Remus, Eniko, Kovacs, Hogea, Cristiana, Mihaela, Dubau, Nicoleta, Daraban, Barbunc, Danut, Maria Nistor, Alina, Stefan, Violeta, Catalina Ionescu, Gabriela, Davidescu, Irina, Teodora Nastase, Alina, Dumitru Rusu, Florin, Badarau, Victoria, Cindea, Iulia, Moscaliuc, Melania, Olteanu, Dana, Petrescu, Luxita, Ceuca, Daniela, Galinescu, Irena, Badeti, Rodica, Capusan, Alin, Cucui-Cozma, Cosmina, Popescu, Barbura, Cimpeanu, Luminita, Birliba, Mihaela-Petronela, Miulescu, Magdalena, Balamat, Stefania, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Pick, Darina, Sirghie, Rodica, Tabacaru, Radu, Trante, Irinel, Horhota, Lucian, Bandrabur, Daniela, Ciobanu, Tudor, Cuciuc, Veaceslav, Munteanu, Valentin, Olaru, Valentin, Paiu, Corneliu, Savu, Anca, Trifan, Oana, Elena Malos, Anca, Glazunov, Anton, Ivanov, Alexander, Poduskov, Evgeny, Popov, Alexander, Guskov, Igor, Lugovoy, Alexander, Nechaev, Vladislav, Ovezov, Alexey, Basov, Mikhail, Kochkin, Vladimir, Lazarev, Vladimir, Chizhov, Dmitri, Ostreikov, Ivan, Tolasov, Konstantin, Budic, Ivana, Marjanovic, Vesna, Draskovic, Biljana, Pandurov, Marina, Simin, Jovana, Dolinaj, Vladimir, Janjevic, Dusanka, Mandras, Ana, Mircetic, Maja, Petrovic, Sladjana, Rebac, Vlatka, Slavkovic, Bojana, Stevanovic, Vesna, Velcev, Ana, Knezevic, Mirjana, Milojevic, Irina, Puric, Selena, Simic, Irena, Stevic, Marija, Stranjanac, Vladimir, Simic, Dusica, Cabanova, Barbora, Hanula, Miloslav, Grynyuk, Andry, Berger, Jelena, Cerne, Uros, Nastran, Andraz, Pirc, Dejan, Popic, Rok, Stupnik, Spela, Rubio, Paloma, del Río, Cristina, Benito, Pilar, Pino, Gema, Gutierrez, Ignacio, Gutierrez Valcarcel, Andrea, León Carsi, Irene, Perez Garcia, Anibal, López Galera, Sílvia, Marco Valls, Joan, Ricol Lainez, Laura, Vallejo Tarrat, Andrea, Artes, David, Banus, Ester, Chirichiello, Luca, De Abreu, Leidy, De Josemaria, Belen, Helena Gaitan, M, Garces, Antonio, Lazaro, Juan J, Manen Berga, Ferran, Molies, Dolors, Monclus, Enric, Navaro, Montserrat, Pamies, Carmen, Perelló, Marina, Prat, Mar, Ribo, Laura, Angeles Sanz, M, Serrano, Silvia, Sola Ruiz, Eva, Anuncia Escontrela Rodríguez, Blanca, Maria Gago Martinez, Andrea, Martínez Ruiz, Alberto, De La Cruz Benito, Fausto, Gabilondo Garcia, Gustavo, Martinez Maldonado, Ever, Noriega, Bryant, Oller Duque, Lara, Olmos Mendez, Alberto, Perez- Ferrer, Antonio, Reinoso Barbero, Francisco, Acevedo Bambaren, Ismael, Domínguez, Fernando, Franco, Teresa, Jiménez, Anabel, Melero, Alicia, Feliu, Montserrat, García, Irene, Montferrer, Núria, Munar, Francisca, Muro, Cristina, Nuño, Rosario, Perera, Remel, Schmucker, Erika, Börjesson, Glenda, Gillberg, Lars, Castellheim, Albert, Sandström, Kerstin, Bauer, Annette, Roos, Torbjörn, Hedlund, Lars, Boegli, Yann, Dolci, Mirko, Marcucci, Carine, Spahr-Schopfer, Isabelle, Habre, Walid, Pellegrini, Michel, Book, Malte, Errass, Loreen, Riggenbach, Christine, Casutt, Mattias, Hölzle, Martin, Hurni, Thomas, Jöhr, Martin, Mauch, Jacqueline, Anselmi, Luciano, Anselmi, Irene, Jacomet, Alfred, Oberhauser, Markus, Wossner, Stephanie, Zettl, Angelika, Erb, Thomas, Mackiewicz, Tomasz, Simitzes, Helena, Ozer, Yetkin, Takil, Arzu, Alanoglu, Zekeriyya, Bermede, Onat, Cakar Turhan, K.Sanem, Alkis, Neslihan, Yildirim Guclu, Cigdem, Ceyda Meco, Basak, Hatipoglu, Zehra, Ozcengiz, Dilek, Begec, Zekine, Ilksen Toprak, Huseyin, Kendigelen, Pinar, Cigdem Tütüncü, Ayse, Karadeniz, Meltem Savran, Seyhan Ozkan, Tulay, Sivrikoz, Nuket, Kemal Arslantas, Mustafa, Hizal, Ayse, Tore Altun, Gülbin, Umuroglu, Tumay, Baris, Sibel, Kazak Bengisun, Zuleyha, Goncharenko, Galyna, Khrapak, Maksym, Klymenko, Tetyana, Pavlenko, Vitaliy, Prysiazhniuk, Dmytro, Rudio, Olga, Varyvoda, Mykhailo, Vodianytskyi, Sergii, Boryshkevych, Ivanna, Kyselova, Iryna, Trikash, Nikolay, Albokrinov, Andrew, Perova-Sharonova, Valentina, Sklyar, Vitaliy, Surkov, Denis, Abdelaal, Amr, Barber, Nicola, Checuti, Sarah, Godsiff, Leisha, Johanne, Lynch, Simpson, Joanna, Underhill, Helen, Diwan, Rishi, Kelgeri, Nivedita, Masip, Nuria, Ravi, Radha, Roberts, Steve, Cillis, Annagrazia, Marcus, Ritchie, Merella, Federica, Love, David, Baraggia, Paolo, Bird, Victoria, Hussey, Joseph, Alderson, Peter, Bartholomew, Karen, Moncreiff, Michael, Davidson, Sarah, Hare, Alison, Kotecha, Ami, Lee, Corina, Liyanage, Ganga, Patel, Shivali, Samani, Amee, Abou-Samra, Mark, Boyd, Matthew, Hullatt, Laurence, Levy, David, Pauling, Mark, Sharman, Sarah-Jane, Smith, Natalie, Rutherford, John, Cavalier, Alison, Locke, Christie, Sage, Frederic, Bapat, Smita, Hammerschlag, Jacinda, Ioannou, Ioannis, King, Stephanie, Pegg, Rachel, Salota, Vishal, Sketcher, Jonathan, Thadsad, Muthu, Zeitlin, Deborah, Jack, Ewan, Lang, Colin, Ahmed, Samira, Ayyash, Reema, Bari, Francoise, Bell, Sarah J, Elizabeth Biercamp, Claire, Briggs, Sandra, Gabriella Elena Clement, Maria, Dalton, Mark, Ali Eissa Eid, Mohamed, Gandhi, Monica, Harmen Herrema, Idse, Khaffaf, Ranj, Jeng Min Law, Savio, McClintock, Joanna, Ireland, Nicholas, Majid Saleem, Mohammed, Smith, Fiona, Cohen, Marc, Lee, Clover-Ann, O'Donahue, Lizanne, Powell, Alex, Rawlinson, Ellen, Snoek, Aarjan, Weiss, Katja, Wellesley, Hugo, Crawford, Michael, Abdel-Hafiz, Mostafa, Day, Alexandra, Rajamani, Balaji, Saha, Rita, Wright, Dave, Chee, Lew-Chin, Bew, Stephanie, Homer, Rachel, Malarkkan, Nalini, Wolfe Barry, Juliet, Angadi, Pradeep, Cagney, Brid, De Melo, Eric, Dekker, Elsa, Helm, Emma, Jones, Gareth, Peiris, Kawshala, Russell, William, Slater, Patricia, Sodhi, Puja, Browning, Mike, Phillips, Trudie, Van Hecke, Rachel, Muir, Vimty, Singh, Piyush, Soskova, Tereza, Cumming, Craig, Farquharson, Pamela, Pearson, Karen, Shaw, Neil, Whiteside, Jonathan, Whyte, Emma, Byers, Gordon, Davies, Kay, Engelhardt, Thomas, Faliszewski, Isabella, Johnston, Graham, Kaufmann, Nils, Kusnirikova, Zuzana, Wilson, Graham, Carachi, Peter, Makin, Andrew, Foster, Brian, Lipczynski, Dariusz, Mawer, Rebecca, Rutherford, William, Rogerson, David, Rushman, Sarah, Taylor, Christopher, Tomlinson, William, Dix, Philippa, Woodward, Tom, Bell, Graham, Boyle, David, Cloherty, Marianne, Cullen, Julia, Cullen, Pauline, Fairgrieve, Ross, Ghent, Robert, Glasgow, Russell, Gordeeva, Elena, Harden, Alison, Hivey, Sarah, Jerome, Kevin, McKee, Lesley, Morton, Neil, Pribul, Vicky, Sinclair, John, Steiner, Maria, Steward, Heather, Sweeney, Lorraine, Thomson, Wendy, Whiteside, Jeanette, Dalton, Andrew, Ross, Mark, Smith, Carolyn, Allen, Claire, Anders, Nicola, Barlow, Victoria, Bassett, Mike, Darwin, Leanne, Davison, Rachel, Diacono, Jacques, Hobbs, Amy, Hutchinson, Adel, Lomas, Bernadette, Lonsdale, Hannah, Nasser, Leila, Oshan, Vimmi, Patel, Pradip, Raistrick, Christopher, Scott-Warren, Victoria, Talbot, Laura, Wai, Carolynn, Childs, Sophie, Dickinson, Matthew, Bloomfield, Tom, Garrioch, Sweyn, Watson, Karen, Gaynor, James, Harrison, Richard, Lee, Juliette, Blythe, Elizabeth, Dorman, Teresa, Eissa, Ayman, Ellwood, James, Gooch, Ingrid, Hearn, Robert, Hodgetts, Vanessa, John, Robert, Kirton, Christine, Ladak, Nadia, Morgan, Judith, Plant, Nina, Shepherd, Elizabeth, Short, Judith, Stack, Charles, Steel, Simon, Taylor, Matthew, Thomas, Deborah, Wilson, Catharine, Wilson-Smith, Elaine, Bradbury, Carol L., Hussain, Nageena, Mayell, Antonia, Mesbah, Ahmed, Qureshi, Arif, Vaidyanath, Chandra, Geary, Tim, Hawksworth, Chris, Parasuraman, Tamaraichelvi, Perry, Nicole, Banerjee, Indrani, Barr, Katharine, Butler, Patrick, Davies, Jack, Flewin, Lisa, Gande, Richard, Montague, James, Plumb, James, Pratt, Thomas, Sutherland, Paul, Vail, Hannah, Wilkins, Andrew, Hunter, Catherine, Russell, Susan, Thomas, Alun, Mifsud, Mark, Strachan, Dominic, Leva, Brigitte, Plichon, Benoit, Harlet, Pierre, Virag, Katalin, Hansen, Tom G, Morton, Neil S, and Boda, Krisztina

Published
2017
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13. Selected aspects of cartel stability : (with reference to UK data)

Author

Lipczynski, J.

Subjects
330, Economics & economic theory
Abstract

The thesis examines the nature of cartel stabilit y by trying to complement standard economic analysis with evidence of the institutional detail surrounding such solutions to the problem of oli g opolistic interdependence. Firstly, the thesis discusses the raison d'etre of cartels as well as the factors responsible for their characteristic instability. Secondly, a systematic anal ysis is presented of the data found in the files at the Office of Fair Trading of oligopolistic agreements registered under the 1956 Restrictive Trade Practices Act. Finally, the thesis will describe and analyse in the context of the prior discussion, the outcome, in the case of eight cartels that successfully passed through the Restrictive Trade Practices Court.

Published
1994

15. Obesity and renal cancer incidence and mortality – a systematic review of prospective cohort studies

Author

Tomasz Golabek, Jakub Bukowczan, Tomasz Szopinski, Piotr Chlosta, Waclaw Lipczynski, Jakub Dobruch, and Andrzej Borowka

Subjects
Obesity, renal cancer, incidence, mortality, systematic review, Agriculture, Environmental sciences, GE1-350
Abstract

[b]Introduction and objective.[/b] There have been many studies published recently on obesity and the risk of renal cancer; however, the epidemiological evidence for such an association has not been consistent. Therefore, a systematic review was conducted of the prospective cohort studies to assess the association between obesity and the risk of renal cancer incidence and death. [b]Materials and methods.[/b] A search was conducted of the PubMed database and references to published studies from inception until May 2013. Guidelines for Assessing Quality in Prognostic Studies on the Basis of Framework for Potential Biases were followed for quality assessment of studies included in the systematic review. [b]Results. [/b]Twenty eligible studies were identified and included in the systematic review. Among the 20 selected studies, overall study quality was high. Although the evidence from the prospective cohort studies, linking obesity with renal cancer incidence, has not been entirely consistent, there is a convincing body of data for a positive relationship. Moreover, cumulative data is compelling for a strong positive association between obesity and fatal renal cancer. [b]Conclusions.[/b] There is a relatively consistent amount of evidence that obesity increases the risk of renal cancer and fatal renal cancer. Further research is needed as better understanding of mechanisms by which obesity may influence renal cancer development and progression will aid the fostering of strategies for prevention and treatment of one of the most lethal human malignancies.

Published
2015
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16. A Study of Minimum Quantity Lubrication (MQL) by Nanofluids in Orbital Drilling and Tribological Testing

Author

Mohsen Mosleh, Khosro A. Shirvani, Sonya T. Smith, John H. Belk, and Gary Lipczynski

Subjects
nanofluid, MQL, orbital drilling, four-ball testing, Production capacity. Manufacturing capacity, T58.7-58.8
Abstract

In minimum quantity lubrication (MQL), an aerosol containing a minimum amount of the cutting fluid is delivered to the tool/workpiece interface during the metal cutting operation. The fluid lubrication by the fluid and the cooling by the compressed air in the aerosol improves the cutting process, while the low consumption rate in MQL provides less cleanup and reduces the associated cost. In this paper, molybdenum disulfide (MoS2) and hexagonal boron nitride (hBN) nanoparticles were added to the aerosol for providing a third functionality to the MQL, which is solid lubrication at the interface. Both orbital drilling and tribological testing using a four-ball tester were studied to examine the effectiveness of solid lubrication in MQL. In orbital drilling of titanium with tungsten carbide tools, MQL with nanofluids containing MoS2 nanoparticles resulted in less transfer film buildup on the tool. In four-ball testing, MQL with nanofluids with MoS2 and hBN nanoparticles yielded lower surface temperatures and less variation of frictional torques in titanium.

Published
2019
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21. Analysis of district heating with ventilation heat recovery : The effects in the form of primary energy and life cycle emissions of carbon dioxide equivalents

Author

Lipczynski, Marcus and Becke, Rasmus

Subjects
Koldioxidekvivalenter, Integrerat värmesystem, Energy Engineering, Bioenergi, Miljöanalys och bygginformationsteknik, Fjärrvärme, Primärenergi, Energiteknik, Värmeåtervinning, Livscykelutsläpp, Bioenergy, Environmental Analysis and Construction Information Technology, Energy Systems, Energieffektivisering, Energisystem
Abstract

För att uppnå Sveriges energi- och klimatmål för energieffektivisering och koldioxidutsläpp måste nya tekniker och innovationer undersökas för att bidra till att göra energianvändningen mer effektiv i bostadssektorn. Ett alternativ för att uppnå målen är att använda ett integrerat värmesystem. De integrerade värmesystemen som undersöks i den här rapporten innefattar värmeåtervinning via ventilation som komplement till fjärrvärme, vilket jämförs med uppvärmning av bara fjärrvärme. De valda integrerade värmesystemen från HögforsGST kommer undersökas ur ett livscykelutsläpps- och primärenergiperspektiv. Analysen ska utreda om systemen bidrar till att sänka energianvändningen och hur stora livscykelutsläppen av koldioxidekvivalenter är för värmesystemen i två olika fastigheter. Slutsatsen för rapporten var att de valda integrerade värmesystemen var mer energieffektiva, då de använde mindre primärenergi, oavsett fall för elproduktion. De använde även 36 procent och 32,8 procent mindre producerad energi, för Lärlingen respektive Rundeln. Fjärrvärmesystemet medförde istället lägre totala livscykelutsläpp av koldioxidekvivalenter än det integrerade värmesystemen, för de flesta fallen av elproduktion. För att få ett mer tillförlitligt resultat bör de integrerade värmesystemen granskas under en längre tidsperiod för att vidare analysera använd primärenergi och livscykelutsläpp.

Published
2020

22. Analys av fjärrvärme med värmeåtervinning via ventilationssystem : Effekterna i form av primärenergi och livscykelutsläpp av koldioxidekvivalenter

Author

Lipczynski, Marcus, Becke, Rasmus, Lipczynski, Marcus, and Becke, Rasmus

Abstract

För att uppnå Sveriges energi- och klimatmål för energieffektivisering och koldioxidutsläpp måste nya tekniker och innovationer undersökas för att bidra till att göra energianvändningen mer effektiv i bostadssektorn. Ett alternativ för att uppnå målen är att använda ett integrerat värmesystem. De integrerade värmesystemen som undersöks i den här rapporten innefattar värmeåtervinning via ventilation som komplement till fjärrvärme, vilket jämförs med uppvärmning av bara fjärrvärme. De valda integrerade värmesystemen från HögforsGST kommer undersökas ur ett livscykelutsläpps- och primärenergiperspektiv. Analysen ska utreda om systemen bidrar till att sänka energianvändningen och hur stora livscykelutsläppen av koldioxidekvivalenter är för värmesystemen i två olika fastigheter. Slutsatsen för rapporten var att de valda integrerade värmesystemen var mer energieffektiva, då de använde mindre primärenergi, oavsett fall för elproduktion. De använde även 36 procent och 32,8 procent mindre producerad energi, för Lärlingen respektive Rundeln. Fjärrvärmesystemet medförde istället lägre totala livscykelutsläpp av koldioxidekvivalenter än det integrerade värmesystemen, för de flesta fallen av elproduktion. För att få ett mer tillförlitligt resultat bör de integrerade värmesystemen granskas under en längre tidsperiod för att vidare analysera använd primärenergi och livscykelutsläpp.

Published
2020

24. Direct digital control of thyristor drives

Author

Lipczynski, R. T.

Subjects
621.31042
Abstract

The investigation described, in this is designed to produce a digital closed loop speed control system for a d.c. motor using a thyristor power amplifier and a digital, minicomputer as integral components of the system. The thyristor amplifier is direct digitally controlled and also has digital current limiting protection. A digital form of a conventional analogue proportional controller, and a scheduled controller based on pre-recorded performance characteristics for the motor are first discussed, but rejected as impractical because of the complexity of the resulting system. Control based on a bang-bang principle with a variable mode switching control action designed to minimise limit cycling is then introduced. This method is shown to produce very acceptable performance using quite simple system software and appears to be immediately applicable to microprocessor implementation. A further refinement, that of dual or adaptive sampling designed to further reduce limit cycling effects in steady state operation, is then introduced. A control or switching matrix is developed as a design method for the switching controller which functions when the control computer recognises the required operating region for the motor as defined by signum functions of error and error rate within the system. The final controller uses multi-mode operation in which the loop gain and feedback constants are controlled as a function of error and error rate. It also incorporates an adaptive sampling period, and results in a digital speed control system which has both simple hardware and software. Suggestions for methods of further improving performance using a system of parallel processing with a view to using a microprocessor as the control computer, but still retaining system simplicity, are also discussed.

Published
1977

26. A Study of Minimum Quantity Lubrication (MQL) by Nanofluids in Orbital Drilling and Tribological Testing

Author

John H. Belk, Mohsen Mosleh, Gary Lipczynski, Sonya T. Smith, and Khosro A. Shirvani

Subjects
0209 industrial biotechnology, Materials science, chemistry.chemical_element, 02 engineering and technology, Industrial and Manufacturing Engineering, chemistry.chemical_compound, 020901 industrial engineering & automation, Nanofluid, 0203 mechanical engineering, Tungsten carbide, orbital drilling, MQL, Molybdenum disulfide, four-ball testing, lcsh:T58.7-58.8, Mechanical Engineering, Metallurgy, Drilling, Tribology, 020303 mechanical engineering & transports, chemistry, Mechanics of Materials, Lubrication, nanofluid, Cutting fluid, lcsh:Production capacity. Manufacturing capacity, Titanium
Abstract

In minimum quantity lubrication (MQL), an aerosol containing a minimum amount of the cutting fluid is delivered to the tool/workpiece interface during the metal cutting operation. The fluid lubrication by the fluid and the cooling by the compressed air in the aerosol improves the cutting process, while the low consumption rate in MQL provides less cleanup and reduces the associated cost. In this paper, molybdenum disulfide (MoS2) and hexagonal boron nitride (hBN) nanoparticles were added to the aerosol for providing a third functionality to the MQL, which is solid lubrication at the interface. Both orbital drilling and tribological testing using a four-ball tester were studied to examine the effectiveness of solid lubrication in MQL. In orbital drilling of titanium with tungsten carbide tools, MQL with nanofluids containing MoS2 nanoparticles resulted in less transfer film buildup on the tool. In four-ball testing, MQL with nanofluids with MoS2 and hBN nanoparticles yielded lower surface temperatures and less variation of frictional torques in titanium.

Published
2019

32. Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Author

Walid Habre, Nicola Disma, Katalin Virag, Karin Becke, Tom G Hansen, Martin Jöhr, Brigitte Leva, Neil S Morton, Petronella M Vermeulen, Marzena Zielinska, Krisztina Boda, Francis Veyckemans, Walter Klimscha, Regina Konecny, Robert Luntzer, Ulrike Morawk-Wintersperger, Franz Neiger, Lydia Rustemeyer, Christian Breschan, Denise Frey, Manuela Platzer, Reinhard Germann, Joachim Oeding, Birgit Stoegermüller, Bernhard Ziegler, Philipp Brotatsch, Anton Gutmann, Gerlinde Mausser, Brigitte Messerer, Wolfgang Toller, Maria Vittinghoff, Gregor Zangl, Natascha Seidel-Ahyai, Christoph Hochhold, Ruth Kroess, Peter Paal, Steven Cnudde, Patricia Coucke, Birgit Loveniers, John Mitchell, David Kahn, Thierry Pirotte, Caroline Pregardien, Marc Coppens, Stefan De Hert, Björn Heyse, Martine Neckebroek, Aliaksandra Parashchanka, Jurgen Van Limmen, Nancy Van Den Eynde, Caroline Vanpeteghem, Piet Wyffels, Michaël Lalot, Jean-Paul Lechat, France Stevens, Sari Casaer, Françoise De Groote, Françoise De Pooter, Andrée De Villé, Marc Gerin, Natalia Magasich, Cristel Sanchez Torres, Denise Van Deenen, Johan Berghmans, Dirk Himpe, Eva Roofthooft, Ellen Joukes, Carine Smitz, Veronique Van Reeth, Christel Huygens, Julie Lauweryns, Karen De Smet, Nadia Najafi, Jan Poelaert, Anne Van de Velde, Veerle Van Mossevelde, Ivan Bekavac, Diana Butkovic, Dubravka Heli Litvic, Ivana Kerovec Soric, Hrvoje Maretic, Djurdjica Moscatello, Ljiljana Popovic, Slobodan Micici, Ivana Stuck Tus, Lada Kalagac Fabris, Tatjana Simurina, Nina Sulen, Gordana Kesic-Valpotic, Dajana Djapic, Jirí Žurek, Lucie Jureckova, Iveta Mackova, Monika Skacel, Stanislava Weinlichova, Jan Divák, Michal Frelich, René Urbanec, Vera Biskupova, Vladimir Mixa, Jana Pavlickova, Arash Afshari, Morten Bøttger, Marguerite B. Ellekvist, Mathias Johansen, Birgitte Ingeborg Madsen, Jens Christian Nilsson, Birgitte MB Schousboe, Nicola G. Clausen, Tom G. Hansen, Nick Phaff Steen, Mari-Liis Ilmoja, Virge Tonise, Juri Karjagin, Reet Kikas, Mika Isohanni, Anniina Lyly, Annika Takala, Johanna Happo, Kai Kiviluoma, Kati Martikainen, Riku Aantaa, Tuula Manner, Sanna Vilo, Catherine Amory, Hugues Ludot, Patricia Lambotte, René Busche, Olivier Jacqmarcq, Corinne Lejus, Julien Corouge, Christian Erb, Delphine Garrigue, Patricia Gillet, Anne Laffargue, Veronique Lambelin, Hélène Le Freche, Daliana Peresbota, Pierre Richart, Jerome Berton, Catherine Chapotte, Laurent Colbus, Thierry Lehousse, Jean Monrigal, Catherine Baujard, Philippe Roulleau, Giuseppe Staiti, Hélène Batoz, Maryline Bordes, Anne Didier, Yann Hamonic, Sylvaine Lagarde, Karine Nouette-Gaulain, François Semjen, Brigitte Zaghet, Jacky Dekens, Axelle Delcuze, Hervé Dupont, Aurélien Legrand, Celine Raffoflandreur, Noémie Audren, Blandine Camus, Marielle Cartal, Chantal Chazelet, Isabelle Davin, Marion Guillier, Luc Desjeux, Claire Larcher, Elodie Grein, Mickeal Leclercq, Roxana Levitchi, Lilica Rosu, Dominique Simon, Aurélien Zang, Anne Migeon, Anne-Charlotte Gagey, Nathalie Bourdaud, Anne-Charlotte Carre, Frédéric Duflo, Jean-Claude Riche, Philippe Robert, Emilie Druot, Olivier Maupain, Gilles Orliaguet, Lucie Sabau, Hanna Taright, Lynn Uhrig, Juliette Verchere-Montmayeur, Lise Debrabant, Clotaire Pilla, Alexandre Podvin, Benjamin Roth, Souhayl Dahmani, Florence Julien-Marsollier, Nada Sabourdin, Bogdan Alexandri, Gilles Brezac, Francois de la Brière, Catherine Hayem, Elizabeth Lhubat, Jean Paul Mission, Charlotte Rémond, Christophe Dadure, Maud Maniora, Anais Marie, Philippe Pirat, Anne-Charlotte Saour, Chrystelle Sola, Claude Ecoffey, Eric Wodey, Christian Adam, Thomas Standl, Ehrenfried Schindler, Tomohiro Yamamoto, Michael Brackhahn, Christoph Bernhard Eich, Holger Guericke, Petra Kindermann, Michael Laschat, Cornel Schink, Frank Wappler, Claudia Hoehne, Natalia Skordou, Johanna Ulrici, Martin Jetzek-Zader, Peter Kienbaum, Tanja Meyer-Treschan, Olaf Picker, Maximilian S. Schaefer, Golo Mielke, Sabine Baethge, Axel Ramminger, Martin Bauer, Matthias Bollinger, José Hinz, Michael Quintel, Sebastian G. Russo, Michael Bauer, Dfominik Geil, Andreas Kortgen, Niels-Peter Preussler, Ulrich Hofmann, Manfred Raber, Doris Reindl, Karin Oppenrieder, Bettina Schierlinger, Jens Roth, Wolfgang Funk, Thomas Fischer, Christian Gernoth, Christina Wiefelspütz, Hauke Volger, Nicole Zederer, Anja Diers, Matthias Huber, Clemens Schorer, Andreas Weyland, Konrad Schwarzkopf, Catharina Grau, Winfried Roth, Rolf Holy, Thomas Mader, Laura Peter, Hauke Supthut, Thomas Kuehhirt, Alexander Milde, Fritz Fiedler, Carsten Isselhorst, Ulrich Grundmann, Alexander Pattar, Jennifer Reinert, Birgit Ehm, Katrin Fritzsche, Ralf Gaebler, Patrick Meybohm, Maximilian Hein, Ines Guzman, Johanna Jokinen, Peter Kranke, Ulrich Goebel, Sarah Harris, Christoph Eisner, Miriam Ochsenreiter, Michael Schoeler, Elke Thil, Richard Ellerkmann, Andreas Hoeft, Claudia Neumann, Stefan Weber, Julia Keilhauer, Jan Kloessing, Michael Schramm, Uwe Trieschmann, Kristina Knauss, Barbara Sinner, Johannes Steinmann, Herbert Koessler, Evagelia Kalliardou, Anna Malisiova, Adelais Tsiotou, Pelagia Chloropoulou, Mpratzou Chrysi, Despoina Iordanidou, Merkourios Ntavlis, Krisztina B Boda, Christilynn Guerin, Janice Irwin, Claire Magner, Solmaz Nakhjavani, Brendan O'Hare, Deborah Galvin, Yosry Jamil, Carlos Lesmes, Yuri Barak, Haran Fisher, Ludmyla Kachko, Jacob Katz, Dmitry Kirilov, Michael Levinzon, Yair Manevich, Konstantin Nekrasov, Elia Peled, Elena Sanko, Dmitri Schmain, Olga Sheinkin, Eliahu Simhi, Alex Tarabikin, Evelina Trabkin, Irena Yagudaev, Yelena Zeitlin, Igor Zunser, Elisabetta Cerutti, Maria Maddalena Schellino, Silvia Valzan, Rosa Lucia Pinciroli, Luciano Bortone, Giorgia Cerati, Fabiana Salici, Leonardo Bussolin, Giuliana Rizzo, Francesca Rossetti, Laura Marchesini, Simonetta Tesoro, Brita De Lorenzo, Fabio Guarracino, Beate Kuppers, Marinella Astuto, Sofia Pitino, Rita Scalisi, Lucia Scordo, Sandra D'Alessandro, Luigi Dei Giudici, Ivano Farinelli, Giuseppe Lofino, Giuliano Marchetti, Sergio Giuseppe Picardo, Simone Reali, Alessandro Vittori, Francesco Antonio Idone, Maria Sammartino, Fabio Sbaraglia, Cinzia Barbera, Michela Bevilacqua, Valeria Cento, Svetlana Kotzeva, Leila Mameli, Giovanni Montobbio, Leandro Passariello, Cinzia Punzo, Rosanna Sileo, Rosanna Viacava, Claudia Volpe, Clelia Zanaboni, Edoardo Calderini, Daniele Genco, Simona Neri, Davide Ottolina, Anna Camporesi, Francesca Izzo, Ida Salvo, Andrea Wolfler, Andrea Sanna, Angela Sciascia, Paolo Stoia, Annamaria Guddo, Maria Lapi, Giorgio Ivani, Annalisa Longobardo, Valeria Mossetti, Dino Pedrotti, Maurizia Grazzini, Luisa Meneghini, Salvatore Metrangolo, Stefania Michelon, Carmelo Minardi, Costanza Tognon, Nicola Zadra, Ilaria Busi, Magda Khotcholava, Bruno Guido Locatelli, Valter Sonzogni, Giusi Starita, Nicole Almenrader, Caterina Aurilio, Pasquale Sansone, Raffaella Albarello, Paolo Bracci, Mariateresa Cecini, Maria Cristina Mondardini, Lorena Pasini, Milo Vason, Gianluca Zani, Roberto Zoppellari, Laura Pistidda, Andrea Cortegiani, Santi Maurizio Raineri, Antigona Hasani, Medita Hashimi, Agris Ancupans, Arta Barzdina, Zane Straume, Anda Zundane, Mikhail Chlopin, Dalia Gestautaite, Laura Lukosiene, Evelina Paliokaite, Ilona Razlevice, Inesa Armoniene, Aurelija Bernotiene, Vidunas Daugelavicius, Ilona Dockiene, Lina Gaidelyte, Nijole Saviciene, Jolita Krikstaponiene, Dominika Sidlovskaite-Baltake, Vladyslav Stasevski, Agne Vaitoskaite, David Gatt, Stephanie Mifsud, Simone Zammit, Celia Allison, Hamid Aslami, Susanne Eberl, Mireille F M van Stijn, Markus F Stevens, Kees Punt, Rob van Osch, Arthur Bauwman, Harm Scholten, Vesna Svircevic, Veronique Adriaens, Maaike Dirckx, Jaap Dogger, Ilse Dons-Sinke, Andreas Machotta, Xavier Moors, Mandana Rad, Lonneke Staals, Anouk van der Knijff - van Dortmont, Caroline van der Marel, Anne Sieben, Tim van der Zwan, Marianne Veldhuizen, David Alders, Wolfgang Buhre, Nicole Engel, Carine Vossen, Ravin Mahadewsing, Patrick Meijer, Volker Gerling, Roelof van der Schatte Olivier, Thea van Doorn, Kristy Vons Mark Hendriks, Sandra Lako, Gert jan Scheffer, Luc Tielens, Marieke Voet, Anthony Absalom, Margot Bergsma, Vera Spanjer, Rob Spanjersberg, Yvette van de Riet, Martin Volkers, Jurgen C. de Graaff, Geranne A.J. Hopman, Teus H. Kappen, J. Hannie, A.M. Megens, Sandra C. Numan, Anton N.J. Schouten, Nigel M. Turner, Désirée B.M. Van Der Werff, Renee T.M. Wensing, Erik Ephraim, Claire Nolte, Tore Reikvam, Ole Fredrik Lund, Lene Skaaden, Kari Marthe Ballovarre, Wenche Bakken Boerke, Guro Grindheim, Pal H H Lindenskov, Anne Beate Solas, Sjur Sponheim, Kyrre Ullensvang, Oddbjorn Viken, Inger Marie Drage, Kasper Gymoese Berthelsen, Bjørn Anders Kroken, Unni Bergland, Miroslaw Pryzmont, Mariola Talalaj, Malgorzata Wasiluk, Dorota Zalewska, Maria Damps, Jadzia Siemek-Mitela, Pawel Wieczorek, Magdalena Juzwa, Jowita Rosada-Kurasinska, Alicja Bartkowska-Sniatkowska, Maciej Cettler, Renata Kopycinska, Iwona Rudewicz, Jaek Sobczyk, Dariusz Wojciechowski, Artur Baranowski, Ewa Basiewicz, Magdalena Mierzewska-Schmidt, Wlodzimierz Retka, Piotr Sawicki, Magdalena Checinska, Magdalena Zurawska, Teresa Leal, Catia Mascarenhas, António Pedro Pina, Maria Joao Susano, Antonio Moniz, Maria Teresa Rocha, Carolina Calvao Santos, M Domingas Patuleia, Ricardo Pereira, Helena Roxo, Rosa Amaral, Isabel Guedes, Cristina Gomes, Marta Gonçalves, Helena Salgado, Maria Santos, Sara Rodrigues, Angela Sa, Elvira Machado, Sandra Pé d'Arca, Manuel Seabra, Ligia Mihaela Gheorghe, Constantin Ivascu, Lucia Moraru-Draghici, Mirela Suvejan, Remus Babici, Kovacs Eniko, Cristiana Hogea, Dubau Mihaela, Daraban Nicoleta, Danut Barbunc, Alina Maria Nistor, Violeta Stefan, Gabriela Catalina Ionescu, Irina Davidescu, Alina Teodora Nastase, Florin Dumitru Rusu, Victoria Badarau, Iulia Cindea, Melania Moscaliuc, Dana Olteanu, Luxita Petrescu, Daniela Ceuca, Irena Galinescu, Rodica Badeti, Alin Capusan, Cosmina Cucui-Cozma, Barbura Popescu, Luminita Cimpeanu, Mihaela-Petronela Birliba, Magdalena Miulescu, Stefania Balamat, Adriana Gurita, Luminita Ilie, Gabriel Mocioiu, Darina Pick, Rodica Sirghie, Radu Tabacaru, Irinel Trante, Lucian Horhota, Daniela Bandrabur, Tudor Ciobanu, Veaceslav Cuciuc, Valentin Munteanu, Valentin Olaru, Corneliu Paiu, Anca Savu, Oana Trifan, Anca Elena Malos, Anton Glazunov, Alexander Ivanov, Evgeny Poduskov, Alexander Popov, Igor Guskov, Alexander Lugovoy, Vladislav Nechaev, Alexey Ovezov, Mikhail Basov, Vladimir Kochkin, Vladimir Lazarev, Dmitri Chizhov, Ivan Ostreikov, Konstantin Tolasov, Ivana Budic, Vesna Marjanovic, Biljana Draskovic, Marina Pandurov, Jovana Simin, Vladimir Dolinaj, Dusanka Janjevic, Ana Mandras, Maja Mircetic, Sladjana Petrovic, Vlatka Rebac, Bojana Slavkovic, Vesna Stevanovic, Ana Velcev, Mirjana Knezevic, Irina Milojevic, Selena Puric, Irena Simic, Marija Stevic, Vladimir Stranjanac, Dusica Simic, Barbora Cabanova, Miloslav Hanula, Andry Grynyuk, Jelena Berger, Uros Cerne, Andraz Nastran, Dejan Pirc, Rok Popic, Spela Stupnik, Paloma Rubio, Cristina del Río, Pilar Benito, Gema Pino, Ignacio Gutierrez, Andrea Gutierrez Valcarcel, Irene León Carsi, Anibal Perez Garcia, Sílvia López Galera, Joan Marco Valls, Laura Ricol Lainez, Andrea Vallejo Tarrat, David Artes, Ester Banus, Luca Chirichiello, Leidy De Abreu, Belen De Josemaria, M Helena Gaitan, Antonio Garces, Juan J Lazaro, Ferran Manen Berga, Dolors Molies, Enric Monclus, Montserrat Navaro, Carmen Pamies, Marina Perelló, Mar Prat, Laura Ribo, M Angeles Sanz, Silvia Serrano, Eva Sola Ruiz, Blanca Anuncia Escontrela Rodríguez, Andrea Maria Gago Martinez, Alberto Martínez Ruiz, Fausto De La Cruz Benito, Gustavo Gabilondo Garcia, Ever Martinez Maldonado, Bryant Noriega, Lara Oller Duque, Alberto Olmos Mendez, Antonio Perez- Ferrer, Francisco Reinoso Barbero, Ismael Acevedo Bambaren, Fernando Domínguez, Teresa Franco, Anabel Jiménez, Alicia Melero, Montserrat Feliu, Irene García, Núria Montferrer, Francisca Munar, Cristina Muro, Rosario Nuño, Remel Perera, Erika Schmucker, Glenda Börjesson, Lars Gillberg, Albert Castellheim, Kerstin Sandström, Annette Bauer, Torbjörn Roos, Lars Hedlund, Yann Boegli, Mirko Dolci, Carine Marcucci, Isabelle Spahr-Schopfer, Michel Pellegrini, Malte Book, Loreen Errass, Christine Riggenbach, Mattias Casutt, Martin Hölzle, Thomas Hurni, Jacqueline Mauch, Luciano Anselmi, Irene Anselmi, Alfred Jacomet, Markus Oberhauser, Stephanie Wossner, Angelika Zettl, Thomas Erb, Tomasz Mackiewicz, Helena Simitzes, Yetkin Ozer, Arzu Takil, Zekeriyya Alanoglu, Onat Bermede, K.Sanem Cakar Turhan, Neslihan Alkis, Cigdem Yildirim Guclu, Basak Ceyda Meco, Zehra Hatipoglu, Dilek Ozcengiz, Zekine Begec, Huseyin Ilksen Toprak, Pinar Kendigelen, Ayse Cigdem Tütüncü, Meltem Savran Karadeniz, Tulay Seyhan Ozkan, Nuket Sivrikoz, Mustafa Kemal Arslantas, Ayse Hizal, Gülbin Tore Altun, Tumay Umuroglu, Sibel Baris, Zuleyha Kazak Bengisun, Galyna Goncharenko, Maksym Khrapak, Tetyana Klymenko, Vitaliy Pavlenko, Dmytro Prysiazhniuk, Olga Rudio, Mykhailo Varyvoda, Sergii Vodianytskyi, Ivanna Boryshkevych, Iryna Kyselova, Nikolay Trikash, Andrew Albokrinov, Valentina Perova-Sharonova, Vitaliy Sklyar, Denis Surkov, Amr Abdelaal, Nicola Barber, Sarah Checuti, Leisha Godsiff, Lynch Johanne, Joanna Simpson, Helen Underhill, Rishi Diwan, Nivedita Kelgeri, Nuria Masip, Radha Ravi, Steve Roberts, Annagrazia Cillis, Ritchie Marcus, Federica Merella, David Love, Paolo Baraggia, Victoria Bird, Joseph Hussey, Peter Alderson, Karen Bartholomew, Michael Moncreiff, Sarah Davidson, Alison Hare, Ami Kotecha, Corina Lee, Ganga Liyanage, Shivali Patel, Amee Samani, Mark Abou-Samra, Matthew Boyd, Laurence Hullatt, David Levy, Mark Pauling, Sarah-Jane Sharman, Natalie Smith, John Rutherford, Alison Cavalier, Christie Locke, Frederic Sage, Smita Bapat, Jacinda Hammerschlag, Ioannis Ioannou, Stephanie King, Rachel Pegg, Vishal Salota, Jonathan Sketcher, Muthu Thadsad, Deborah Zeitlin, Ewan Jack, Colin Lang, Samira Ahmed, Reema Ayyash, Francoise Bari, Sarah J Bell, Claire Elizabeth Biercamp, Sandra Briggs, Maria Gabriella Elena Clement, Mark Dalton, Mohamed Ali Eissa Eid, Monica Gandhi, Idse Harmen Herrema, Ranj Khaffaf, Savio Jeng Min Law, Joanna McClintock, Nicholas Ireland, Mohammed Majid Saleem, Fiona Smith, Marc Cohen, Clover-Ann Lee, Lizanne O'Donahue, Alex Powell, Ellen Rawlinson, Aarjan Snoek, Katja Weiss, Hugo Wellesley, Michael Crawford, Mostafa Abdel-Hafiz, Alexandra Day, Balaji Rajamani, Rita Saha, Dave Wright, Lew-Chin Chee, Stephanie Bew, Rachel Homer, Nalini Malarkkan, Juliet Wolfe Barry, Pradeep Angadi, Brid Cagney, Eric De Melo, Elsa Dekker, Emma Helm, Gareth Jones, Kawshala Peiris, William Russell, Patricia Slater, Puja Sodhi, Mike Browning, Trudie Phillips, Rachel Van Hecke, Vimty Muir, Piyush Singh, Tereza Soskova, Craig Cumming, Pamela Farquharson, Karen Pearson, Neil Shaw, Jonathan Whiteside, Emma Whyte, Gordon Byers, Kay Davies, Thomas Engelhardt, Isabella Faliszewski, Graham Johnston, Nils Kaufmann, Zuzana Kusnirikova, Graham Wilson, Peter Carachi, Andrew Makin, Brian Foster, Dariusz Lipczynski, Rebecca Mawer, William Rutherford, David Rogerson, Sarah Rushman, Christopher Taylor, William Tomlinson, Philippa Dix, Tom Woodward, Graham Bell, David Boyle, Marianne Cloherty, Julia Cullen, Pauline Cullen, Ross Fairgrieve, Robert Ghent, Russell Glasgow, Elena Gordeeva, Alison Harden, Sarah Hivey, Kevin Jerome, Lesley McKee, Neil Morton, Vicky Pribul, John Sinclair, Maria Steiner, Heather Steward, Lorraine Sweeney, Wendy Thomson, Jeanette Whiteside, Andrew Dalton, Mark Ross, Carolyn Smith, Claire Allen, Nicola Anders, Victoria Barlow, Mike Bassett, Leanne Darwin, Rachel Davison, Jacques Diacono, Amy Hobbs, Adel Hutchinson, Bernadette Lomas, Hannah Lonsdale, Leila Nasser, Vimmi Oshan, Pradip Patel, Christopher Raistrick, Victoria Scott-Warren, Laura Talbot, Carolynn Wai, Sophie Childs, Matthew Dickinson, Tom Bloomfield, Sweyn Garrioch, Karen Watson, James Gaynor, Richard Harrison, Juliette Lee, Elizabeth Blythe, Teresa Dorman, Ayman Eissa, James Ellwood, Ingrid Gooch, Robert Hearn, Vanessa Hodgetts, Robert John, Christine Kirton, Nadia Ladak, Judith Morgan, Nina Plant, Elizabeth Shepherd, Judith Short, Charles Stack, Simon Steel, Matthew Taylor, Deborah Thomas, Catharine Wilson, Elaine Wilson-Smith, Carol L. Bradbury, Nageena Hussain, Antonia Mayell, Ahmed Mesbah, Arif Qureshi, Chandra Vaidyanath, Tim Geary, Chris Hawksworth, Tamaraichelvi Parasuraman, Nicole Perry, Indrani Banerjee, Katharine Barr, Patrick Butler, Jack Davies, Lisa Flewin, Richard Gande, James Montague, James Plumb, Thomas Pratt, Paul Sutherland, Hannah Vail, Andrew Wilkins, Catherine Hunter, Susan Russell, Alun Thomas, Mark Mifsud, Dominic Strachan, Benoit Plichon, Pierre Harlet, Anesthesiology, APH - Quality of Care, Graduate School, Other Research, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ANS - Neuroinfection & -inflammation, ACS - Heart failure & arrhythmias, ACS - Diabetes & metabolism, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), APRICOT Grp European Soc Anaesthes, Habre, Walid, Disma, Nicola, Virag, Katalin, Becke, Karin, Hansen, Tom G, Jöhr, Martin, Leva, Brigitte, Morton, Neil S, Vermeulen, Petronella M, Zielinska, Marzena, Boda, Krisztina, Veyckemans, Franci, Klimscha, Walter, Konecny, Regina, Luntzer, Robert, Morawk Wintersperger, Ulrike, Neiger, Franz, Rustemeyer, Lydia, Breschan, Christian, Frey, Denise, Platzer, Manuela, Germann, Reinhard, Oeding, Joachim, Stoegermüller, Birgit, Ziegler, Bernhard, Brotatsch, Philipp, Gutmann, Anton, Mausser, Gerlinde, Messerer, Brigitte, Toller, Wolfgang, Vittinghoff, Maria, Zangl, Gregor, Seidel Ahyai, Natascha, Hochhold, Christoph, Kroess, Ruth, Paal, Peter, Cnudde, Steven, Coucke, Patricia, Loveniers, Birgit, Mitchell, John, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Coppens, Marc, De Hert, Stefan, Heyse, Björn, Neckebroek, Martine, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Van Den Eynde, Nancy, Vanpeteghem, Caroline, Wyffels, Piet, Lalot, Michaël, Lechat, Jean Paul, Stevens, France, Casaer, Sari, De Groote, Françoise, De Pooter, Françoise, De Villé, Andrée, Gerin, Marc, Magasich, Natalia, Sanchez Torres, Cristel, Van Deenen, Denise, Berghmans, Johan, Himpe, Dirk, Roofthooft, Eva, Joukes, Ellen, Smitz, Carine, Van Reeth, Veronique, Huygens, Christel, Lauweryns, Julie, De Smet, Karen, Najafi, Nadia, Poelaert, Jan, Van de Velde, Anne, Van Mossevelde, Veerle, Bekavac, Ivan, Butkovic, Diana, Heli Litvic, Dubravka, Kerovec Soric, Ivana, Maretic, Hrvoje, Moscatello, Djurdjica, Popovic, Ljiljana, Micici, Slobodan, Stuck Tus, Ivana, Kalagac Fabris, Lada, Simurina, Tatjana, Sulen, Nina, Kesic Valpotic, Gordana, Djapic, Dajana, Žurek, Jirí, Jureckova, Lucie, Mackova, Iveta, Skacel, Monika, Weinlichova, Stanislava, Divák, Jan, Frelich, Michal, Urbanec, René, Biskupova, Vera, Mixa, Vladimir, Pavlickova, Jana, Afshari, Arash, Bøttger, Morten, Ellekvist, Marguerite B., Johansen, Mathia, Ingeborg Madsen, Birgitte, Christian Nilsson, Jen, Schousboe, Birgitte MB, Clausen, Nicola G., Hansen, Tom G., Phaff Steen, Nick, Ilmoja, Mari Lii, Tonise, Virge, Karjagin, Juri, Kikas, Reet, Isohanni, Mika, Lyly, Anniina, Takala, Annika, Happo, Johanna, Kiviluoma, Kai, Martikainen, Kati, Aantaa, Riku, Manner, Tuula, Vilo, Sanna, Amory, Catherine, Ludot, Hugue, Lambotte, Patricia, Busche, René, Jacqmarcq, Olivier, Lejus, Corinne, Corouge, Julien, Erb, Christian, Garrigue, Delphine, Gillet, Patricia, Laffargue, Anne, Lambelin, Veronique, Le Freche, Hélène, Peresbota, Daliana, Richart, Pierre, Berton, Jerome, Chapotte, Catherine, Colbus, Laurent, Lehousse, Thierry, Monrigal, Jean, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Batoz, Hélène, Bordes, Maryline, Didier, Anne, Hamonic, Yann, Lagarde, Sylvaine, Nouette Gaulain, Karine, Semjen, Françoi, Zaghet, Brigitte, Dekens, Jacky, Delcuze, Axelle, Dupont, Hervé, Legrand, Aurélien, Raffoflandreur, Celine, Audren, Noémie, Camus, Blandine, Cartal, Marielle, Chazelet, Chantal, Davin, Isabelle, Guillier, Marion, Desjeux, Luc, Larcher, Claire, Grein, Elodie, Leclercq, Mickeal, Levitchi, Roxana, Rosu, Lilica, Simon, Dominique, Zang, Aurélien, Migeon, Anne, Gagey, Anne Charlotte, Bourdaud, Nathalie, Carre, Anne Charlotte, Duflo, Frédéric, Riche, Jean Claude, Robert, Philippe, Druot, Emilie, Maupain, Olivier, Orliaguet, Gille, Sabau, Lucie, Taright, Hanna, Uhrig, Lynn, Verchere Montmayeur, Juliette, Debrabant, Lise, Pilla, Clotaire, Podvin, Alexandre, Roth, Benjamin, Dahmani, Souhayl, Julien Marsollier, Florence, Sabourdin, Nada, Alexandri, Bogdan, Brezac, Gille, de la Brière, Francoi, Hayem, Catherine, Lhubat, Elizabeth, Paul Mission, Jean, Rémond, Charlotte, Dadure, Christophe, Maniora, Maud, Marie, Anai, Pirat, Philippe, Saour, Anne Charlotte, Sola, Chrystelle, Ecoffey, Claude, Wodey, Eric, Adam, Christian, Standl, Thoma, Schindler, Ehrenfried, Yamamoto, Tomohiro, Brackhahn, Michael, Bernhard Eich, Christoph, Guericke, Holger, Kindermann, Petra, Laschat, Michael, Schink, Cornel, Wappler, Frank, Hoehne, Claudia, Skordou, Natalia, Ulrici, Johanna, Jetzek Zader, Martin, Kienbaum, Peter, Meyer Treschan, Tanja, Picker, Olaf, Schaefer, Maximilian S., Mielke, Golo, Baethge, Sabine, Ramminger, Axel, Bauer, Martin, Bollinger, Matthia, Hinz, José, Quintel, Michael, Russo, Sebastian G., Bauer, Michael, Geil, Dfominik, Kortgen, Andrea, Preussler, Niels Peter, Hofmann, Ulrich, Raber, Manfred, Reindl, Dori, Oppenrieder, Karin, Schierlinger, Bettina, Roth, Jen, Funk, Wolfgang, Fischer, Thoma, Gernoth, Christian, Wiefelspütz, Christina, Volger, Hauke, Zederer, Nicole, Diers, Anja, Huber, Matthia, Schorer, Clemen, Weyland, Andrea, Schwarzkopf, Konrad, Grau, Catharina, Roth, Winfried, Holy, Rolf, Mader, Thoma, Peter, Laura, Supthut, Hauke, Kuehhirt, Thoma, Milde, Alexander, Fiedler, Fritz, Isselhorst, Carsten, Grundmann, Ulrich, Pattar, Alexander, Reinert, Jennifer, Ehm, Birgit, Fritzsche, Katrin, Gaebler, Ralf, Meybohm, Patrick, Hein, Maximilian, Guzman, Ine, Jokinen, Johanna, Kranke, Peter, Goebel, Ulrich, Harris, Sarah, Eisner, Christoph, Ochsenreiter, Miriam, Schoeler, Michael, Thil, Elke, Ellerkmann, Richard, Hoeft, Andrea, Neumann, Claudia, Weber, Stefan, Keilhauer, Julia, Kloessing, Jan, Schramm, Michael, Trieschmann, Uwe, Knauss, Kristina, Sinner, Barbara, Steinmann, Johanne, Koessler, Herbert, Kalliardou, Evagelia, Malisiova, Anna, Tsiotou, Adelai, Chloropoulou, Pelagia, Chrysi, Mpratzou, Iordanidou, Despoina, Ntavlis, Merkourio, Boda, Krisztina B, Guerin, Christilynn, Irwin, Janice, Magner, Claire, Nakhjavani, Solmaz, O'Hare, Brendan, Galvin, Deborah, Jamil, Yosry, Lesmes, Carlo, Barak, Yuri, Fisher, Haran, Kachko, Ludmyla, Katz, Jacob, Kirilov, Dmitry, Levinzon, Michael, Manevich, Yair, Nekrasov, Konstantin, Peled, Elia, Sanko, Elena, Schmain, Dmitri, Sheinkin, Olga, Simhi, Eliahu, Tarabikin, Alex, Trabkin, Evelina, Yagudaev, Irena, Zeitlin, Yelena, Zunser, Igor, Cerutti, Elisabetta, Maddalena Schellino, Maria, Valzan, Silvia, Lucia Pinciroli, Rosa, Bortone, Luciano, Cerati, Giorgia, Salici, Fabiana, Bussolin, Leonardo, Rizzo, Giuliana, Rossetti, Francesca, Marchesini, Laura, Tesoro, Simonetta, De Lorenzo, Brita, Guarracino, Fabio, Kuppers, Beate, Astuto, Marinella, Pitino, Sofia, Scalisi, Rita, Scordo, Lucia, D'Alessandro, Sandra, Dei Giudici, Luigi, Farinelli, Ivano, Lofino, Giuseppe, Marchetti, Giuliano, Giuseppe Picardo, Sergio, Reali, Simone, Vittori, Alessandro, Antonio Idone, Francesco, Sammartino, Maria, Sbaraglia, Fabio, Barbera, Cinzia, Bevilacqua, Michela, Cento, Valeria, Kotzeva, Svetlana, Mameli, Leila, Montobbio, Giovanni, Passariello, Leandro, Punzo, Cinzia, Sileo, Rosanna, Viacava, Rosanna, Volpe, Claudia, Zanaboni, Clelia, Calderini, Edoardo, Genco, Daniele, Neri, Simona, Ottolina, Davide, Camporesi, Anna, Izzo, Francesca, Salvo, Ida, Wolfler, Andrea, Sanna, Andrea, Sciascia, Angela, Stoia, Paolo, Guddo, Annamaria, Lapi, Maria, Ivani, Giorgio, Longobardo, Annalisa, Mossetti, Valeria, Pedrotti, Dino, Grazzini, Maurizia, Meneghini, Luisa, Metrangolo, Salvatore, Michelon, Stefania, Minardi, Carmelo, Tognon, Costanza, Zadra, Nicola, Busi, Ilaria, Khotcholava, Magda, Guido Locatelli, Bruno, Sonzogni, Valter, Starita, Giusi, Almenrader, Nicole, Aurilio, Caterina, Sansone, Pasquale, Albarello, Raffaella, Bracci, Paolo, Cecini, Mariateresa, Cristina Mondardini, Maria, Pasini, Lorena, Vason, Milo, Zani, Gianluca, Zoppellari, Roberto, Pistidda, Laura, Cortegiani, Andrea, Maurizio Raineri, Santi, Hasani, Antigona, Hashimi, Medita, Ancupans, Agri, Barzdina, Arta, Straume, Zane, Zundane, Anda, Chlopin, Mikhail, Gestautaite, Dalia, Lukosiene, Laura, Paliokaite, Evelina, Razlevice, Ilona, Armoniene, Inesa, Bernotiene, Aurelija, Daugelavicius, Viduna, Dockiene, Ilona, Gaidelyte, Lina, Saviciene, Nijole, Krikstaponiene, Jolita, Sidlovskaite Baltake, Dominika, Stasevski, Vladyslav, Vaitoskaite, Agne, Gatt, David, Mifsud, Stephanie, Zammit, Simone, Allison, Celia, Aslami, Hamid, Eberl, Susanne, van Stijn, Mireille F. M, Stevens, Markus F, Punt, Kee, van Osch, Rob, Bauwman, Arthur, Scholten, Harm, Svircevic, Vesna, Adriaens, Veronique, Dirckx, Maaike, Dogger, Jaap, Dons Sinke, Ilse, Machotta, Andrea, Moors, Xavier, Rad, Mandana, Staals, Lonneke, Van, der Knijff, van der Marel, Caroline, Sieben, Anne, van der Zwan, Tim, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Engel, Nicole, Vossen, Carine, Mahadewsing, Ravin, Meijer, Patrick, Gerling, Volker, van der Schatte Olivier, Roelof, van Doorn, Thea, Vons Mark Hendriks, Kristy, Lako, Sandra, jan Scheffer, Gert, Tielens, Luc, Voet, Marieke, Absalom, Anthony, Bergsma, Margot, Spanjer, Vera, Spanjersberg, Rob, van de Riet, Yvette, Volkers, Martin, de Graaff, Jurgen C., Hopman, Geranne A. J., Kappen, Teus H., Hannie, J., Megens, A. M., Numan, Sandra C., Schouten, Anton N. J., Turner, Nigel M., Van Der Werff, Désirée B. M., Wensing, Renee T. M., Ephraim, Erik, Nolte, Claire, Reikvam, Tore, Fredrik Lund, Ole, Skaaden, Lene, Marthe Ballovarre, Kari, Bakken Boerke, Wenche, Grindheim, Guro, Lindenskov, Pal H. H, Beate Solas, Anne, Sponheim, Sjur, Ullensvang, Kyrre, Viken, Oddbjorn, Marie Drage, Inger, Gymoese Berthelsen, Kasper, Anders Kroken, Bjørn, Bergland, Unni, Pryzmont, Miroslaw, Talalaj, Mariola, Wasiluk, Malgorzata, Zalewska, Dorota, Damps, Maria, Siemek Mitela, Jadzia, Wieczorek, Pawel, Juzwa, Magdalena, Rosada Kurasinska, Jowita, Bartkowska Sniatkowska, Alicja, Cettler, Maciej, Kopycinska, Renata, Rudewicz, Iwona, Sobczyk, Jaek, Wojciechowski, Dariusz, Baranowski, Artur, Basiewicz, Ewa, Mierzewska Schmidt, Magdalena, Retka, Wlodzimierz, Sawicki, Piotr, Checinska, Magdalena, Zurawska, Magdalena, Leal, Teresa, Mascarenhas, Catia, Pedro Pina, António, Joao Susano, Maria, Moniz, Antonio, Teresa Rocha, Maria, Calvao Santos, Carolina, Domingas Patuleia, M., Pereira, Ricardo, Roxo, Helena, Amaral, Rosa, Guedes, Isabel, Gomes, Cristina, Gonçalves, Marta, Salgado, Helena, Santos, Maria, Rodrigues, Sara, Sa, Angela, Machado, Elvira, Pé d'Arca, Sandra, Seabra, Manuel, Mihaela Gheorghe, Ligia, Ivascu, Constantin, Moraru Draghici, Lucia, Suvejan, Mirela, Babici, Remu, Eniko, Kovac, Hogea, Cristiana, Mihaela, Dubau, Nicoleta, Daraban, Barbunc, Danut, Maria Nistor, Alina, Stefan, Violeta, Catalina Ionescu, Gabriela, Davidescu, Irina, Teodora Nastase, Alina, Dumitru Rusu, Florin, Badarau, Victoria, Cindea, Iulia, Moscaliuc, Melania, Olteanu, Dana, Petrescu, Luxita, Ceuca, Daniela, Galinescu, Irena, Badeti, Rodica, Capusan, Alin, Cucui Cozma, Cosmina, Popescu, Barbura, Cimpeanu, Luminita, Birliba, Mihaela Petronela, Miulescu, Magdalena, Balamat, Stefania, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Pick, Darina, Sirghie, Rodica, Tabacaru, Radu, Trante, Irinel, Horhota, Lucian, Bandrabur, Daniela, Ciobanu, Tudor, Cuciuc, Veaceslav, Munteanu, Valentin, Olaru, Valentin, Paiu, Corneliu, Savu, Anca, Trifan, Oana, Elena Malos, Anca, Glazunov, Anton, Ivanov, Alexander, Poduskov, Evgeny, Popov, Alexander, Guskov, Igor, Lugovoy, Alexander, Nechaev, Vladislav, Ovezov, Alexey, Basov, Mikhail, Kochkin, Vladimir, Lazarev, Vladimir, Chizhov, Dmitri, Ostreikov, Ivan, Tolasov, Konstantin, Budic, Ivana, Marjanovic, Vesna, Draskovic, Biljana, Pandurov, Marina, Simin, Jovana, Dolinaj, Vladimir, Janjevic, Dusanka, Mandras, Ana, Mircetic, Maja, Petrovic, Sladjana, Rebac, Vlatka, Slavkovic, Bojana, Stevanovic, Vesna, Velcev, Ana, Knezevic, Mirjana, Milojevic, Irina, Puric, Selena, Simic, Irena, Stevic, Marija, Stranjanac, Vladimir, Simic, Dusica, Cabanova, Barbora, Hanula, Miloslav, Grynyuk, Andry, Berger, Jelena, Cerne, Uro, Nastran, Andraz, Pirc, Dejan, Popic, Rok, Stupnik, Spela, Rubio, Paloma, del Río, Cristina, Benito, Pilar, Pino, Gema, Gutierrez, Ignacio, Gutierrez Valcarcel, Andrea, León Carsi, Irene, Perez Garcia, Anibal, López Galera, Sílvia, Marco Valls, Joan, Ricol Lainez, Laura, Vallejo Tarrat, Andrea, Artes, David, Banus, Ester, Chirichiello, Luca, De Abreu, Leidy, De Josemaria, Belen, Helena Gaitan, M., Garces, Antonio, Lazaro, Juan J, Manen Berga, Ferran, Molies, Dolor, Monclus, Enric, Navaro, Montserrat, Pamies, Carmen, Perelló, Marina, Prat, Mar, Ribo, Laura, Angeles Sanz, M., Serrano, Silvia, Sola Ruiz, Eva, Anuncia Escontrela Rodríguez, Blanca, Maria Gago Martinez, Andrea, Martínez Ruiz, Alberto, De La Cruz Benito, Fausto, Gabilondo Garcia, Gustavo, Martinez Maldonado, Ever, Noriega, Bryant, Oller Duque, Lara, Olmos Mendez, Alberto, Perez Ferrer, Antonio, Reinoso Barbero, Francisco, Acevedo Bambaren, Ismael, Domínguez, Fernando, Franco, Teresa, Jiménez, Anabel, Melero, Alicia, Feliu, Montserrat, García, Irene, Montferrer, Núria, Munar, Francisca, Muro, Cristina, Nuño, Rosario, Perera, Remel, Schmucker, Erika, Börjesson, Glenda, Gillberg, Lar, Castellheim, Albert, Sandström, Kerstin, Bauer, Annette, Roos, Torbjörn, Hedlund, Lar, Boegli, Yann, Dolci, Mirko, Marcucci, Carine, Spahr Schopfer, Isabelle, Pellegrini, Michel, Book, Malte, Errass, Loreen, Riggenbach, Christine, Casutt, Mattia, Hölzle, Martin, Hurni, Thoma, Mauch, Jacqueline, Anselmi, Luciano, Anselmi, Irene, Jacomet, Alfred, Oberhauser, Marku, Wossner, Stephanie, Zettl, Angelika, Erb, Thoma, Mackiewicz, Tomasz, Simitzes, Helena, Ozer, Yetkin, Takil, Arzu, Alanoglu, Zekeriyya, Bermede, Onat, Cakar Turhan, K. Sanem, Alkis, Neslihan, Yildirim Guclu, Cigdem, Ceyda Meco, Basak, Hatipoglu, Zehra, Ozcengiz, Dilek, Begec, Zekine, Ilksen Toprak, Huseyin, Kendigelen, Pinar, Cigdem Tütüncü, Ayse, Karadeniz, Meltem Savran, Seyhan Ozkan, Tulay, Sivrikoz, Nuket, Kemal Arslantas, Mustafa, Hizal, Ayse, Tore Altun, Gülbin, Umuroglu, Tumay, Baris, Sibel, Kazak Bengisun, Zuleyha, Goncharenko, Galyna, Khrapak, Maksym, Klymenko, Tetyana, Pavlenko, Vitaliy, Prysiazhniuk, Dmytro, Rudio, Olga, Varyvoda, Mykhailo, Vodianytskyi, Sergii, Boryshkevych, Ivanna, Kyselova, Iryna, Trikash, Nikolay, Albokrinov, Andrew, Perova Sharonova, Valentina, Sklyar, Vitaliy, Surkov, Deni, Abdelaal, Amr, Barber, Nicola, Checuti, Sarah, Godsiff, Leisha, Johanne, Lynch, Simpson, Joanna, Underhill, Helen, Diwan, Rishi, Kelgeri, Nivedita, Masip, Nuria, Ravi, Radha, Roberts, Steve, Cillis, Annagrazia, Marcus, Ritchie, Merella, Federica, Love, David, Baraggia, Paolo, Bird, Victoria, Hussey, Joseph, Alderson, Peter, Bartholomew, Karen, Moncreiff, Michael, Davidson, Sarah, Hare, Alison, Kotecha, Ami, Lee, Corina, Liyanage, Ganga, Patel, Shivali, Samani, Amee, Abou Samra, Mark, Boyd, Matthew, Hullatt, Laurence, Levy, David, Pauling, Mark, Sharman, Sarah Jane, Smith, Natalie, Rutherford, John, Cavalier, Alison, Locke, Christie, Sage, Frederic, Bapat, Smita, Hammerschlag, Jacinda, Ioannou, Ioanni, King, Stephanie, Pegg, Rachel, Salota, Vishal, Sketcher, Jonathan, Thadsad, Muthu, Zeitlin, Deborah, Jack, Ewan, Lang, Colin, Ahmed, Samira, Ayyash, Reema, Bari, Francoise, Bell, Sarah J, Elizabeth Biercamp, Claire, Briggs, Sandra, Gabriella Elena Clement, Maria, Dalton, Mark, Ali Eissa Eid, Mohamed, Gandhi, Monica, Harmen Herrema, Idse, Khaffaf, Ranj, Jeng Min Law, Savio, Mcclintock, Joanna, Ireland, Nichola, Majid Saleem, Mohammed, Smith, Fiona, Cohen, Marc, Lee, Clover Ann, O'Donahue, Lizanne, Powell, Alex, Rawlinson, Ellen, Snoek, Aarjan, Weiss, Katja, Wellesley, Hugo, Crawford, Michael, Abdel Hafiz, Mostafa, Day, Alexandra, Rajamani, Balaji, Saha, Rita, Wright, Dave, Chee, Lew Chin, Bew, Stephanie, Homer, Rachel, Malarkkan, Nalini, Wolfe Barry, Juliet, Angadi, Pradeep, Cagney, Brid, De Melo, Eric, Dekker, Elsa, Helm, Emma, Jones, Gareth, Peiris, Kawshala, Russell, William, Slater, Patricia, Sodhi, Puja, Browning, Mike, Phillips, Trudie, Van Hecke, Rachel, Muir, Vimty, Singh, Piyush, Soskova, Tereza, Cumming, Craig, Farquharson, Pamela, Pearson, Karen, Shaw, Neil, Whiteside, Jonathan, Whyte, Emma, Byers, Gordon, Davies, Kay, Engelhardt, Thoma, Faliszewski, Isabella, Johnston, Graham, Kaufmann, Nil, Kusnirikova, Zuzana, Wilson, Graham, Carachi, Peter, Makin, Andrew, Foster, Brian, Lipczynski, Dariusz, Mawer, Rebecca, Rutherford, William, Rogerson, David, Rushman, Sarah, Taylor, Christopher, Tomlinson, William, Dix, Philippa, Woodward, Tom, Bell, Graham, Boyle, David, Cloherty, Marianne, Cullen, Julia, Cullen, Pauline, Fairgrieve, Ro, Ghent, Robert, Glasgow, Russell, Gordeeva, Elena, Harden, Alison, Hivey, Sarah, Jerome, Kevin, Mckee, Lesley, Morton, Neil, Pribul, Vicky, Sinclair, John, Steiner, Maria, Steward, Heather, Sweeney, Lorraine, Thomson, Wendy, Whiteside, Jeanette, Dalton, Andrew, Ross, Mark, Smith, Carolyn, Allen, Claire, Anders, Nicola, Barlow, Victoria, Bassett, Mike, Darwin, Leanne, Davison, Rachel, Diacono, Jacque, Hobbs, Amy, Hutchinson, Adel, Lomas, Bernadette, Lonsdale, Hannah, Nasser, Leila, Oshan, Vimmi, Patel, Pradip, Raistrick, Christopher, Scott Warren, Victoria, Talbot, Laura, Wai, Carolynn, Childs, Sophie, Dickinson, Matthew, Bloomfield, Tom, Garrioch, Sweyn, Watson, Karen, Gaynor, Jame, Harrison, Richard, Lee, Juliette, Blythe, Elizabeth, Dorman, Teresa, Eissa, Ayman, Ellwood, Jame, Gooch, Ingrid, Hearn, Robert, Hodgetts, Vanessa, John, Robert, Kirton, Christine, Ladak, Nadia, Morgan, Judith, Plant, Nina, Shepherd, Elizabeth, Short, Judith, Stack, Charle, Steel, Simon, Taylor, Matthew, Thomas, Deborah, Wilson, Catharine, Wilson Smith, Elaine, Bradbury, Carol L., Hussain, Nageena, Mayell, Antonia, Mesbah, Ahmed, Qureshi, Arif, Vaidyanath, Chandra, Geary, Tim, Hawksworth, Chri, Parasuraman, Tamaraichelvi, Perry, Nicole, Banerjee, Indrani, Barr, Katharine, Butler, Patrick, Davies, Jack, Flewin, Lisa, Gande, Richard, Montague, Jame, Plumb, Jame, Pratt, Thoma, Sutherland, Paul, Vail, Hannah, Wilkins, Andrew, Hunter, Catherine, Russell, Susan, Thomas, Alun, Mifsud, Mark, Strachan, Dominic, Plichon, Benoit, Harlet, Pierre, Child and Adolescent Psychiatry / Psychology, Morawk-Wintersperger, Ulrike, Seidel-Ahyai, Natascha, Lechat, Jean-Paul, Kesic-Valpotic, Gordana, Ilmoja, Mari-Lii, Nouette-Gaulain, Karine, Gagey, Anne-Charlotte, Carre, Anne-Charlotte, Riche, Jean-Claude, Verchere-Montmayeur, Juliette, Julien-Marsollier, Florence, Saour, Anne-Charlotte, Jetzek-Zader, Martin, Meyer-Treschan, Tanja, Preussler, Niels-Peter, Sidlovskaite-Baltake, Dominika, van Stijn, Mireille F M, Dons-Sinke, Ilse, van der Knijff - van Dortmont, Anouk, Hopman, Geranne A.J., Megens, A.M., Schouten, Anton N.J., Van Der Werff, Désirée B.M., Wensing, Renee T.M., Lindenskov, Pal H H, Siemek-Mitela, Jadzia, Rosada-Kurasinska, Jowita, Bartkowska-Sniatkowska, Alicja, Mierzewska-Schmidt, Magdalena, Moraru-Draghici, Lucia, Cucui-Cozma, Cosmina, Birliba, Mihaela-Petronela, Perez- Ferrer, Antonio, Spahr-Schopfer, Isabelle, Cakar Turhan, K.Sanem, Perova-Sharonova, Valentina, Abou-Samra, Mark, Sharman, Sarah-Jane, McClintock, Joanna, Lee, Clover-Ann, Abdel-Hafiz, Mostafa, Chee, Lew-Chin, McKee, Lesley, Scott-Warren, Victoria, and Wilson-Smith, Elaine

Subjects
Male, Pediatrics, Health Status, OPERATING-ROOM, Respiratory Tract Diseases, CHILDREN, 0302 clinical medicine, REGIONAL ANESTHESIA, Postoperative Complications, 030202 anesthesiology, CARDIAC-ARREST, Medicine, General anaesthesia, Prospective Studies, Prospective cohort study, Child, Intraoperative Complications, COMPLICATIONS, ddc:617, Incidence (epidemiology), Mortality rate, musculoskeletal, neural, and ocular physiology, Incidence, Age Factors, Hospitals, Europe, Cardiovascular Diseases, Child, Preschool, RESPIRATORY ADVERSE EVENTS, Female, Clinical Competence, Cohort study, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Adolescent, macromolecular substances, Anesthesia, General, Drug Hypersensitivity, 03 medical and health sciences, MORBIDITY, Journal Article, Humans, business.industry, Infant, Newborn, Infant, 030208 emergency & critical care medicine, Perioperative, nervous system, PROSPECTIVE COHORT, Relative risk, RISK-FACTORS, Observational study, Human medicine, Nervous System Diseases, business, SYSTEM
Abstract

Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0–5·5) with an incidence of respiratory critical events of 3·1% (2·9–3·3). Cardiovascular instability occurred in 1·9% (1·7–2·1), with an immediate poor outcome in 5·4% (3·7–7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86–0·90; p

Published
2017

34. Fiber orientation angle effects in machining of unidirectional CFRP laminated composites

Author

Eric P. Whitenton, Viswanathan Madhavan, Brandon M. Lane, and Gary Lipczynski

Subjects
Materials science, Dynamometer, Machining, Strategy and Management, Fiber orientation, Composite number, Thrust, Management Science and Operations Research, Composite material, Fibre-reinforced plastic, Tool wear, Industrial and Manufacturing Engineering, Finite element method
Abstract

Experiments were carried out at the National Institute of Standards and Technology, in collaboration with The Boeing Company, to obtain force and temperature data as a function of feed, speed, and fiber orientation angle (FOA), for validation of finite element simulations of composite machining. The outer diameter portions of disks of unidirectional carbon fiber reinforced plastic (CFRP) laminates were cut orthogonally. Tabs were machined into the outer diameter (OD) to cause cutting to begin at a FOA of 0° and end at a FOA of 90°. Cutting forces were measured using a dynamometer and the chip morphology was recorded using a high speed camera. It was observed that the variation of cutting force with FOA depended on the feed. For large feed, the cutting force increases with FOA until an angle of 90°, whereas for low feed the cutting force decreases beyond 65°. The chip morphology also changes with FOA and feed. Significant tool flank wear is noted even in these short duration experiments, which causes the thrust and cutting forces to increase significantly for FOA from 0° to 60°. For 65°–80° FOA, force signals change cyclically. A small spike in the cutting force seems to be correlated with fibers being pulled out in clumps, and is followed by lower forces in subsequent revolutions while the pitted surface is machined.

Published
2015

35. Pre-emptive analgesic effect of lornoxicam in mandibular third molar surgery : a prospective, randomized, double-blind clinical trial

Author

M. Zaleska, K. Lipczynski, J. Stypulkowska, I. Mojsa, P. Novak, and Katarzyna Szczeklik

Subjects
Analgesic effect, Adult, Male, medicine.medical_specialty, Adolescent, Visual analogue scale, Analgesic, Mandible, Placebo, Double blind, 03 medical and health sciences, Piroxicam, 0302 clinical medicine, Third molar surgery, Double-Blind Method, 030202 anesthesiology, Lornoxicam, Medicine, Humans, Prospective Studies, Pain Measurement, Pain, Postoperative, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Tooth, Impacted, 030206 dentistry, Middle Aged, Surgery, Clinical trial, Treatment Outcome, Otorhinolaryngology, Anesthesia, Female, Molar, Third, Oral Surgery, business, medicine.drug
Abstract

The aim of this study was to establish whether the pre-emptive use of lornoxicam (16mg) in third molar surgery ensures successful postoperative analgesia and reduces rescue analgesic intake when compared to postoperative application, and in comparison with placebo. Ninety patients were split randomly into three groups: group A received lornoxicam 60min before surgery and placebo 60min after surgery; group B received placebo 60min before surgery and lornoxicam 60min after surgery; group C received placebo 60min before surgery and placebo 60min after surgery. Postoperative pain was recorded on a visual analogue scale and on a numerical rating scale at 1, 2, 4, 6, 8, 12, and 24h after surgery. The patients recorded total dose of paracetamol intake during the 24h after the procedure. The efficacy of postoperative analgesia was greater in lornoxicam groups when compared to the placebo group; there was no difference between the two lornoxicam groups (A and B). Patients in group C took their first rescue analgesic dose earlier after surgery than patients in the two lornoxicam groups. The average dose of paracetamol taken in group C was 1000mg, while it was500 mg in the lornoxicam groups.

Published
2017

36. Effect of submucosal dexamethasone injection on postoperative pain, oedema, and trismus following mandibular third molar surgery : a prospective, randomized, double-blind clinical trial

Author

R. Pokrowiecki, Katarzyna Szczeklik, K. Lipczynski, I.M. Mojsa, D. Czerwonka, and M. Zaleska

Subjects
Molar, Male, medicine.medical_specialty, Visual analogue scale, Analgesic, Anti-Inflammatory Agents, Mandible, Trismus, Placebo, Dexamethasone, Injections, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Double-Blind Method, medicine, Edema, Humans, Pain Management, Prospective Studies, Pain Measurement, Pain, Postoperative, business.industry, 030206 dentistry, Surgery, Clinical trial, Treatment Outcome, Otorhinolaryngology, McGill Pain Questionnaire, 030220 oncology & carcinogenesis, Anesthesia, Tooth Extraction, Female, Molar, Third, Oral Surgery, medicine.symptom, business, medicine.drug
Abstract

The aim of this study was to investigate the effect of the submucosal injection of 1ml dexamethasone (4mg/ml) on pain, swelling, and trismus following the extraction of retained lower third molars. Ninety patients (mean age 23.5 years) were split randomly into three equal study groups (30 patients in each): the 'before' group received dexamethasone 15min before surgery and placebo 15min after surgery; the 'after' group received placebo 15min before surgery and dexamethasone 15min after surgery; the 'placebo' group received placebo 15min before surgery and placebo 15min after surgery. Postoperative pain was recorded by the patients using a visual analogue scale, numerical rating scale, and the McGill Pain Questionnaire at 1, 2, 4, 6, 8, 12, and 24h after surgery. The patients also recorded the total number of analgesic doses consumed during the 24h after the procedure. Swelling (determined using linear measurements of the face) and trismus (determined through measurement of maximum mouth opening) were assessed at 48h, 72h, and 7 days following surgery. Better control of pain, swelling, and trismus was demonstrated for dexamethasone in comparison to placebo. Postoperative dexamethasone provided better pain control than preoperative dexamethasone. There was no difference in total rescue analgesic intake between the preoperative and postoperative dexamethasone groups.

Published
2017

37. Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort

Author

GUARD C, Study Group, Hassanein, T, Bakalos, G, Ahlers, S, Shiffman, Ml, Tallarico, L, Reddy, Kr, Orlandini, A, Ferenci, P, Derbala, M, Coppola, C, Foster, Gr, Basho, J, Shabanaj, G, Harxhi, A, Debzi, N, Afredj, N, Guessab, N, Mahindad, N, Mahiou, H, Aissaoui, M, Al Qameesh, J, Al Ghandoor, Z, Assene, C, Bastens, B, Brixko, C, Cool, M, De Galocsy, C, Delwaide, J, George, C, Laukens, P, Lefebvre, V, Mulkay, Jp, Nevens, F, Servais, B, Van Vlierberghe, H, Horsmans, Y, Henrion, J, Sprengers, D, Michielsen, P, Bourgeois, S, Lasser, L, Langlet, P, Robaeys, G, Martinet, Jp, Warzee, P, Hoste, P, Reynaert, H, Juriens, I, Decaestecker, J, Van Der Meersch, F, Janssens, F, Ahmetagic, S, Verhaz, A, Bevanda, M, Calkic, L, Ibrahimpasic, N, Mesihovic, R, Mello, Ce, Ruiz, Fj, Martins Junior, E, Ferraz, Ml, Silva, G, Mendes, C, Lyra, A, Silva, Mh, Gomide, G, Fernandes, Jc, Pereira, P, Correa, Mc, Teixeira, R, Yousry, A, Hanno, A, Gabr, M, Omar, A, Esmat, G, Karatapanis, S, Nikolopoulou, V, Giannoulis, G, Manolakopoulos, S, Elefsiniotis, I, Drakoulis, C, Dimitroulopoulos, D, Kanatakis, S, Ketikoglou, I, Mimidis, K, Evgenidis, N, Akriviades, E, Vafiadi Zoubouli, I, Tsianos, E, Mela, M, Orfanou, E, Mousoulis, G, Karagiannis, I, Manesis, E, Varga, M, Nemesánszky, E, Fried, K, Schuller, J, Szalay, F, Lengyel, G, Tornai, I, Banyai, T, Lesch, M, Nagy, I, Gervain, J, Tusnadi, A, Schneider, F, Szentgyörgyi, L, Hunyady, B, Vincze, A, Tolvaj, G, Varkonyi, I, Makkai, E, Enyedi, J, Racz, I, Hausinger, P, Váczi, Z, Patai, Á, Ozsvár, Z, Lakner, L, Ribiczey, P, Bhalla, A, Somani, S, Luaia, R, Rao, P, Philip, M, Lawate, P, Nagral, A, Sood, A, Parikh, S, Merat, S, Nassiri Toosi, M, Alavian, Sm, Zali, Mr, Daryani, Ne, Drenaggi, D, Attili, Af, Bandiera, F, Bassi, P, Bellati, G, Bellantani, S, Brunetto, MAURIZIA ROSSANA, Bruno, S, Castelli, F, Castellacci, R, Cattelan, Am, Colombo, M, Craxi, A, D'Angelo, S, Colombo, S, Demelia, L, Di Perri, G, Di Giacomo, A, Ferrari, C, Francisci, D, Casinelli, K, Ganga, R, Costa, C, Mangia, A, Russo, Fp, Matarazzo, F, Mazzella, G, Mazzeo, M, Memoli, M, Montalbano, M, Montalto, G, Pieri, A, Passariello, N, Picciotto, A, Pietrangelo, A, Pirisi, M, Quirino, T, Raimondo, G, Rapaccini, Gl, Rizzardini, G, Rizzetto, M, Russello, M, Sabusco, G, Santantonio, T, Soardo, G, Amedea, A, Verucchi, G, Vinelli, F, Zignego, Al, Zuin, M, Ascione, A, Vinci, M, Pigozzi, Mg, Tundo, P, Saracco, Gm, Amoroso, P, Andreoni, M, Colletta, C, Erne, E, Megna, As, Biglino, A, Chiriaco, P, Foti, G, Spinzi, G, D'Amico, E, Paik, Sw, Ahn, Sh, Lee, Yn, Kim, Y, Yang, J, Han, Sy, Varghese, R, Al Gharabally, A, Askar, H, Sharara, A, Yaghi, C, Rached, Aa, Houmani, Z, Zaarour, F, Dohaibi, A, Ivanovski, L, Joksimovic, N, Abbas, Z, Memon, S, Mohsin, A, Masood, S, Hashmi, Z, Halota, W, Deron, Z, Mazur, W, Flisiak, R, Lipczynski, A, Musialik, J, Piekarska, A, Augustyniak, K, Baka Cwierz, B, Simon, K, Gietka, A, Berak, H, Sieklucki, J, Radowska, D, Szlauer, B, Piekos, T, Olszok, I, Jablkowski, M, Orszulak, G, Warakomska, I, Aleixo, Mj, Valente, C, Macedo, G, Sarmento Castro, R, Roxo, F, Faria, T, Mansinho, K, Velez, J, Ramos, Jp, Guerreiro, H, Alberto, S, Monteverde, C, Serejo, F, Peixe, P, Malhado, J, Curescu, M, Streinu Cercel, A, Caruntu, F, Livia, H, Preotescu, L, Arama, V, Ancuta, I, Gheorghe, L, Stanciu, C, Trifan, A, Acalovschi, M, Andreica, V, Pascu, O, Lencu, M, Sporea, I, Olteanu, D, Ionita Radu, F, Fierbinteanu Braticevici, C, Motoc, A, Silaghi, R, Musat, M, Coman, F, Stan, M, Cijevschi, C, Miftode, E, Delic, D, Jesic, R, Nozic, D, Svorcan, P, Fabri, M, Konstantinovic, L, Pelemis, M, Jankovic, G, Todorovic, Z, Nagorni, A, Kupcova, V, Skladany, L, Szantova, M, Krkoska, D, Jarcuska, P, Schreter, I, Oltman, M, Bocakova, J, Bunganic, I, Holoman, J, Giguere, A, Abdou, A. M., Basic (bio-) Medical Sciences, Gastroenterology, Laboratory of Molecullar and Cellular Therapy, Liver Cell Biology, Michielsen, Peter, GUARD-C Study Group, Graham R. Foster, Carmine Coppola, Moutaz Derbala, Peter Ferenci, Alessandra Orlandini, K. Rajender Reddy, Ludovico Tallarico, Mitchell L. Shiffman, Silke Ahler, Georgios Bakalo, Tarek Hassanein, GUARD-C Study Group: [.., Davide Drenaggi, Adolfo Francesco Attili, Franco Bandiera, Paolo Bassi, Giorgio Bellati, Stefano Bellantani, Maurizia Brunetto, Savino Bruno, Francesco Castelli, Roberto Castellacci, Anna Maria Cattelan, Massimo Colombo, Antonio Craxi, Salvatore D'angelo, Silvia Colombo, Luigi Demelia, Giovanni Di Perri, Antonio Di Giacomo, Carlo Ferrari, Daniela Francisci, Katia Casinelli, Roberto Ganga, Chiara Costa, Alessandra Mangia, Francesco Paolo Russo, Filippo Matarazzo, Giuseppe Mazzella, Maurizio Mazzeo, Massimo Memoli, Marzia Montalbano, Giuseppe Montalto, Alessandro Pieri, Nicola Passariello, Antonio Picciotto, Antonello Pietrangelo, Mario Pirisi, Tiziana Quirino, Giovanni Raimondo, Gian Ludovico Rapaccini, Giuliano Rizzardini, Mario Rizzetto, Maurizio Russello, Giuseppe Sabusco, Teresa Santantonio, Giorgio Soardo, Alessandri Amedea, Gabriella Verucchi, Francesco Vinelli, Anna Linda Zignego, Massimo Zuin, Antonio Ascione, Maria Vinci, Maria Graziella Pigozzi, Paolo Tundo, Giorgio Maria Saracco, Pietro Amoroso, Massimo Andreoni, Cosimo Colletta, Elke Erne, Angelo Salomone Megna, Alberto Biglino, Piergiorgio Chiriaco, Giuseppe Foti, Giancarlo Spinzi, Emilio D'amico, …], Foster G.R., Coppola C., Derbala M., Ferenci P., Orlandini A., Reddy K.R., Tallarico L., Shiffman M.L., Ahlers S., Bakalos G., Hassanein T., Basho J., Shabanaj G., Harxhi A., Debzi N., Afredj N., Guessab N., Mahindad N., Mahiou H., Aissaoui M., Al Qameesh J., Al Ghandoor Z., Assene C., Bastens B., Brixko C., Cool M., De Galocsy C., Delwaide J., George C., Laukens P., Lefebvre V., Mulkay J.-P., Nevens F., Servais B., Van Vlierberghe H., Horsmans Y., Henrion J., Sprengers D., Michielsen P., Bourgeois S., Lasser L., Langlet P., Robaeys G., Martinet J.-P., Warzee P., Hoste P., Reynaert H., Juriens I., Decaestecker J., Van Der Meersch F., Janssens F., Ahmetagic S., Verhaz A., Bevanda M., Calkic L., Ibrahimpasic N., Mesihovic R., Mello C.E., Ruiz F.J., Junior E.M., Ferraz M.L., Silva G., Mendes C., Lyra A., Silva M.H., Gomide G., Fernandes J.C., Pereira P., Correa M.C., Teixeira R., Yousry A., Hanno A., Gabr M., Omar A., Esmat G., Karatapanis S., Nikolopoulou V., Giannoulis G., Manolakopoulos S., Elefsiniotis I., Drakoulis C., Dimitroulopoulos D., Kanatakis S., Ketikoglou I., Mimidis K., Evgenidis N., Akriviades E., Vafiadi-Zoubouli I., Tsianos E., Mela M., Orfanou E., Mousoulis G., Karagiannis I., Manesis E., Varga M., Nemesanszky E., Fried K., Schuller J., Szalay F., Lengyel G., Tornai I., Banyai T., Lesch M., Nagy I., Gervain J., Tusnadi A., Schneider F., Szentgyorgyi L., Hunyady B., Vincze A., Tolvaj G., Varkonyi I., Makkai E., Enyedi J., Racz I., Hausinger P., Vaczi Z., Patai A., Ozsvar Z., Lakner L., Ribiczey P., Bhalla A., Somani S., Luaia R., Rao P., Philip M., Lawate P., Nagral A., Sood A., Parikh S., Merat S., Nassiri-Toosi M., Alavian S.-M., Zali M.R., Daryani N.E., Drenaggi D., Attili A.F., Bandiera F., Bassi P., Bellati G., Bellantani S., Brunetto M., Bruno S., Castelli F., Castellacci R., Cattelan A.M., Colombo M., Craxi A., D'angelo S., Colombo S., Demelia L., Di Perri G., Di Giacomo A., Ferrari C., Francisci D., Casinelli K., Ganga R., Costa C., Mangia A., Russo F.P., Matarazzo F., Mazzella G., Mazzeo M., Memoli M., Montalbano M., Montalto G., Pieri A., Passariello N., Picciotto A., Pietrangelo A., Pirisi M., Quirino T., Raimondo G., Rapaccini G.L., Rizzardini G., Rizzetto M., Russello M., Sabusco G., Santantonio T., Soardo G., Amedea A., Verucchi G., Vinelli F., Zignego A.L., Zuin M., Ascione A., Vinci M., Pigozzi M.G., Tundo P., Saracco G.M., Amoroso P., Andreoni M., Colletta C., Erne E., Megna A.S., Biglino A., Chiriaco P., Foti G., Spinzi G., D'amico E., Paik S.W., Ahn S.-H., Lee Y.N., Kim Y., Yang J., Han S.Y., Varghese R., Al Gharabally A., Askar H., Sharara A., Yaghi C., Abou Rached A., Houmani Z., Zaarour F., Dohaibi A., Ivanovski L., Joksimovic N., Abbas Z., Memon S., Mohsin A., Masood S., Hashmi Z., Halota W., Deron Z., Mazur W., Flisiak R., Lipczynski A., Musialik J., Piekarska A., Augustyniak K., Baka-Cwierz B., Simon K., Gietka A., Berak H., Sieklucki J., Radowska D., Szlauer B., Piekos T., Olszok I., Jablkowski M., Orszulak G., Warakomska I., Aleixo M.J., Valente C., Macedo G., Sarmento-Castro R., Roxo F., Faria T., Mansinho K., Velez J., Ramos J.P., Guerreiro H., Alberto S., Monteverde C., Serejo F., Peixe P., Malhado J., Curescu M., Streinu-Cercel A., Caruntu F., Livia H., Preotescu L., Arama V., Ancuta I., Gheorghe L., Stanciu C., Trifan A., Acalovschi M., Andreica V., Pascu O., Lencu M., Sporea I., Olteanu D., Ionita-Radu F., Fierbinteanu-Braticevici C., Motoc A., Silaghi R., Musat M., Coman F., Stan M., Cijevschi C., Miftode E., Delic D., Jesic R., Nozic D., Svorcan P., Fabri M., Konstantinovic L., Pelemis M., Jankovic G., Todorovic Z., Nagorni A., Kupcova V., Skladany L., Szantova M., Krkoska D., Jarcuska P., Schreter I., Oltman M., Bocakova J., Bunganic I., Holoman J., Giguere A., Abdou A.M.S., UCL - SSS/IREC-Institut de recherche expérimentale et clinique, UCL - SSS/IREC/GAEN-Pôle d'Hépato-gastro-entérologie, and UCL - (SLuc) Service de gastro-entérologie

Subjects
Genetics and Molecular Biology (all), Male, Chronic Hepatitis, Hepacivirus, Ribavirin/adverse effects, Asthenia/chemically induced, Polyethylene Glycol, Biochemistry, Polyethylene Glycols, Body Mass Index, Chronic Liver Disease, 0302 clinical medicine, Neutropenia/chemically induced, Interferon-alpha/adverse effects, Medicine, Chronic, lcsh:Science, Liver Diseases, virus diseases, Antiviral Agents/adverse effects, Cohort, Science & Technology - Other Topics, 030211 gastroenterology & hepatology, Drug Therapy, Combination, Cohort study, Human, medicine.medical_specialty, Alpha interferon, Gastroenterology and Hepatology, Antiviral Agents, Microbiology, Dose-Response Relationship, 03 medical and health sciences, Pharmacotherapy, Hepatitis C, Chronic/drug therapy, Dose Prediction Methods, Drug Therapy, Anemia/chemically induced, Humans, Hemoglobin, Aged, Medicine and health sciences, Biochemistry, Genetics and Molecular Biology (all), Hepaciviru, Science & Technology, Dose-Response Relationship, Drug, Flaviviruses, lcsh:R, Organisms, Biology and Life Sciences, Proteins, medicine.disease, digestive system diseases, chemistry, Agricultural and Biological Sciences (all), Withholding Treatment, Asthenia, Immunology, Proportional Hazards Model, lcsh:Q, Human medicine, RNA viruses, Physiology, lcsh:Medicine, Peginterferon-alfa, Polyethylene Glycols/adverse effects, Adult, Anemia, Cohort Studies, Female, Hepatitis C, Chronic, Host-Pathogen Interactions, Interferon-alpha, Middle Aged, Neutropenia, Outcome Assessment (Health Care), Proportional Hazards Models, RNA, Viral, Recombinant Proteins, Ribavirin, Medicine (all), chemistry.chemical_compound, Outcome Assessment, Health Care, Medicine and Health Sciences, 030212 general & internal medicine, Viral, Pathology and laboratory medicine, Multidisciplinary, biology, Hepatitis C virus, Pharmaceutics, Hepatitis C, Hematology, Recombinant Protein, Outcome Assessment (Health Care)/methods, Medical microbiology, Host-Pathogen Interaction, Multidisciplinary Sciences, Physiological Parameters, Research Design, Combination, Viruses, Drug, Pathogens, Host-Pathogen Interactions/drug effects, Research Article, Clinical Research Design, Research and Analysis Methods, Internal medicine, Recombinant Proteins/adverse effects, RNA, Viral/blood, Antiviral Agent, business.industry, Body Weight, Hepacivirus/drug effects, Viral pathogens, biology.organism_classification, Hepatitis viruses, Microbial pathogens, RNA, Adverse Events, Cohort Studie, business
Abstract

Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA

Published
2015

38. Economia industriale. Concorrenza, strategie e politiche pubbliche. 2° edizione

Author

Solimene, L (ORCID:0000-0003-3042-9628), Lipczynski,J, Wilson, OS, Goddard, J, Solimene, Laura, Solimene, L (ORCID:0000-0003-3042-9628), Lipczynski,J, Wilson, OS, Goddard, J, and Solimene, Laura

Abstract

Nel corso degli ultimi decenni, il segmento degli studi economici, conosciuto nel nostro paese con il nome di Economia industriale, e nel mondo anglosassone con quello di Industrial Organization, è profondamente cambiato. L’approccio tradizionale, sviluppato tra gli anni trenta e sessanta del secolo scorso dai grandi studiosi della scuola di Harvard, e riassumibile nel paradigma struttura-comportamenti-risultati economici, è stato arricchito da molteplici contributi di carattere microeconomico, che hanno ampliato notevolmente sia il ventaglio di tematiche oggetto di studio in quest’area, sia la strumentazione teorica ed empirica utilizzabile per affrontarle. Gli sviluppi, che si sono rivelati essenziali per l’evoluzione dell’Economia industriale, riguardano principalmente i costi di transazione e i contratti imperfetti, la contendibilità dei mercati e le caratteristiche dell’informazione, mentre la teoria dei giochi ha avuto un impatto rilevante nello studio dei mercati oligopolistici, principale oggetto d’analisi di questa disciplina. Gli effetti sono stati rilevanti: i vecchi libri di testo sono diventati rapidamente obsoleti e sono stati pubblicati numerosi manuali che cercano di fornire conoscenze e strumenti più aggiornati. Molti di essi, però, presentano gravi limiti, perché la ricerca del nuovo ha indotto molti autori ad accantonare alcune delle acquisizioni più rilevanti dell’approccio tradizionale. Il volume di Lipczynski, Wilson e Goddard, un testo utilizza in maniera equilibrata approcci tradizionali e nuovi. Da un lato, infatti, presenta in maniera aggiornata le tematiche che sono fondamentali per comprendere gli elementi della struttura dei mercati, come le economie di scala, le barriere all’entrata e la concentrazione dei mercati, che ne modellano la fisionomia e condizionano fortemente i processi produttivi. Dall’altro, tuttavia, presenta anche gli sviluppi più recenti, come il posizionamento dei prodotti (differenziazione, pubblicità, ricerc

Published
2017

39. Obesity and renal cancer incidence and mortality - a systematic review of prospective cohort studies

Author

Jakub Dobruch, W. Lipczynski, Andrzej Borówka, Piotr Chlosta, Jakub Bukowczan, Tomasz Golabek, and Tomasz Szopiński

Subjects
medicine.medical_specialty, renal cancer, Risk Assessment, lcsh:Agriculture, systematic review, Epidemiology, medicine, Humans, Obesity, Intensive care medicine, Prospective cohort study, Waste Management and Disposal, lcsh:Environmental sciences, Ecology, Evolution, Behavior and Systematics, lcsh:GE1-350, business.industry, Incidence, Incidence (epidemiology), lcsh:S, Public Health, Environmental and Occupational Health, Cancer, medicine.disease, mortality, Kidney Neoplasms, Cancer incidence, Positive relationship, Cancer development, business
Abstract

[b]Introduction and objective.[/b] There have been many studies published recently on obesity and the risk of renal cancer; however, the epidemiological evidence for such an association has not been consistent. Therefore, a systematic review was conducted of the prospective cohort studies to assess the association between obesity and the risk of renal cancer incidence and death. [b]Materials and methods.[/b] A search was conducted of the PubMed database and references to published studies from inception until May 2013. Guidelines for Assessing Quality in Prognostic Studies on the Basis of Framework for Potential Biases were followed for quality assessment of studies included in the systematic review. [b]Results. [/b]Twenty eligible studies were identified and included in the systematic review. Among the 20 selected studies, overall study quality was high. Although the evidence from the prospective cohort studies, linking obesity with renal cancer incidence, has not been entirely consistent, there is a convincing body of data for a positive relationship. Moreover, cumulative data is compelling for a strong positive association between obesity and fatal renal cancer. [b]Conclusions.[/b] There is a relatively consistent amount of evidence that obesity increases the risk of renal cancer and fatal renal cancer. Further research is needed as better understanding of mechanisms by which obesity may influence renal cancer development and progression will aid the fostering of strategies for prevention and treatment of one of the most lethal human malignancies.

Published
2016

40. A Detailed Study of Sulfonate Ester Formation and Solvolysis Reaction Rates and Application toward Establishing Sulfonate Ester Control in Pharmaceutical Manufacturing Processes

Author

Van D. Reif, Stephen C. Eyley, Andrew M. Lipczynski, Simon Golec, Pat Sandra, Kevin L. Facchine, Edward J. Delaney, David P. Elder, Rolf Schulte Oestrich, Wilfried Hoffmann, Andrew Teasdale, Karine Jacq, Karen Taylor-Worth, and Frank David

Subjects
Reaction rate, chemistry.chemical_compound, Sulfonate, Chemistry, Innovator, Organic Chemistry, Pharmaceutical manufacturing, Organic chemistry, Solvolysis, Physical and Theoretical Chemistry
Abstract

Sulfonate esters of lower alcohols possess the capacity to react with DNA and cause mutagenic events, which in turn may be cancer inducing. Consequently, the control of residues of such substances in products that may be ingested by man (in food or pharmaceuticals) is of importance to both pharmaceutical producers and to regulatory agencies. Given that a detailed study of sulfonate ester reaction dynamics (mechanism, rates, and equilibria) has not been published to date, a detailed kinetic and mechanistic study was undertaken and is reported herein as a follow-up to our earlier communication in this journal. The study definitively demonstrates that sulfonate esters cannot form even at trace level if any acid present is neutralized with even the slightest excess of base. A key conclusion from this work is that the high level of regulatory concern over the potential presence of sulfonate esters in API sulfonate salts is largely unwarranted and that sulfonate salts should not be shunned by innovator pharmace...

Published
2010

41. Mechanism and Processing Parameters Affecting the Formation of Methyl Methanesulfonate from Methanol and Methanesulfonic Acid: An Illustrative Example for Sulfonate Ester Impurity Formation

Author

Stephen C. Eyley, Rolf Schulte Oestrich, David P. Elder, Andrew Teasdale, Karen Taylor-Worth, Ed Delaney, Andrew M. Lipczynski, Frank David, Kevin L. Facchine, Patrick Sandra, Van D. Reif, Karine Jacq, and Simon Golec

Subjects
Active ingredient, chemistry.chemical_compound, Sulfonate, chemistry, Impurity, Organic Chemistry, Organic chemistry, Solvolysis, Methanol, Physical and Theoretical Chemistry, Methanesulfonic acid, Bond cleavage, Methyl methanesulfonate
Abstract

Sulfonate salts offer useful modification of physicochemical properties of active pharmaceutical ingredients (APIs) containing basic groups, but there are regulatory concerns over the presence of sulfonate esters as potential genotoxic impurities (PGIs). Whilst sulfonate esters could theoretically result from interaction between sulfonic acids and alcohols, literature on their formation is sparse. GC−MS analysis of reactions of methanesulfonic acid (MSA) and isotopically labeled methanol (18O-label) confirm methanol C−O bond cleavage in the formation of the methyl methanesulfonate (MMS), consistent with reversal of well-established mechanisms for solvolysis of sulfonate esters. Studies of reaction profiles quantify methyl methanesulfonate formation under a range of conditions relevant to API processing. Maximum conversion to MMS in reaction mixtures was 0.35%, determined by analytical methods developed specifically for reaction mixture analysis. Sulfonate ester formation is dramatically reduced at lower t...

Published
2009

42. Control and analysis of alkyl and benzyl halides and other related reactive organohalides as potential genotoxic impurities in active pharmaceutical ingredients (APIs)

Author

David P. Elder, Andrew Teasdale, and Andrew M. Lipczynski

Subjects
Active ingredient, Alkylating Agents, Drug Contamination, Chemistry, business.industry, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, High-performance liquid chromatography, Analytical Chemistry, Halogens, Capillary electrophoresis, Pharmaceutical Preparations, Drug development, Drug Discovery, Organic chemistry, Salts, Gas chromatography, Pharmaceutical sciences, business, Spectroscopy, Mutagens, Pharmaceutical industry
Abstract

This paper continues the review of the relevant scientific literature associated with the control and analysis of potential genotoxic impurities (PGIs) in active pharmaceutical ingredients (APIs). The initial review [D.P. Elder, A. Teasdale, A.M. Lipczynski, J. Pharm. Biomed. Anal. 46 (2008) 1-8.] focused on the specific class of sulfonate esters but in this instance reference is made to the analysis of alkyl and benzyl halides and other related reactive organohalide alkylating agents. Such reactive materials are commonly employed in pharmaceutical research and development as raw materials, reagents and intermediates in the chemical synthesis of new drug substances. Consequently a great deal of attention and effort is extended by the innovative and ethical pharmaceutical industry to ensure that appropriate and practicable control strategies are established during drug development to ensure residues of such agents, as potential impurities in new drug substances, are either eliminated or minimized to such an extent so as to not present a significant safety risk to volunteers and patients in clinical trials and beyond. The reliable trace analysis of such reactive organohalides is central to such control strategies and invariably involves a state-of-the-art combination of high-resolution separation science techniques coupled to sensitive and selective modes of detection. This article reports on the most recent developments in the regulatory environment, overall strategies for the control of alkylating agents and the latest developments in analysis culminating in a literature review of analytical approaches. The literature is sub-categorized by separation technique (gas chromatography (GC), high-performance liquid chromatography (HPLC), thin layer chromatography (TLC) and capillary zone electrophoresis (CZE)) and further tabulated by API type and impurity with brief method details and references. As part of this exercise, a selection of relevant pharmacopoeial monographs was also reviewed. The continued reliance on relatively non-specific and insensitive TLC methodologies in several monographs was noteworthy.

Published
2008

43. Development of Orbital Drilling for the Boeing 787

Author

Gary Lipczynski, Ingvar Eriksson, and Eric Whinnem

Subjects
Computer science, business.industry, Drilling system, Aerospace Engineering, New materials, Drilling, Aerospace engineering, business, Hard metals
Abstract

The new materials and material combinations such as composites and titanium combinations used on today’s new airplanes are proving to be very challenging when drilling holes during manufacturing and assembly operations. Orbital hole drilling technology has shown a great deal of promise for generating burr free, high quality holes in hard metals and in composite materials. This paper will show some of the orbital drilling development work Boeing is doing with Novator to overcome the obstacles of drilling holes in a combination of both hard metals and composites. The paper will include a new portable orbital drilling system designed for these challenging applications as well as some test results achieved with this system.

Published
2008

44. Barriers to Adult Immunization

Author

David R. Johnson, Kim Lipczynski, and Kristin L. Nichol

Subjects
Adult, Male, Adult Immunization, Health Knowledge, Attitudes, Practice, medicine.medical_specialty, MEDLINE, Health Services Accessibility, Pneumococcal Vaccines, Tetanus Toxoid, Humans, Medicine, Aged, business.industry, Tetanus, Vaccination, General Medicine, Middle Aged, medicine.disease, Fear of needles, United States, Socioeconomic Factors, Immunization, Influenza Vaccines, Health Care Surveys, Family medicine, Female, business, Healthcare providers, Insurance coverage
Abstract

Our aim was to provide a better understanding of why many adults fail to receive recommended immunizations. Consumers (N = 2,002) and healthcare providers (N = 200) completed structured telephone interviews concerning their attitudes and knowledge about adult vaccines and factors affecting their vaccination decisions. Self-reported immunization rates for tetanus, influenza, and pneumococcal vaccines (which were emphasized in the surveys) were lower than goal rates set by national guidelines. Among the most common reasons consumers gave for not receiving immunizations were lack of physician recommendations and mistaken assumptions (e.g., healthy people do not need immunizations). Healthcare providers tended to cite concerns such as side effects, fear of needles, and lack of insurance coverage as reasons consumers forego vaccination. Providers also cited practice issues, such as lack of an effective reminder system, as barriers to increasing adult immunization rates. We conclude that a better understanding of why adults do not get vaccinated is important for efforts to increase immunization rates in this broad age group.

Published
2008

45. Control and analysis of alkyl esters of alkyl and aryl sulfonic acids in novel active pharmaceutical ingredients (APIs)

Author

David P. Elder, Andrew M. Lipczynski, and Andrew Teasdale

Subjects
Alkanesulfonates, Chromatography, Gas, Drug Industry, Process chemistry, Clinical Biochemistry, Pharmaceutical Science, Excipient, Sulfonic acid, Chemistry Techniques, Analytical, Mass Spectrometry, Analytical Chemistry, chemistry.chemical_compound, Drug Discovery, medicine, Organic chemistry, Solid phase extraction, Arylsulfonates, Chromatography, High Pressure Liquid, Spectroscopy, Alkyl, chemistry.chemical_classification, Active ingredient, Molecular Structure, Aryl, Sulfonate, Pharmaceutical Preparations, chemistry, medicine.drug
Abstract

This article reviews current regulatory guidelines and relevant scientific literature pertaining to the control and analysis of potential genotoxic impurities (PGIs) in new active pharmaceutical ingredients (APIs) with specific reference to a certain sub-class of PGIs, namely alkyl esters of alkyl and aryl sulfonic acids. Sulfonic acids are very important in pharmaceutical R&D employed both as counter-ions in the formation of acid-addition salts and also as reagents and catalysts in the synthesis of new drug substances. The article reviews the evolution of analytical methodology from early studies in the mid 1970s through development of direct injection GC and HPLC methods to liquid-liquid/solid phase extraction and headspace based techniques coupled to HPLC and GC methodologies employing UV and MS detection to new derivatisation-based techniques. The paper also reflects on the significant challenges in developing robust analytical methodology capable of the trace determination of sulfonate esters, the challenges in transferring methodology from R&D to QC labs and on the cost of inappropriate limits for genotox impurities. In so doing, the authors seek to inform the debate that the control of genotoxic impurities should be driven primarily by safety and risk/benefit considerations rather than by state-of-the-art analytical and process chemistry capabilities that drive controls to levels 'as low as practicable' regardless of the risk/safety requirements.

Published
2008

46. Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Author

Habre, Walid, primary, Disma, Nicola, additional, Virag, Katalin, additional, Becke, Karin, additional, Hansen, Tom G, additional, Jöhr, Martin, additional, Leva, Brigitte, additional, Morton, Neil S, additional, Vermeulen, Petronella M, additional, Zielinska, Marzena, additional, Boda, Krisztina, additional, Veyckemans, Francis, additional, Klimscha, Walter, additional, Konecny, Regina, additional, Luntzer, Robert, additional, Morawk-Wintersperger, Ulrike, additional, Neiger, Franz, additional, Rustemeyer, Lydia, additional, Breschan, Christian, additional, Frey, Denise, additional, Platzer, Manuela, additional, Germann, Reinhard, additional, Oeding, Joachim, additional, Stoegermüller, Birgit, additional, Ziegler, Bernhard, additional, Brotatsch, Philipp, additional, Gutmann, Anton, additional, Mausser, Gerlinde, additional, Messerer, Brigitte, additional, Toller, Wolfgang, additional, Vittinghoff, Maria, additional, Zangl, Gregor, additional, Seidel-Ahyai, Natascha, additional, Hochhold, Christoph, additional, Kroess, Ruth, additional, Paal, Peter, additional, Cnudde, Steven, additional, Coucke, Patricia, additional, Loveniers, Birgit, additional, Mitchell, John, additional, Kahn, David, additional, Pirotte, Thierry, additional, Pregardien, Caroline, additional, Coppens, Marc, additional, De Hert, Stefan, additional, Heyse, Björn, additional, Neckebroek, Martine, additional, Parashchanka, Aliaksandra, additional, Van Limmen, Jurgen, additional, Van Den Eynde, Nancy, additional, Vanpeteghem, Caroline, additional, Wyffels, Piet, additional, Lalot, Michaël, additional, Lechat, Jean-Paul, additional, Stevens, France, additional, Casaer, Sari, additional, De Groote, Françoise, additional, De Pooter, Françoise, additional, De Villé, Andrée, additional, Gerin, Marc, additional, Magasich, Natalia, additional, Sanchez Torres, Cristel, additional, Van Deenen, Denise, additional, Berghmans, Johan, additional, Himpe, Dirk, additional, Roofthooft, Eva, additional, Joukes, Ellen, additional, Smitz, Carine, additional, Van Reeth, Veronique, additional, Huygens, Christel, additional, Lauweryns, Julie, additional, De Smet, Karen, additional, Najafi, Nadia, additional, Poelaert, Jan, additional, Van de Velde, Anne, additional, Van Mossevelde, Veerle, additional, Bekavac, Ivan, additional, Butkovic, Diana, additional, Heli Litvic, Dubravka, additional, Kerovec Soric, Ivana, additional, Maretic, Hrvoje, additional, Moscatello, Djurdjica, additional, Popovic, Ljiljana, additional, Micici, Slobodan, additional, Stuck Tus, Ivana, additional, Kalagac Fabris, Lada, additional, Simurina, Tatjana, additional, Sulen, Nina, additional, Kesic-Valpotic, Gordana, additional, Djapic, Dajana, additional, Žurek, Jirí, additional, Jureckova, Lucie, additional, Mackova, Iveta, additional, Skacel, Monika, additional, Weinlichova, Stanislava, additional, Divák, Jan, additional, Frelich, Michal, additional, Urbanec, René, additional, Biskupova, Vera, additional, Mixa, Vladimir, additional, Pavlickova, Jana, additional, Afshari, Arash, additional, Bøttger, Morten, additional, Ellekvist, Marguerite B., additional, Johansen, Mathias, additional, Ingeborg Madsen, Birgitte, additional, Christian Nilsson, Jens, additional, Schousboe, Birgitte MB, additional, Clausen, Nicola G., additional, Hansen, Tom G., additional, Phaff Steen, Nick, additional, Ilmoja, Mari-Liis, additional, Tonise, Virge, additional, Karjagin, Juri, additional, Kikas, Reet, additional, Isohanni, Mika, additional, Lyly, Anniina, additional, Takala, Annika, additional, Happo, Johanna, additional, Kiviluoma, Kai, additional, Martikainen, Kati, additional, Aantaa, Riku, additional, Manner, Tuula, additional, Vilo, Sanna, additional, Amory, Catherine, additional, Ludot, Hugues, additional, Lambotte, Patricia, additional, Busche, René, additional, Jacqmarcq, Olivier, additional, Lejus, Corinne, additional, Corouge, Julien, additional, Erb, Christian, additional, Garrigue, Delphine, additional, Gillet, Patricia, additional, Laffargue, Anne, additional, Lambelin, Veronique, additional, Le Freche, Hélène, additional, Peresbota, Daliana, additional, Richart, Pierre, additional, Berton, Jerome, additional, Chapotte, Catherine, additional, Colbus, Laurent, additional, Lehousse, Thierry, additional, Monrigal, Jean, additional, Baujard, Catherine, additional, Roulleau, Philippe, additional, Staiti, Giuseppe, additional, Batoz, Hélène, additional, Bordes, Maryline, additional, Didier, Anne, additional, Hamonic, Yann, additional, Lagarde, Sylvaine, additional, Nouette-Gaulain, Karine, additional, Semjen, François, additional, Zaghet, Brigitte, additional, Dekens, Jacky, additional, Delcuze, Axelle, additional, Dupont, Hervé, additional, Legrand, Aurélien, additional, Raffoflandreur, Celine, additional, Audren, Noémie, additional, Camus, Blandine, additional, Cartal, Marielle, additional, Chazelet, Chantal, additional, Davin, Isabelle, additional, Guillier, Marion, additional, Desjeux, Luc, additional, Larcher, Claire, additional, Grein, Elodie, additional, Leclercq, Mickeal, additional, Levitchi, Roxana, additional, Rosu, Lilica, additional, Simon, Dominique, additional, Zang, Aurélien, additional, Migeon, Anne, additional, Gagey, Anne-Charlotte, additional, Bourdaud, Nathalie, additional, Carre, Anne-Charlotte, additional, Duflo, Frédéric, additional, Riche, Jean-Claude, additional, Robert, Philippe, additional, Druot, Emilie, additional, Maupain, Olivier, additional, Orliaguet, Gilles, additional, Sabau, Lucie, additional, Taright, Hanna, additional, Uhrig, Lynn, additional, Verchere-Montmayeur, Juliette, additional, Debrabant, Lise, additional, Pilla, Clotaire, additional, Podvin, Alexandre, additional, Roth, Benjamin, additional, Dahmani, Souhayl, additional, Julien-Marsollier, Florence, additional, Sabourdin, Nada, additional, Alexandri, Bogdan, additional, Brezac, Gilles, additional, de la Brière, Francois, additional, Hayem, Catherine, additional, Lhubat, Elizabeth, additional, Paul Mission, Jean, additional, Rémond, Charlotte, additional, Dadure, Christophe, additional, Maniora, Maud, additional, Marie, Anais, additional, Pirat, Philippe, additional, Saour, Anne-Charlotte, additional, Sola, Chrystelle, additional, Ecoffey, Claude, additional, Wodey, Eric, additional, Adam, Christian, additional, Standl, Thomas, additional, Schindler, Ehrenfried, additional, Yamamoto, Tomohiro, additional, Brackhahn, Michael, additional, Eich, Christoph Bernhard, additional, Guericke, Holger, additional, Kindermann, Petra, additional, Laschat, Michael, additional, Schink, Cornel, additional, Wappler, Frank, additional, Hoehne, Claudia, additional, Skordou, Natalia, additional, Ulrici, Johanna, additional, Jetzek-Zader, Martin, additional, Kienbaum, Peter, additional, Meyer-Treschan, Tanja, additional, Picker, Olaf, additional, Schaefer, Maximilian S., additional, Mielke, Golo, additional, Baethge, Sabine, additional, Ramminger, Axel, additional, Bauer, Martin, additional, Bollinger, Matthias, additional, Hinz, José, additional, Quintel, Michael, additional, Russo, Sebastian G., additional, Bauer, Michael, additional, Geil, Dfominik, additional, Kortgen, Andreas, additional, Preussler, Niels-Peter, additional, Hofmann, Ulrich, additional, Raber, Manfred, additional, Reindl, Doris, additional, Oppenrieder, Karin, additional, Schierlinger, Bettina, additional, Roth, Jens, additional, Funk, Wolfgang, additional, Fischer, Thomas, additional, Gernoth, Christian, additional, Wiefelspütz, Christina, additional, Volger, Hauke, additional, Zederer, Nicole, additional, Diers, Anja, additional, Huber, Matthias, additional, Schorer, Clemens, additional, Weyland, Andreas, additional, Schwarzkopf, Konrad, additional, Grau, Catharina, additional, Roth, Winfried, additional, Holy, Rolf, additional, Mader, Thomas, additional, Peter, Laura, additional, Supthut, Hauke, additional, Kuehhirt, Thomas, additional, Milde, Alexander, additional, Fiedler, Fritz, additional, Isselhorst, Carsten, additional, Grundmann, Ulrich, additional, Pattar, Alexander, additional, Reinert, Jennifer, additional, Ehm, Birgit, additional, Fritzsche, Katrin, additional, Gaebler, Ralf, additional, Meybohm, Patrick, additional, Hein, Maximilian, additional, Guzman, Ines, additional, Jokinen, Johanna, additional, Kranke, Peter, additional, Goebel, Ulrich, additional, Harris, Sarah, additional, Eisner, Christoph, additional, Ochsenreiter, Miriam, additional, Schoeler, Michael, additional, Thil, Elke, additional, Ellerkmann, Richard, additional, Hoeft, Andreas, additional, Neumann, Claudia, additional, Weber, Stefan, additional, Keilhauer, Julia, additional, Kloessing, Jan, additional, Schramm, Michael, additional, Trieschmann, Uwe, additional, Knauss, Kristina, additional, Sinner, Barbara, additional, Steinmann, Johannes, additional, Koessler, Herbert, additional, Kalliardou, Evagelia, additional, Malisiova, Anna, additional, Tsiotou, Adelais, additional, Chloropoulou, Pelagia, additional, Chrysi, Mpratzou, additional, Iordanidou, Despoina, additional, Ntavlis, Merkourios, additional, Boda, Krisztina B, additional, Guerin, Christilynn, additional, Irwin, Janice, additional, Magner, Claire, additional, Nakhjavani, Solmaz, additional, O'Hare, Brendan, additional, Galvin, Deborah, additional, Jamil, Yosry, additional, Lesmes, Carlos, additional, Barak, Yuri, additional, Fisher, Haran, additional, Kachko, Ludmyla, additional, Katz, Jacob, additional, Kirilov, Dmitry, additional, Levinzon, Michael, additional, Manevich, Yair, additional, Nekrasov, Konstantin, additional, Peled, Elia, additional, Sanko, Elena, additional, Schmain, Dmitri, additional, Sheinkin, Olga, additional, Simhi, Eliahu, additional, Tarabikin, Alex, additional, Trabkin, Evelina, additional, Yagudaev, Irena, additional, Zeitlin, Yelena, additional, Zunser, Igor, additional, Cerutti, Elisabetta, additional, Maddalena Schellino, Maria, additional, Valzan, Silvia, additional, Lucia Pinciroli, Rosa, additional, Bortone, Luciano, additional, Cerati, Giorgia, additional, Salici, Fabiana, additional, Bussolin, Leonardo, additional, Rizzo, Giuliana, additional, Rossetti, Francesca, additional, Marchesini, Laura, additional, Tesoro, Simonetta, additional, De Lorenzo, Brita, additional, Guarracino, Fabio, additional, Kuppers, Beate, additional, Astuto, Marinella, additional, Pitino, Sofia, additional, Scalisi, Rita, additional, Scordo, Lucia, additional, D'Alessandro, Sandra, additional, Dei Giudici, Luigi, additional, Farinelli, Ivano, additional, Lofino, Giuseppe, additional, Marchetti, Giuliano, additional, Giuseppe Picardo, Sergio, additional, Reali, Simone, additional, Vittori, Alessandro, additional, Antonio Idone, Francesco, additional, Sammartino, Maria, additional, Sbaraglia, Fabio, additional, Barbera, Cinzia, additional, Bevilacqua, Michela, additional, Cento, Valeria, additional, Kotzeva, Svetlana, additional, Mameli, Leila, additional, Montobbio, Giovanni, additional, Passariello, Leandro, additional, Punzo, Cinzia, additional, Sileo, Rosanna, additional, Viacava, Rosanna, additional, Volpe, Claudia, additional, Zanaboni, Clelia, additional, Calderini, Edoardo, additional, Genco, Daniele, additional, Neri, Simona, additional, Ottolina, Davide, additional, Camporesi, Anna, additional, Izzo, Francesca, additional, Salvo, Ida, additional, Wolfler, Andrea, additional, Sanna, Andrea, additional, Sciascia, Angela, additional, Stoia, Paolo, additional, Guddo, Annamaria, additional, Lapi, Maria, additional, Ivani, Giorgio, additional, Longobardo, Annalisa, additional, Mossetti, Valeria, additional, Pedrotti, Dino, additional, Grazzini, Maurizia, additional, Meneghini, Luisa, additional, Metrangolo, Salvatore, additional, Michelon, Stefania, additional, Minardi, Carmelo, additional, Tognon, Costanza, additional, Zadra, Nicola, additional, Busi, Ilaria, additional, Khotcholava, Magda, additional, Guido Locatelli, Bruno, additional, Sonzogni, Valter, additional, Starita, Giusi, additional, Almenrader, Nicole, additional, Aurilio, Caterina, additional, Sansone, Pasquale, additional, Albarello, Raffaella, additional, Bracci, Paolo, additional, Cecini, Mariateresa, additional, Cristina Mondardini, Maria, additional, Pasini, Lorena, additional, Vason, Milo, additional, Zani, Gianluca, additional, Zoppellari, Roberto, additional, Pistidda, Laura, additional, Cortegiani, Andrea, additional, Maurizio Raineri, Santi, additional, Hasani, Antigona, additional, Hashimi, Medita, additional, Ancupans, Agris, additional, Barzdina, Arta, additional, Straume, Zane, additional, Zundane, Anda, additional, Chlopin, Mikhail, additional, Gestautaite, Dalia, additional, Lukosiene, Laura, additional, Paliokaite, Evelina, additional, Razlevice, Ilona, additional, Armoniene, Inesa, additional, Bernotiene, Aurelija, additional, Daugelavicius, Vidunas, additional, Dockiene, Ilona, additional, Gaidelyte, Lina, additional, Saviciene, Nijole, additional, Krikstaponiene, Jolita, additional, Sidlovskaite-Baltake, Dominika, additional, Stasevski, Vladyslav, additional, Vaitoskaite, Agne, additional, Gatt, David, additional, Mifsud, Stephanie, additional, Zammit, Simone, additional, Allison, Celia, additional, Aslami, Hamid, additional, Eberl, Susanne, additional, van Stijn, Mireille F M, additional, Stevens, Markus F, additional, Punt, Kees, additional, van Osch, Rob, additional, Bauwman, Arthur, additional, Scholten, Harm, additional, Svircevic, Vesna, additional, Adriaens, Veronique, additional, Dirckx, Maaike, additional, Dogger, Jaap, additional, Dons-Sinke, Ilse, additional, Machotta, Andreas, additional, Moors, Xavier, additional, Rad, Mandana, additional, Staals, Lonneke, additional, van der Knijff - van Dortmont, Anouk, additional, van der Marel, Caroline, additional, Sieben, Anne, additional, van der Zwan, Tim, additional, Veldhuizen, Marianne, additional, Alders, David, additional, Buhre, Wolfgang, additional, Engel, Nicole, additional, Vossen, Carine, additional, Mahadewsing, Ravin, additional, Meijer, Patrick, additional, Gerling, Volker, additional, van der Schatte Olivier, Roelof, additional, van Doorn, Thea, additional, Vons Mark Hendriks, Kristy, additional, Lako, Sandra, additional, jan Scheffer, Gert, additional, Tielens, Luc, additional, Voet, Marieke, additional, Absalom, Anthony, additional, Bergsma, Margot, additional, Spanjer, Vera, additional, Spanjersberg, Rob, additional, van de Riet, Yvette, additional, Volkers, Martin, additional, de Graaff, Jurgen C., additional, Hopman, Geranne A.J., additional, Kappen, Teus H., additional, Hannie, J., additional, Megens, A.M., additional, Numan, Sandra C., additional, Schouten, Anton N.J., additional, Turner, Nigel M., additional, Van Der Werff, Désirée B.M., additional, Wensing, Renee T.M., additional, Ephraim, Erik, additional, Nolte, Claire, additional, Reikvam, Tore, additional, Fredrik Lund, Ole, additional, Skaaden, Lene, additional, Marthe Ballovarre, Kari, additional, Bakken Boerke, Wenche, additional, Grindheim, Guro, additional, Lindenskov, Pal H H, additional, Beate Solas, Anne, additional, Sponheim, Sjur, additional, Ullensvang, Kyrre, additional, Viken, Oddbjorn, additional, Marie Drage, Inger, additional, Gymoese Berthelsen, Kasper, additional, Anders Kroken, Bjørn, additional, Bergland, Unni, additional, Pryzmont, Miroslaw, additional, Talalaj, Mariola, additional, Wasiluk, Malgorzata, additional, Zalewska, Dorota, additional, Damps, Maria, additional, Siemek-Mitela, Jadzia, additional, Wieczorek, Pawel, additional, Juzwa, Magdalena, additional, Rosada-Kurasinska, Jowita, additional, Bartkowska-Sniatkowska, Alicja, additional, Cettler, Maciej, additional, Kopycinska, Renata, additional, Rudewicz, Iwona, additional, Sobczyk, Jaek, additional, Wojciechowski, Dariusz, additional, Baranowski, Artur, additional, Basiewicz, Ewa, additional, Mierzewska-Schmidt, Magdalena, additional, Retka, Wlodzimierz, additional, Sawicki, Piotr, additional, Checinska, Magdalena, additional, Zurawska, Magdalena, additional, Leal, Teresa, additional, Mascarenhas, Catia, additional, Pedro Pina, António, additional, Joao Susano, Maria, additional, Moniz, Antonio, additional, Teresa Rocha, Maria, additional, Calvao Santos, Carolina, additional, Domingas Patuleia, M, additional, Pereira, Ricardo, additional, Roxo, Helena, additional, Amaral, Rosa, additional, Guedes, Isabel, additional, Gomes, Cristina, additional, Gonçalves, Marta, additional, Salgado, Helena, additional, Santos, Maria, additional, Rodrigues, Sara, additional, Sa, Angela, additional, Machado, Elvira, additional, Pé d'Arca, Sandra, additional, Seabra, Manuel, additional, Mihaela Gheorghe, Ligia, additional, Ivascu, Constantin, additional, Moraru-Draghici, Lucia, additional, Suvejan, Mirela, additional, Babici, Remus, additional, Eniko, Kovacs, additional, Hogea, Cristiana, additional, Mihaela, Dubau, additional, Nicoleta, Daraban, additional, Barbunc, Danut, additional, Maria Nistor, Alina, additional, Stefan, Violeta, additional, Catalina Ionescu, Gabriela, additional, Davidescu, Irina, additional, Teodora Nastase, Alina, additional, Dumitru Rusu, Florin, additional, Badarau, Victoria, additional, Cindea, Iulia, additional, Moscaliuc, Melania, additional, Olteanu, Dana, additional, Petrescu, Luxita, additional, Ceuca, Daniela, additional, Galinescu, Irena, additional, Badeti, Rodica, additional, Capusan, Alin, additional, Cucui-Cozma, Cosmina, additional, Popescu, Barbura, additional, Cimpeanu, Luminita, additional, Birliba, Mihaela-Petronela, additional, Miulescu, Magdalena, additional, Balamat, Stefania, additional, Gurita, Adriana, additional, Ilie, Luminita, additional, Mocioiu, Gabriel, additional, Pick, Darina, additional, Sirghie, Rodica, additional, Tabacaru, Radu, additional, Trante, Irinel, additional, Horhota, Lucian, additional, Bandrabur, Daniela, additional, Ciobanu, Tudor, additional, Cuciuc, Veaceslav, additional, Munteanu, Valentin, additional, Olaru, Valentin, additional, Paiu, Corneliu, additional, Savu, Anca, additional, Trifan, Oana, additional, Elena Malos, Anca, additional, Glazunov, Anton, additional, Ivanov, Alexander, additional, Poduskov, Evgeny, additional, Popov, Alexander, additional, Guskov, Igor, additional, Lugovoy, Alexander, additional, Nechaev, Vladislav, additional, Ovezov, Alexey, additional, Basov, Mikhail, additional, Kochkin, Vladimir, additional, Lazarev, Vladimir, additional, Chizhov, Dmitri, additional, Ostreikov, Ivan, additional, Tolasov, Konstantin, additional, Budic, Ivana, additional, Marjanovic, Vesna, additional, Draskovic, Biljana, additional, Pandurov, Marina, additional, Simin, Jovana, additional, Dolinaj, Vladimir, additional, Janjevic, Dusanka, additional, Mandras, Ana, additional, Mircetic, Maja, additional, Petrovic, Sladjana, additional, Rebac, Vlatka, additional, Slavkovic, Bojana, additional, Stevanovic, Vesna, additional, Velcev, Ana, additional, Knezevic, Mirjana, additional, Milojevic, Irina, additional, Puric, Selena, additional, Simic, Irena, additional, Stevic, Marija, additional, Stranjanac, Vladimir, additional, Simic, Dusica, additional, Cabanova, Barbora, additional, Hanula, Miloslav, additional, Grynyuk, Andry, additional, Berger, Jelena, additional, Cerne, Uros, additional, Nastran, Andraz, additional, Pirc, Dejan, additional, Popic, Rok, additional, Stupnik, Spela, additional, Rubio, Paloma, additional, del Río, Cristina, additional, Benito, Pilar, additional, Pino, Gema, additional, Gutierrez, Ignacio, additional, Gutierrez Valcarcel, Andrea, additional, León Carsi, Irene, additional, Perez Garcia, Anibal, additional, López Galera, Sílvia, additional, Marco Valls, Joan, additional, Ricol Lainez, Laura, additional, Vallejo Tarrat, Andrea, additional, Artes, David, additional, Banus, Ester, additional, Chirichiello, Luca, additional, De Abreu, Leidy, additional, De Josemaria, Belen, additional, Helena Gaitan, M, additional, Garces, Antonio, additional, Lazaro, Juan J, additional, Manen Berga, Ferran, additional, Molies, Dolors, additional, Monclus, Enric, additional, Navaro, Montserrat, additional, Pamies, Carmen, additional, Perelló, Marina, additional, Prat, Mar, additional, Ribo, Laura, additional, Angeles Sanz, M, additional, Serrano, Silvia, additional, Sola Ruiz, Eva, additional, Anuncia Escontrela Rodríguez, Blanca, additional, Maria Gago Martinez, Andrea, additional, Martínez Ruiz, Alberto, additional, De La Cruz Benito, Fausto, additional, Gabilondo Garcia, Gustavo, additional, Martinez Maldonado, Ever, additional, Noriega, Bryant, additional, Oller Duque, Lara, additional, Olmos Mendez, Alberto, additional, Perez- Ferrer, Antonio, additional, Reinoso Barbero, Francisco, additional, Acevedo Bambaren, Ismael, additional, Domínguez, Fernando, additional, Franco, Teresa, additional, Jiménez, Anabel, additional, Melero, Alicia, additional, Feliu, 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additional, Vodianytskyi, Sergii, additional, Boryshkevych, Ivanna, additional, Kyselova, Iryna, additional, Trikash, Nikolay, additional, Albokrinov, Andrew, additional, Perova-Sharonova, Valentina, additional, Sklyar, Vitaliy, additional, Surkov, Denis, additional, Abdelaal, Amr, additional, Barber, Nicola, additional, Checuti, Sarah, additional, Godsiff, Leisha, additional, Johanne, Lynch, additional, Simpson, Joanna, additional, Underhill, Helen, additional, Diwan, Rishi, additional, Kelgeri, Nivedita, additional, Masip, Nuria, additional, Ravi, Radha, additional, Roberts, Steve, additional, Cillis, Annagrazia, additional, Marcus, Ritchie, additional, Merella, Federica, additional, Love, David, additional, Baraggia, Paolo, additional, Bird, Victoria, additional, Hussey, Joseph, additional, Alderson, Peter, additional, Bartholomew, Karen, additional, Moncreiff, Michael, additional, Davidson, Sarah, additional, Hare, Alison, additional, Kotecha, Ami, additional, Lee, Corina, additional, Liyanage, Ganga, additional, Patel, Shivali, additional, Samani, Amee, additional, Abou-Samra, Mark, additional, Boyd, Matthew, additional, Hullatt, Laurence, additional, Levy, David, additional, Pauling, Mark, additional, Sharman, Sarah-Jane, additional, Smith, Natalie, additional, Rutherford, John, additional, Cavalier, Alison, additional, Locke, Christie, additional, Sage, Frederic, additional, Bapat, Smita, additional, Hammerschlag, Jacinda, additional, Ioannou, Ioannis, additional, King, Stephanie, additional, Pegg, Rachel, additional, Salota, Vishal, additional, Sketcher, Jonathan, additional, Thadsad, Muthu, additional, Zeitlin, Deborah, additional, Jack, Ewan, additional, Lang, Colin, additional, Ahmed, Samira, additional, Ayyash, Reema, additional, Bari, Francoise, additional, Bell, Sarah J, additional, Elizabeth Biercamp, Claire, additional, Briggs, Sandra, additional, Gabriella Elena Clement, Maria, additional, Dalton, Mark, additional, Ali Eissa Eid, Mohamed, additional, Gandhi, Monica, additional, Harmen Herrema, Idse, additional, Khaffaf, Ranj, additional, Jeng Min Law, Savio, additional, McClintock, Joanna, additional, Ireland, Nicholas, additional, Majid Saleem, Mohammed, additional, Smith, Fiona, additional, Cohen, Marc, additional, Lee, Clover-Ann, additional, O'Donahue, Lizanne, additional, Powell, Alex, additional, Rawlinson, Ellen, additional, Snoek, Aarjan, additional, Weiss, Katja, additional, Wellesley, Hugo, additional, Crawford, Michael, additional, Abdel-Hafiz, Mostafa, additional, Day, Alexandra, additional, Rajamani, Balaji, additional, Saha, Rita, additional, Wright, Dave, additional, Chee, Lew-Chin, additional, Bew, Stephanie, additional, Homer, Rachel, additional, Malarkkan, Nalini, additional, Wolfe Barry, Juliet, additional, Angadi, Pradeep, additional, Cagney, Brid, additional, De Melo, Eric, additional, Dekker, Elsa, additional, Helm, Emma, additional, Jones, Gareth, additional, Peiris, Kawshala, additional, Russell, William, additional, Slater, Patricia, additional, Sodhi, Puja, additional, Browning, Mike, additional, Phillips, Trudie, additional, Van Hecke, Rachel, additional, Muir, Vimty, additional, Singh, Piyush, additional, Soskova, Tereza, additional, Cumming, Craig, additional, Farquharson, Pamela, additional, Pearson, Karen, additional, Shaw, Neil, additional, Whiteside, Jonathan, additional, Whyte, Emma, additional, Byers, Gordon, additional, Davies, Kay, additional, Engelhardt, Thomas, additional, Faliszewski, Isabella, additional, Johnston, Graham, additional, Kaufmann, Nils, additional, Kusnirikova, Zuzana, additional, Wilson, Graham, additional, Carachi, Peter, additional, Makin, Andrew, additional, Foster, Brian, additional, Lipczynski, Dariusz, additional, Mawer, Rebecca, additional, Rutherford, William, additional, Rogerson, David, additional, Rushman, Sarah, additional, Taylor, Christopher, additional, Tomlinson, William, additional, Dix, Philippa, additional, Woodward, Tom, additional, Bell, Graham, additional, Boyle, David, additional, Cloherty, Marianne, additional, Cullen, Julia, additional, Cullen, Pauline, additional, Fairgrieve, Ross, additional, Ghent, Robert, additional, Glasgow, Russell, additional, Gordeeva, Elena, additional, Harden, Alison, additional, Hivey, Sarah, additional, Jerome, Kevin, additional, McKee, Lesley, additional, Morton, Neil, additional, Pribul, Vicky, additional, Sinclair, John, additional, Steiner, Maria, additional, Steward, Heather, additional, Sweeney, Lorraine, additional, Thomson, Wendy, additional, Whiteside, Jeanette, additional, Dalton, Andrew, additional, Ross, Mark, additional, Smith, Carolyn, additional, Allen, Claire, additional, Anders, Nicola, additional, Barlow, Victoria, additional, Bassett, Mike, additional, Darwin, Leanne, additional, Davison, Rachel, additional, Diacono, Jacques, additional, Hobbs, Amy, additional, Hutchinson, Adel, additional, Lomas, Bernadette, additional, Lonsdale, Hannah, additional, Nasser, Leila, additional, Oshan, Vimmi, additional, Patel, Pradip, additional, Raistrick, Christopher, additional, Scott-Warren, Victoria, additional, Talbot, Laura, additional, Wai, Carolynn, additional, Childs, Sophie, additional, Dickinson, Matthew, additional, Bloomfield, Tom, additional, Garrioch, Sweyn, additional, Watson, Karen, additional, Gaynor, James, additional, Harrison, Richard, additional, Lee, Juliette, additional, Blythe, Elizabeth, additional, Dorman, Teresa, additional, Eissa, Ayman, additional, Ellwood, James, additional, Gooch, Ingrid, additional, Hearn, Robert, additional, Hodgetts, Vanessa, additional, John, Robert, additional, Kirton, Christine, additional, Ladak, Nadia, additional, Morgan, Judith, additional, Plant, Nina, additional, Shepherd, Elizabeth, additional, Short, Judith, additional, Stack, Charles, additional, Steel, Simon, additional, Taylor, Matthew, additional, Thomas, Deborah, additional, Wilson, Catharine, additional, Wilson-Smith, Elaine, additional, Bradbury, Carol L., additional, Hussain, Nageena, additional, Mayell, Antonia, additional, Mesbah, Ahmed, additional, Qureshi, Arif, additional, Vaidyanath, Chandra, additional, Geary, Tim, additional, Hawksworth, Chris, additional, Parasuraman, Tamaraichelvi, additional, Perry, Nicole, additional, Banerjee, Indrani, additional, Barr, Katharine, additional, Butler, Patrick, additional, Davies, Jack, additional, Flewin, Lisa, additional, Gande, Richard, additional, Montague, James, additional, Plumb, James, additional, Pratt, Thomas, additional, Sutherland, Paul, additional, Vail, Hannah, additional, Wilkins, Andrew, additional, Hunter, Catherine, additional, Russell, Susan, additional, Thomas, Alun, additional, Mifsud, Mark, additional, Strachan, Dominic, additional, Plichon, Benoit, additional, and Harlet, Pierre, additional

Published
2017
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47. A generic approach for the determination of residues of alkylating agents in active pharmaceutical ingredients by in situ derivatization–headspace–gas chromatography–mass spectrometry

Author

Andrew M. Lipczynski, Roberto Alzaga, Karen Taylor-Worth, Robert W. Ryan, Roman Szucs, and Pat Sandra

Subjects
Alkylating Agents, Analyte, Chromatography, Molecular Structure, Chemistry, Clinical Biochemistry, Pharmaceutical Science, Reference Standards, Mass spectrometry, Sensitivity and Specificity, Gas Chromatography-Mass Spectrometry, Dosage form, Analytical Chemistry, chemistry.chemical_compound, Pharmaceutical Preparations, Drug Discovery, Solvents, Analytical procedures, Gas chromatography, Gas chromatography–mass spectrometry, Drug Contamination, Derivatization, Quantitative analysis (chemistry), Spectroscopy
Abstract

A simple, reliable and fast procedure for the simultaneous determination of residues of some common alkylating agents (AAs), such as mesylates, besylates, tosylates and sulfates, employed in drug synthesis, has been developed by in situ derivatization-headspace-gas chromatography-mass spectrometry. Pentafluorothiophenol is used as a derivatizing agent in different water/dimethyl sulfoxide ratios. Compared to former analytical procedures, this approach returns improvements in analysis time, selectivity, analyte stability and method sensitivity (LOD=0.11 microgg(-1) for methyl tosylate). The method exhibits low matrix dependence, excellent accuracy, precision (R.S.D.=2.8-10% range at 1 microgg(-1)) and robustness through the use of deuterated internal standards. Knowledge of the synthetic route allows a targeted approach to the determination of specific AAs since the procedure does not distinguish between acid species. The procedure was successfully applied to different pharmaceutical matrixes, and is particularly suitable for routine analysis with high sample throughput.

Published
2007

48. Preparation and characteristics of polypropylene composites

Author

Jerzy Lipczynski and Zdzislawa Majchrzak

Subjects
Polypropylene, chemistry.chemical_classification, Materials science, Polymers and Plastics, Magnesium, General Chemical Engineering, chemistry.chemical_element, Polymer, engineering.material, Catalysis, chemistry.chemical_compound, chemistry, Polymerization, Filler (materials), Ultimate tensile strength, Materials Chemistry, engineering, Copolymer, Composite material
Abstract

Polypropylene and propylene/ethylene copolymers filled with modified or unmodified mineral fillers were obtained using two methods. In the first one the fillers were introduced in the polymerization process carried out in the presence of TiCl 4 /AIEt 3 catalyst on magnesium support. The other method consisted in mixing of the filler with a polymer and further melting of the whole system. The effects of the type and amount of the filler on the activity of catalytic system (reaction rate) were determined (Fig. 1,2). The dependences of density and tensile properties of the composites obtained on the method of preparation were investigated (Table 1 and 2). The results show the polymers prepared by melt blending of the polymers with the fillers, both modified and unmodified, show good mechanical properties. What concerns the composites prepared in the polymerization step, only in the case of use of unmodified bentonite the polymer obtained showed good strength properties and lack of catalytic system deactivation. However, organophilized fillers containing polar groups cause decrease in catalyst activity during the polymerization as well as deterioration of mechanical properties of the product.

Published
2007

49. Low-power photovoltaic demonstration system with a supercapacitor intermediary stage

Author

Lukasz Starzak and Rafal Lipczynski

Subjects
Battery (electricity), Supercapacitor, Engineering, Battery charger, business.industry, Photovoltaics, Photovoltaic system, Electrical engineering, business, Energy storage, Maximum power point tracking, Power (physics)
Abstract

A low-power photovoltaic system has been designed where energy storage is performed in two stages: a standard final one based on a battery, and an intermediary one based on supercapacitors. A prototype of the system, including a simple maximum power point tracker and a battery charger, has been realised and tested. Measurements have shown that considerable additional energy can be obtained using this approach. It will prove especially useful in climatic zones where insolation shows considerable variations within short time intervals. The circuit has been sized for a single low-power photovoltaic module which makes it suitable for investigation by students in a photovoltaics lab.

Published
2015

50. Sex reversal syndrome (64,XY; SRY-positive) in a mare demonstrating masculine behaviour

Author

Izabela Szczerbal, A. Lipczynski, Marek Switonski, Agata Chmurzynska, A. Nowicka‐Posłuszna, and Fengtang Yang

Subjects
Infertility, X Chromosome, Chromosome Disorders, Biology, Sexual Behavior, Animal, Food Animals, medicine, Animals, Testosterone, Horses, Genes, sry, X chromosome, Chromosome Aberrations, Genetics, Testicular feminization, Chromosome, Genitalia, Female, Sequence Analysis, DNA, General Medicine, Sex reversal, medicine.disease, Testis determining factor, Cytogenetic Analysis, Female, Horse Diseases, Animal Science and Zoology, Androgen insensitivity syndrome
Abstract

Summary A 5-year-old Thoroughbred mare was subjected to cytogenetic and molecular analysis because of infertility and masculine behaviour. Chromosome studies, including painting with the whole X chromosome specific probe, revealed a male chromosome complement (64,XY). The PCR amplification of the SRY and ZFY genes showed the presence of both those genes, while the endocrinological study demonstrated a high level of testosterone (9.7 nmol/l). Sequencing of the SRY gene (1121 bp), comprising also 5′- and 3′-UTRs, did not reveal any differences when compared with the sequence of normal stallions. It was proposed that this mare represents the androgen insensitivity syndrome (testicular feminization syndrome).

Published
2005

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